LU88694I2 - Timolol ou un sel pharmaceutuquement acceptable de celui-ci en particulier le maléate de timolol en combinaison avec une gomme gélifiante - Google Patents

Timolol ou un sel pharmaceutuquement acceptable de celui-ci en particulier le maléate de timolol en combinaison avec une gomme gélifiante

Info

Publication number
LU88694I2
LU88694I2 LU88694C LU88694C LU88694I2 LU 88694 I2 LU88694 I2 LU 88694I2 LU 88694 C LU88694 C LU 88694C LU 88694 C LU88694 C LU 88694C LU 88694 I2 LU88694 I2 LU 88694I2
Authority
LU
Luxembourg
Prior art keywords
timolol
combination
pharmaceutically acceptable
acceptable salt
gelling gum
Prior art date
Application number
LU88694C
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of LU88694I2 publication Critical patent/LU88694I2/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LU88694C 1985-10-03 1986-10-02 Timolol ou un sel pharmaceutuquement acceptable de celui-ci en particulier le maléate de timolol en combinaison avec une gomme gélifiante LU88694I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8514689A FR2588189B1 (fr) 1985-10-03 1985-10-03 Composition pharmaceutique de type a transition de phase liquide-gel

Publications (1)

Publication Number Publication Date
LU88694I2 true LU88694I2 (fr) 1996-04-29

Family

ID=9323509

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88694C LU88694I2 (fr) 1985-10-03 1986-10-02 Timolol ou un sel pharmaceutuquement acceptable de celui-ci en particulier le maléate de timolol en combinaison avec une gomme gélifiante

Country Status (25)

Country Link
US (1) US4861760A (fr)
EP (1) EP0227494B1 (fr)
JP (1) JPH0667853B2 (fr)
KR (1) KR940000229B1 (fr)
CN (1) CN1046094C (fr)
AT (1) ATE72990T1 (fr)
AU (1) AU595240B2 (fr)
CA (1) CA1280367C (fr)
CY (1) CY1779A (fr)
DE (2) DE227494T1 (fr)
DK (1) DK170500B1 (fr)
ES (1) ES2002401A6 (fr)
FI (1) FI91217C (fr)
FR (1) FR2588189B1 (fr)
GR (1) GR862444B (fr)
HK (1) HK42594A (fr)
IE (1) IE59464B1 (fr)
IL (1) IL80156A (fr)
LU (1) LU88694I2 (fr)
LV (1) LV5725B4 (fr)
NL (1) NL950012I1 (fr)
NO (2) NO173212C (fr)
NZ (1) NZ217662A (fr)
PT (1) PT83471B (fr)
ZA (1) ZA867464B (fr)

