LU88299I2 - Cilazapril (Vascace / Inhibace) - Google Patents

Cilazapril (Vascace / Inhibace)

Info

Publication number
LU88299I2
LU88299I2 LU88299C LU88299C LU88299I2 LU 88299 I2 LU88299 I2 LU 88299I2 LU 88299 C LU88299 C LU 88299C LU 88299 C LU88299 C LU 88299C LU 88299 I2 LU88299 I2 LU 88299I2
Authority
LU
Luxembourg
Prior art keywords
vascace
inhibace
cilazapril
Prior art date
Application number
LU88299C
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of LU88299I2 publication Critical patent/LU88299I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
LU88299C 1982-05-12 1993-06-09 Cilazapril (Vascace / Inhibace) LU88299I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (1)

Publication Number Publication Date
LU88299I2 true LU88299I2 (fr) 1994-09-09

Family

ID=26282820

Family Applications (2)

Application Number Title Priority Date Filing Date
LU84803A LU84803A1 (fr) 1982-05-12 1983-05-11 Bicyclische verbindungen
LU88299C LU88299I2 (fr) 1982-05-12 1993-06-09 Cilazapril (Vascace / Inhibace)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU84803A LU84803A1 (fr) 1982-05-12 1983-05-11 Bicyclische verbindungen

Country Status (32)

