HK42594A - Pharmaceutical composition of the type which undergoes liquid-gel phase transition - Google Patents

Pharmaceutical composition of the type which undergoes liquid-gel phase transition Download PDF

Info

Publication number
HK42594A
HK42594A HK42594A HK42594A HK42594A HK 42594 A HK42594 A HK 42594A HK 42594 A HK42594 A HK 42594A HK 42594 A HK42594 A HK 42594A HK 42594 A HK42594 A HK 42594A
Authority
HK
Hong Kong
Prior art keywords
composition
active substance
polysaccharide
pharmaceutically active
liquid
Prior art date
Application number
HK42594A
Other languages
German (de)
English (en)
Inventor
Mazuel Claude
Friteyre Marie-Claire
Original Assignee
Laboratoires Merck Sharp & Dohme-Chibret Snc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Merck Sharp & Dohme-Chibret Snc filed Critical Laboratoires Merck Sharp & Dohme-Chibret Snc
Publication of HK42594A publication Critical patent/HK42594A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (14)

  1. Composition ophtalmologique conçue pour entrer en contact avec le fluide lacrymal, ladite composition étant conçue pour être administrée sous une forme liquide non gélifiée et conçue pour se gélifier in situ, cette composition contenant au moins un polysaccharide en solution aqueuse, du type qui subit une gélification par transition de phases liquide-gel in situ sous l'effet d'une augmentation de la force ionique dudit fluide lacrymal.
  2. Composition selon la revendication 1, dans laquelle le polysaccharide est obtenu par fermentation d'un micro-organisme.
  3. Composition selon la revendication 2 dans laquelle le micro-organisme est Pseudomonas elodea.
  4. Composition selon la revendication 1, dans laquelle le polysaccharide a comme unité tétrasaccharide de base         → 3)-β-D-Glcp-(1→ 4)-β-D-GLcpA-(1→ 4)-β-D-Glcp-(1→ 4)-α-L-Rhap-(1→ qui peut, ou non, être partiellement 0-acétylée sur ses résidus β-D-glycopyranosyle.
  5. Composition selon l'une des revendications 1 à 4, qui contient de 0,1 à 2,0% en poids dudit polysaccharide.
  6. Composition selon l'une des revendications 1 à 5 qui contient en outre un agent d'ajustement de la tonicité.
  7. Composition selon la revendication 6, dans laquelle l'agent d'ajustement de la tonicité est un sucre tel que le mannitol ou le sorbitol.
  8. Composition selon l'une quelconque des revendications 1 à 7, qui contient au moins une substance pharmaceutiquement active dans des buts curatifs ou de diagnostic.
  9. Composition selon la revendication 8, dans laquelle la substance pharmaceutiquement active est le timolol ou un de ses dérivés.
  10. Composition selon la revendication 8 ou 9, qui contient de 0,1 à 2,0% en poids de polysaccharide et de 0,001 à 5% en poids d'au moins une substance pharmaceutiquement active dans des buts curatifs ou de diagnostic.
  11. Composition selon l'une des revendications 1 à 10 dans laquelle la substance pharmaceutiquement active est en solution.
  12. Composition selon l'une des revendications 1 à 10 dans laquelle la substance pharmaceutiquement active est en suspension.
  13. Composition selon l'une des revendications 1 à 10 dans laquelle la substance pharmaceutiquement active est en émulsion.
  14. Composition pour application à une membrane muqueuse selon l'une des revendications 1 à 13.
HK42594A 1985-10-03 1994-05-05 Pharmaceutical composition of the type which undergoes liquid-gel phase transition HK42594A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8514689A FR2588189B1 (fr) 1985-10-03 1985-10-03 Composition pharmaceutique de type a transition de phase liquide-gel

Publications (1)

Publication Number Publication Date
HK42594A true HK42594A (en) 1994-05-13

Family

ID=9323509

Family Applications (1)

Application Number Title Priority Date Filing Date
HK42594A HK42594A (en) 1985-10-03 1994-05-05 Pharmaceutical composition of the type which undergoes liquid-gel phase transition

Country Status (25)

Country Link
US (1) US4861760A (fr)
EP (1) EP0227494B1 (fr)
JP (1) JPH0667853B2 (fr)
KR (1) KR940000229B1 (fr)
CN (1) CN1046094C (fr)
AT (1) ATE72990T1 (fr)
AU (1) AU595240B2 (fr)
CA (1) CA1280367C (fr)
CY (1) CY1779A (fr)
DE (2) DE3684121D1 (fr)
DK (1) DK170500B1 (fr)
ES (1) ES2002401A6 (fr)
FI (1) FI91217C (fr)
FR (1) FR2588189B1 (fr)
GR (1) GR862444B (fr)
HK (1) HK42594A (fr)
IE (1) IE59464B1 (fr)
IL (1) IL80156A (fr)
LU (1) LU88694I2 (fr)
LV (1) LV5725B4 (fr)
NL (1) NL950012I1 (fr)
NO (2) NO173212C (fr)
NZ (1) NZ217662A (fr)
PT (1) PT83471B (fr)
ZA (1) ZA867464B (fr)