Families Citing this family (388)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095026A (en) * 1983-02-04 1992-03-10 University Of Iowa Research Foundation Prodrugs of carbonic anhydrase inhibitors
US5200180A (en) * 1987-06-26 1993-04-06 Christian Bannert Pharmaceutical composition for the treatment of the human eye
FR2618333B1 (fr) * 1987-07-20 1990-07-13 Merck Sharp & Dohme Composition pharmaceutique et/ou cosmetique a usage topique contenant de la gomme rhamsam
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
US5034406A (en) * 1989-09-26 1991-07-23 Allergan, Inc. Method for reducing or maintaining intraocular pressure
US5461081A (en) * 1989-09-28 1995-10-24 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
US5521222A (en) * 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
FR2653018A1 (fr) * 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique non solide a base de microparticules de polymere contenant au moins un principe actif en suspension dans un milieu dispersant et procede de preparation de ladite composition.
FR2653021A1 (fr) * 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.
US5141928B1 (en) * 1989-12-20 1995-11-14 Brujo Inc Ophthalmic medication
US5496471A (en) * 1990-01-08 1996-03-05 Ciba-Geigy Corporation Apparatus for removing components from solutions
FR2657018A1 (fr) * 1990-01-12 1991-07-19 Merck Sharp & Dohme Composition ophtalmique fluide a base de microparticules lipidiques contenant au moins un principe actif et son procede de preparation.
US5593683A (en) * 1990-05-01 1997-01-14 Mdv Technologies, Inc. Method of making thermoreversible polyoxyalkylene gels
US5298260A (en) * 1990-05-01 1994-03-29 Mediventures, Inc. Topical drug delivery with polyoxyalkylene polymer thermoreversible gels adjustable for pH and osmolality
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
CA2044878C (fr) * 1990-08-07 2000-12-26 Tacey X. Viegas Gels thermoreversibles et thermo-irreversibles
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
FR2665635A1 (fr) * 1990-08-10 1992-02-14 Merck Sharp & Dohme Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation.
US5847023A (en) * 1990-10-26 1998-12-08 Mdv Technologies, Inc. Thermal irreversible gel corneal contact lens formed in situ
JP2594486B2 (ja) * 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
RU2108112C1 (ru) * 1993-04-16 1998-04-10 Вакамото Фармасьютикал Ко., Лтд. Водная лекарственная композиция, обладающая свойством обратимого терморегулируемого гелеобразования
SE9301877D0 (sv) * 1993-06-02 1993-06-02 Kabi Pharmacia Ab In situ gel for therapeutic use
US5545617A (en) * 1993-11-12 1996-08-13 The Schepens Eye Research Institute, Inc. Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion
CN1129400A (zh) * 1994-05-06 1996-08-21 阿尔康实验室公司 维生素e生育酚衍生物在眼科组合物中的应用
IL114193A (en) * 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
DK0725628T3 (da) * 1994-08-30 2001-12-27 Alcon Lab Inc Termisk geldannende lægemiddelindgivelsesvehikler indeholdende celluloseethere
US5827835A (en) * 1994-08-30 1998-10-27 Alcon Laboratories, Inc. Thermally-gelling emulsions
US5516808A (en) * 1994-10-27 1996-05-14 Sawaya; Assad S. Topical cellulose pharmaceutical formulation
US5603929A (en) * 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US6165490A (en) * 1996-04-05 2000-12-26 Staar Surgical Ag Biological material, method of preparing such materials, uses thereof and products made therefrom
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
US5843470A (en) * 1995-10-06 1998-12-01 Mdv Technologies, Inc. Method and composition for inhibiting post-surgical adhesions
EP1057486A1 (fr) * 1995-11-17 2000-12-06 Alcon Laboratories, Inc. L'utilisation d'une combinaison de produits pharmacologiques dans le traitement du glaucome
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US5641532A (en) * 1995-12-15 1997-06-24 The Procter & Gamble Company Beverages having stable flavor/cloud emulsions in the presence of polyphosphate-containing preservative systems by including gellan gum
JP4259613B2 (ja) 1996-02-13 2009-04-30 大日本住友製薬株式会社 ガラクトキシログルカンを用いるドラッグ・デリバリー・システム
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
US5888493A (en) * 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
KR20010006027A (ko) * 1997-04-03 2001-01-15 포인트 바이오메디칼 코퍼레이션 방광내 약물 송달 시스템
GB9707934D0 (en) * 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
AU8570498A (en) 1997-07-29 1999-02-22 Alcon Laboratories, Inc. Switchable viscoelastic systems containing galactomannan polymers and borate
DE69839355T2 (de) * 1997-07-29 2009-06-04 Alcon Laboratories, Inc., Fort Worth Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat
DK1203808T3 (da) * 1997-07-29 2005-01-31 Alcon Lab Inc Konditioneringsoplösninger til pleje af hårde kontaktlinser
US20040063678A1 (en) * 1997-10-06 2004-04-01 Bausch & Lomb Incorporated Dexamethasone Gel
US6174524B1 (en) 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6669927B2 (en) 1998-11-12 2003-12-30 3M Innovative Properties Company Dental compositions
US6312666B1 (en) * 1998-11-12 2001-11-06 3M Innovative Properties Company Methods of whitening teeth
US6312667B1 (en) * 1998-11-12 2001-11-06 3M Innovative Properties Company Methods of etching hard tissue in the oral environment
IL143687A0 (en) * 1998-12-11 2002-04-21 Khamar Bakulesh Mafatlal The process for manufacturing formulation of topical beta blockers with improved efficacy
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
PT1225898E (pt) 1999-11-01 2003-10-31 Alcon Inc Composicoes farmaceuticas contendo um farmaco antibiotico de fluoroquinolona e goma xantana
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
BR0112787B1 (pt) 2000-07-28 2013-03-05 composiÇço de soluÇço topicamente administrÁvel.
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
JP2002154989A (ja) * 2000-11-14 2002-05-28 Lion Corp 眼科用組成物、及び生体粘膜への薬物の滞留性向上組成物
AU2002228955B2 (en) * 2000-12-20 2005-09-29 Alcon Inc. Solution for removing cataracts via liquefracture
AU2002232437A1 (en) * 2000-12-20 2002-07-01 Alcon Universal Ltd. Ophthalmic lubricating solution adapted for use in lasik surgery
AU2002239601B2 (en) * 2000-12-20 2005-09-01 Alcon Inc. Intraocular irrigating solution having improved flow characteristics
WO2002049610A2 (fr) * 2000-12-20 2002-06-27 Alcon, Inc. Solution d'irrigation ophtalmique conçue pour etre utilisee dans la chirurgie au lasik
US20090258955A1 (en) * 2000-12-20 2009-10-15 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
US20040121947A1 (en) * 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
EP1439842A4 (fr) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
DK1435945T3 (da) * 2001-06-05 2008-12-01 Ronald Aung-Din Topisk migræne terapi
US20030220376A1 (en) * 2001-08-10 2003-11-27 Pharmacia Corporation Methods for treating carbonic anhydrase mediated disorders
WO2003013612A1 (fr) 2001-08-10 2003-02-20 Toray Industries, Inc. Compositions contenant du polysaccharide et leur utilisation
US20080199524A1 (en) * 2001-08-10 2008-08-21 Toray Industries, Inc. Eyedrops containing particulate agar
JP4547152B2 (ja) * 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
US6620405B2 (en) 2001-11-01 2003-09-16 3M Innovative Properties Company Delivery of hydrogel compositions as a fine mist
MXPA04008171A (es) * 2002-02-22 2004-11-26 Pharmacia Corp Formulacion oftalmica con sistema de goma.
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US7030149B2 (en) 2002-04-19 2006-04-18 Allergan, Inc. Combination of brimonidine timolol for topical ophthalmic use
US7642258B2 (en) * 2002-04-19 2010-01-05 Allergan, Inc. Combination of brimonidine and timolol for topical ophthalmic use
US20030232741A1 (en) * 2002-05-06 2003-12-18 Washington University Methods of treatment of glaucoma and other conditions mediated by NOS-2 expression via inhibition of the EGFR pathway
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
NZ540885A (en) * 2002-12-20 2009-02-28 Chakshu Res Inc Ophthalmic formulation for the prevention and treatment of ocular conditions
