LU90310I2 - Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti - Google Patents

Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti

Info

Publication number: LU90310I2
Authority: LU; Luxembourg
Prior art keywords: amino acid; trovafloxacin; pharmaceutically acceptable; precursors; prodrugs
Prior art date: 1989-08-16

Application number

LU90310C

Other languages

English (en)

Inventor

Katherine Elizabeth Brighty

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-16

Filing date

1998-11-04

Publication date

1999-01-25

1998-11-04 Application filed by Pfizer filed Critical Pfizer

1999-01-25 Publication of LU90310I2 publication Critical patent/LU90310I2/fr

Links

150000003839 salts Chemical class 0.000 title abstract 3
229940002612 prodrug Drugs 0.000 title abstract 2
239000000651 prodrug Substances 0.000 title abstract 2
125000000539 amino acid group Chemical group 0.000 title 3
239000002243 precursor Substances 0.000 title 2
WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 title 2
229960000497 trovafloxacin Drugs 0.000 title 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title 1
UUZPPAMZDFLUHD-VUJLHGSVSA-N alatrofloxacin Chemical compound C([C@@H]1[C@H]([C@@H]1C1)NC(=O)[C@H](C)NC(=O)[C@@H](N)C)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F UUZPPAMZDFLUHD-VUJLHGSVSA-N 0.000 title 1
229960000919 alatrofloxacin Drugs 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
-1 quinolone carboxylic acids Chemical class 0.000 abstract 2
XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 abstract 1
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
125000006519 CCH3 Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
AQIAIZBHFAKICS-UHFFFAOYSA-N methylaminomethyl Chemical compound [CH2]NC AQIAIZBHFAKICS-UHFFFAOYSA-N 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

LU90310C 1989-08-16 1998-11-04 Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti LU90310I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/003489 WO1991002526A1 (fr)	1989-08-16	1989-08-16	Acides azabicyclo quinolone carboxyliques

Publications (1)

Publication Number	Publication Date
LU90310I2 true LU90310I2 (fr)	1999-01-25

Family

ID=22215165

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU90311C LU90311I2 (fr)	1989-08-16	1998-11-04	Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci
LU90310C LU90310I2 (fr)	1989-08-16	1998-11-04	Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LU90311C LU90311I2 (fr)	1989-08-16	1998-11-04	Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci

Country Status (29)

Country	Link
EP (1)	EP0413455B1 (fr)
JP (2)	JPH072734B2 (fr)
KR (1)	KR930004844B1 (fr)
CN (1)	CN1025192C (fr)
AT (1)	ATE124040T1 (fr)
AU (1)	AU623801B2 (fr)
BA (1)	BA98299A (fr)
CA (2)	CA2023217C (fr)
CY (2)	CY1969A (fr)
CZ (1)	CZ281127B6 (fr)
DD (1)	DD298399A5 (fr)
DE (3)	DE19875052I2 (fr)
DK (1)	DK0413455T3 (fr)
EG (1)	EG19251A (fr)
ES (1)	ES2074131T4 (fr)
FI (2)	FI108228B (fr)
GR (1)	GR3017072T3 (fr)
HU (2)	HU219403B (fr)
IE (1)	IE66202B1 (fr)
IL (1)	IL95331A (fr)
LU (2)	LU90311I2 (fr)
NL (2)	NL980032I2 (fr)
NO (1)	NO300214B1 (fr)
NZ (1)	NZ234920A (fr)
PL (1)	PL166381B1 (fr)
PT (1)	PT94998B (fr)
RU (1)	RU2049777C1 (fr)
WO (1)	WO1991002526A1 (fr)
ZA (1)	ZA906450B (fr)