Families Citing this family (390)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095026A (en) * 1983-02-04 1992-03-10 University Of Iowa Research Foundation Prodrugs of carbonic anhydrase inhibitors
US5200180A (en) * 1987-06-26 1993-04-06 Christian Bannert Pharmaceutical composition for the treatment of the human eye
FR2618333B1 (fr) * 1987-07-20 1990-07-13 Merck Sharp & Dohme Composition pharmaceutique et/ou cosmetique a usage topique contenant de la gomme rhamsam
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
US5034406A (en) * 1989-09-26 1991-07-23 Allergan, Inc. Method for reducing or maintaining intraocular pressure
US5461081A (en) * 1989-09-28 1995-10-24 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
US5521222A (en) * 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
FR2653021A1 (fr) * 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.
FR2653018A1 (fr) * 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique non solide a base de microparticules de polymere contenant au moins un principe actif en suspension dans un milieu dispersant et procede de preparation de ladite composition.
US5141928B1 (en) * 1989-12-20 1995-11-14 Brujo Inc Ophthalmic medication
US5496471A (en) * 1990-01-08 1996-03-05 Ciba-Geigy Corporation Apparatus for removing components from solutions
FR2657018A1 (fr) * 1990-01-12 1991-07-19 Merck Sharp & Dohme Composition ophtalmique fluide a base de microparticules lipidiques contenant au moins un principe actif et son procede de preparation.
US5593683A (en) * 1990-05-01 1997-01-14 Mdv Technologies, Inc. Method of making thermoreversible polyoxyalkylene gels
US5298260A (en) * 1990-05-01 1994-03-29 Mediventures, Inc. Topical drug delivery with polyoxyalkylene polymer thermoreversible gels adjustable for pH and osmolality
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
CA2044878C (fr) * 1990-08-07 2000-12-26 Tacey X. Viegas Gels thermoreversibles et thermo-irreversibles
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
FR2665635A1 (fr) * 1990-08-10 1992-02-14 Merck Sharp & Dohme Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation.
US5847023A (en) * 1990-10-26 1998-12-08 Mdv Technologies, Inc. Thermal irreversible gel corneal contact lens formed in situ
DK0495421T3 (da) * 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5624962A (en) * 1993-04-16 1997-04-29 Wakamoto Pharmaceutical Co., Ltd. Aqueous drug composition having property of reversible thermosetting gelation
SE9301877D0 (sv) * 1993-06-02 1993-06-02 Kabi Pharmacia Ab In situ gel for therapeutic use
US5545617A (en) * 1993-11-12 1996-08-13 The Schepens Eye Research Institute, Inc. Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion
AU684950B2 (en) * 1994-05-06 1998-01-08 Alcon Laboratories, Inc. Use of vitamin E tocopheryl derivatives in ophthalmic compositions
IL114193A (en) * 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5827835A (en) * 1994-08-30 1998-10-27 Alcon Laboratories, Inc. Thermally-gelling emulsions
WO1996006597A1 (fr) * 1994-08-30 1996-03-07 Alcon Laboratories, Inc. Excipients ophtalmiques a gelification thermique contenant des ethers cellulosiques
US5516808A (en) * 1994-10-27 1996-05-14 Sawaya; Assad S. Topical cellulose pharmaceutical formulation
US5603929A (en) * 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US6165490A (en) * 1996-04-05 2000-12-26 Staar Surgical Ag Biological material, method of preparing such materials, uses thereof and products made therefrom
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
US5843470A (en) * 1995-10-06 1998-12-01 Mdv Technologies, Inc. Method and composition for inhibiting post-surgical adhesions
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
CA2237898A1 (fr) * 1995-11-17 1997-05-29 Louis Desantis Jr. Therapie combinee pour le traitement du glaucome
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5641532A (en) * 1995-12-15 1997-06-24 The Procter & Gamble Company Beverages having stable flavor/cloud emulsions in the presence of polyphosphate-containing preservative systems by including gellan gum
WO1997029777A1 (fr) 1996-02-13 1997-08-21 Dainippon Pharmaceutical Co., Ltd. Systeme d'administration de medicament utilisant une galactoxyloglucane
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
US5888493A (en) * 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
AU6876498A (en) * 1997-04-03 1998-10-22 Point Biomedical Corporation Intravesical drug delivery system
GB9707934D0 (en) * 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
BR9806123A (pt) * 1997-07-29 1999-08-31 Alcon Lab Inc Soluções condicionantes para cuidado de lente de contato dura
DK0999854T3 (da) * 1997-07-29 2004-02-09 Alcon Mfg Ltd Omskiftelige viskoelastiske systemer, der indeholder galactomannanpolymerer og -borater
DE69818675T2 (de) 1997-07-29 2004-07-29 Alcon Laboratories, Inc., Fort Worth Galaktomannanpolymere und borat enthaltende augenarzneimittel
US20040063678A1 (en) * 1997-10-06 2004-04-01 Bausch & Lomb Incorporated Dexamethasone Gel
US6174524B1 (en) 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6669927B2 (en) 1998-11-12 2003-12-30 3M Innovative Properties Company Dental compositions
US6312667B1 (en) * 1998-11-12 2001-11-06 3M Innovative Properties Company Methods of etching hard tissue in the oral environment
US6312666B1 (en) * 1998-11-12 2001-11-06 3M Innovative Properties Company Methods of whitening teeth
EA004050B1 (ru) * 1998-12-11 2003-12-25 Бакулиш Мафатлал Хамар Способ изготовления состава местных бета-блокаторов улучшенного действия
ATE312103T1 (de) * 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
DE60003445T2 (de) 1999-11-01 2003-12-24 Alcon, Inc. Pharmazeutische zusammensetzungen ein fluorchinolonantibiotikum und xanthangummi enthaltend
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
AU2001270593A1 (en) 2000-07-28 2002-02-13 Alcon Universal Ltd. Pharmaceutical compositions containing tobramycin and xanthan gum
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
AR031135A1 (es) 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
JP2002154989A (ja) * 2000-11-14 2002-05-28 Lion Corp 眼科用組成物、及び生体粘膜への薬物の滞留性向上組成物
US20090258955A1 (en) * 2000-12-20 2009-10-15 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
US7169755B2 (en) * 2000-12-20 2007-01-30 Alcon, Inc. Solution for removing cataracts via liquefracture
US6878694B2 (en) * 2000-12-20 2005-04-12 Alcon, Inc. Ophthalmic irrigating solution adapted for use in lasik surgery
AU3960102A (en) * 2000-12-20 2002-07-01 Alcon Universal Ltd Intraocular irrigating solution having improved flow characteristics
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
WO2002049611A2 (fr) * 2000-12-20 2002-06-27 Alcon, Inc. Solution ophtalmique lubrifiante convenant a la chirurgie lasik
US20040121947A1 (en) * 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
EP1439842A4 (fr) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US20030013753A1 (en) * 2001-06-05 2003-01-16 Ronald Aung-Din Transdermal migraine therapy
US20040266725A1 (en) 2001-08-10 2004-12-30 Toray Industries., Inc. Polysaccharide-containing compositions and use thereof
US20030220376A1 (en) * 2001-08-10 2003-11-27 Pharmacia Corporation Methods for treating carbonic anhydrase mediated disorders
US20080199524A1 (en) * 2001-08-10 2008-08-21 Toray Industries, Inc. Eyedrops containing particulate agar
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
EP1448218A4 (fr) * 2001-10-23 2009-01-14 Oklahoma Med Res Found Inhibiteurs de la beta-secretase et leurs procede d'utilisation
US6620405B2 (en) 2001-11-01 2003-09-16 3M Innovative Properties Company Delivery of hydrogel compositions as a fine mist
JP2005521690A (ja) * 2002-02-22 2005-07-21 ファルマシア・コーポレーション ゴム系を含む眼科用製剤
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US7030149B2 (en) 2002-04-19 2006-04-18 Allergan, Inc. Combination of brimonidine timolol for topical ophthalmic use
US7642258B2 (en) * 2002-04-19 2010-01-05 Allergan, Inc. Combination of brimonidine and timolol for topical ophthalmic use
AU2003241398A1 (en) * 2002-05-06 2003-11-17 Washington University Methods of treatment of glaucoma and other conditions mediated by nos-2 expression via inhibition of the egfr pathway
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US20060177430A1 (en) * 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
