PL2337849T3 - Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego otrzymywania - Google Patents

Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego otrzymywania

Info

Publication number
PL2337849T3
PL2337849T3 PL09748260T PL09748260T PL2337849T3 PL 2337849 T3 PL2337849 T3 PL 2337849T3 PL 09748260 T PL09748260 T PL 09748260T PL 09748260 T PL09748260 T PL 09748260T PL 2337849 T3 PL2337849 T3 PL 2337849T3
Authority
PL
Poland
Prior art keywords
factor
production
polypeptide mutant
mutant
polypeptide
Prior art date
Application number
PL09748260T
Other languages
English (en)
Inventor
Paolo Simioni
Original Assignee
Uniqure Biopharma B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41397565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2337849(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from ITBO2008A000564A external-priority patent/IT1394177B1/it
Priority claimed from ITBO2009A000275A external-priority patent/IT1395980B1/it
Application filed by Uniqure Biopharma B.V. filed Critical Uniqure Biopharma B.V.
Publication of PL2337849T3 publication Critical patent/PL2337849T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL09748260T 2008-09-15 2009-09-15 Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego otrzymywania PL2337849T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITBO2008A000564A IT1394177B1 (it) 2008-09-15 2008-09-15 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
ITBO2009A000275A IT1395980B1 (it) 2009-05-06 2009-05-06 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
EP09748260.8A EP2337849B1 (en) 2008-09-15 2009-09-15 Factor ix polypeptide mutant, its uses and a method for its production
PCT/EP2009/061935 WO2010029178A1 (en) 2008-09-15 2009-09-15 Factor ix polypeptide mutant, its uses and a method for its production

Publications (1)

Publication Number Publication Date
PL2337849T3 true PL2337849T3 (pl) 2018-11-30

Family

ID=41397565

Family Applications (3)

Application Number Title Priority Date Filing Date
PL09748260T PL2337849T3 (pl) 2008-09-15 2009-09-15 Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego otrzymywania
PL19174517.3T PL3581650T3 (pl) 2008-09-15 2009-09-15 Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego wytwarzania
PL21200005.3T PL4032979T3 (pl) 2008-09-15 2009-09-15 Mutant polipeptydu czynnika ix, jego zastosowania i sposób jego otrzymywania

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL19174517.3T PL3581650T3 (pl) 2008-09-15 2009-09-15 Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego wytwarzania
PL21200005.3T PL4032979T3 (pl) 2008-09-15 2009-09-15 Mutant polipeptydu czynnika ix, jego zastosowania i sposób jego otrzymywania

Country Status (20)

Country Link
US (13) USRE50288E1 (pl)
EP (5) EP3252157A1 (pl)
CA (1) CA2737094C (pl)
CY (3) CY1125885T1 (pl)
DK (2) DK2337849T3 (pl)
ES (3) ES2687038T3 (pl)
FI (5) FI3581650T3 (pl)
FR (4) FR23C1028I1 (pl)
HK (1) HK1244507A1 (pl)
HR (2) HRP20181442T1 (pl)
HU (6) HUE067487T2 (pl)
LT (5) LT3581650T (pl)
LU (1) LUC00311I2 (pl)
NO (2) NO2023029I1 (pl)
PL (3) PL2337849T3 (pl)
PT (1) PT3581650T (pl)
SI (1) SI3581650T1 (pl)
SM (2) SMT202300084T1 (pl)
TR (1) TR201813067T4 (pl)
WO (1) WO2010029178A1 (pl)

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CN110945127B (zh) 2017-05-22 2024-07-12 武田药品工业株式会社 用于血友病b的基因疗法的编码具有增加的表达的重组fix的病毒载体
JP7764129B2 (ja) 2017-07-10 2025-11-05 ユニキュアー アイピー ビー．ブイ． ヒトにおけるａａｖ遺伝子療法のための手段及び方法
US11491212B1 (en) 2017-09-27 2022-11-08 Catalyst Biosciences, Inc. Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B
TW202016314A (zh) 2018-05-09 2020-05-01 美商拜奧馬林製藥公司 治療苯丙酮尿症之方法
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TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
JP2021533799A (ja) * 2018-08-20 2021-12-09 ユーシーエル ビジネス リミテッド 第ｉｘ因子をコードするヌクレオチド
GB201813528D0 (en) 2018-08-20 2018-10-03 Ucl Business Plc Factor IX encoding nucleotides
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides
UY38389A (es) * 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
AU2019360270B2 (en) 2018-10-18 2025-08-07 Intellia Therapeutics, Inc. Compositions and methods for expressing factor IX.
KR20220097891A (ko) 2019-09-30 2022-07-08 바이오버라티브 테라퓨틱스 인크. 렌티바이러스 벡터 제형
WO2021154414A2 (en) 2020-01-29 2021-08-05 Catalyst Biosciences, Inc. Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides
MX2023000156A (es) 2020-06-24 2023-02-16 Bioverativ Therapeutics Inc Metodos para la eliminacion de factor viii libre de preparaciones de vectores lentivirales modificados para expresar dicha proteina.
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Also Published As