US20060172972A1 (en) * 2002-12-20 2006-08-03 Chakshu Research Inc Formulation and method for administration of ophthalmologically active agents
US20060166879A1 (en) * 2002-12-20 2006-07-27 Chakshu Research Inc Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders
US20060177430A1 (en) * 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US20070077278A1 (en) * 2003-11-10 2007-04-05 Yukiko Sugihara Polysaccharide-containing composition and tear film stabilizing ophthalmic solution
EP1696878A1 (fr) * 2003-12-11 2006-09-06 Alcon, Inc. Compositions ophtalmologiques contenant un systeme gelifiant a base de polysaccharide/borate
US20050129770A1 (en) * 2003-12-11 2005-06-16 Alcon, Inc. Ophthalmic compositions containing a PVA/borate gelling system
JP4771044B2 (ja) * 2004-09-15 2011-09-14 大正製薬株式会社 粘膜適用液剤
AU2005286844A1 (en) * 2004-09-17 2006-03-30 Comentis, Inc Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
EP1799660A2 (fr) * 2004-09-17 2007-06-27 Comentis, Inc. Composes amino inhibant l'activite de la beta-secretase memapsin 2 et methodes d'utilisation
US20080096859A1 (en) * 2004-10-01 2008-04-24 Sullivan Kathleen A Compositions and Methods for Treating Ophthalmic Diseases
EP1831225A2 (fr) 2004-11-19 2007-09-12 The Regents of the University of California Pyrazolopyrimidines anti-inflammatoires
US20070059274A1 (en) * 2004-12-01 2007-03-15 Bahram Asgharian Ophthalmic compositions containing a PVA/borate gelling system
US7485619B2 (en) * 2005-01-31 2009-02-03 Yeon Sook KIM Antimicrobial agent
NZ562314A (en) * 2005-04-08 2010-02-26 Comentis Inc Compounds which inhibit beta-secretase activity and methods of use thereof
CN101262887A (zh) * 2005-07-15 2008-09-10 视可舒研究公司 糖尿病的眼科并发症的预防和治疗
US7534795B2 (en) * 2005-10-25 2009-05-19 Allergan, Inc. Compounds and their use related to compositions for treating disease
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
AU2006331790A1 (en) * 2005-12-19 2007-07-05 Comentis, Inc. Topical mecamylamine formulations for ocular administration and uses therof
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
KR100802534B1 (ko) 2006-06-13 2008-02-14 주식회사태준제약 저자극성 점안제 조성물 및 이의 제조 방법
EP2038272B8 (fr) 2006-06-30 2013-10-23 Sunesis Pharmaceuticals, Inc. Inhibiteurs de pyridinonyle pdk1
CA2691531C (fr) 2007-06-22 2016-11-01 Board Of Regents,The University Of Texas System Formation de particules de peptide ou de proteine submicroniques stables par congelation de film mince
US20100286145A1 (en) * 2007-07-26 2010-11-11 Comentis, Inc. Isophthalamide derivatives inhibiting beta-secretase activity
JP5055432B2 (ja) * 2007-09-24 2012-10-24 コメンティス,インコーポレーテッド 治療のためのβ−セクレターゼ阻害剤としての(3−ヒドロキシ−4−アミノブタン−2−イル)−3−(2−チアゾール−2−イル−ピロリジン−1−カルボニル)ベンズアミド誘導体及び関連する化合物
BRPI0909797A2 (pt) * 2008-03-07 2017-08-22 Sun Pharma Advanced Res Co Ltd Composição oftálmica
CN102105146A (zh) 2008-05-23 2011-06-22 国立犹太保健医院 用于治疗与暴露于烷化物质有关的损伤的方法
JP2011526889A (ja) 2008-06-30 2011-10-20 アフギン ファーマ,エルエルシー 局所局部的神経作用療法
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
US8618096B2 (en) * 2008-07-21 2013-12-31 The Regents Of The University Of California Prodrug compositions and methods for using the same in treating cancer and malaria
CN104230901A (zh) 2008-09-15 2014-12-24 加利福尼亚大学董事会 用于调节ire1、src和abl活性的方法和组合物
JP2010132587A (ja) * 2008-12-03 2010-06-17 Teika Seiyaku Kk 眼科用剤
US8470997B2 (en) * 2009-02-05 2013-06-25 Gene Signal International Sa Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
US8580947B2 (en) 2009-02-05 2013-11-12 Gene Signal International Sa Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
RU2482851C2 (ru) * 2009-02-20 2013-05-27 Микро Лабс Лимитед Хранение стабильного продукта простагландина
NZ713361A (en) 2009-08-17 2017-06-30 Memorial Sloan Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
EP2485589A4 (fr) 2009-09-04 2013-02-06 Biogen Idec Inc Inhibiteurs hétéroaryles de btk
NZ598985A (en) 2009-09-04 2013-07-26 Biogen Idec Inc Bruton's tyrosine kinase inhibitors
US8679511B2 (en) * 2009-10-01 2014-03-25 Duquesne University of the Holy Spririt In-situ gel ophthalmic drug delivery system of estradiol or other estrogen for prevention of cataracts
IL266563B (en) 2009-10-06 2022-09-01 Millennium Pharm Inc Heterocyclic compounds useful as pdk1 inhibitors
WO2011047384A2 (fr) 2009-10-16 2011-04-21 The Regents Of The University Of California Procédés d'inhibition de l'activité ire1
EP2853262B1 (fr) 2009-10-26 2016-11-30 Sephoris Pharmaceuticals, LLC Traitement de l'érythème solaire utilisant des analgésiques et des antihistaminiques
US20130035325A1 (en) 2009-11-16 2013-02-07 The Regents Of The University Of California Kinase inhibitors
SI2509940T1 (sl) 2009-12-10 2015-09-30 The Regents Of The University Of California Sredstva za vezavo amiloida
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
DE102010009475B4 (de) 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
CN102918034B (zh) 2010-03-30 2015-06-03 维颂公司 多取代芳族化合物作为凝血酶的抑制剂
WO2011127151A2 (fr) 2010-04-07 2011-10-13 Allergan, Inc. Combinaisons de conservateurs pour les compositions ophtalmiques
JP2013523825A (ja) 2010-04-07 2013-06-17 アラーガン インコーポレイテッド 眼科製剤のための保存剤組成物の組み合わせ
JP5713791B2 (ja) * 2010-05-12 2015-05-07 テイカ製薬株式会社 眼科用剤
US20130149394A1 (en) 2010-08-27 2013-06-13 Wakamoto Pharmaceutical Co., Ltd. Aqueous ophthalmic composition
US8530449B2 (en) 2010-09-09 2013-09-10 Assad S. Sawaya Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye
PH12013500477A1 (en) 2010-09-13 2018-01-17 Bev Rx Inc Aqueous drug delivery system comprising off-flavor masking agent
WO2012058645A1 (fr) 2010-10-29 2012-05-03 Biogen Idec Ma Inc. Inhibiteurs de tyrosine kinase hétérocycliques
CN103459368B (zh) 2011-02-14 2016-06-08 阿勒根公司 比马前列素组合物的酯衍生物和方法
WO2012158795A1 (fr) 2011-05-17 2012-11-22 Principia Biopharma Inc. Dérivés de pyrazolopyrimidine utilisés comme inhibiteurs de tyrosine kinase
PL2710005T3 (pl) 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
ES2770550T3 (es) 2011-05-17 2020-07-02 Univ California Inhibidores de quinasa
EP2714069A4 (fr) 2011-05-25 2015-06-24 Amylin Pharmaceuticals Llc Conjugués de deux hormones longue durée
EP2726097A4 (fr) 2011-07-01 2015-03-11 Univ California Vaccin contre le virus de l'herpès et procédés d'utilisation
CA2846496C (fr) 2011-09-02 2020-07-14 The Regents Of The University Of California Pyrazolo[3,4-d]pyrimidines substituees et utilisations de celles-ci
EP2771341A4 (fr) 2011-10-28 2015-09-23 Univ Texas Nouvelles compositions et procédés pour traiter le cancer
EP2836482B1 (fr) 2012-04-10 2019-12-25 The Regents of The University of California Compositions et méthodes pour le traitement du cancer
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
WO2013188452A1 (fr) 2012-06-11 2013-12-19 The Regents Of The University Of California Composés et procédés de traitement du cancer
ES2711425T3 (es) 2012-08-27 2019-05-03 Allergan Inc Espesamiento de la córnea central reducido mediante el uso de profármacos de éster hidrófilos de beta-clorociclopentanos
US9090595B2 (en) 2012-08-27 2015-07-28 Allergan, Inc. Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
SI2892900T1 (en) 2012-09-10 2018-01-31 Principia Biopharma Inc. Pyrazolopyrimidine compounds as kinase inhibitors
JP2015532287A (ja) 2012-09-26 2015-11-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Ire1の調節
CN108440571B (zh) 2012-10-22 2022-11-04 希望之城 Etp衍生物
US9364462B2 (en) 2012-10-30 2016-06-14 The Regents Of The University Of California Alpha-1-adrenergic receptor agonist therapy
WO2014124458A1 (fr) 2013-02-11 2014-08-14 The Regents Of The University Of California Compositions et méthodes de traitement de maladies neurodégénératives
WO2014143591A1 (fr) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition de la néovascularisation par inhibition simultanée de prostanoïde ip et des récepteurs ep4
EP2968296B1 (fr) 2013-03-12 2020-09-02 The Regents of the University of California Modulateurs de gamma-secrétase