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FR2675144B1 (fr) *	1991-04-10	1995-06-16	Bouchara Sa	Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
CA2111463C (fr) *	1991-06-19	1997-08-26	Bingwei V. Yang	Agents antibacteriens azaspiro quinolone
US5256791A (en) *	1992-03-02	1993-10-26	Pfizer Inc.	Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) *	1992-10-30	1999-07-31	Procter & Gamble	Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) *	1992-12-30	1996-06-18	Cheil Foods & Chemicals, Inc.	Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) *	1993-12-03	1997-01-07	Cheil Foods & Chemicals, Inc.	Solid oral formulations of pyridone carboxylic acids
PT812838E (pt) *	1994-02-04	2002-10-31	Dainippon Pharmaceutical Co	Derivado de acido piridonacarboxilico substituido com o grupo amino biciclico seu ester seu sal e amina biciclica como seu intermediario
DK0807630T3 (da) *	1995-02-02	2003-09-01	Daiichi Seiyaku Co	Heterocykliske forbindelser
JPH08213881A (ja) *	1995-02-02	1996-08-20	Fujitsu Ltd	周波数制御回路
WO1996024593A1 (fr) *	1995-02-07	1996-08-15	Daiichi Pharmaceutical Co., Ltd.	Derives spiro heterocycliques
JP3145715B2 (ja) *	1995-06-06	2001-03-12	ファイザー・インコーポレーテッド	無水７−（［１α，５α，６α］−６−アミノ−３−アザビシクロ［３．１．０］ヘキサ−３−イル）−６−フルオロ−１−（２，４−ジフルオロフェニル）−１，４−ジヒドロ−４−オキソ−１，８−ナフチリディン−３−カルボン酸メタンスルホン酸塩の新規な結晶形態
US5939550A (en) *	1995-06-15	1999-08-17	Pfizer Inc.	Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide
WO1997029102A1 (fr) *	1996-02-09	1997-08-14	Toyama Chemical Co., Ltd.	Derives de l'acide quinolonecarboxylique et leurs sels
AP788A (en) *	1996-08-26	1999-12-03	Pfizer	Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) *	1996-09-27	2003-02-01	Daiichi Seiyaku Co	Bicyclic amine derivative
US6384050B1 (en) *	1996-10-25	2002-05-07	Daiichi Pharmaceutical Co., Ltd.	Tricyclic amine derivatives
MA24500A1 (fr)	1997-03-21	1998-10-01	Lg Life Sciences Ltd	Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en)	1997-03-21	2002-03-14	Lg Chemical Ltd.	Salt of naphthyridine carboxylic acid derivative
DE19733439A1 (de) *	1997-08-02	1999-02-04	Bayer Ag	Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
ES2321042T3 (es)	1997-09-15	2009-06-01	THE PROCTER & GAMBLE COMPANY	Quinolonas antimicrobianas, composiciones y usos de las mismas.
PA8464701A1 (es) *	1998-01-16	2000-09-29	Pfizer Prod Inc	Procedimiento e intermedios para preparar naftiridonas
US6184380B1 (en) *	1999-01-25	2001-02-06	Pfizer Inc.	Process for preparing naphthyridones and intermediates
US7019142B2 (en)	1998-01-16	2006-03-28	Pfizer Inc.	Process for preparing naphthyridones and intermediates
GB9820405D0 (en) *	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
CA2367373C (fr)	1999-03-17	2011-09-20	Daiichi Pharmaceutical Co., Ltd.	Compositions medicamenteuses
GB9920919D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
GB9920917D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
JP2004515549A (ja)	2000-12-14	2004-05-27	ザプロクターアンドギャンブルカンパニー	抗微生物２−ピリドン類、その組成物と使用
NZ525571A (en)	2000-12-14	2004-09-24	Procter & Gamble	Antimicrobial quinolones
KR100517638B1 (ko)	2002-04-08	2005-09-28	주식회사 엘지생명과학	게미플록사신 산염의 새로운 제조방법
NZ537584A (en)	2002-07-08	2006-07-28	Ranbaxy Lab Ltd	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
JP2006501236A (ja)	2002-08-23	2006-01-12	ランバクシーラボラトリーズリミテッド	ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体
WO2004089898A1 (fr)	2003-04-09	2004-10-21	Ranbaxy Laboratories Limited	Derives d'azabicyclo hexane substitues en tant qu'antagonistes de recepteurs muscariniques
CA2521788A1 (fr)	2003-04-10	2004-10-21	Ranbaxy Laboratories Limited	Derives d'azabicyclo hexanes substitues en tant qu'antagonistes des recepteurs muscariniques
BRPI0409302A (pt)	2003-04-11	2006-04-11	Ranbaxy Lab Ltd	derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
SG144936A1 (en)	2003-09-10	2008-08-28	Kyorin Seiyaku Kk	7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
EP1670759A1 (fr) *	2003-09-18	2006-06-21	Ranbaxy Laboratories Limited	Procede de preparation de (1$g(a), 5$g(a), 6$g(a))-6-aminomethyl-3-benzyl-3-azabicyclo 3.1.0\|hexane
TWI391378B (zh) *	2006-03-16	2013-04-01	Astellas Pharma Inc	喹啉酮衍生物或其製藥學上可被容許之鹽
WO2007110835A2 (fr)	2006-03-28	2007-10-04	The Procter & Gamble Company	Procede de couplage pour preparer des intermediaires quinolone
PL2001862T3 (pl)	2006-03-28	2011-09-30	Warner Chilcott Co Llc	Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego
US7902227B2 (en) *	2007-07-27	2011-03-08	Janssen Pharmaceutica Nv.	C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
WO2020073031A1 (fr) *	2018-10-05	2020-04-09	New York University	Hétérocycles bicycliques fusionnés en tant qu'agents thérapeutiques
CN112442084B (zh) *	2020-12-03	2022-09-09	国药集团致君（深圳）制药有限公司	一种抗菌药中间体的制备方法
CN113307768B (zh) *	2021-04-29	2023-12-12	中国农业科学院兰州畜牧与兽药研究所	喹诺酮类衍生物及其制备方法和用途