US20060166879A1 (en) * 2002-12-20 2006-07-27 Chakshu Research Inc Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders
US20060172972A1 (en) * 2002-12-20 2006-08-03 Chakshu Research Inc Formulation and method for administration of ophthalmologically active agents
WO2004058289A1 (fr) * 2002-12-20 2004-07-15 Chakshu Research, Inc. Formulation ophtalmique pour la prevention et le traitement de pathologies oculaires
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
EP1644004A4 (fr) 2003-06-20 2010-10-06 Ronald Aung-Din Therapie locale pour le traitement des migraines, des claquages musculaires, des spasmes musculaires, de la spasticite et d'etats apparentes
CA2549737A1 (fr) * 2003-11-10 2005-05-26 Toray Industries, Inc. Composition contenant des polysaccharides et solution ophtalmique stabilisant le film lacrymal
US20050129770A1 (en) * 2003-12-11 2005-06-16 Alcon, Inc. Ophthalmic compositions containing a PVA/borate gelling system
WO2005060933A1 (fr) * 2003-12-11 2005-07-07 Alcon, Inc. Compositions ophtalmologiques contenant un systeme gelifiant a base de polysaccharide/borate
JP4771044B2 (ja) * 2004-09-15 2011-09-14 大正製薬株式会社 粘膜適用液剤
JP2008513495A (ja) * 2004-09-17 2008-05-01 コメンティス，インコーポレーテッド ベータ−セクレターゼ活性を阻害する二環式化合物およびその使用方法
US7659289B2 (en) * 2004-09-17 2010-02-09 Comentis, Inc. Hydroxyethylene-based β-secretase inhibitors and use thereof
JP2008514709A (ja) * 2004-10-01 2008-05-08 メルク エンド カムパニー インコーポレーテッド 眼科疾患を治療するための組成物および方法
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
US20070059274A1 (en) * 2004-12-01 2007-03-15 Bahram Asgharian Ophthalmic compositions containing a PVA/borate gelling system
WO2006083927A2 (fr) * 2005-01-31 2006-08-10 Coram Bioscience, Inc. Agent antimicrobien
MX2007012341A (es) * 2005-04-08 2008-02-12 Comentis Inc Compuestos que inhiben actividad beta-secretasa y metodos de uso de los mismos.
EA200800338A1 (ru) * 2005-07-15 2008-08-29 Чакшу Рисерч Инк. Профилактика и лечение офтальмологических осложнений диабета
US7534795B2 (en) * 2005-10-25 2009-05-19 Allergan, Inc. Compounds and their use related to compositions for treating disease
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
JP2009519962A (ja) * 2005-12-19 2009-05-21 コメンティス，インコーポレーテッド 眼投与用局所メカミルアミン製剤およびその使用
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
KR100802534B1 (ko) 2006-06-13 2008-02-14 주식회사태준제약 저자극성 점안제 조성물 및 이의 제조 방법
ES2431466T3 (es) 2006-06-30 2013-11-26 Sunesis Pharmaceuticals, Inc. Inhibidores de piridinonil pdk1
EP2170283B1 (fr) 2007-06-22 2019-01-09 Board of Regents, The University of Texas System Formation de particules de peptide ou de protéine submicroniques stables par congélation de film mince
EP2178837A2 (fr) * 2007-07-26 2010-04-28 Comentis, Inc. Composés qui inhibent l'activité de la bêta-sécrétase et procédés d'utilisation de ceux-ci
CN101868457B (zh) * 2007-09-24 2013-02-13 科门蒂斯公司 作为β-分泌酶抑制剂用于治疗的(3-羟基-4-氨基-丁-2-基)-3-(2-噻唑-2-基-吡咯烷-1-羰基)苯甲酰胺衍生物和相关化合物
MX2010009857A (es) * 2008-03-07 2010-12-07 Sun Pharma Advanced Res Co Ltd Composicion oftalmica.
DK2300003T3 (da) 2008-05-23 2014-05-26 Nat Jewish Health Forbindelser til anvendelse i behandling af skade forbundet med eksponering for en alkylerende art
CA2729346A1 (fr) 2008-06-30 2010-01-14 Afgin Pharma, Llc Traitement neuro-affectif regional topique
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
US8618096B2 (en) * 2008-07-21 2013-12-31 The Regents Of The University Of California Prodrug compositions and methods for using the same in treating cancer and malaria
CN104230901A (zh) 2008-09-15 2014-12-24 加利福尼亚大学董事会 用于调节ire1、src和abl活性的方法和组合物
JP2010132587A (ja) * 2008-12-03 2010-06-17 Teika Seiyaku Kk 眼科用剤
US8470997B2 (en) * 2009-02-05 2013-06-25 Gene Signal International Sa Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
US8580947B2 (en) 2009-02-05 2013-11-12 Gene Signal International Sa Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
RU2482851C2 (ru) * 2009-02-20 2013-05-27 Микро Лабс Лимитед Хранение стабильного продукта простагландина
NZ623069A (en) 2009-08-17 2015-11-27 Sloan Kettering Inst Cancer Heat shock protein binding compounds, compositions, and methods for making and using same
TWI557127B (zh) 2009-09-04 2016-11-11 百健Ｍａ公司 布魯頓氏酪胺酸激酶抑制劑
WO2011029043A1 (fr) 2009-09-04 2011-03-10 Biogen Idec Ma Inc. Inhibiteurs hétéroaryles de btk
US8679511B2 (en) * 2009-10-01 2014-03-25 Duquesne University of the Holy Spririt In-situ gel ophthalmic drug delivery system of estradiol or other estrogen for prevention of cataracts
PL2485731T4 (pl) 2009-10-06 2017-07-31 Millennium Pharmaceuticals, Inc. Związki heterocykliczne użyteczne jako inhibitory PDK1
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
DK2853262T3 (en) 2009-10-26 2017-03-06 Sephoris Pharmaceuticals Llc Treatment of sunburn using analgesics and antihistamines
CN102711765A (zh) 2009-11-16 2012-10-03 加利福尼亚大学董事会 激酶抑制剂
ES2546063T3 (es) 2009-12-10 2015-09-18 The Regents Of The University Of California Agentes de enlace a amiloides
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
DE102010009475B4 (de) 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
KR20130041803A (ko) 2010-04-07 2013-04-25 알러간, 인코포레이티드 안과 조성물을 위한 보존제의 조합
EP2555750A2 (fr) 2010-04-07 2013-02-13 Allergan, Inc. Combinaisons de compositions de conservation pour les formulations ophtalmiques
JP5713791B2 (ja) * 2010-05-12 2015-05-07 テイカ製薬株式会社 眼科用剤
CN103079595B (zh) 2010-08-27 2015-11-25 若素制药株式会社 滴眼用水性组合物
US8530449B2 (en) 2010-09-09 2013-09-10 Assad S. Sawaya Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye
WO2012037117A1 (fr) 2010-09-13 2012-03-22 Bev-Rx, Inc. Système d'administration aqueux de médicament comportant un agent masquant une saveur désagréable
US9273028B2 (en) 2010-10-29 2016-03-01 Biogen Ma Inc. Heterocyclic tyrosine kinase inhibitors
JP5885271B2 (ja) 2011-02-14 2016-03-15 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ビマトプロストのエステル誘導体の組成物および方法
WO2012158795A1 (fr) 2011-05-17 2012-11-22 Principia Biopharma Inc. Dérivés de pyrazolopyrimidine utilisés comme inhibiteurs de tyrosine kinase
DK2710007T3 (da) 2011-05-17 2020-01-27 Principia Biopharma Inc Kinasehæmmere
AU2012255860C1 (en) 2011-05-17 2015-12-10 Principia Biopharma Inc. Tyrosine kinase inhibitors
WO2012162547A2 (fr) 2011-05-25 2012-11-29 Amylin Pharmaceuticals, Inc. Conjugués de deux hormones longue durée
EP2726097A4 (fr) 2011-07-01 2015-03-11 Univ California Vaccin contre le virus de l'herpès et procédés d'utilisation
WO2013077921A2 (fr) 2011-09-02 2013-05-30 The Regents Of The University Of California Pyrazolo[3,4-d]pyrimidines substituées et utilisations de celles-ci
US9073851B2 (en) 2011-10-28 2015-07-07 Board Of Regents, The University Of Texas System Compositions and methods for treating cancer
WO2013155223A1 (fr) 2012-04-10 2013-10-17 The Regents Of The University Of California Compositions et méthodes pour le traitement du cancer
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
EP2858500A4 (fr) 2012-06-08 2016-04-06 Biogen Ma Inc Inhibiteurs de la tyrosine kinase de bruton
CA2913736A1 (fr) 2012-06-11 2013-12-19 The Regents Of The University Of California Composes et procedes de traitement du cancer
JP6270848B2 (ja) 2012-08-27 2018-01-31 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中央部肥厚の低下
US9090595B2 (en) 2012-08-27 2015-07-28 Allergan, Inc. Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
SMT201900344T1 (it) 2012-09-10 2019-07-11 Principia Biopharma Inc Composti di pirazolopirimidina come inibitori di chinasi
CA2886240A1 (fr) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation de ire1
WO2014066435A1 (fr) 2012-10-22 2014-05-01 City Of Hope Dérivés d'étoposide
US9364462B2 (en) 2012-10-30 2016-06-14 The Regents Of The University Of California Alpha-1-adrenergic receptor agonist therapy
AU2014214561C1 (en) 2013-02-11 2019-01-17 Mitokinin, Inc. Compositions and methods for treating neurodegenerative diseases
WO2014143591A1 (fr) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition de la néovascularisation par inhibition simultanée de prostanoïde ip et des récepteurs ep4
EP2968296B1 (fr) 2013-03-12 2020-09-02 The Regents of the University of California Modulateurs de gamma-secrétase
WO2014143592A1 (fr) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition de la néovascularisation par inhibition des récepteurs de prostanoïde ip
