LU87809A1 - Exopolymere extracellulaire,son procede de preparation et compositions pharmaceutiques le contenant - Google Patents

Exopolymere extracellulaire,son procede de preparation et compositions pharmaceutiques le contenant Download PDF

Info

Publication number: LU87809A1
Authority: LU; Luxembourg
Prior art keywords: exopolymer; daltons; isolated; culture medium; molecular weight
Prior art date: 1989-09-29

Application number

LU87809A

Other languages

English (en)

French (fr)

Original Assignee

Om Lab Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-29

Filing date

1990-09-19

Publication date

1991-02-18

1990-09-19 Application filed by Om Lab Sa filed Critical Om Lab Sa

1991-02-18 Publication of LU87809A1 publication Critical patent/LU87809A1/fr

Links

229920000912 exopolymer Polymers 0.000 title claims description 50
238000004519 manufacturing process Methods 0.000 title claims description 6
239000008194 pharmaceutical composition Substances 0.000 title claims description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
238000000034 method Methods 0.000 claims description 14
230000002519 immonomodulatory effect Effects 0.000 claims description 10
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
239000001963 growth medium Substances 0.000 claims description 8
244000005700 microbiome Species 0.000 claims description 8
241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 7
229940004120 bifidobacterium infantis Drugs 0.000 claims description 7
239000008103 glucose Substances 0.000 claims description 7
150000004676 glycans Chemical class 0.000 claims description 7
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 6
230000001580 bacterial effect Effects 0.000 claims description 6
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 6
229930182830 galactose Natural products 0.000 claims description 6
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229960004397 cyclophosphamide Drugs 0.000 description 7
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PPQNQXQZIWHJRB-UHFFFAOYSA-N Methylcholanthrene Chemical compound C1=CC=C2C3=CC4=CC=C(C)C(CC5)=C4C5=C3C=CC2=C1 PPQNQXQZIWHJRB-UHFFFAOYSA-N 0.000 description 3
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 3
229920006926 PFC Polymers 0.000 description 3
102100038567 Properdin Human genes 0.000 description 3
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000006140 methanolysis reaction Methods 0.000 description 2
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BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 2
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230000004083 survival effect Effects 0.000 description 2
238000005583 trifluoroacetylation reaction Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
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208000035143 Bacterial infection Diseases 0.000 description 1
102100024133 Coiled-coil domain-containing protein 50 Human genes 0.000 description 1
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102000004127 Cytokines Human genes 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
108010067770 Endopeptidase K Proteins 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
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102000007562 Serum Albumin Human genes 0.000 description 1
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VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
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241000194017 Streptococcus Species 0.000 description 1
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241000700605 Viruses Species 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
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XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
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235000019359 magnesium stearate Nutrition 0.000 description 1
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229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
235000018343 nutrient deficiency Nutrition 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000005022 packaging material Substances 0.000 description 1
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150000002972 pentoses Chemical class 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
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150000004804 polysaccharides Polymers 0.000 description 1
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239000002244 precipitate Substances 0.000 description 1
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108020001775 protein parts Proteins 0.000 description 1
238000000746 purification Methods 0.000 description 1
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239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
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239000000724 thymus hormone Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

LU87809A 1989-09-29 1990-09-19 Exopolymere extracellulaire,son procede de preparation et compositions pharmaceutiques le contenant LU87809A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH3536/89A CH679677A5 (de)	1989-09-29	1989-09-29

Publications (1)

Publication Number	Publication Date
LU87809A1 true LU87809A1 (fr)	1991-02-18

Family

ID=4258109

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU87809A LU87809A1 (fr)	1989-09-29	1990-09-19	Exopolymere extracellulaire,son procede de preparation et compositions pharmaceutiques le contenant

Country Status (37)