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1989
- 1989-08-16 RU SU5011662/04A patent/RU2049777C1/ru not_active IP Right Cessation
- 1989-08-16 IE IE295090A patent/IE66202B1/en not_active IP Right Cessation
- 1989-08-16 HU HU9200460A patent/HU219403B/hu not_active IP Right Cessation
- 1989-08-16 WO PCT/US1989/003489 patent/WO1991002526A1/fr not_active Ceased
- 1989-08-16 PL PL90286484A patent/PL166381B1/pl unknown
1990
- 1990-07-30 DE DE19875052C patent/DE19875052I2/de active Active
- 1990-07-30 DE DE19875050C patent/DE19875050I2/de active Active
- 1990-07-30 AT AT90308331T patent/ATE124040T1/de active
- 1990-07-30 ES ES90308331T patent/ES2074131T4/es not_active Expired - Lifetime
- 1990-07-30 EP EP90308331A patent/EP0413455B1/fr not_active Expired - Lifetime
- 1990-07-30 DE DE69020262T patent/DE69020262T2/de not_active Expired - Fee Related
- 1990-07-30 DK DK90308331.9T patent/DK0413455T3/da active
- 1990-08-09 IL IL9533190A patent/IL95331A/en not_active IP Right Cessation
- 1990-08-14 CA CA002023217A patent/CA2023217C/fr not_active Expired - Lifetime
- 1990-08-14 CA CA002127561A patent/CA2127561C/fr not_active Expired - Lifetime
- 1990-08-14 EG EG48390A patent/EG19251A/xx active
- 1990-08-14 PT PT94998A patent/PT94998B/pt not_active IP Right Cessation
- 1990-08-14 KR KR1019900012528A patent/KR930004844B1/ko not_active Expired - Fee Related
- 1990-08-15 NZ NZ234920A patent/NZ234920A/en unknown
- 1990-08-15 DD DD90343474A patent/DD298399A5/de unknown
- 1990-08-15 AU AU61042/90A patent/AU623801B2/en not_active Expired
- 1990-08-15 ZA ZA906450A patent/ZA906450B/xx unknown
- 1990-08-15 CN CN90106794A patent/CN1025192C/zh not_active Expired - Fee Related
- 1990-08-16 CZ CS904027A patent/CZ281127B6/cs not_active IP Right Cessation
- 1990-08-16 JP JP2216461A patent/JPH072734B2/ja not_active Expired - Fee Related
1992
- 1992-02-14 NO NO920599A patent/NO300214B1/no not_active IP Right Cessation
- 1992-02-14 FI FI920632A patent/FI108228B/fi active Protection Beyond IP Right Term
1994
- 1994-07-08 JP JP6157008A patent/JPH0819099B2/ja not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00380P patent/HU211681A9/hu unknown
- 1995-08-09 GR GR950402200T patent/GR3017072T3/el unknown
1996
- 1996-11-11 FI FI964520A patent/FI103879B/fi active
1997
- 1997-09-05 CY CY196997A patent/CY1969A/xx unknown
1998
- 1998-03-30 BA BA980299A patent/BA98299A/bs unknown
- 1998-11-04 LU LU90311C patent/LU90311I2/fr unknown
- 1998-11-04 LU LU90310C patent/LU90310I2/fr unknown
- 1998-11-17 NL NL980032C patent/NL980032I2/nl unknown
- 1998-11-17 NL NL980033C patent/NL980033I2/nl unknown
1999
- 1999-05-24 CY CY1999010C patent/CY99010I2/el unknown