US9321745B2 (en) 2013-03-12 2016-04-26 Allergan, Inc. Inhibition of neovascularization by inhibition of prostanoid IP receptors
EP2968215B1 (fr) 2013-03-14 2021-05-05 The Regents of the University of California Agents mucolytiques thiosaccharidiques
CA2902914A1 (fr) 2013-03-14 2014-09-25 City Of Hope 5-bromo-indirubines
JP2016519662A (ja) 2013-03-14 2016-07-07 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア K2pチャネルの調節
ES2791749T3 (es) 2013-03-15 2020-11-05 Verseon Corp Halogenopirazoles como inhibidores de la trombina
WO2014146111A2 (fr) 2013-03-15 2014-09-18 The Regents Of The University Of California Composés antalgiques et leurs méthodes d'utilisation
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
RU2015134772A (ru) 2013-03-15 2017-04-21 Аллерган, Инк. Применение биматопроста для повышения выработки лептина
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
ES2708565T3 (es) 2013-03-15 2019-04-10 Atyr Pharma Inc Conjugados de Fc-histidil-ARNt sintetasa
LT2968297T (lt) 2013-03-15 2019-01-10 Verseon Corporation Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
JP6806562B2 (ja) 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CA2949048A1 (fr) 2013-05-22 2014-11-27 The Regents Of The University Of California Inhibiteurs d'aurora kinase
US9795691B2 (en) 2013-06-24 2017-10-24 City Of Hope Chemically-linked nanoparticles
EP3022207A4 (fr) 2013-07-15 2016-12-07 Univ Texas Composés et méthodes pour le traitement du cancer, des troubles neurologiques, du sevrage de l'éthanol, de l'anxiété, de la dépression, et de la douleur neuropathique
DK3035926T3 (da) 2013-08-19 2020-08-31 Univ California Forbindelser og fremgangsmåder til behandling af en epilepsilidelse
EP3035924A4 (fr) 2013-08-20 2017-04-19 City of Hope Inhibiteurs de l'hdac8 pour le traitement du cancer
WO2015031799A1 (fr) 2013-08-30 2015-03-05 The Regents Of The University Of California, A California Corporation Compositions contenant des nanocristaux scintillateurs et leurs procédés d'utilisation
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
AU2014362231B2 (en) 2013-12-11 2019-04-04 Biogen Ma Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
EP3444251B1 (fr) 2013-12-11 2023-06-07 Biogen MA Inc. Composés biaryles utiles dans le traitement de maladies humaines en oncologie, neurologie et immunologie
WO2015138039A1 (fr) 2013-12-23 2015-09-17 Memorial Sloan-Kettering Cancer Center Procédés et réactifs de radiomarquage
EP3091985B1 (fr) 2014-01-10 2024-05-08 Manistee Therapeutics, Inc. Prostanglandines pour leur utilisation topique dans le traitement des migraines.
WO2015116856A2 (fr) 2014-01-29 2015-08-06 City Of Hope Antagonistes du récepteur x de farnésoïde
ES2919024T3 (es) 2014-02-11 2022-07-21 Mitokinin Inc Composiciones y procedimientos que utilizan las mismas para el tratamiento de enfermedades neurodegenerativas y mitocondriales
WO2015123595A1 (fr) 2014-02-14 2015-08-20 The Regents Of The University Of California Peroxydes cycliques utilisés en tant que promédicaments pour l'administration sélective d'agents
JP6626831B2 (ja) 2014-02-20 2019-12-25 アラーガン、インコーポレイテッドAllergan,Incorporated ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中心肥厚の減少
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
US20150259288A1 (en) 2014-03-14 2015-09-17 City Of Hope 5-bromo-indirubins
CN106132203B (zh) 2014-03-26 2020-05-15 希望之城 Brca1缺陷性癌症或抗性癌症的治疗
ES2908240T3 (es) 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
JP6607870B2 (ja) 2014-05-13 2019-11-20 メモリアル スローン ケタリング キャンサー センター Hsp70モジュレーターならびにその作製および使用方法
WO2015183794A1 (fr) 2014-05-27 2015-12-03 City Of Hope Complexes d'agonistes de tgr5 pour le traitement du diabète et du cancer
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
WO2016004383A1 (fr) 2014-07-03 2016-01-07 City Of Hope Antagonistes de ctla-4 ciblant spécifiquement les tumeurs
WO2016018917A2 (fr) 2014-07-28 2016-02-04 The Regents Of The University Of Califoria Compositions et procédés de fabrication d'acides nucléiques polymérisés
US10980744B2 (en) 2014-08-08 2021-04-20 The Regents Of The University Of California High density peptide polymers
CN113620978A (zh) 2014-09-11 2021-11-09 加利福尼亚大学董事会 mTORC1抑制剂
CN111808136B (zh) 2014-09-15 2024-06-11 加利福尼亚大学董事会 核苷酸类似物
CN106687445A (zh) 2014-09-17 2017-05-17 维颂公司 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
JP2017528498A (ja) 2014-09-25 2017-09-28 アラクセス ファーマ エルエルシー Kras g12c変異体タンパク質のインヒビター
WO2016049568A1 (fr) 2014-09-25 2016-03-31 Araxes Pharma Llc Méthodes et compositions permettant l'inhibition de la ras
ES2757798T3 (es) 2014-10-02 2020-04-30 Allergan Inc Profármacos de éster de gamma-lactamas y su uso
WO2016061147A1 (fr) 2014-10-13 2016-04-21 John Eric Paderi Revêtement d'une lumière vasculaire en vue d'une fistule artério-veineuse
WO2016061145A1 (fr) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Protéoglycanes synthétiques pour empêcher l'adhérence tissulaire
WO2016065083A1 (fr) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycanes comprenant des peptides se fixant au collagène pour le traitement d'une lésion gastro-œsophagienne
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
ES2789351T3 (es) 2015-01-13 2020-10-26 Hope City Máscaras de enlace peptídico de proteínas de unión a CTLA4
UY36519A (es) 2015-01-16 2016-08-31 Hope City Anticuerpos de penetración celular
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
HUE059559T2 (hu) 2015-02-25 2022-12-28 Univ California 5HT agonisták az epilepsziás rendellenességek kezelésére
RU2017131562A (ru) 2015-02-27 2019-03-27 Версеон Корпорейшн Замещенные пиразольные соединения как ингибиторы сериновых протеаз
KR20170122788A (ko) 2015-02-27 2017-11-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연골 재생을 가능하게 하는 소분자
MX394452B (es) 2015-02-27 2025-03-21 Curtana Pharmaceuticals Inc Inhibicion de la actividad de olig2.
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
HK1244715A1 (zh) 2015-03-02 2018-08-17 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
JP6976854B2 (ja) 2015-03-30 2021-12-08 シティ・オブ・ホープCity of Hope 機械的にかみ合った複合体
ES2898765T3 (es) 2015-04-10 2022-03-08 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos
US10428064B2 (en) 2015-04-15 2019-10-01 Araxes Pharma Llc Fused-tricyclic inhibitors of KRAS and methods of use thereof
WO2016166604A1 (fr) 2015-04-17 2016-10-20 Ludwig Institute For Cancer Research Ltd Inhibiteurs de plk4
JP6704000B2 (ja) 2015-04-24 2020-06-03 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Ror1−ror2結合のモジュレーター
EP3842448A1 (fr) 2015-05-15 2021-06-30 City of Hope Compositions de récepteur d'antigène chimérique
US10787664B2 (en) 2015-05-26 2020-09-29 City Of Hope Compounds of chemically modified oligonucleotides and methods of use thereof
US10765696B2 (en) 2015-06-10 2020-09-08 City Of Hope Compositions of and methods of treatment with zwitterionic polysaccharide
US20180282310A1 (en) 2015-06-10 2018-10-04 Biogen Ma Inc. Forms and compositions of biaryl inhibitors of bruton's tyrosine kinase
WO2016210165A1 (fr) 2015-06-24 2016-12-29 Principia Biopharma Inc. Inhibiteurs de la tyrosine kinase
US10758624B2 (en) 2015-07-02 2020-09-01 City Of Hope Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3331543A4 (fr) 2015-08-06 2019-03-20 City of Hope Conjugués de pénétration cellulaire formés de protéine et d'anticorps et méthodes d'utilisation
EP3128007A1 (fr) 2015-08-07 2017-02-08 Gene Signal International SA Émulsion stérile comprenant un oligonucléotide de phosphorothioate stable
US11136301B2 (en) 2015-08-31 2021-10-05 The Regents of the University of California, A California Corporation et al. Broad spectrum antiviral compounds and uses thereof
EP3350181B1 (fr) 2015-09-02 2023-11-01 The Regents of The University of California Ligands her3 et utilisations de ceux-ci
EP3350167A4 (fr) 2015-09-04 2019-04-03 City of Hope Antagonistes du récepteur des androgènes
CN108348512B (zh) 2015-09-17 2021-09-03 希望之城 Pcna抑制剂
WO2017051251A1 (fr) 2015-09-25 2017-03-30 Ludwig Institute For Cancer Research Ltd Dérivés de 3-hydroxy-quinazoline-2,4-dione et leur utilisation comme modulateurs de nucléase
