LUC00311I2 - - Google Patents

Info

Publication number
LUC00311I2
LUC00311I2 LU00311C LUC00311C LUC00311I2 LU C00311 I2 LUC00311 I2 LU C00311I2 LU 00311 C LU00311 C LU 00311C LU C00311 C LUC00311 C LU C00311C LU C00311 I2 LUC00311 I2 LU C00311I2
Authority
LU
Luxembourg
Application number
LU00311C
Original Assignee
Uniqure Biopharma B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41397565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LUC00311(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from ITBO2008A000564A external-priority patent/IT1394177B1/it
Priority claimed from ITBO2009A000275A external-priority patent/IT1395980B1/it
Application filed by Uniqure Biopharma B V filed Critical Uniqure Biopharma B V
Publication of LUC00311I2 publication Critical patent/LUC00311I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LU00311C 2008-09-15 2023-07-25 LUC00311I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO2008A000564A IT1394177B1 (it) 2008-09-15 2008-09-15 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
ITBO2009A000275A IT1395980B1 (it) 2009-05-06 2009-05-06 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione

Publications (1)

Publication Number Publication Date
LUC00311I2 true LUC00311I2 (fr) 2026-02-02

Family

ID=41397565

Family Applications (1)

Application Number Title Priority Date Filing Date
LU00311C LUC00311I2 (fr) 2008-09-15 2023-07-25

Country Status (20)

Country Link
US (13) USRE50288E1 (fr)
EP (5) EP2337849B1 (fr)
CA (1) CA2737094C (fr)
CY (3) CY1125885T1 (fr)
DK (2) DK2337849T3 (fr)
ES (3) ES2985035T3 (fr)
FI (5) FI3581650T3 (fr)
FR (4) FR23C1028I1 (fr)
HK (1) HK1244507A1 (fr)
HR (2) HRP20181442T1 (fr)
HU (6) HUE067487T2 (fr)
LT (5) LT3581650T (fr)
LU (1) LUC00311I2 (fr)
NO (2) NO2023029I1 (fr)
PL (3) PL3581650T3 (fr)
PT (1) PT3581650T (fr)
SI (1) SI3581650T1 (fr)
SM (2) SMT201800468T1 (fr)
TR (1) TR201813067T4 (fr)
WO (1) WO2010029178A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2985035T3 (es) 2008-09-15 2024-11-04 Uniqure Biopharma B V Mutante de polipéptido de factor IX, sus usos y su procedimiento de producción
TWI595004B (zh) 2010-11-03 2017-08-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
KR102049900B1 (ko) 2012-07-25 2019-11-28 카탈리스트 바이오사이언시즈, 인코포레이티드 변형 인자 x 폴리펩티드 및 이의 용도
RS61387B2 (sr) 2013-02-15 2024-06-28 Bioverativ Therapeutics Inc Gen optimizovanog faktora viii
US11008561B2 (en) 2014-06-30 2021-05-18 Bioverativ Therapeutics Inc. Optimized factor IX gene
GB201420139D0 (en) 2014-11-12 2014-12-24 Ucl Business Plc Factor IX gene therapy
EP4378487A3 (fr) 2015-06-23 2024-09-04 The Children's Hospital of Philadelphia Facteur ix modifié, et compositions, procédés et utilisations pour le transfert de gènes dans des cellules, des organes et des tissus
KR20180118659A (ko) 2016-02-01 2018-10-31 바이오버라티브 테라퓨틱스 인크. 최적화된 viii 인자 유전자
JP6994018B2 (ja) 2016-07-26 2022-01-14 バイオマリン ファーマシューティカル インコーポレイテッド 新規アデノ随伴ウイルスキャプシドタンパク質
CN116732066A (zh) * 2016-10-14 2023-09-12 四川至善唯新生物科技有限公司 一种高活性凝血因子ix突变体、重组蛋白与融合蛋白的制备与应用
TWI753168B (zh) 2017-05-22 2022-01-21 日商武田藥品工業股份有限公司 用於血友病ｂ基因療法之編碼具有增強表現的重組ｆｉｘ變異體之病毒載體
US11452749B2 (en) 2017-07-10 2022-09-27 Uniqure Ip B.V. Means and methods for AAV gene therapy in humans
US11491212B1 (en) 2017-09-27 2022-11-08 Catalyst Biosciences, Inc. Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B
KR20210008501A (ko) 2018-05-09 2021-01-22 바이오마린 파머수티컬 인크. 페닐케톤뇨증을 치료하는 방법
CN112424345A (zh) 2018-05-14 2021-02-26 生物马林药物股份有限公司 Aav载体在青少年对象中的稳定表达
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
AU2019323747A1 (en) * 2018-08-20 2021-03-04 Ucl Business Ltd Factor ix encoding nucleotides
GB201813528D0 (en) 2018-08-20 2018-10-03 Ucl Business Plc Factor IX encoding nucleotides
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides
UY38389A (es) * 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
JP7578590B2 (ja) 2018-10-18 2024-11-06 インテリア セラピューティクス，インコーポレーテッド 第ｉｘ因子を発現するための組成物及び方法
JP7803014B2 (ja) 2019-09-30 2026-01-21 バイオベラティブ セラピューティクス インコーポレイテッド レンチウイルスベクター製剤
WO2021154414A2 (fr) 2020-01-29 2021-08-05 Catalyst Biosciences, Inc. Thérapie génique pour l'hémophilie b avec un vecteur de capside d'aav chimérique codant pour des polypeptides du facteur ix modifiés
JP2023537565A (ja) 2020-06-24 2023-09-04 バイオベラティブ セラピューティクス インコーポレイテッド タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第ｖｉｉｉ因子を除去する方法
WO2023275024A1 (fr) * 2021-07-01 2023-01-05 CSL Behring Lengnau AG Administration sous-cutanée de facteur ix à sécurité renforcée
WO2025022005A1 (fr) * 2023-07-26 2025-01-30 Le Quellec Sandra Administration intranasale de polypeptides du facteur ix