Also Published As

Publication number	Publication date
NL980032I1 (nl)	1999-02-01
NZ234920A (en)	1992-06-25
JPH072734B2 (ja)	1995-01-18
LU90311I2 (fr)	1999-01-25
DE69020262T2 (de)	1995-10-26
CA2023217C (fr)	1996-12-10
CA2127561A1 (fr)	1991-02-17
PT94998A (pt)	1991-04-18
DE19875052I2 (de)	2009-05-28
DK0413455T3 (da)	1995-08-14
KR910004572A (ko)	1991-03-28
KR930004844B1 (ko)	1993-06-09
CZ402790A3 (en)	1996-04-17
ES2074131T4 (es)	1996-05-01
CA2127561C (fr)	1998-07-28
EP0413455A2 (fr)	1991-02-20
CN1025192C (zh)	1994-06-29
HK1000207A1 (en)	1998-02-06
JPH0819099B2 (ja)	1996-02-28
IL95331A0 (en)	1991-06-30
BA98299A (bs)	2001-09-14
CA2023217A1 (fr)	1991-02-17
GR3017072T3 (en)	1995-11-30
NL980032I2 (nl)	1999-05-03
FI108228B (fi)	2001-12-14
WO1991002526A1 (fr)	1991-03-07
DE69020262D1 (de)	1995-07-27
CN1049501A (zh)	1991-02-27
PT94998B (pt)	1997-05-28
FI103879B1 (fi)	1999-10-15
FI964520A0 (fi)	1996-11-11
AU6104290A (en)	1991-02-21
CZ281127B6 (cs)	1996-06-12
EG19251A (en)	1994-09-29
NL980033I2 (nl)	1999-05-03
JPH07149758A (ja)	1995-06-13
JPH0386875A (ja)	1991-04-11
NO920599L (no)	1992-04-14
EP0413455B1 (fr)	1995-06-21
DD298399A5 (de)	1992-02-20
HU219403B (hu)	2001-04-28
PL286484A1 (en)	1991-05-20
HU211681A9 (en)	1995-12-28
AU623801B2 (en)	1992-05-21
ZA906450B (en)	1992-03-25
CY99010I2 (en)	2010-07-28
RU2049777C1 (ru)	1995-12-10
IE66202B1 (en)	1995-12-13
NO920599D0 (no)	1992-02-14
IE902950A1 (en)	1991-02-27
DE19875050I2 (de)	2009-05-28
FI920632A0 (fi)	1992-02-14
ES2074131T3 (es)	1995-09-01
PL166381B1 (pl)	1995-05-31
ATE124040T1 (de)	1995-07-15
NL980033I1 (nl)	1999-02-01
CY1969A (en)	1997-09-05
IL95331A (en)	1995-07-31
NO300214B1 (no)	1997-04-28
EP0413455A3 (en)	1991-10-09
FI964520L (fi)	1996-11-11
FI103879B (fi)	1999-10-15

Publication	Publication Date	Title
LU90311I2 (fr)	1999-01-25	Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci
RU2000111540A (ru)	2002-05-10	Агонисты аполипопротеина а-1 и их применение для лечения заболеваний, связанных с дислипидемией
KR970042553A (ko)	1997-07-24	캠프토테신 유도체
ATE293453T1 (de)	2005-05-15	Verbindungen zur behandlung von sexuellen funktionsstörungen
ES8105698A1 (es)	1981-06-16	Procedimiento para la obtencion de octapeptidos ciclicos
EE02950B1 (et)	1996-12-16	Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon
KR900009692A (ko)	1990-07-05	레트로바이러스 프로테아제 억제제
JPH05506254A (ja)	1993-09-16	良性および悪性増殖性皮膚病の治療方法
UA74421C2 (uk)	2005-12-15	Похідні індолону, які є антагоністами gal3 рецептора для лікування депресії і/або тривоги та композиції, придатні для такого лікування
EP1181933A3 (fr)	2002-04-10	Utilisation d'un secretagogue de l'hormone de croissance comme comme inducteur de la faim
JPH09124692A5 (fr)	2004-09-30
BG101796A (en)	1998-10-30	New cumarine quinocarbonic acids and methods for their preparation
JPH07509215A (ja)	1995-10-12	ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物
EP0346068A3 (fr)	1991-01-30	Antagonistes de D-Cys6-vasopressine
HUT59919A (en)	1992-07-28	Process for producing azabicyclo-quinolon and naphtiridone derivatives and pharmaceutical compositions containing them
WO1994004565A3 (fr)	1994-06-09	Vaccin vnpi
US6218364B1 (en)	2001-04-17	Fluorinated neurokinin A antagonists
KR890013058A (ko)	1989-09-21	아미노산 유도체
ES2005778A6 (es)	1989-03-16	Procedimiento para la obtencion de derivados de diisobutilxantina.
RU98117609A (ru)	2000-06-20	Пептидные производные
DE68911394D1 (de)	1994-01-27	2-Amino-7-hydroxytetralin-ether.
RU99100332A (ru)	2000-10-20	Производные пептидов
TH35870A (th)	1999-11-19	สารอนุพันธ์ของเปปไทด์