Country	Link
US (1)	US5114848A (de)
JP (1)	JPH03170503A (de)
KR (1)	KR910006489A (de)
AR (1)	AR242263A1 (de)
AT (1)	ATA188490A (de)
AU (1)	AU644604B2 (de)
BE (1)	BE1004569A3 (de)
BG (1)	BG60275B2 (de)
BR (1)	BR9004147A (de)
CA (1)	CA2025155A1 (de)
CH (1)	CH679677A5 (de)
CZ (1)	CZ466590A3 (de)
DD (1)	DD295764A5 (de)
DE (1)	DE4028018A1 (de)
DK (1)	DK191290A (de)
EG (1)	EG19285A (de)
ES (1)	ES2025972A6 (de)
FI (1)	FI95483C (de)
FR (1)	FR2652590B1 (de)
GB (1)	GB2244998B (de)
GR (1)	GR900100706A (de)
HU (1)	HU210826B (de)
IT (1)	IT1243709B (de)
LU (1)	LU87809A1 (de)
MA (1)	MA21945A1 (de)
NL (1)	NL9001998A (de)
NO (1)	NO178345C (de)
NZ (1)	NZ235338A (de)
PE (1)	PE15391A1 (de)
PL (1)	PL165512B1 (de)
PT (1)	PT95346A (de)
RU (2)	RU2023445C1 (de)
SE (1)	SE9002557L (de)
TN (1)	TNSN90122A1 (de)
TR (1)	TR25353A (de)
YU (1)	YU47646B (de)
ZA (1)	ZA906492B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2276728T3 (es)	2001-02-23	2007-07-01	Chemisches Laboratorium Dr. Kurt Richter Gmbh	Composicion de uso topico.
RU2192874C1 (ru) *	2001-08-14	2002-11-20	Колганова Нина Алексеевна	Концентрат для получения противоаллергического, противовоспалительного средства
JP2007508233A (ja) *	2003-10-08	2007-04-05	雅美森山	抗ウイルス剤
RU2373957C2 (ru)	2006-10-13	2009-11-27	Александр Метталинович Тишин	Носитель для лекарственных средств и биологически активных веществ для лечения и диагностики и применение его для создания лекарственных средств и способа регулируемой управляемой доставки лекарственного средства или биологически активного вещества с регулируемой десорбцией его
BRPI0811451A2 (pt)	2007-05-04	2014-11-04	Alimentary Health Ltd	Exopolissacarídeo

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56103194A (en) *	1980-01-23	1981-08-18	Meiji Seika Kaisha Ltd	Antitumor substance and its preparation
US4435389A (en) *	1980-07-07	1984-03-06	Kabushiki Kaisha Yakult Honsha	Composition for promoting growth of bifidobacteria
JPS58203913A (ja) *	1982-05-25	1983-11-28	Meiji Milk Prod Co Ltd	高分子多糖類物質ｍｐｓ−８２及びその利用
JPS59118712A (ja) *	1982-12-27	1984-07-09	Morinaga Milk Ind Co Ltd	抗腫瘍剤及びその製造法
JPS61257930A (ja) *	1985-05-09	1986-11-15	Morinaga Milk Ind Co Ltd	感染防御剤
US4701907C1 (en) *	1986-02-03	2002-08-27	Collins Mary	Dynamically reconfigurable time-space-time digital switch and network
EP0295961A3 (de) *	1987-06-18	1989-07-12	Kureha Kagaku Kogyo Kabushiki Kaisha	Polysaccharide und antivirale Medikamente mit Polysacchariden als wirksamer Inhaltsstoff