AU2014236370C1 (en) 2013-03-14 2019-01-17 City Of Hope 5-bromo-indirubins
AU2014236356A1 (en) 2013-03-14 2015-09-24 The Regents Of The University Of California Thiosaccharide mucolytic agents
EP2968270A4 (fr) 2013-03-14 2016-08-17 Univ California Modulation de canaux k2p
WO2014144952A2 (fr) 2013-03-15 2014-09-18 Peter Walter Modulateurs de la voie eif2 alpha
KR20150129735A (ko) 2013-03-15 2015-11-20 알러간, 인코포레이티드 렙틴 생성의 향상을 위한 비마토프로스트
KR20150130355A (ko) 2013-03-15 2015-11-23 더 리전트 오브 더 유니버시티 오브 캘리포니아 비환식 뉴클레오사이드 포스포네이트 디에스테르
DK2968297T3 (en) 2013-03-15 2019-01-07 Verseon Inc MULTI-SUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS
CN114717206A (zh) 2013-03-15 2022-07-08 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
WO2014146111A2 (fr) 2013-03-15 2014-09-18 The Regents Of The University Of California Composés antalgiques et leurs méthodes d'utilisation
WO2014149139A2 (fr) 2013-03-15 2014-09-25 Verseon, Inc. Halogénopyrazoles en tant qu'inhibiteurs de la thrombine
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CA2949048A1 (fr) 2013-05-22 2014-11-27 The Regents Of The University Of California Inhibiteurs d'aurora kinase
US9795691B2 (en) 2013-06-24 2017-10-24 City Of Hope Chemically-linked nanoparticles
WO2015009742A2 (fr) 2013-07-15 2015-01-22 Board Of Regents, The University Of Texas System Composés et méthodes pour le traitement du cancer, des troubles neurologiques, du sevrage de l'éthanol, de l'anxiété, de la dépression, et de la douleur neuropathique
DK3035926T3 (da) 2013-08-19 2020-08-31 Univ California Forbindelser og fremgangsmåder til behandling af en epilepsilidelse
JP2016530273A (ja) 2013-08-20 2016-09-29 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ 癌を治療するためのｈｄａｃ８阻害剤
WO2015031799A1 (fr) 2013-08-30 2015-03-05 The Regents Of The University Of California, A California Corporation Compositions contenant des nanocristaux scintillateurs et leurs procédés d'utilisation
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
WO2015089327A1 (fr) 2013-12-11 2015-06-18 Biogen Idec Ma Inc. Composés biaryliques utiles pour le traitement de maladies humaines en oncologie, neurologie et immunologie
HRP20181109T1 (hr) 2013-12-11 2018-11-02 Biogen Ma Inc. Spojevi biarila korisni za liječenje ljudskih bolesti u onkologiji, neurologiji i imunologiji
MX2016008418A (es) 2013-12-23 2017-01-11 Memorial Sloan Kettering Cancer Center Metodos y reactivos para el radiomarcaje.
WO2015106068A1 (fr) 2014-01-10 2015-07-16 Manistee Partners Llc Traitement de migraines
WO2015116856A2 (fr) 2014-01-29 2015-08-06 City Of Hope Antagonistes du récepteur x de farnésoïde
ES2919024T3 (es) 2014-02-11 2022-07-21 Mitokinin Inc Composiciones y procedimientos que utilizan las mismas para el tratamiento de enfermedades neurodegenerativas y mitocondriales
CA2937752C (fr) 2014-02-14 2023-02-07 The Regents Of The University Of California Peroxydes cycliques utilises en tant que promedicaments pour l'administration selective d'agents
WO2015175075A1 (fr) 2014-02-20 2015-11-19 Allergan, Inc. Réduction de l'épaississement cornéen central par utilisation de promédicaments d'esters hydrophiles de bêta-chlorocyclopentanes
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
US20150259288A1 (en) 2014-03-14 2015-09-17 City Of Hope 5-bromo-indirubins
WO2015148839A1 (fr) 2014-03-26 2015-10-01 City Of Hope Traitement de cancers déficients en brca1 ou de cancers résistants
ES2908240T3 (es) 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
EA201692155A1 (ru) 2014-05-13 2017-04-28 Мемориал Слоун-Кеттеринг Кэнсэ Сентр МОДУЛЯТОРЫ Hsp70 И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2015183794A1 (fr) 2014-05-27 2015-12-03 City Of Hope Complexes d'agonistes de tgr5 pour le traitement du diabète et du cancer
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
WO2016004383A1 (fr) 2014-07-03 2016-01-07 City Of Hope Antagonistes de ctla-4 ciblant spécifiquement les tumeurs
WO2016018917A2 (fr) 2014-07-28 2016-02-04 The Regents Of The University Of Califoria Compositions et procédés de fabrication d'acides nucléiques polymérisés
US10980744B2 (en) 2014-08-08 2021-04-20 The Regents Of The University Of California High density peptide polymers
EP3193902A4 (fr) 2014-09-11 2018-03-28 The Regents of The University of California Inhibiteurs de mtorc1
MX377983B (es) 2014-09-15 2025-03-04 Univ California Análogos de nucleótidos.
JP2017528486A (ja) 2014-09-17 2017-09-28 ヴァーセオン コーポレイション セリンプロテアーゼ阻害剤としてのピラゾリル置換ピリドン化合物
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
US9862701B2 (en) 2014-09-25 2018-01-09 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10011600B2 (en) 2014-09-25 2018-07-03 Araxes Pharma Llc Methods and compositions for inhibition of Ras
ES2757798T3 (es) 2014-10-02 2020-04-30 Allergan Inc Profármacos de éster de gamma-lactamas y su uso
WO2016061145A1 (fr) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Protéoglycanes synthétiques pour empêcher l'adhérence tissulaire
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016065083A1 (fr) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycanes comprenant des peptides se fixant au collagène pour le traitement d'une lésion gastro-œsophagienne
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
WO2016115275A1 (fr) 2015-01-13 2016-07-21 City Of Hope Masques de lieur peptidique de protéines de liaison au ctla4
AU2016206475B2 (en) 2015-01-16 2021-11-04 City Of Hope Cell penetrating antibodies
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
DK3261640T3 (da) 2015-02-25 2022-07-11 Univ California 5ht-agonister til behandling af epilepsilidelser
EA039121B1 (ru) 2015-02-27 2021-12-07 Куртана Фармасьютикалс, Инк. ИНГИБИРОВАНИЕ АКТИВНОСТИ Olig2
ES2931460T3 (es) 2015-02-27 2022-12-29 Verseon Int Corporation Compuestos de pirazol sustituido como inhibidores de serina proteasa
KR20170122788A (ko) 2015-02-27 2017-11-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연골 재생을 가능하게 하는 소분자
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
BR112017018944A2 (en) 2015-03-02 2018-05-15 Afgin Pharma, Llc method of treating a disease state or condition in humans with a carbinoid drug, and method of treating a disease state or condition in a mammal other than a human with carbinoid drug (s)
CA2981504C (fr) 2015-03-30 2023-10-24 City Of Hope Complexes a interverrouillage mecanique
AU2016245864C1 (en) 2015-04-10 2021-09-09 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
ES2856880T3 (es) 2015-04-15 2021-09-28 Araxes Pharma Llc Inhibidores tricíclicos condensados de KRAS y métodos de uso de los mismos
CA2982890C (fr) 2015-04-17 2023-08-22 Ludwig Institute For Cancer Research Ltd Inhibiteurs de plk4
CA2983293C (fr) 2015-04-24 2023-06-20 The Regents Of The University Of California Modulateurs de la liaison ror1-ror2
CN107849102B (zh) 2015-05-15 2022-05-13 希望之城 嵌合抗原受体组合物
US10787664B2 (en) 2015-05-26 2020-09-29 City Of Hope Compounds of chemically modified oligonucleotides and methods of use thereof
US10765696B2 (en) 2015-06-10 2020-09-08 City Of Hope Compositions of and methods of treatment with zwitterionic polysaccharide
MA42510A (fr) 2015-06-10 2018-06-06 Biogen Ma Inc Formes et compositions d'inhibiteurs biaryles de la tyrosine kinase de bruton
US20180305350A1 (en) 2015-06-24 2018-10-25 Principia Biopharma Inc. Tyrosine kinase inhibitors
WO2017004357A1 (fr) 2015-07-02 2017-01-05 City Of Hope Composés et compositions comprenant des oligodésoxynucléotides phosphorothioés, et procédés d'utilisation associés
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3331543A4 (fr) 2015-08-06 2019-03-20 City of Hope Conjugués de pénétration cellulaire formés de protéine et d'anticorps et méthodes d'utilisation
EP3128007A1 (fr) 2015-08-07 2017-02-08 Gene Signal International SA Émulsion stérile comprenant un oligonucléotide de phosphorothioate stable
US11136301B2 (en) 2015-08-31 2021-10-05 The Regents of the University of California, A California Corporation et al. Broad spectrum antiviral compounds and uses thereof
WO2017040982A1 (fr) 2015-09-02 2017-03-09 The Regents Of The University Of California Ligands her3 et utilisations de ceux-ci
EP3350167A4 (fr) 2015-09-04 2019-04-03 City of Hope Antagonistes du récepteur des androgènes
KR102768838B1 (ko) 2015-09-17 2025-02-14 시티 오브 호프 Pcna 억제제
JP7163180B2 (ja) 2015-09-25 2022-10-31 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ・リミテツド ３－ヒドロキシ－キナゾリン－２，４－ジオン誘導体およびヌクレアーゼ調節因子としてのこの使用
