LU85366A1 - Methods immunologiques de determination de l'activite metastatique de cellules - Google Patents

Methods immunologiques de determination de l'activite metastatique de cellules Download PDF

Info

Publication number
LU85366A1
LU85366A1 LU85366A LU85366A LU85366A1 LU 85366 A1 LU85366 A1 LU 85366A1 LU 85366 A LU85366 A LU 85366A LU 85366 A LU85366 A LU 85366A LU 85366 A1 LU85366 A1 LU 85366A1
Authority
LU
Luxembourg
Prior art keywords
type
collagenase
enzyme
antibody
antigen
Prior art date
Application number
LU85366A
Other languages
English (en)
French (fr)
Inventor
Karl Tryggvason
Lance Allen Liotta
Original Assignee
Karl Tryggvason
Liotta Lance A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Tryggvason, Liotta Lance A filed Critical Karl Tryggvason
Publication of LU85366A1 publication Critical patent/LU85366A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
    • G01N2474/20—Immunohistochemistry assay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/813—Cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
LU85366A 1983-05-19 1984-05-17 Methods immunologiques de determination de l'activite metastatique de cellules LU85366A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/496,230 US4677058A (en) 1983-05-19 1983-05-19 Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme
US49623083 1983-05-19

Publications (1)

Publication Number Publication Date
LU85366A1 true LU85366A1 (fr) 1984-11-19

Family

ID=23971775

Family Applications (1)

Application Number Title Priority Date Filing Date
LU85366A LU85366A1 (fr) 1983-05-19 1984-05-17 Methods immunologiques de determination de l'activite metastatique de cellules

Country Status (26)

Country Link
US (1) US4677058A (no)
JP (1) JPS602187A (no)
AU (1) AU2808784A (no)
BE (1) BE899663A (no)
CA (1) CA1230052A (no)
CH (1) CH668838A5 (no)
DD (1) DD251208A5 (no)
DE (1) DE3418625A1 (no)
DK (1) DK243184A (no)
ES (1) ES8605904A1 (no)
FI (1) FI841897L (no)
FR (1) FR2546302B1 (no)
GB (1) GB2142030B (no)
HU (1) HU195004B (no)
IL (1) IL71802A0 (no)
IT (1) IT1175842B (no)
LU (1) LU85366A1 (no)
NL (1) NL8401616A (no)
NO (1) NO841993L (no)
NZ (1) NZ208108A (no)
PL (1) PL247745A1 (no)
PT (1) PT78610B (no)
RO (1) RO92427A (no)
SE (1) SE8402703L (no)
YU (1) YU86984A (no)
ZA (1) ZA843539B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294172B1 (en) 1983-08-12 2001-09-25 Dade Behring Marburg Gmbh Monoclonal antibodies with specificity for membrane-associated antigens
US4859581A (en) * 1986-03-10 1989-08-22 Board Of Regents, The University Of Texas System Endoglycosidase assay
US4923818A (en) * 1987-09-04 1990-05-08 Washington University DNA clone of human type IV collagenase
GB2209526B (en) * 1987-09-04 1992-06-03 Univ Washington Dna clone of human type iv collagenase
US4876332A (en) * 1987-10-08 1989-10-24 Regents Of The Univeristy Of Minnesota Polypeptides with type IV collagen activity
US5280106A (en) * 1988-05-20 1994-01-18 Liotta Lance A Matrix metalloproteinase peptides: role in diagnosis and therapy
US5030555A (en) * 1988-09-12 1991-07-09 University Of Florida Membrane-strip reagent serodiagnostic apparatus and method
DE3909799A1 (de) * 1989-03-24 1990-09-27 Behringwerke Ag Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung
US4992537A (en) * 1989-05-15 1991-02-12 Washington University cDNA encoding 92-kDA type IV collagenase
ES2164634T3 (es) * 1989-10-18 2002-03-01 Us Health Produccion y uso de proteina nm23-h2 humana y anticuerpos previstos a tal efecto.
WO1991011714A1 (en) * 1990-01-26 1991-08-08 The United States Of America, Represented By The Secretary, United States Department Of Commerce A method for quantitatively measuring collagenase
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5324634A (en) * 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
JP2673929B2 (ja) * 1993-04-12 1997-11-05 富士薬品工業株式会社 ヒト間質型コラゲナーゼと阻害剤との複合体の免疫学的定量法および臨床診断への応用
EP1789195B1 (en) * 2004-08-26 2010-10-27 Life Technologies Corporation Electrowetting dispensing devices and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE343949B (no) * 1966-06-02 1972-03-20 Pharmacia Ab
DE2363854C3 (de) * 1973-12-21 1980-01-03 Behringwerke Ag, 3550 Marburg Substrat zur Proteinasebestimmung sowie dessen Herstellung
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
AT392004B (de) * 1981-10-27 1991-01-10 Hybritech Inc Verfahren zur herstellung eines monoklonalen antikoerpers gegen tumor-assoziiertes antigen und dessen verwendung
US4424278A (en) * 1981-11-16 1984-01-03 Research Corporation Cancer detection procedure using an acyl carrier protein
US4443367A (en) * 1982-04-08 1984-04-17 Monsanto Company Peptide and peptolide substrates for mammalian collagenase