EP3356349A1 (fr) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibiteurs de protéines mutantes kras g12c
EP3356347A1 (fr) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibiteurs de protéines kras portant la mutation g12c
EP3356351A1 (fr) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibiteurs de protéines kras portant la mutation g12c
WO2017058902A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines mutantes kras g12c
EP3356359B1 (fr) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibiteurs de protéines kras portant la mutation g12c
WO2017058805A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines kras portant la mutation g12c
WO2017058728A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines kras portant la mutation g12c
TW201718028A (zh) 2015-10-13 2017-06-01 賽米克Ip有限責任公司 Ve-鈣黏蛋白結合性生物結合物
CN108367021A (zh) 2015-10-15 2018-08-03 希望之城 包含硫代磷酸化寡脱氧核苷酸的化合物和组合物及其使用方法
WO2017070256A2 (fr) 2015-10-19 2017-04-27 Araxes Pharma Llc Méthode de criblage d'inhibiteurs de ras
EP3364976B1 (fr) 2015-10-19 2026-03-18 Board of Regents, The University of Texas System Composés de pipérazinyl norbenzomorphane et procédés d'utilisation de ceux-ci
JP7034078B2 (ja) 2015-10-23 2022-03-11 イーアールエックス ファーマシューティカルズ インコーポレイテッド セラストロールの類似体
AU2016342352B2 (en) 2015-10-23 2022-06-02 Sunesis Pharmaceuticals, Inc. Heterocyclic PDK1 inhibitors for use to treat cancer
AU2016344349B2 (en) 2015-10-25 2022-05-19 Iview Therapeutics, Inc. Pharmaceutical formulations that form gel in situ
US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
KR20180081596A (ko) 2015-11-16 2018-07-16 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
CN108603037B (zh) 2015-12-10 2020-11-17 希望之城 细胞穿透花青偶联抗体
ES2913051T3 (es) 2015-12-24 2022-05-31 Univ California Reguladores de CFTR y métodos de uso de los mismos
MX383072B (es) 2015-12-24 2025-03-13 Univ California Reguladores del cftr y métodos para su uso
CA3010445A1 (fr) 2016-01-05 2017-07-13 The Regents Of The University Of California Amphophiles de benzothiazole
US10519442B2 (en) 2016-02-11 2019-12-31 City Of Hope Twist signaling inhibitor compositions and methods of using the same
US11208411B2 (en) 2016-03-17 2021-12-28 The Regents Of The University Of California Compositions and methods for treating parasitic diseases
WO2017172979A1 (fr) 2016-03-30 2017-10-05 Araxes Pharma Llc Composés quinazoline substitués et procédés d'utilisation
GR1009006B (el) 2016-04-01 2017-04-04 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χρηση περιεχον βιματοπροστη και τιμολολη
GR1009040B (el) 2016-04-19 2017-05-19 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου
PL3458448T3 (pl) 2016-04-25 2021-12-06 Forma Therapeutics, Inc. Inhibitory fasn do zastosowania w leczeniu niealkoholowego stłuszczeniowego zapalenia wątroby
CA3022432A1 (fr) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Liants de recepteur sigma
TW201808914A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TWI763668B (zh) 2016-05-05 2022-05-11 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
CR20180560A (es) 2016-05-12 2019-01-25 Anacor Pharmaceuticals Inc Ésteres de oxaboral y sus usos
CA3063834C (fr) 2016-05-26 2025-05-06 The Regents Of The University Of California Associations de modulateurs du récepteur des œstrogènes
CN115054586B (zh) 2016-06-29 2024-08-02 普林斯匹亚生物制药公司 改性的释放制剂
US11045493B2 (en) 2016-07-11 2021-06-29 The Regents Of The University Of California Synthetic melanin nanoparticles and uses thereof
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
JP7214632B2 (ja) 2016-07-21 2023-01-30 バイオジェン エムエー インク. ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物
AU2017302635B2 (en) 2016-07-29 2021-09-16 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
WO2018039612A1 (fr) 2016-08-26 2018-03-01 The Regents Of The University Of California Compositions et méthodes favorisant la croissance des cheveux au moyen d'inhibiteurs de mpc1
WO2018053035A1 (fr) 2016-09-13 2018-03-22 The Jackson Laboratory Déméthylation et méthylation d'adn ciblées
CN109952104B (zh) 2016-09-15 2023-03-28 希望之城 二硫etp衍生物
US10849955B2 (en) 2016-09-28 2020-12-01 City Of Hope Methods of treating pancreatic cancer using GPCR antagonists
WO2018064510A1 (fr) 2016-09-29 2018-04-05 Araxes Pharma Llc Inhibiteurs de protéines mutantes kras g12c
EP3523289A1 (fr) 2016-10-07 2019-08-14 Araxes Pharma LLC Composés hétérocycliques en tant qu'inhibiteurs de ras et leurs procédés d'utilisation
US10646540B2 (en) 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
KR20190095355A (ko) 2016-12-15 2019-08-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 암의 치료를 위한 조성물 및 방법
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
WO2018140599A1 (fr) 2017-01-26 2018-08-02 Araxes Pharma Llc Composés à base de benzothiophène et de benzothiazole et leurs procédés d'utilisation
JP7327802B2 (ja) 2017-01-26 2023-08-16 アラクセス ファーマ エルエルシー 縮合ヘテロ-ヘテロ二環式化合物およびその使用方法
WO2018140513A1 (fr) 2017-01-26 2018-08-02 Araxes Pharma Llc Dérivés de 1-(3-(6-(3-hydroxynaphtalen-1-yl)benzofuran-2-yl)azétidin-1yl)prop-2-en-1-one et composés similaires utilisés en tant que modulateurs de kras g12c pour le traitement du cancer
EP3573954A1 (fr) 2017-01-26 2019-12-04 Araxes Pharma LLC Composés benzohétéroaromatiques bicycliques fusionnés et leurs procédés d'utilisation
LT3576753T (lt) 2017-02-03 2024-07-25 Laboratoires Kôl Sterili emulsija, apimanti stabilų fosforotioato oligonukleotidą
US10052343B1 (en) 2017-02-03 2018-08-21 Gene Signal International Sa Sterile formulation comprising a stable phosphorothioate oligonucleotide
WO2018218069A1 (fr) 2017-05-25 2018-11-29 Araxes Pharma Llc Dérivés de quinazoline utilisés en tant que modulateurs de kras, hras ou nras mutants
CN110869357A (zh) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 化合物及其用于治疗癌症的使用方法
US10745385B2 (en) 2017-05-25 2020-08-18 Araxes Pharma Llc Covalent inhibitors of KRAS
AU2018290225A1 (en) 2017-06-21 2020-01-23 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
US11554178B2 (en) 2017-06-30 2023-01-17 City Of Hope Compositions and methods of modulating macrophage activity
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface
US11389460B2 (en) 2017-09-15 2022-07-19 City Of Hope Methods and compositions for treating endometrial cancer
CN111386283A (zh) 2017-09-29 2020-07-07 基因泰克公司 肽抗菌复合物及其使用方法
WO2019067015A1 (fr) 2017-09-29 2019-04-04 City Of Hope Récepteurs d'antigènes chimériques et anticorps bispécifiques pour le traitement du lymphome à cellules du manteau
WO2019070917A1 (fr) 2017-10-03 2019-04-11 The Schepens Eye Research Institute, Inc. Composés et compositions pour inhiber la dégénérescence de l'épithélium pigmentaire rétinien et procédés les utilisant
RU2020115154A (ru) 2017-10-10 2021-11-15 Сирос Фармасьютикалз, Инк. Производные пирролотриазина и способы ингибирования киназ там
US11618780B2 (en) 2017-10-20 2023-04-04 City Of Hope Composition and method for activating latent human immunodeficiency virus (HIV)
EP3704096B1 (fr) 2017-11-02 2026-04-22 Calico Life Sciences LLC Modulateurs de la voie de réponse intégrée au stress
US11939320B2 (en) 2017-11-02 2024-03-26 Abbvie Inc. Modulators of the integrated stress pathway
EP3704098B1 (fr) 2017-11-02 2024-01-24 Calico Life Sciences LLC Modulateurs de la voie de réponse intégrée au stress
SG11202004009TA (en) 2017-11-02 2020-05-28 Calico Life Sciences Llc Modulators of the integrated stress pathway
UY37958A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
CA3080804A1 (fr) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulateurs de la voie de reponse integree au stress
EP3704125B1 (fr) 2017-11-02 2026-03-11 Calico Life Sciences LLC Modulateurs de la voie de réponse intégrée au stress
UY37956A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
EP3706750A1 (fr) 2017-11-06 2020-09-16 RAPT Therapeutics, Inc. Modulateurs du récepteur de chimiokine pour le traitement de cancers positifs au virus epstein-barr