WO2017058728A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines kras portant la mutation g12c
US10730867B2 (en) 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356347A1 (fr) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibiteurs de protéines kras portant la mutation g12c
US10975071B2 (en) 2015-09-28 2021-04-13 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058902A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines mutantes kras g12c
WO2017058768A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines kras portant la mutation g12c
EP3356359B1 (fr) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibiteurs de protéines kras portant la mutation g12c
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate
CA3001723A1 (fr) 2015-10-15 2017-04-20 City Of Hope Composes et compositions comprenant des oligodesoxynucleotides phosphorothioes, et procedes d'utilisation associes
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤をスクリーニングするための方法
US11046670B2 (en) 2015-10-19 2021-06-29 Board Of Regents, The University Of Texas System Piperazinyl norbenzomorphan compounds and methods for using the same
CN108697699A (zh) 2015-10-23 2018-10-23 苏尼西斯制药有限公司 用于治疗癌症的杂环pdk1抑制剂
CN119241632A (zh) 2015-10-23 2025-01-03 Erx制药股份有限公司 雷公藤红素的类似物
EP3365022A4 (fr) 2015-10-25 2019-07-24 IVIEW Therapeutics, Inc. Formulations pharmaceutiques qui forment un gel in situ
US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
KR102932353B1 (ko) 2015-11-16 2026-02-27 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
WO2017100546A1 (fr) 2015-12-09 2017-06-15 Araxes Pharma Llc Procédés de préparation de dérivés de quinazoléine
CN108603037B (zh) 2015-12-10 2020-11-17 希望之城 细胞穿透花青偶联抗体
ES2909316T3 (es) 2015-12-24 2022-05-06 Univ California Reguladores de CFTR y métodos de uso de los mismos
RU2730855C2 (ru) 2015-12-24 2020-08-26 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа Кфтр регуляторы и способы их применения
CA3010445A1 (fr) 2016-01-05 2017-07-13 The Regents Of The University Of California Amphophiles de benzothiazole
US10519442B2 (en) 2016-02-11 2019-12-31 City Of Hope Twist signaling inhibitor compositions and methods of using the same
WO2017161344A1 (fr) 2016-03-17 2017-09-21 The Regants Of The University Of California Compositions et méthodes pour traiter les parasitoses
WO2017172979A1 (fr) 2016-03-30 2017-10-05 Araxes Pharma Llc Composés quinazoline substitués et procédés d'utilisation
GR1009006B (el) 2016-04-01 2017-04-04 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χρηση περιεχον βιματοπροστη και τιμολολη
GR1009040B (el) 2016-04-19 2017-05-19 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου
PT3458448T (pt) 2016-04-25 2021-09-10 Forma Therapeutics Inc Inibidores fasn para uso no tratamento de esteato-hepatite não-alcoólica
CA3022432A1 (fr) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Liants de recepteur sigma
TW201808914A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TWI920577B (zh) 2016-05-05 2026-04-01 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
PE20190119A1 (es) 2016-05-12 2019-01-17 Anacor Pharmaceuticals Inc Esteres de oxaborol y sus usos
CA3063834C (fr) 2016-05-26 2025-05-06 The Regents Of The University Of California Associations de modulateurs du récepteur des œstrogènes
IL263815B (en) 2016-06-29 2022-07-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(Oxtan-3-yl)piperazin-1-yl)pent-2-ananitrile
WO2018013609A2 (fr) 2016-07-11 2018-01-18 The Regents The University Of California Nanoparticules synthétiques de mélanine et leurs utilisations
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CA3031443A1 (fr) 2016-07-21 2018-01-25 Biogen Ma Inc. Succinate de derives de pyrimidinyle et formes solides connexes comme inhibiteurs de tyrosine kinase de bruton
ES2925564T3 (es) 2016-07-29 2022-10-18 Rapt Therapeutics Inc Derivados de azetidina tal como moduladores de receptores de quimiocinas y usos de los mismos
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
WO2018039612A1 (fr) 2016-08-26 2018-03-01 The Regents Of The University Of California Compositions et méthodes favorisant la croissance des cheveux au moyen d'inhibiteurs de mpc1
AU2017327384B2 (en) 2016-09-13 2021-05-20 The Jackson Laboratory Targeted enhanced DNA demethylation
CN109952104B (zh) 2016-09-15 2023-03-28 希望之城 二硫etp衍生物
US10849955B2 (en) 2016-09-28 2020-12-01 City Of Hope Methods of treating pancreatic cancer using GPCR antagonists
JP2019529484A (ja) 2016-09-29 2019-10-17 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質の阻害剤
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
US10646540B2 (en) 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
CN110291084A (zh) 2016-12-15 2019-09-27 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
WO2018140599A1 (fr) 2017-01-26 2018-08-02 Araxes Pharma Llc Composés à base de benzothiophène et de benzothiazole et leurs procédés d'utilisation
EP3573954A1 (fr) 2017-01-26 2019-12-04 Araxes Pharma LLC Composés benzohétéroaromatiques bicycliques fusionnés et leurs procédés d'utilisation
EP3573971A1 (fr) 2017-01-26 2019-12-04 Araxes Pharma LLC Dérivés de 1-(3-(6-(3-hydroxynaphtalen-1-yl)benzofuran-2-yl)azétidin-1yl)prop-2-en-1-one et composés similaires utilisés en tant que modulateurs de kras g12c pour le traitement du cancer
JP7327802B2 (ja) 2017-01-26 2023-08-16 アラクセス ファーマ エルエルシー 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
US10052343B1 (en) 2017-02-03 2018-08-21 Gene Signal International Sa Sterile formulation comprising a stable phosphorothioate oligonucleotide
PT3576753T (pt) 2017-02-03 2024-06-26 Laboratoires Kol Emulsão estéril que compreende um oligonucleótido fosforotioato estável
TW201906832A (zh) 2017-05-25 2019-02-16 美商亞瑞克西斯製藥公司 用於癌症治療之化合物及其使用方法
CN110869358A (zh) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 Kras的共价抑制剂
WO2018218069A1 (fr) 2017-05-25 2018-11-29 Araxes Pharma Llc Dérivés de quinazoline utilisés en tant que modulateurs de kras, hras ou nras mutants
WO2018237145A1 (fr) 2017-06-21 2018-12-27 Mitokinin, Inc. Compositions et méthodes les utilisant pour le traitement d'une maladie neurodégénérative et mitochondriale
US11554178B2 (en) 2017-06-30 2023-01-17 City Of Hope Compositions and methods of modulating macrophage activity
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface
US11389460B2 (en) 2017-09-15 2022-07-19 City Of Hope Methods and compositions for treating endometrial cancer
WO2019067015A1 (fr) 2017-09-29 2019-04-04 City Of Hope Récepteurs d'antigènes chimériques et anticorps bispécifiques pour le traitement du lymphome à cellules du manteau
JP2020536072A (ja) 2017-09-29 2020-12-10 ジェネンテック， インコーポレイテッド ペプチド抗生物質複合体およびその使用方法
US11260048B2 (en) 2017-10-03 2022-03-01 The Schepens Eye Research Institute, Inc. Compounds and compositions for inhibiting retinal pigment epithelium degeneration and methods using the same
EP3694860A1 (fr) 2017-10-10 2020-08-19 Syros Pharmaceuticals, Inc. Composés de pyrrolotriazine et procédés d'inhibition de kinases tam
WO2019079819A1 (fr) 2017-10-20 2019-04-25 City Of Hope Composition et procédé d'activation du virus de l'immunodéficience humaine (vih) latent
MX2020004537A (es) 2017-11-02 2020-10-05 Calico Life Sciences Llc Moduladores de la vía integrada del estrés.
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
UY37956A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
SG11202004009TA (en) 2017-11-02 2020-05-28 Calico Life Sciences Llc Modulators of the integrated stress pathway
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
MX2020004538A (es) 2017-11-02 2020-09-18 Calico Life Sciences Llc Moduladores de la vía de estrés integrada.
UY37958A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
EP3704125B1 (fr) 2017-11-02 2026-03-11 Calico Life Sciences LLC Modulateurs de la voie de réponse intégrée au stress
BR112020008825A2 (pt) 2017-11-02 2020-10-20 Calico Life Sciences Llc moduladores da via de estresse integrada
AU2018360766B2 (en) 2017-11-06 2024-09-19 Rapt Therapeutics, Inc. Anticancer agents
US11612604B2 (en) 2017-12-06 2023-03-28 Ludwig Institute For Cancer Research Ltd Methods of treating cancer with PLK4 inhibitors
EP3720438B1 (fr) 2017-12-07 2023-08-30 Amplyx Pharmaceuticals, Inc. Agents antifongiques dérivés de pyridine substitués par un hétérocycle