Also Published As

Publication number Publication date
GB2142030B (en) 1987-02-04
IT8420998A1 (it) 1985-11-18
CH668838A5 (de) 1989-01-31
GB8411959D0 (en) 1984-06-13
JPS602187A (ja) 1985-01-08
FI841897A0 (fi) 1984-05-11
ES8605904A1 (es) 1986-04-01
DK243184D0 (da) 1984-05-17
NO841993L (no) 1984-11-20
PT78610B (en) 1986-07-15
HU195004B (en) 1988-03-28
IT8420998A0 (it) 1984-05-18
BE899663A (fr) 1984-08-31
FI841897A7 (fi) 1984-11-20
PL247745A1 (en) 1985-08-27
ZA843539B (en) 1985-07-31
DK243184A (da) 1984-11-20
FR2546302B1 (fr) 1988-03-04
RO92427A (ro) 1987-09-30
FR2546302A1 (fr) 1984-11-23
YU86984A (en) 1991-01-28
US4677058A (en) 1987-06-30
AU2808784A (en) 1984-11-22
SE8402703D0 (sv) 1984-05-18
FI841897L (fi) 1984-11-20
IL71802A0 (en) 1984-09-30
CA1230052A (en) 1987-12-08
DE3418625A1 (de) 1984-11-22
GB2142030A (en) 1985-01-09
SE8402703L (sv) 1984-11-20
NZ208108A (en) 1988-04-29
PT78610A (en) 1984-06-01
IT1175842B (it) 1987-07-15
DD251208A5 (de) 1987-11-04
ES532597A0 (es) 1986-04-01
NL8401616A (nl) 1984-12-17
HUT34261A (en) 1985-02-28

Similar Documents

Publication Publication Date Title
US4628027A (en) Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
Chang et al. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium
US20040170631A1 (en) Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
FR2596062A1 (fr) Anticorps monoclonaux et antigene du carcinome pulmonaire humain a cellules non petites et de certains autres carcinomes humains
FR2546302A1 (fr) Methodes immunologiques pour la determination de l'activite cellulaire metastasique
JPH09507754A (ja) 哺乳類悪性細胞の選択的メチオニン飢餓方法
JP2001017167A (ja) ビメンチンの切断産物に対する抗体
EP0109434A1 (en) In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
LU83015A1 (fr) Procede de detection de cellules cancereuses par des anticorps et procede de preparation de ceux-ci
DE69827223T2 (de) Antiangiogene substanz zur behandlung von krebs, arthritis und netzhauterkrankungen
US4816400A (en) Basement membrane collagen degrading enzyme and method of purifying same
JPH02497A (ja) ヒト前立腺特異性抗原に対する抗体組成物
JPH058679B2 (no)
US4808528A (en) Antibody composition for the detection of malignant cells with metastatic cell activity
EP1852442A1 (en) Antibody for assay of adamts13 activity and method of activity assay
US5296352A (en) Monoclonal antibodies directed against complexes formed by thrombin and hirudin
JPH0753757B2 (ja) モノクローナル抗体及びその使用方法
JPH08226918A (ja) 遊離の活性型マトリックスメタロプロテアーゼ類の分別定量法
EP0460016A1 (en) METASTASE-RELATED COLLAGENOLYTIC METALLOPROTEINASE.
JPH0646876A (ja) モノクローナル抗体
JP2946216B2 (ja) 新規ハイブリドーマ，モノクローナル抗体および用途
JP2026012139A (ja) 抗体及びその応用
Takada et al. Immunohistologic characterization of angiotensin converting enzyme in the human kidney using monoclonal and polyclonal antibodies
JP3124008B2 (ja) ヒト９２ｋＤａゼラチナーゼに対するモノクローナル抗体およびその利用
EP0252787A1 (fr) Polypeptides de surfaces cellulaires, isolés et purifiés, reconnus par les anticorps responsables de la pathogénie du lupus érythémateux disséminé (LED), leur méthode d'obtention et leur application au diagnostic du LED