LU91021I2 - (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-((1E)-2-((1R,3R,4S)-4-chloro-3-méthoxycyclohenyl)-17-éthyl-1,14-dihydroxy-23.25-diméthoxy-13,19,21,27-tétraméthyl-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacos-18-ène-2,3,10,16-tétraone ou 4"-épichloro-4"désoxyascomycine;sous toute forme y compris le cas échéant ses sels et esters - Google Patents

(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-((1E)-2-((1R,3R,4S)-4-chloro-3-méthoxycyclohenyl)-17-éthyl-1,14-dihydroxy-23.25-diméthoxy-13,19,21,27-tétraméthyl-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacos-18-ène-2,3,10,16-tétraone ou 4"-épichloro-4"désoxyascomycine;sous toute forme y compris le cas échéant ses sels et esters

Info

Publication number
LU91021I2
LU91021I2 LU91021C LU91021C LU91021I2 LU 91021 I2 LU91021 I2 LU 91021I2 LU 91021 C LU91021 C LU 91021C LU 91021 C LU91021 C LU 91021C LU 91021 I2 LU91021 I2 LU 91021I2
Authority
LU
Luxembourg
Prior art keywords
treatment
méthoxycyclohenyl
deoxyascomycin
octacos
epichloro
Prior art date
Application number
LU91021C
Other languages
English (en)
Original Assignee
Novartis Ag
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Sandoz Ag filed Critical Novartis Ag
Publication of LU91021I2 publication Critical patent/LU91021I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
LU91021C 1989-11-09 2003-04-23 (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-((1E)-2-((1R,3R,4S)-4-chloro-3-méthoxycyclohenyl)-17-éthyl-1,14-dihydroxy-23.25-diméthoxy-13,19,21,27-tétraméthyl-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacos-18-ène-2,3,10,16-tétraone ou 4"-épichloro-4"désoxyascomycine;sous toute forme y compris le cas échéant ses sels et esters LU91021I2 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE3937336 1989-11-09
DE3938132 1989-11-16
DE3942831 1989-12-23
DE3942833 1989-12-23
DE4006819 1990-03-05

Publications (1)

Publication Number Publication Date
LU91021I2 true LU91021I2 (fr) 2003-06-24

Family

ID=27511355

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91021C LU91021I2 (fr) 1989-11-09 2003-04-23 (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-((1E)-2-((1R,3R,4S)-4-chloro-3-méthoxycyclohenyl)-17-éthyl-1,14-dihydroxy-23.25-diméthoxy-13,19,21,27-tétraméthyl-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacos-18-ène-2,3,10,16-tétraone ou 4"-épichloro-4"désoxyascomycine;sous toute forme y compris le cas échéant ses sels et esters

Country Status (18)