Country Link
US (3) US4512924A (fr)
EP (1) EP0094095B1 (fr)
KR (1) KR890002106B1 (fr)
AR (1) AR240940A1 (fr)
AU (1) AU567873B2 (fr)
BG (1) BG61123B2 (fr)
CA (1) CA1234568A (fr)
CS (2) CS249128B2 (fr)
CU (1) CU21532A3 (fr)
DE (2) DE3381884D1 (fr)
DK (1) DK160612C (fr)
DO (1) DOP1983004163A (fr)
DZ (1) DZ540A1 (fr)
ES (6) ES522291A0 (fr)
FI (1) FI77244C (fr)
FR (1) FR2531956B1 (fr)
GB (1) GB2128984B (fr)
GR (1) GR77462B (fr)
HK (1) HK91692A (fr)
HU (3) HU198935B (fr)
IE (1) IE56480B1 (fr)
IL (1) IL68620A (fr)
IT (1) IT1212738B (fr)
LU (2) LU84803A1 (fr)
MC (1) MC1515A1 (fr)
MY (1) MY102889A (fr)
NL (2) NL8301640A (fr)
NO (1) NO160368C (fr)
PT (1) PT76681B (fr)
SE (1) SE461792B (fr)
SG (1) SG81192G (fr)
ZW (1) ZW9883A1 (fr)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4902707A (en) * 1985-04-30 1990-02-20 Eli Lilly And Company Bicyclic pyrazolidinones, compositions and use
US4940718A (en) * 1985-04-30 1990-07-10 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
US4826992A (en) * 1985-04-30 1989-05-02 Eli Lilly And Company 2,3-(Dihydro) bicyclic pyrazolidinones
ATE60605T1 (de) * 1985-04-30 1991-02-15 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
US4832763A (en) * 1985-10-15 1989-05-23 Westinghouse Electric Corp. Method of stress-relief annealing a magnetic core containing amorphous material
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
EP0566157A1 (fr) 1986-06-20 1993-10-20 Schering Corporation Inhibiteurs de la métallo-Endopeptidase neutre dans le traitement de l'hypertension
EP0254032A3 (fr) 1986-06-20 1990-09-05 Schering Corporation Inhibiteurs de la métallo-endopeptidase neutre dans le traitement de l'hypertension
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
US4956490A (en) * 1989-03-09 1990-09-11 Merck & Co., Inc. Process for preparing benzylpyruvic acids and esters
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
DE3917255A1 (de) * 1989-05-26 1990-11-29 Schopf Masch Verfahren und vorrichtung zum aufnehmen eines flugzeugbugfahrwerks durch einen flugzeugschlepper
US5011938A (en) * 1989-10-02 1991-04-30 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones
CA2069112A1 (fr) * 1989-11-21 1991-05-22 Bernard R. Neustadt Inhibiteurs de la carboxyalkylcarbonyl-aminoacide-endopeptidase
WO1991009840A1 (fr) * 1989-12-22 1991-07-11 Schering Corporation Inhibiteurs aminoacides mercaptocycloacyliques d'endopeptidase
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
EP0487453B1 (fr) * 1990-11-21 1996-05-22 Ciba-Geigy Ag Acylphosphine-oxyde silylée
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
ES2089506T3 (es) * 1991-03-19 1996-10-01 Ciba Geigy Ag Nuevos compuestos con actividad herbicida, acaricida o insecticida.
TW216770B (fr) * 1991-07-23 1993-12-01 Hoffmann La Roche
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (fr) * 1991-09-27 2003-09-16 Alan M. Warshawsky Derives carboxyalkyliques, utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
JPH06107661A (ja) * 1991-10-24 1994-04-19 Upjohn Co:The イミダゾール誘導体およびこれを有効成分とする医薬組成物
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DK0640086T3 (da) * 1992-05-15 1999-12-06 Merrell Pharma Inc Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
ES2164056T3 (es) * 1992-05-18 2002-02-16 Hoffmann La Roche Hidrogenacion asimetrica.
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
DE69329701T2 (de) * 1992-10-30 2001-05-10 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer
JPH072859A (ja) * 1993-01-28 1995-01-06 Upjohn Co:The ピラゾール誘導体およびこれを有効成分とする医薬組成物
US5476395A (en) * 1993-03-01 1995-12-19 Methode Electronics, Inc. Planar fuse panel
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
PT634175E (pt) * 1993-07-15 2001-06-29 Hoffmann La Roche Combinacao farmaceutica que contem um inibidor do sistema renina-angiotensina e o antagonista de endotelina
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
DE69516128T2 (de) * 1994-02-14 2000-12-21 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
FI963784A0 (fi) * 1994-03-24 1996-09-23 Merrell Pharma Inc Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia
ATE189392T1 (de) * 1994-03-24 2000-02-15 Merrell Pharma Inc Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
FR2777888B1 (fr) * 1998-04-27 2004-07-16 Hoechst Marion Roussel Inc Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
AU2003200034B2 (en) * 1998-04-27 2006-07-20 Aventis Pharma S.A. New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
FR2777889B1 (fr) * 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
FR2788276B1 (fr) * 1999-01-12 2001-02-16 Hoechst Marion Roussel Inc NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
US6585995B1 (en) * 1999-09-21 2003-07-01 Hanson Stephen R Methods and compositions for treating platelet-related disorders
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
ES2375268T3 (es) 2000-12-14 2012-02-28 The Brigham And Women's Hospital, Inc. Marcadores inflamatorios para la detección y prevención de diabetes mellitus.
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
DK3072978T3 (en) 2002-05-09 2018-09-17 Brigham & Womens Hospital Inc : 1L1RL-1 AS A CARDIOVASCULAR DISEASE MARKER
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
EP1585500B8 (fr) * 2002-12-20 2017-07-26 Auritec Pharmaceuticals Particules enrobees destinees a l'administration prolongee d'ingredients pharmaceutiques
US20060293517A1 (en) * 2003-03-06 2006-12-28 Yatendra Kumar Enantiomerically pure cilazapril, process for preparation
WO2005003134A1 (fr) * 2003-07-07 2005-01-13 Hetero Drugs Limited Procede d'elaboration de cilazapril
EP2384753B1 (fr) 2003-08-29 2016-01-06 The Brigham and Women's Hospital, Inc. Inhibiteurs de nécrose cellulaire
ES2381551T3 (es) 2003-12-05 2012-05-29 The Cleveland Clinic Foundation Marcadores de riesgo para enfermedad cardiovascular
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
WO2005122682A2 (fr) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Procede de preparation d'esters d'acide piperazique
EP2927693A1 (fr) 2004-10-06 2015-10-07 The Brigham and Women's Hospital Pertinence de niveaux obténus de marqueurs d'inflammation géneralisée à la suite d'un traitement
AU2006206249A1 (en) * 2005-01-21 2006-07-27 Nicox S.A. Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
AU2005332300B2 (en) 2005-05-31 2011-07-07 Mylan Laboratories, Inc. Compositions comprising nebivolol
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
DE602006000402T8 (de) 2006-06-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Stabile Zubereitung enthaltend eine feuchtigkeitsempfindliche aktive Substanz und Verfahren zur Herstellung der Zubereitung.
US20070281000A1 (en) * 2006-06-02 2007-12-06 Michael Fox Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
US20080057590A1 (en) * 2006-06-07 2008-03-06 Mickey Urdea Markers associated with arteriovascular events and methods of use thereof
US20080008751A1 (en) * 2006-07-10 2008-01-10 Michael Fox Stable formulation comprising a combination of a moisture sensitive drug and a second drug and manufacturing procedure thereof
CA2684308A1 (fr) 2007-04-18 2008-10-30 Tethys Bioscience, Inc. Biomarqueurs associes au diabete et leurs procedes d'utilisation
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
EP2221299A3 (fr) 2009-02-11 2010-11-03 Dr. Reddy's Laboratories Ltd. Préparation d'intermédiaires du cilazapril
KR20120139723A (ko) 2010-02-01 2012-12-27 더 호스피탈 포 식 칠드런 재발협착증의 치료 및 예방을 위한 원격 허혈 처치
CA2795053A1 (fr) 2010-03-31 2011-10-06 The Hospital For Sick Children Utilisation de conditionnement ischemique a distance pour ameliorer l'evolution apres un infarctus du myocarde
SG10201908576VA (en) 2010-04-08 2019-10-30 Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
WO2012049646A1 (fr) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Procédé de préparation d'un intermédiaire de cilazapril
EP2537534B1 (fr) 2011-06-22 2014-12-17 Hexal AG Esters d'acide (1S,9S)-9-[[(1S)-1-carboxy-3-phénylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazépine-1-carboxylique et leur utilisation thérapeutique
CA2842072A1 (fr) 2011-07-18 2013-01-24 James V. Snider Methodes de traitement des maladies cardiovasculaires et de prevision de l'efficacite d'un traitement par l'exercice physique
CN107674071B (zh) 2012-05-11 2021-12-31 同步制药公司 作为隐花色素调节剂的含有咔唑的磺酰胺类
ES2786506T3 (es) 2012-08-01 2020-10-13 Zahra Tavakoli Composiciones congeladas fluidas que comprenden un agente terapéutico
US20160024098A1 (en) 2013-03-15 2016-01-28 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
BR112015024234B1 (pt) 2013-03-21 2022-11-16 Eupraxia Pharmaceuticals USA LLC Composição farmacêutica de liberação sustentada injetável, uso da mesma para diminuir inflamação ou controlar dor e método para formar micropartículas revestidas
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
DK3206672T3 (en) 2015-10-27 2018-06-18 Eupraxia Pharmaceuticals Inc Formulations for sustained release of local anesthetics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (fr) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de la pyrazolopyridazine, intermédiaires et leur procédés de préparation, et médicaments les contenant
EP0047620B1 (fr) * 1980-09-10 1985-03-13 Beecham Group Plc Aryl amides diazabicycliques, procédé pour leur préparation et leur application
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds

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IE831084L (en) 1983-11-12
CU21532A3 (en) 1987-06-09
NO160368C (no) 1989-04-12
SE8302716L (sv) 1983-11-13
FI831661L (fi) 1983-11-13
DK194783A (da) 1983-11-13
IE56480B1 (en) 1991-08-14
GB2128984A (en) 1984-05-10
IL68620A (en) 1987-11-30
HU198935B (en) 1989-12-28
NL930055I2 (nl) 1993-10-01
ES8607970A1 (es) 1986-06-16
MY102889A (en) 1993-03-31
IT1212738B (it) 1989-11-30
AU1436483A (en) 1983-11-17
DE3381884D1 (de) 1990-10-25
PT76681B (en) 1986-05-20
CS249128B2 (en) 1987-03-12
AR240940A1 (es) 1991-03-27
US4512924A (en) 1985-04-23
DZ540A1 (fr) 2004-09-13
HU199842B (en) 1990-03-28
GB8305505D0 (en) 1983-03-30
FR2531956B1 (fr) 1987-02-20
ES8407049A1 (es) 1984-08-16
GR77462B (fr) 1984-09-24
ES528628A0 (es) 1987-07-16
ES528630A0 (es) 1986-06-16
HU195965B (en) 1988-08-29
FI831661A0 (fi) 1983-05-12
CS402191A3 (en) 1992-10-14
BG61123B2 (bg) 1996-11-29
NL8301640A (nl) 1983-12-01
SE461792B (sv) 1990-03-26
FI77244C (fi) 1989-02-10
NO160368B (no) 1989-01-02
CA1234568A (fr) 1988-03-29
ES528627A0 (es) 1985-11-16
US4772701A (en) 1988-09-20
ES528625A0 (es) 1985-05-16
ES8706672A1 (es) 1987-07-16
ES8505173A1 (es) 1985-05-16
IT8321000A0 (it) 1983-05-09
IL68620A0 (en) 1983-09-30
DK160612B (da) 1991-04-02
DK160612C (da) 1991-09-23
NL930055I1 (nl) 1993-09-01
AU567873B2 (en) 1987-12-10
SG81192G (en) 1993-01-29
HK91692A (en) 1992-11-27
ES8800170A1 (es) 1987-11-01
KR890002106B1 (ko) 1989-06-19
US4658024A (en) 1987-04-14
PT76681A (en) 1983-06-01
GB2128984B (en) 1985-05-22
EP0094095A3 (en) 1984-11-21
NO831675L (no) 1983-11-14
ES8601994A1 (es) 1985-11-16
EP0094095A2 (fr) 1983-11-16
EP0094095B1 (fr) 1990-09-19
ES522291A0 (es) 1984-08-16
FR2531956A1 (fr) 1984-02-24
FI77244B (fi) 1988-10-31
DK194783D0 (da) 1983-05-02
LU84803A1 (fr) 1985-03-21
MC1515A1 (fr) 1984-02-10
AR240940A2 (es) 1991-03-27
DE3317290A1 (de) 1983-11-17
SE8302716D0 (sv) 1983-05-11
KR840004754A (ko) 1984-10-24
ZW9883A1 (en) 1984-11-21
ES554935A0 (es) 1987-11-01
DOP1983004163A (es) 1988-09-20

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