IL275059B2 (en) 2017-12-15 2023-11-01 Pyramid Biosciences Inc 5-(2-(5,2-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo[5,1-A]pyrimidine derivatives and related compounds as TRK kinase inhibitors for cancer therapy
US11939575B2 (en) 2017-12-19 2024-03-26 City Of Hope Modified tracrRNAs gRNAs, and uses thereof
AU2019209470A1 (en) 2018-01-16 2020-08-13 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
CA3088529A1 (fr) 2018-01-16 2019-07-25 Syros Pharmaceuticals, Inc. Inhibiteurs de la kinase cycline-dependante 7 (cdk7)
US10683280B2 (en) 2018-01-26 2020-06-16 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
CN112135825A (zh) 2018-03-13 2020-12-25 夏尔人类遗传性治疗公司 血浆激肽释放酶抑制剂及其用途
MX2020011344A (es) 2018-04-27 2021-02-09 Spruce Biosciences Inc Métodos para tratar tumores en reposo suprarrenales testiculares y de ovarios.
EP3788050B1 (fr) 2018-05-01 2024-08-28 Revolution Medicines, Inc. Analogues de rapamycine liés à c26 utilisés en tant qu'inhibiteurs de mtor
PL3788049T3 (pl) 2018-05-01 2023-06-19 Revolution Medicines, Inc. Połączone z C40, C28 i C32 analogi rapamycyny jako inhibitory mTOR
WO2019213611A1 (fr) 2018-05-04 2019-11-07 Cirius Therapeutics, Inc. Analogues de thiazolidinedione pour le traitement de nafld et de maladies métaboliques
EP3802544A1 (fr) 2018-06-05 2021-04-14 RAPT Therapeutics, Inc. Composés de pyrazolo-pyrimidin-amino-cycloalkyle et leurs utilisations thérapeutiques
WO2019236901A1 (fr) 2018-06-06 2019-12-12 The Regents Of The University Of California Inhibiteurs de récepteurs des oestrogènes et utilisations correspondantes
TWI888352B (zh) 2018-06-21 2025-07-01 美商嘉來克生命科學有限責任公司 蛋白質酪胺酸磷酸酯酶抑制劑及其使用方法
JP2021530445A (ja) 2018-06-25 2021-11-11 アンプリックス ファーマシューティカルズ，インク． 複素環およびアミノ基によって置換されたピリジン誘導体
BR112021001709A2 (pt) 2018-08-01 2021-05-04 Araxes Pharma Llc compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
JP2021534153A (ja) 2018-08-15 2021-12-09 アイビバ バイオファーマ インコーポレイテッド Ｖｅｇｆおよびｔｇｆベータのマルチキナーゼ阻害剤およびその使用
WO2020041758A1 (fr) 2018-08-24 2020-02-27 City Of Hope Conjugués de cytokine masqués
EA202190590A1 (ru) 2018-08-31 2021-07-16 Ампликс Фармасьютикалз, Инк. Соединения и способы лечения грибковых инфекций
CN118271374A (zh) 2018-09-10 2024-07-02 加利福尼亚大学董事会 二硫醇糖粘液溶解剂和其用途
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
AU2019372677B2 (en) 2018-11-01 2024-05-30 Lynk Pharmaceuticals Co. Ltd. Tricyclic Janus kinase 1 inhibitors, and compositions and methods thereof
KR102888598B1 (ko) * 2018-11-26 2025-11-20 아이비바 바이오파마, 인크. 약물 전달을 위한 약학적 생분해성 겔
WO2020118683A1 (fr) 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides de dérivés de pyrazolyl-amino-pyrimidinyle, compositions et procédés associés
KR102983496B1 (ko) 2019-03-14 2026-06-29 칼리코 라이프 사이언시스 엘엘씨 단백질 티로신 포스파타제 억제제 및 이의 사용 방법
PH12021552759A1 (en) 2019-04-30 2022-07-04 Abbvie Inc Substituted cycloalkyls as modulators of the integrated stress pathway
FR3095592B1 (fr) * 2019-05-02 2021-05-21 Unither Pharmaceuticals Composition à base de gomme gellane et de phényléphrine, procédé de fabrication et utilisation comme produit ophtalmique
EP3968979B1 (fr) 2019-05-15 2026-07-01 Bexson Biomedical, Inc. Formulation de kétamine pour injection sous-cutanée
WO2020252487A1 (fr) 2019-06-14 2020-12-17 Children's Hospital Medical Center Ciblage thérapeutique rationnel d'états de signalisation immunitaire oncogènes dans des malignités myéloïdes par l'intermédiaire de l'enzyme de conjugaison d'ubiquitine ube2n
WO2021055589A1 (fr) 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Inhibiteurs hétéroaryles de la kallicréine plasmatique
US20220348632A1 (en) 2019-09-18 2022-11-03 Novartis Ag Nkg2d fusion proteins and uses thereof
CN114728962B (zh) 2019-09-18 2025-09-19 武田药品工业有限公司 血浆激肽释放酶抑制剂及其用途
US12516145B2 (en) 2019-09-30 2026-01-06 Northwestern University Bioactive peptide brush polymers via photoinduced reversible-deactivation radical polymerization
AU2020365951B2 (en) 2019-10-14 2026-07-16 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
US12441890B2 (en) 2019-10-30 2025-10-14 Northwestern University Selenium-containing analogues of pheomelanin and related materials and methods of making
US12006318B2 (en) 2019-11-13 2024-06-11 Rapt Therapeutics, Inc. Crystalline forms of C-C chemokine receptor type 4 antagonist and uses thereof
MX2022007441A (es) 2019-12-18 2022-09-02 Calico Life Sciences Llc Inhibidores de proteína tirosina fosfatasa y sus métodos de uso.
KR102993352B1 (ko) 2019-12-20 2026-07-22 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-에네니트릴의 고체 형태
WO2021150723A1 (fr) 2020-01-22 2021-07-29 Principia Biopharma Inc. Formes cristallines de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényle) -1h-pyrazolo [3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4- (oxétane-3-yl)) pipérazine-1-yl] pent-2-enenitrile
EP4126076A1 (fr) 2020-03-31 2023-02-08 Sentiss Pharma Private Limited Processus de stérilisation de solution de formation de gel de timolol par filtration aseptique
IL296921B1 (en) 2020-04-15 2026-08-01 Pyramid Biosciences Inc Methods for preparing receptor tyrosine kinase inhibitors
US12678510B2 (en) 2020-05-01 2026-07-14 Northwestern University Drug loaded peptide brush polymers
GR1010024B (el) 2020-05-06 2021-06-01 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση που περιλαμβανει βριμονιδινη
IL312785B2 (en) 2020-05-19 2026-06-01 Cybin Irl Ltd Deuterated tryptamine derivatives and methods of use
JP2023539113A (ja) 2020-08-18 2023-09-13 サイビン アイアールエル リミテッド フェネチルアミン誘導体、組成物およびその使用方法
CA3194653A1 (fr) 2020-10-02 2022-04-07 Mitokinin, Inc. Compositions et methodes de traitement d'affection renale et de fibrose
PE20231656A1 (es) 2020-11-02 2023-10-17 Trethera Corp Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos
EP4247340A4 (fr) 2020-11-18 2024-10-02 Bexson Biomedical, Inc. Formulations salines de composés pharmaceutiques à base d'agents complexants
US20240058344A1 (en) 2020-12-18 2024-02-22 Cornell University Methods of treating neurodegenerative disorders and stat3-linked cancers using suppressors of electron leak
WO2022197755A1 (fr) 2021-03-17 2022-09-22 Shire Human Genetic Therapies, Inc. Inhibiteurs imidazopyridinyle de la kallicréine plasmatique
US11918582B2 (en) 2021-03-15 2024-03-05 Rapt Therapeutics, Inc. Pyrazole pyrimidine compounds and uses thereof
US20240226106A1 (en) 2021-03-17 2024-07-11 Shire Human Genetic Therapies, Inc. Inhibitors of plasma kallikrein
US20240199613A1 (en) 2021-03-17 2024-06-20 Takeda Pharmaceutical Company Limited Polycyclic inhibitors of plasma kallikrein
EP4585265A3 (fr) 2021-03-17 2025-10-15 Takeda Pharmaceutical Company Limited Inhibiteurs hétéroaryles de la kallicréine plasmatique
US20240382482A1 (en) 2021-03-17 2024-11-21 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors
US20240217981A1 (en) 2021-04-13 2024-07-04 Pipeline Therapeutics, Inc. Crystalline compound of muscarinic acetylcholine m1 receptor antagonists
AU2023222126A1 (en) 2022-02-15 2024-08-08 Cybin Irl Limited Phenethylamine derivatives, compositions, and methods of use
US20250236589A1 (en) 2022-02-15 2025-07-24 Cybin Irl Limited Therapeutic phenethylamine compositions and methods of use
CA3255429A1 (fr) 2022-04-06 2023-10-12 Rapt Therapeutics, Inc. Modulateurs du récepteur de la chimiokine et leurs utilisations
EP4531859A4 (fr) 2022-05-25 2026-05-27 Revolution Medicines Inc Méthodes de traitement du cancer au moyen d'un inhibiteur de mtor
US12377036B2 (en) 2022-06-21 2025-08-05 Northwestern University Melanin hair dye with thickeners
US20250034115A1 (en) 2023-07-12 2025-01-30 Rapt Therapeutics, Inc. Crystalline forms of c-c chemokine receptor type 4 antagonist and uses thereof
EP4743061A1 (fr) 2023-07-13 2026-05-20 Comanche Biopharma Corp. Formulations de composés d'acide nucléique et leurs utilisations
WO2025027529A1 (fr) 2023-07-31 2025-02-06 Advesya Conjugués médicament-anticorps anti-il-1rap et leurs procédés d'utilisation
WO2025068803A1 (fr) 2023-09-26 2025-04-03 Astrazeneca Ab Combinaisons thérapeutiques comprenant des lymphocytes t récepteurs antigéniques chimériques anti-steap2
TW202530255A (zh) 2023-12-15 2025-08-01 法商亞維西亞有限公司 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物
WO2026022243A1 (fr) 2024-07-23 2026-01-29 The Trustees Of The University Of Pennsylvania Combinaison d'un inhibiteur de gsk-3 et d'un inhibiteur de lsd-1 pour une utilisation dans le traitement du cancer