1989
- 1989-09-29 CH CH3536/89A patent/CH679677A5/fr not_active IP Right Cessation
1990
- 1990-07-27 FI FI903777A patent/FI95483C/fi not_active IP Right Cessation
- 1990-08-02 SE SE9002557A patent/SE9002557L/ not_active Application Discontinuation
- 1990-08-09 US US07/566,294 patent/US5114848A/en not_active Expired - Fee Related
- 1990-08-10 DK DK191290A patent/DK191290A/da not_active Application Discontinuation
- 1990-08-15 YU YU156990A patent/YU47646B/sh unknown
- 1990-08-16 ZA ZA906492A patent/ZA906492B/xx unknown
- 1990-08-17 PE PE1990173716A patent/PE15391A1/es unknown
- 1990-08-22 BR BR909004147A patent/BR9004147A/pt not_active Application Discontinuation
- 1990-08-29 IT IT02133290A patent/IT1243709B/it active IP Right Grant
- 1990-09-01 EG EG52290A patent/EG19285A/xx active
- 1990-09-04 DE DE4028018A patent/DE4028018A1/de not_active Withdrawn
- 1990-09-06 ES ES9002324A patent/ES2025972A6/es not_active Expired - Fee Related
- 1990-09-06 MA MA22217A patent/MA21945A1/fr unknown
- 1990-09-10 PL PL90286821A patent/PL165512B1/pl unknown
- 1990-09-11 NL NL9001998A patent/NL9001998A/nl not_active Application Discontinuation
- 1990-09-12 CA CA002025155A patent/CA2025155A1/en not_active Abandoned
- 1990-09-14 TN TNTNSN90122A patent/TNSN90122A1/fr unknown
- 1990-09-14 GB GB9020112A patent/GB2244998B/en not_active Expired - Fee Related
- 1990-09-17 BE BE9000883A patent/BE1004569A3/fr not_active IP Right Cessation
- 1990-09-17 AT AT0188490A patent/ATA188490A/de not_active Application Discontinuation
- 1990-09-17 NZ NZ235338A patent/NZ235338A/xx unknown
- 1990-09-17 AR AR90317880A patent/AR242263A1/es active
- 1990-09-17 NO NO904041A patent/NO178345C/no unknown
- 1990-09-17 FR FR9011823A patent/FR2652590B1/fr not_active Expired - Fee Related
- 1990-09-17 DD DD90344062A patent/DD295764A5/de not_active IP Right Cessation
- 1990-09-18 AU AU62631/90A patent/AU644604B2/en not_active Ceased
- 1990-09-18 PT PT95346A patent/PT95346A/pt not_active Application Discontinuation
- 1990-09-18 TR TR90/0878A patent/TR25353A/xx unknown
- 1990-09-18 GR GR900100706A patent/GR900100706A/el unknown
- 1990-09-19 LU LU87809A patent/LU87809A1/fr unknown
- 1990-09-20 JP JP2251646A patent/JPH03170503A/ja active Pending
- 1990-09-20 HU HU905988A patent/HU210826B/hu not_active IP Right Cessation
- 1990-09-24 BG BG92896A patent/BG60275B2/xx unknown
- 1990-09-25 CZ CS904665A patent/CZ466590A3/cs unknown
- 1990-09-27 KR KR1019900015336A patent/KR910006489A/ko not_active Abandoned
- 1990-09-28 RU SU904831269A patent/RU2023445C1/ru active
1991
- 1991-04-01 RU SU914894870A patent/RU2025127C1/ru active