EP3720560A4 (fr) 2017-12-06 2022-01-05 Ludwig Institute for Cancer Research Ltd Méthodes de traitement du cancer par des inhibiteurs de plk4
IL275121B2 (en) 2017-12-07 2025-11-01 Amplyx Pharmaceuticals Inc Heterocycle substituted pyridine derivative antifungal agents
SG11202005237SA (en) 2017-12-15 2020-07-29 Pyramid Biosciences Inc 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
WO2019126037A1 (fr) 2017-12-19 2019-06-27 City Of Hope Arncr transactivateurs et arng modifiés et leurs utilisations
AU2019209470A1 (en) 2018-01-16 2020-08-13 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
US11918592B2 (en) 2018-01-16 2024-03-05 Syros Pharmaceuticals, Inc. Inhibitors of cyclin dependent kinase 7 (CDK7)
DK3743418T3 (da) 2018-01-26 2024-09-09 Rapt Therapeutics Inc Chemokinreceptormodulatorer og anvendelser deraf
EP3765459A1 (fr) 2018-03-13 2021-01-20 Shire Human Genetic Therapies, Inc. Imidazopyridines substituées en tant qu'inhibiteurs de la kallicréine plasmatique et leurs utilisations
EP4643950A3 (fr) 2018-04-27 2026-01-14 Spruce Biosciences, Inc. Méthodes de traitement de tumeurs de repos surrénales testiculaires et ovariennes
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
MX2020011565A (es) 2018-05-01 2021-01-29 Revolution Medicines Inc Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor.
WO2019213611A1 (fr) 2018-05-04 2019-11-07 Cirius Therapeutics, Inc. Analogues de thiazolidinedione pour le traitement de nafld et de maladies métaboliques
EP3802544A1 (fr) 2018-06-05 2021-04-14 RAPT Therapeutics, Inc. Composés de pyrazolo-pyrimidin-amino-cycloalkyle et leurs utilisations thérapeutiques
US20220133747A1 (en) 2018-06-06 2022-05-05 The Regents Of The University Of California Estrogen receptor inhibitors and uses therof
BR112020026086A2 (pt) 2018-06-21 2021-03-23 Calico Life Sciences Llc inibidores da proteína tirosina fosfatase e métodos de uso destes
KR20210023984A (ko) 2018-06-25 2021-03-04 앰플릭스 파마슈티컬스, 인크. 헤테로환형 고리 및 아미노기로 치환된 피리딘 유도체
MX2021000887A (es) 2018-08-01 2021-03-31 Araxes Pharma Llc Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer.
CN112839652A (zh) 2018-08-15 2021-05-25 艾葳生物科技有限公司 VEGF和TGFβ的多激酶抑制剂及其用途
US20210221864A1 (en) 2018-08-24 2021-07-22 City Of Hope Masked cytokine conjugates
WO2020047510A1 (fr) 2018-08-31 2020-03-05 Amplyx Pharmaceuticals, Inc. Composés et méthodes pour le traitement d'infections fongiques
CN112955187A (zh) 2018-09-10 2021-06-11 加利福尼亚大学董事会 二硫醇糖粘液溶解剂和其用途
TWI877863B (zh) 2018-10-11 2025-03-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
CN113396150B (zh) 2018-11-01 2024-03-12 凌科药业(杭州)有限公司 三环janus激酶1抑制剂及其组合物和方法
KR102888598B1 (ko) * 2018-11-26 2025-11-20 아이비바 바이오파마, 인크. 약물 전달을 위한 약학적 생분해성 겔
WO2020118683A1 (fr) 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides de dérivés de pyrazolyl-amino-pyrimidinyle, compositions et procédés associés
IL286373B2 (en) 2019-03-14 2026-03-01 Calico Life Sciences Llc Protein tyrosine phosphate inhibitor compounds and uses thereof
MX2021013197A (es) 2019-04-30 2022-02-24 Calico Life Sciences Llc Cicloalquilos sustituidos como moduladores de la vía integrada del estrés.
FR3095592B1 (fr) * 2019-05-02 2021-05-21 Unither Pharmaceuticals Composition à base de gomme gellane et de phényléphrine, procédé de fabrication et utilisation comme produit ophtalmique
EP3968979A4 (fr) 2019-05-15 2023-03-01 Bexson Biomedical, Inc. Formulation de kétamine pour injection sous-cutanée
EP4516300A3 (fr) 2019-06-14 2025-08-06 Children's Hospital Medical Center Ciblage thérapeutique rationnel d'états de signalisation immunitaire oncogènes dans des tumeurs malignes myéloïdes par l'intermédiaire de l'enzyme de conjugaison d'ubiquitine ube2n
DK4031547T3 (da) 2019-09-18 2024-09-09 Takeda Pharmaceuticals Co Plasmakallikreininhibitorer og anvendelser deraf
WO2021053556A1 (fr) 2019-09-18 2021-03-25 Novartis Ag Protéines de fusion nkg2d et leurs utilisations
EP4031245A1 (fr) 2019-09-18 2022-07-27 Takeda Pharmaceutical Company Limited Inhibiteurs hétéroaryles de la kallicréine plasmatique
US12516145B2 (en) 2019-09-30 2026-01-06 Northwestern University Bioactive peptide brush polymers via photoinduced reversible-deactivation radical polymerization
US20210106584A1 (en) 2019-10-14 2021-04-15 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
WO2021087076A1 (fr) 2019-10-30 2021-05-06 Northwestern University Analogues de phéomélanine contenant du sélénium et matériaux apparentés et procédés de fabrication
EP4058456A1 (fr) 2019-11-13 2022-09-21 RAPT Therapeutics, Inc. Formes cristallines d'un antagoniste du récepteur de chimiokine c-c de type 4 et leurs utilisations
CA3162069A1 (fr) 2019-12-18 2021-06-24 Elliot P. Farney Inhibiteurs de proteine tyrosine phosphatase et leurs methodes d'utilisation
US11814390B2 (en) 2020-01-22 2023-11-14 Principia Biopharma Inc. Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
WO2021198911A1 (fr) 2020-03-31 2021-10-07 Sentiss Pharma Private Limited Processus de stérilisation de solution de formation de gel de timolol par filtration aseptique
IL296921A (en) 2020-04-15 2022-12-01 Pyramid Biosciences Inc Methods for making receptor tyrosine kinase inhibitors
GR1010024B (el) 2020-05-06 2021-06-01 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση που περιλαμβανει βριμονιδινη
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
AU2021328671A1 (en) 2020-08-18 2023-02-16 Cybin Irl Limited Phenethylamine derivatives, compositions, and methods of use
JP2023545015A (ja) 2020-10-02 2023-10-26 ミトキニン インコーポレイテッド 腎疾患及び線維症を治療する組成物及び方法
WO2022094409A1 (fr) 2020-11-02 2022-05-05 Trethera Corporation Formes cristallines d'un inhibiteur de la désoxycytidine kinase et leurs utilisations
JP2023551145A (ja) 2020-11-18 2023-12-07 ベクソン バイオメディカル,インク. 医薬化合物の錯化剤塩製剤
US20240058344A1 (en) 2020-12-18 2024-02-22 Cornell University Methods of treating neurodegenerative disorders and stat3-linked cancers using suppressors of electron leak
US11918582B2 (en) 2021-03-15 2024-03-05 Rapt Therapeutics, Inc. Pyrazole pyrimidine compounds and uses thereof
CN117396474A (zh) 2021-03-17 2024-01-12 武田药品工业株式会社 血浆激肽释放酶抑制剂
US20240199613A1 (en) 2021-03-17 2024-06-20 Takeda Pharmaceutical Company Limited Polycyclic inhibitors of plasma kallikrein
CN117396473A (zh) 2021-03-17 2024-01-12 武田药品工业株式会社 血浆激肽释放酶的咪唑并吡啶基抑制剂
BR112023018619A2 (pt) 2021-03-17 2023-11-28 Takeda Pharmaceuticals Co Inibidores de heteroaril de calicreína plasmática
JP2024512497A (ja) 2021-03-17 2024-03-19 武田薬品工業株式会社 血漿カリクレインの阻害剤
AU2022258467A1 (en) 2021-04-13 2023-11-30 Contineum Therapeutics, Inc. Crystalline compound of muscarinic acetylcholine m1 receptor antagonists
EP4479373A1 (fr) 2022-02-15 2024-12-25 Cybin IRL Limited Compositions de phénéthylamine thérapeutique et procédés d'utilisation
WO2023156453A1 (fr) 2022-02-15 2023-08-24 Cybin Irl Limited Dérivés de phénétylamine, compositions et procédés d'utilisation
US12240837B2 (en) 2022-04-06 2025-03-04 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
CA3256390A1 (fr) 2022-05-25 2023-11-30 Revolution Medicines, Inc. Méthodes de traitement du cancer au moyen d'un inhibiteur de mtor
US12377036B2 (en) 2022-06-21 2025-08-05 Northwestern University Melanin hair dye with thickeners
TW202517627A (zh) 2023-07-12 2025-05-01 美商瑞佩特治療公司 C-c趨化因子受體4型拮抗劑的結晶型及其用途
WO2025015189A1 (fr) 2023-07-13 2025-01-16 Comanche Biopharma Corp. Formulations de composés d'acide nucléique et leurs utilisations
WO2025027529A1 (fr) 2023-07-31 2025-02-06 Advesya Conjugués médicament-anticorps anti-il-1rap et leurs procédés d'utilisation
WO2025068803A1 (fr) 2023-09-26 2025-04-03 Astrazeneca Ab Combinaisons thérapeutiques comprenant des lymphocytes t récepteurs antigéniques chimériques anti-steap2
TW202530255A (zh) 2023-12-15 2025-08-01 法商亞維西亞有限公司 抗il-1rap結合結構域及其抗體-藥物偶聯物
WO2026022243A1 (fr) 2024-07-23 2026-01-29 The Trustees Of The University Of Pennsylvania Combinaison d'un inhibiteur de gsk-3 et d'un inhibiteur de lsd-1 pour une utilisation dans le traitement du cancer