Publication number Publication date
EP3581650B1 (en) 2022-12-28
CY2023016I2 (el) 2024-02-16
WO2010029178A1 (en) 2010-03-18
US20250179462A1 (en) 2025-06-05
NO2023029I1 (no) 2023-07-31
USRE50288E1 (en) 2025-02-04
CA2737094C (en) 2018-02-20
US20200231958A1 (en) 2020-07-23
FR24C1041I1 (fr) 2024-12-06
US20220002702A1 (en) 2022-01-06
DK2337849T3 (en) 2018-10-01
ES2940323T3 (es) 2023-05-05
LTPA2023521I1 (pl) 2023-08-25
TR201813067T4 (tr) 2018-09-21
EP3581650A2 (en) 2019-12-18
US20220090042A1 (en) 2022-03-24
PT3581650T (pt) 2023-03-08
EP3252157A1 (en) 2017-12-06
FIC20240036I1 (fi) 2024-10-29
DK3581650T3 (da) 2023-03-13
US20170355973A1 (en) 2017-12-14
HK1244507A1 (en) 2018-08-10
FIC20250007I1 (fi) 2025-01-22
US20200199564A1 (en) 2020-06-25
HRP20230259T1 (hr) 2023-04-28
US9249405B2 (en) 2016-02-02
HRP20181442T1 (hr) 2018-12-14
EP4032979B1 (en) 2024-05-01
EP2337849A1 (en) 2011-06-29
LTPA2024530I1 (pl) 2024-11-25
SMT201800468T1 (it) 2018-11-09
EP4219547A2 (en) 2023-08-02
CY1125885T1 (el) 2024-02-16
FIC20240037I1 (fi) 2024-10-30
US20110244550A1 (en) 2011-10-06
NO2025007I1 (no) 2025-01-21
HUS2400036I1 (hu) 2024-11-28
FR24C1040I1 (fr) 2024-12-06
EP4219547A3 (en) 2023-10-18
CY2023016I1 (el) 2024-02-16
SMT202300084T1 (it) 2023-05-12
CA2737094F (en) 2010-03-18
FR23C1028I1 (fr) 2023-10-06
ES2687038T3 (es) 2018-10-23
HUE067487T2 (hu) 2024-10-28
EP4032979C0 (en) 2024-05-01
EP4032979A1 (en) 2022-07-27
HUS2500006I1 (hu) 2025-02-28
PL4032979T3 (pl) 2024-09-30
LT3581650T (lt) 2023-05-10
EP2337849B1 (en) 2018-06-13
CA2737094A1 (en) 2010-03-18
US20210238573A1 (en) 2021-08-05
US20200190498A1 (en) 2020-06-18
ES2985035T3 (es) 2024-11-04
FI3581650T3 (fi) 2023-03-23
PL3581650T3 (pl) 2023-05-22
HUE061345T2 (hu) 2023-06-28
EP3581650A3 (en) 2020-03-25
US20210214704A1 (en) 2021-07-15
HUS2400037I1 (hu) 2024-11-28
LTPA2024529I1 (pl) 2024-12-10
FIC20230026I1 (fi) 2023-07-25
SI3581650T1 (sl) 2023-06-30
CY2025002I1 (el) 2026-02-25
US20160122740A1 (en) 2016-05-05
FR25C1004I1 (fr) 2025-02-28
US10465180B2 (en) 2019-11-05
LTPA2025503I1 (pl) 2025-02-10
HUS2300024I1 (hu) 2023-08-28
LUC00311I2 (pl) 2026-02-02
US20180258413A1 (en) 2018-09-13
US9982248B2 (en) 2018-05-29

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