Country Link
EP (1) EP0427680B1 (fr)
JP (1) JP2750302B2 (fr)
KR (1) KR0166074B1 (fr)
AT (1) ATE126803T1 (fr)
AU (1) AU640963B2 (fr)
CA (1) CA2029694C (fr)
DE (2) DE69021833T2 (fr)
DK (1) DK0427680T3 (fr)
ES (1) ES2077663T3 (fr)
GR (1) GR3017858T3 (fr)
HK (1) HK30096A (fr)
HU (1) HU210900A9 (fr)
IE (1) IE69974B1 (fr)
LU (1) LU91021I2 (fr)
LV (1) LV11621B (fr)
MY (1) MY111430A (fr)
NL (1) NL300134I2 (fr)
NZ (1) NZ235991A (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356399A3 (fr) * 1988-08-26 1991-03-20 Sandoz Ag Dérivés substitués du 4-azatricyclo (22.3.1.04.9) octacos-18-ène, leur préparation et les compositions pharmaceutiques les contenant
WO1990015805A1 (fr) * 1989-06-14 1990-12-27 Sandoz Ltd Composes tricycliques contenant des heteroatomes
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
EP0480623A1 (fr) * 1990-10-11 1992-04-15 Merck & Co. Inc. Halomacrolides et dérivés ayant une activité immunosuppressive
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
WO1992020688A1 (fr) * 1991-05-13 1992-11-26 Merck & Co., Inc. Macrolides d'o-aryle, d'o-alkyle, d'o-alcenyle et d'o-alcynyle amino
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
JP3644957B2 (ja) * 1991-09-05 2005-05-11 アボット・ラボラトリーズ 大環式イムノモジュレーター
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
CA2131373C (fr) * 1992-03-02 1999-01-26 Kevin Koch 2-aminoglycomacrolides
CA2091194A1 (fr) * 1992-04-08 1993-10-09 Richard D. Connell Derives 2-oxoethyliques utilises comme immunosuppresseurs
US5284877A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkyl and alkenyl macrolides having immunosuppressive activity
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
WO1995015328A1 (fr) * 1993-11-30 1995-06-08 Abbott Laboratories Immunomodulateurs macrocycliques a noveaux substituants du cycle clyclohexyle
US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5550233A (en) * 1994-06-21 1996-08-27 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
US5545734A (en) * 1994-10-25 1996-08-13 Merck & Co., Inc. Aryl and heteroaryl macrolides having immunosuppressive activity
MY129435A (en) 1994-10-26 2007-04-30 Novartis Ag Pharmaceutical microemulsion preconcentrates
DK0786986T3 (da) * 1994-10-26 2002-04-29 Novartis Ag Anvendelse af en umættet fedtalkohol
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
JP3282945B2 (ja) * 1995-06-07 2002-05-20 松下電器産業株式会社 スピンドルモータ
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
GB9601120D0 (en) * 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
AU749623B2 (en) 1998-03-26 2002-06-27 Astellas Pharma Inc. Sustained release preparations
TR200003108T2 (tr) * 1998-04-27 2001-02-21 Fujisawa Pharmaceutical Co., Ltd. İlaç kompozisyonları
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
GB0003932D0 (en) 2000-02-18 2000-04-12 Novartis Ag Pharmaceutical compositions
GB0008785D0 (en) 2000-04-10 2000-05-31 Novartis Ag Organic compounds
GB0012383D0 (en) 2000-05-22 2000-07-12 Novartis Ag Organic compounds
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
CN101897662B (zh) 2002-07-23 2013-05-22 诺瓦提斯公司 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物
WO2004045578A2 (fr) * 2002-11-15 2004-06-03 Novartis Ag Composes organiques
CA2513731A1 (fr) * 2003-02-10 2004-08-19 Novartis Ag Combinaisons pharmaceutiques contenant des corticoides et des immunodepresseurs pour traiter des maladies resistant aux inhibiteurs de corticoides et/ou de la calcineurine
AR043504A1 (es) * 2003-03-17 2005-08-03 Novartis Ag Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias
CA2559915C (fr) 2004-03-23 2013-07-02 Novartis Ag Compositions pharmaceutiques
GT200500282A (es) * 2004-10-12 2006-05-04 Heteroatomos conteniendo compuestos triciclicos.
WO2006060615A1 (fr) * 2004-12-01 2006-06-08 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Pimecrolimus amorphe non hygroscopique pulverulent
CA2668134A1 (fr) * 2006-11-06 2008-05-15 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Ascomycine et pimecrolimus ayant des niveaux reduits de desmethylascomycine et de 32-desoxy-32-epichloro-desmethylascomycine respectivement, et leurs procedes de preparation
US20100087550A1 (en) 2008-10-06 2010-04-08 Zora Marlowe Formulations with a Tertiary Amine Oxide
US20100106128A1 (en) 2008-10-23 2010-04-29 Shane Mao Contact lens cases for delivery of ophthalmic agents
IT1394309B1 (it) * 2009-05-22 2012-06-06 Poli Ind Chimica Spa Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus
GB0914589D0 (en) * 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
US10143682B2 (en) 2014-10-28 2018-12-04 Koushi Yamaguchi Medicine for improving state of pregnancy, and use thereof
EP3178824A1 (fr) 2015-12-08 2017-06-14 Medichem, S.A. Procédé de préparation de pimecrolimus
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
CA3060330A1 (fr) 2017-05-01 2018-11-08 Meda Pharma Gmbh & Co. Kg Procede de conversion d'ascomycine brute en pimecrolimus purifie
AU2019318035A1 (en) 2018-08-10 2021-03-04 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship
CN113226331A (zh) 2018-12-18 2021-08-06 山口晃史 用于改善不孕不育症或妊娠状态的药物
EP3741367A1 (fr) 2019-05-21 2020-11-25 Premark Pharma GmbH Traitement de maladies oculaires
CN121263183A (zh) 2023-04-06 2026-01-02 普利马克制药有限责任公司 吡美莫司用于治疗患者的特征在于牛津分级量表角膜染色评分为4或5分的干眼症的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
EP0346427B1 (fr) * 1987-12-09 1995-03-29 FISONS plc Composes macrocycliques
WO1990015805A1 (fr) * 1989-06-14 1990-12-27 Sandoz Ltd Composes tricycliques contenant des heteroatomes
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina

Also Published As

Publication number Publication date
NL300134I2 (nl) 2004-05-03
DE10299040I1 (de) 2003-02-20
JP2750302B2 (ja) 1998-05-13
HU210900A9 (en) 1995-09-28
CA2029694C (fr) 2001-05-08
CA2029694A1 (fr) 1991-05-10
EP0427680A1 (fr) 1991-05-15
ES2077663T3 (es) 1995-12-01
EP0427680B1 (fr) 1995-08-23
AU640963B2 (en) 1993-09-09
ATE126803T1 (de) 1995-09-15
NZ235991A (en) 1993-05-26
GR3017858T3 (en) 1996-01-31
KR910009711A (ko) 1991-06-28
LV11621A (lv) 1996-12-20
AU6584390A (en) 1991-05-23
MY111430A (en) 2000-05-31
DE10299040I2 (de) 2006-08-24
HK30096A (en) 1996-02-23
DE69021833D1 (de) 1995-09-28
JPH03223291A (ja) 1991-10-02
IE69974B1 (en) 1996-10-16
IE904023A1 (en) 1991-05-22
LV11621B (en) 1997-04-20
DE69021833T2 (de) 1996-03-21
NL300134I1 (nl) 2003-11-03
DK0427680T3 (da) 1995-12-18
KR0166074B1 (ko) 1999-01-15

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