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441729A (en) * 1943-12-08 1948-05-18 Kelco Co Algin gel-forming compositions
US2935447A (en) * 1957-02-19 1960-05-03 Kelco Co Appetite depressant containing alginate
FR1312244A (fr) * 1962-01-09 1962-12-14 Bernburg Serum Werk Veb Procédé de fabrication de supports de pommade exempts de corps gras
BE731578A (fr) * 1969-04-16 1969-10-01
AU7776275A (en) * 1974-04-11 1976-08-05 Warner Lambert Co Production of base for topical steroids
US4013792A (en) * 1974-04-11 1977-03-22 Warner-Lambert Company Process for the production of base for topical steroids
NL188266C (nl) * 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
US4039662A (en) * 1975-12-04 1977-08-02 Alcon Laboratories, Inc. Ophthalmic solution
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
CA1072413A (fr) * 1976-07-13 1980-02-26 West Laboratories Systemes de gel de type poloxamer, a temperature de gelification superieure a la temperature ambiante
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
KR830002802B1 (ko) * 1978-12-04 1983-12-16 제임스 에프 · 너우톤 박테리아 발효에 의한 다당류 s-60의 제조방법
US4326053A (en) * 1978-12-04 1982-04-20 Merck & Co., Inc. Polysaccharide S-60 and bacterial fermentation process for its preparation
US4409205A (en) * 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4407792A (en) * 1979-05-09 1983-10-04 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4503084A (en) * 1983-05-31 1985-03-05 Merck & Co., Inc. Non-heated gellan gum gels
US4563366A (en) * 1983-05-31 1986-01-07 Merck & Co., Inc. Non-heated gellan gum gels
GB8318403D0 (en) * 1983-07-07 1983-08-10 Sutherland I W Gel-forming polysaccharides
DE3335593A1 (de) * 1983-09-30 1985-04-11 Diamalt AG, 8000 München Gelier- und verdickungsmittel auf der basis von cassia-galactomannanen
US4717713A (en) * 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
US4517216A (en) * 1984-03-05 1985-05-14 Merck & Co., Inc. Gellan gum/gelatin blends
GB8431699D0 (en) * 1984-12-14 1985-01-30 Mars G B Ltd Gel system