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441729A (en) * 1943-12-08 1948-05-18 Kelco Co Algin gel-forming compositions
US2935447A (en) * 1957-02-19 1960-05-03 Kelco Co Appetite depressant containing alginate
FR1312244A (fr) * 1962-01-09 1962-12-14 Bernburg Serum Werk Veb Procédé de fabrication de supports de pommade exempts de corps gras
BE731578A (fr) * 1969-04-16 1969-10-01
US4013792A (en) * 1974-04-11 1977-03-22 Warner-Lambert Company Process for the production of base for topical steroids
AU7776275A (en) * 1974-04-11 1976-08-05 Warner Lambert Co Production of base for topical steroids
NL188266C (nl) * 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
US4039662A (en) * 1975-12-04 1977-08-02 Alcon Laboratories, Inc. Ophthalmic solution
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
CA1072413A (fr) * 1976-07-13 1980-02-26 West Laboratories Systemes de gel de type poloxamer, a temperature de gelification superieure a la temperature ambiante
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4326053A (en) * 1978-12-04 1982-04-20 Merck & Co., Inc. Polysaccharide S-60 and bacterial fermentation process for its preparation
KR830002802B1 (ko) * 1978-12-04 1983-12-16 제임스 에프 · 너우톤 박테리아 발효에 의한 다당류 s-60의 제조방법
US4409205A (en) * 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4407792A (en) * 1979-05-09 1983-10-04 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4503084A (en) * 1983-05-31 1985-03-05 Merck & Co., Inc. Non-heated gellan gum gels
US4563366A (en) * 1983-05-31 1986-01-07 Merck & Co., Inc. Non-heated gellan gum gels
GB8318403D0 (en) * 1983-07-07 1983-08-10 Sutherland I W Gel-forming polysaccharides
DE3335593A1 (de) * 1983-09-30 1985-04-11 Diamalt AG, 8000 München Gelier- und verdickungsmittel auf der basis von cassia-galactomannanen
US4717713A (en) * 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
US4517216A (en) * 1984-03-05 1985-05-14 Merck & Co., Inc. Gellan gum/gelatin blends
GB8431699D0 (en) * 1984-12-14 1985-01-30 Mars G B Ltd Gel system