Also Published As

Publication number	Publication date
TNSN90122A1 (fr)	1991-03-05
AU644604B2 (en)	1993-12-16
FI903777A0 (fi)	1990-07-27
IT1243709B (it)	1994-06-21
EG19285A (en)	1994-10-30
HU905988D0 (en)	1991-03-28
GB2244998A (en)	1991-12-18
ATA188490A (de)	1997-05-15
PE15391A1 (es)	1991-05-04
HUT61333A (en)	1992-12-28
MA21945A1 (fr)	1991-04-01
DK191290A (da)	1991-03-30
TR25353A (tr)	1993-03-01
IT9021332A1 (it)	1992-02-29
GR900100706A (el)	1992-01-20
DK191290D0 (da)	1990-08-10
NO178345C (no)	1996-03-06
BR9004147A (pt)	1991-09-03
CA2025155A1 (en)	1991-03-30
BG60275B1 (bg)	1994-03-31
CZ466590A3 (en)	1997-03-12
RU2023445C1 (ru)	1994-11-30
NO904041D0 (no)	1990-09-17
CH679677A5 (de)	1992-03-31
NZ235338A (en)	1991-09-25
ZA906492B (en)	1991-05-29
YU156990A (sh)	1992-12-21
BE1004569A3 (fr)	1992-12-15
RU2025127C1 (ru)	1994-12-30
FR2652590A1 (fr)	1991-04-05
DD295764A5 (de)	1991-11-14
BG60275B2 (en)	1994-03-31
JPH03170503A (ja)	1991-07-24
AR242263A1 (es)	1993-03-31
NL9001998A (nl)	1991-04-16
NO904041L (no)	1991-04-02
YU47646B (sh)	1995-12-04
AU6263190A (en)	1991-04-11
ES2025972A6 (es)	1992-04-01
FI95483C (fi)	1996-02-12
FR2652590B1 (fr)	1993-06-25
DE4028018A1 (de)	1991-04-11
KR910006489A (ko)	1991-04-29
SE9002557D0 (sv)	1990-08-02
US5114848A (en)	1992-05-19
NO178345B (no)	1995-11-27
IT9021332A0 (it)	1990-08-29
GB9020112D0 (en)	1990-10-24
PL165512B1 (pl)	1994-12-30
PL286821A1 (en)	1991-11-04
GB2244998B (en)	1993-10-06
PT95346A (pt)	1991-05-22
FI95483B (fi)	1995-10-31
SE9002557L (sv)	1991-03-01
HU210826B (en)	1995-08-28

Publication	Publication Date	Title
FR2475900A1 (fr)	1981-08-21	Complexe vaccinal contenant un antigene specifique et vaccin le contenant
EP0037522B1 (de)	1983-10-19	Derivate des wärmebeständigen Enterotoxins von Escherichia-Coli und deren Herstellung
EP0001945B1 (de)	1981-03-25	Polysaccharide extrahiert aus mikrobiellen Zellen von Haemophilus influenzae, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
BE1004569A3 (fr)	1992-12-15	Exopolymere extracellulaire, son procede de preparation et compositions pharmaceutiques le contenant.
EP0089266B2 (de)	1989-08-30	Verfahren zur Herstellung von interferoninduzierenden immunostimulierenden Proteoglykanen, die so erhaltenen Proteoglykane und das dieselben enthaltende Arzneimittel
WO1993016190A1 (fr)	1993-08-19	Extrait de macromolecules bacteriennes, procede pour sa preparation et composition pharmaceutique contenant cet extrait
CA2063721C (fr)	1998-10-27	Medicament immunostimulant a base de glycopeptidolipides polaires de mycobacterium chelonae
CH639395A5 (fr)	1983-11-15	Glycoproteines constitutives d'hafnia, procede de preparation et compositions pharmaceutiques.
FR2500753A1 (fr)	1982-09-03	Glycoproteine ayant une activite biologique, procede pour la preparer et compositions pharmaceutiques immunoactives la contenant
CH669386A5 (de)	1989-03-15
EP0049181A1 (de)	1982-04-07	Aus Klebsiella Pneumoniae extrahierte wasserlösliche immunostimulierende Glycoproteine, Verfahren zu deren Gewinnung, ihre Anwendung als Arzneimittel und diese enthaltende Zusammensetzungen
FR2655267A1 (fr)	1991-06-07	Nouveau derive sulfate du galactanne extrait de klebsiella, procede de preparation, application a titre de medicaments et compositions pharmaceutiques le renfermant.
FR2650506A1 (fr)	1991-02-08	Galactanne extrait de klebsiella, procede d'obtention et application a titre de medicament
JPH0816119B2 (ja)	1996-02-21	蛋白多糖体ｋｖ−０７１及びそれを有効成分とするヒトロタウイルス感染症予防剤