Also Published As

Publication number Publication date
PT83471B (pt) 1988-11-30
JPS62181228A (ja) 1987-08-08
CA1280367C (fr) 1991-02-19
GR862444B (en) 1987-01-27
ZA867464B (en) 1987-07-29
ES2002401A6 (es) 1988-08-01
NO863916L (no) 1987-04-06
FI863990L (fi) 1987-04-04
IL80156A0 (en) 1986-12-31
CN86106637A (zh) 1987-04-08
NO863916D0 (no) 1986-10-02
NZ217662A (en) 1990-02-26
JPH0667853B2 (ja) 1994-08-31
KR940000229B1 (ko) 1994-01-12
FR2588189B1 (fr) 1988-12-02
DK170500B1 (da) 1995-10-02
NO1995003I1 (no) 1995-04-10
CN1046094C (zh) 1999-11-03
NL950012I1 (nl) 1996-10-01
FR2588189A1 (fr) 1987-04-10
DE227494T1 (de) 1988-03-17
EP0227494A1 (fr) 1987-07-01
EP0227494B1 (fr) 1992-03-04
IE862481L (en) 1987-04-03
FI863990A0 (fi) 1986-10-02
FI91217B (fi) 1994-02-28
NO173212B (no) 1993-08-09
FI91217C (fi) 1994-06-10
US4861760A (en) 1989-08-29
DE3684121D1 (de) 1992-04-09
KR870003773A (ko) 1987-05-04
CY1779A (en) 1995-10-20
AU6318986A (en) 1987-04-09
IE59464B1 (en) 1994-02-23
PT83471A (en) 1986-11-01
NO173212C (no) 1993-11-17
DK469886A (da) 1987-04-04
LV5725B4 (lv) 1996-06-20
LU88694I2 (fr) 1996-04-29
AU595240B2 (en) 1990-03-29
ATE72990T1 (de) 1992-03-15
LV5725A4 (lv) 1996-02-20
IL80156A (en) 1990-09-17
DK469886D0 (da) 1986-10-02

Similar Documents

Publication Publication Date Title
EP0227494B1 (fr) Composition pharmaceutique du type subissant une transition de phase liquide-gel
US4474751A (en) Ophthalmic drug delivery system utilizing thermosetting gels
US5077033A (en) Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5300295A (en) Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US4255415A (en) Polyvinyl alcohol ophthalmic gel
EP0533836B1 (fr) Compositions de gelification reversible et modes d'emploi
US4100271A (en) Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
KR20020021320A (ko) 안과용 의약 조성물
EP0424043B1 (fr) Composition ophthalmique aqueuse liquide à transition de phase liquide-gel
JP3238715B2 (ja) 少なくとも１種の有効成分を含む脂質微粒子に基づく眼科用液体組成物
EP4039248B1 (fr) Composition ophtalmique
FR2679773A1 (fr) Preparation ophtalmique contenant un agent osmotique acceptable antimicrobien.
WO1997033562A1 (fr) Composition ophtalmologique subissant une transition de phase liquide/gel
EP0056420A1 (fr) Gel ophtalmique
WO1990013284A1 (fr) Composition pharmaceutique contenant du chromoglycate
US20190151352A1 (en) Ophthalmic composition comprising a synergistic combination of glycogen and hyaluronic acid or a salt thereof
EP0555717A1 (fr) Compositions pharmaceutiques en forme de solutions contenant du nédocromil
FR2746014A1 (fr) Composition ophtalmologique du type subissant une transition de phase liquide-gel

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20061001