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US11008561B2 (en) 2014-06-30 2021-05-18 Bioverativ Therapeutics Inc. Optimized factor IX gene
JP6879486B2 (ja) 2015-03-17 2021-06-02 フリーイェ・ユニヴェルシテイト・ブリュッセルＶｒｉｊｅ Ｕｎｉｖｅｒｓｉｅｉｔ Ｂｒｕｓｓｅｌ Ｆｖｉｉｉおよびｆｉｘ用の最適化された肝臓特異的発現系
CN115094062A (zh) 2015-04-16 2022-09-23 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
EP4378487A3 (fr) 2015-06-23 2024-09-04 The Children's Hospital of Philadelphia Facteur ix modifié, et compositions, procédés et utilisations pour le transfert de gènes dans des cellules, des organes et des tissus
UA126016C2 (uk) 2015-08-03 2022-08-03 Біовератів Терапеутікс Інк. Злитий білок фактора іх
US11191847B2 (en) 2016-04-15 2021-12-07 The Trustees Of The University Of Pennsylvania Gene therapy for treating hemophilia B
PE20181922A1 (es) 2016-04-15 2018-12-11 Univ Pennsylvania Terapia genica para tratar la hemofilia a
US11452749B2 (en) 2017-07-10 2022-09-27 Uniqure Ip B.V. Means and methods for AAV gene therapy in humans
US20210228738A1 (en) 2017-07-17 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins

Also Published As

Publication number Publication date
US20250179462A1 (en) 2025-06-05
US9982248B2 (en) 2018-05-29
CA2737094F (fr) 2010-03-18
PT3581650T (pt) 2023-03-08
DK3581650T3 (da) 2023-03-13
US20200190498A1 (en) 2020-06-18
USRE50288E1 (en) 2025-02-04
US20110244550A1 (en) 2011-10-06
EP3581650B1 (fr) 2022-12-28
EP2337849A1 (fr) 2011-06-29
DK2337849T3 (en) 2018-10-01
CY2023016I1 (el) 2024-02-16
LTPA2024530I1 (fr) 2024-11-25
FR25C1004I1 (fr) 2025-02-28
SMT201800468T1 (it) 2018-11-09
NO2023029I1 (no) 2023-07-31
FIC20240037I1 (fi) 2024-10-30
US20210238573A1 (en) 2021-08-05
US20180258413A1 (en) 2018-09-13
HK1244507A1 (en) 2018-08-10
CA2737094C (fr) 2018-02-20
HUS2500006I1 (hu) 2025-02-28
US9249405B2 (en) 2016-02-02
LTPA2023521I1 (fr) 2023-08-25
LTPA2025503I1 (fr) 2025-02-10
FIC20240036I1 (fi) 2024-10-29
EP2337849B1 (fr) 2018-06-13
PL2337849T3 (pl) 2018-11-30
CY2025002I1 (el) 2026-02-25
EP3581650A3 (fr) 2020-03-25
HRP20230259T1 (hr) 2023-04-28
US20200199564A1 (en) 2020-06-25
CY1125885T1 (el) 2024-02-16
US20210214704A1 (en) 2021-07-15
FIC20230026I1 (fi) 2023-07-25
CY2023016I2 (el) 2024-02-16
EP4219547A2 (fr) 2023-08-02
HUS2400037I1 (hu) 2024-11-28
HUE061345T2 (hu) 2023-06-28
US20220002702A1 (en) 2022-01-06
US20170355973A1 (en) 2017-12-14
EP3252157A1 (fr) 2017-12-06
WO2010029178A1 (fr) 2010-03-18
HUE067487T2 (hu) 2024-10-28
EP3581650A2 (fr) 2019-12-18
US10465180B2 (en) 2019-11-05
CA2737094A1 (fr) 2010-03-18
HUS2400036I1 (hu) 2024-11-28
ES2985035T3 (es) 2024-11-04
FR23C1028I1 (fr) 2023-10-06
EP4219547A3 (fr) 2023-10-18
SI3581650T1 (sl) 2023-06-30
FR24C1040I1 (fr) 2024-12-06
US20200231958A1 (en) 2020-07-23
LTPA2024529I1 (fr) 2024-12-10
PL3581650T3 (pl) 2023-05-22
FR24C1041I1 (fr) 2024-12-06
HUS2300024I1 (hu) 2023-08-28
ES2687038T3 (es) 2018-10-23
HRP20181442T1 (hr) 2018-12-14
FI3581650T3 (fi) 2023-03-23
EP4032979C0 (fr) 2024-05-01
ES2940323T3 (es) 2023-05-05
NO2025007I1 (no) 2025-01-21
SMT202300084T1 (it) 2023-05-12
US20160122740A1 (en) 2016-05-05
EP4032979B1 (fr) 2024-05-01
FIC20250007I1 (fi) 2025-01-22
LT3581650T (lt) 2023-05-10
EP4032979A1 (fr) 2022-07-27
TR201813067T4 (tr) 2018-09-21
US20220090042A1 (en) 2022-03-24
PL4032979T3 (pl) 2024-09-30

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