Also Published As

Publication number Publication date
FR2588189A1 (fr) 1987-04-10
LV5725A4 (lv) 1996-02-20
US4861760A (en) 1989-08-29
KR940000229B1 (ko) 1994-01-12
IE59464B1 (en) 1994-02-23
NO863916L (no) 1987-04-06
IE862481L (en) 1987-04-03
DE3684121D1 (de) 1992-04-09
NO173212C (no) 1993-11-17
FR2588189B1 (fr) 1988-12-02
GR862444B (en) 1987-01-27
FI863990L (fi) 1987-04-04
IL80156A0 (en) 1986-12-31
CA1280367C (fr) 1991-02-19
AU6318986A (en) 1987-04-09
KR870003773A (ko) 1987-05-04
FI91217B (fi) 1994-02-28
IL80156A (en) 1990-09-17
EP0227494A1 (fr) 1987-07-01
NZ217662A (en) 1990-02-26
FI91217C (fi) 1994-06-10
CY1779A (en) 1995-10-20
FI863990A0 (fi) 1986-10-02
NL950012I1 (nl) 1996-10-01
ES2002401A6 (es) 1988-08-01
PT83471A (en) 1986-11-01
ATE72990T1 (de) 1992-03-15
DE227494T1 (de) 1988-03-17
DK469886D0 (da) 1986-10-02
JPH0667853B2 (ja) 1994-08-31
DK170500B1 (da) 1995-10-02
JPS62181228A (ja) 1987-08-08
NO1995003I1 (no) 1995-04-10
CN1046094C (zh) 1999-11-03
HK42594A (en) 1994-05-13
EP0227494B1 (fr) 1992-03-04
NO863916D0 (no) 1986-10-02
LV5725B4 (lv) 1996-06-20
NO173212B (no) 1993-08-09
DK469886A (da) 1987-04-04
CN86106637A (zh) 1987-04-08
AU595240B2 (en) 1990-03-29
PT83471B (pt) 1988-11-30
ZA867464B (en) 1987-07-29

Similar Documents

Publication Publication Date Title
LU88694I2 (fr) Timolol ou un sel pharmaceutuquement acceptable de celui-ci en particulier le maléate de timolol en combinaison avec une gomme gélifiante
CA2059403A1 (fr) Utilisation de carragenines dans des compositions ophtalmiques a application topique
EA200401009A1 (ru) Предварительно желатинированный крахмал в композиции с контролируемым высвобождением
BR9901782A (pt) Forma para dosagem de nefazodona.
EA200100799A1 (ru) Антагонисты фактора опухолевого некроза и их применение при эндометриозе
KR900015768A (ko) 고형겔 외용약 전달 시스템
KR880007060A (ko) 제약 조성물
NZ331051A (en) Instant release forms of gelled active substances
GR3003539T3 (fr)
IT1215172B (it) Preparati farmaceutici ad effetto antiipertensivo e cardioprotettivo
DE69923832D1 (de) Hemmung der tnf-aktivität mit zusammensetzungen enthaltend heparin und lösliche tnf rezeptoren
EE200100066A (et) Naatriumkloriidi kasutamine kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsetekõrvaltoimete vähendamiseks
IE840977L (en) Pharmaceutical preparations
MXPA00003363A (es) Gel de dexametasona.
IT8720271A0 (it) Nuovi derivati dell'ergolene, composizioni farmaceutiche che licontengono e procedimento per lapreparazione dei medesimi.
ES8600050A1 (es) Un procedimiento para preparar una crema dental
GB1485382A (en) Injectable therapeutic compositions
ES2058316T3 (es) Procedimiento para la obtencion de un medicamento antitusigeno.