LV10685B - Device for transdermal administration of dexamedethomidine - Google Patents

Device for transdermal administration of dexamedethomidine Download PDF

Info

Publication number: LV10685B
Authority: LV; Latvia
Prior art keywords: layer; dexmedetomidine; contact; skin; adhesive
Prior art date: 1989-08-18

Application number

LVP-93-1079A

Other languages

English (en)

Latvian (lv)

Other versions

LV10685A (lv

Inventor

Kenneth J Colley

Donald R Wilson

Gary W Cleary

Lammintausta Risto

Jalonen Harry

Original Assignee

Cygnus Therapeutic Systems

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-18

Filing date

1993-09-22

Publication date

1995-12-20

1993-09-22 Application filed by Cygnus Therapeutic Systems, Orion Corp filed Critical Cygnus Therapeutic Systems

1995-06-20 Publication of LV10685A publication Critical patent/LV10685A/xx

1995-12-20 Publication of LV10685B publication Critical patent/LV10685B/lv

Links

239000010410 layer Substances 0.000 claims abstract 14
HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 claims abstract 8
229960004253 dexmedetomidine Drugs 0.000 claims abstract 8
239000012790 adhesive layer Substances 0.000 claims abstract 3
239000004821 Contact adhesive Substances 0.000 claims abstract 2
239000000203 mixture Substances 0.000 claims description 2
239000000853 adhesive Substances 0.000 claims 4
230000001070 adhesive effect Effects 0.000 claims 4
BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical group CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 claims 2
239000003623 enhancer Substances 0.000 claims 2
239000011229 interlayer Substances 0.000 claims 2
239000000463 material Substances 0.000 claims 2
229940026235 propylene glycol monolaurate Drugs 0.000 claims 2
231100000245 skin permeability Toxicity 0.000 claims 2
WITKSCOBOCOGSC-UHFFFAOYSA-N 2-dodecanoyloxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCCCC WITKSCOBOCOGSC-UHFFFAOYSA-N 0.000 claims 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
229920002367 Polyisobutene Polymers 0.000 claims 1
239000004820 Pressure-sensitive adhesive Substances 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
239000003961 penetration enhancing agent Substances 0.000 claims 1
230000037317 transdermal delivery Effects 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 abstract 2
206010039897 Sedation Diseases 0.000 abstract 1
239000002131 composite material Substances 0.000 abstract 1
239000007933 dermal patch Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 abstract 1
229960002140 medetomidine Drugs 0.000 abstract 1
230000036280 sedation Effects 0.000 abstract 1
230000001624 sedative effect Effects 0.000 abstract 1
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
241000208202 Linaceae Species 0.000 description 3
235000004431 Linum usitatissimum Nutrition 0.000 description 3
DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 3
101100384273 Dictyostelium discoideum clua gene Proteins 0.000 description 2
241001362576 Eana Species 0.000 description 2
241001191378 Moho Species 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
IFQAUICFVCGLJL-NWDWNXPCSA-N (4r)-4-[(3s,5s,7r,8r,9s,10s,12s,13r,17r)-3-azido-7,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-n-[2-(2-iodo-1h-imidazol-5-yl)ethyl]pentanamide Chemical compound C([C@@H](C)[C@@H]1[C@]2([C@@H](O)C[C@@H]3[C@@]4(C)CC[C@@H](C[C@H]4C[C@@H](O)[C@H]3C2CC1)N=[N+]=[N-])C)CC(=O)NCCC1=CN=C(I)N1 IFQAUICFVCGLJL-NWDWNXPCSA-N 0.000 description 1
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
241001535291 Analges Species 0.000 description 1
229920002799 BoPET Polymers 0.000 description 1
101100162168 Mus musculus Adam1a gene Proteins 0.000 description 1
101100495145 Mus musculus Ccno gene Proteins 0.000 description 1
101100066898 Mus musculus Flna gene Proteins 0.000 description 1
101100017009 Mus musculus Hhat gene Proteins 0.000 description 1
101100366940 Mus musculus Stom gene Proteins 0.000 description 1
239000005041 Mylar™ Substances 0.000 description 1
101100322557 Rattus norvegicus Adam1 gene Proteins 0.000 description 1
101100425901 Rattus norvegicus Tpm1 gene Proteins 0.000 description 1
101100495142 Xenopus laevis ccno-a gene Proteins 0.000 description 1
210000004124 hock Anatomy 0.000 description 1
101150115538 nero gene Proteins 0.000 description 1
238000009304 pastoral farming Methods 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

LVP-93-1079A 1989-08-18 1993-09-22 Device for transdermal administration of dexamedethomidine LV10685B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/395,717 US5124157A (en)	1989-08-18	1989-08-18	Method and device for administering dexmedetomidine transdermally
PCT/US1990/004575 WO1991002505A1 (en)	1989-08-18	1990-08-14	Method and device for administering dexmedetomidine transdermally

Publications (2)

Publication Number	Publication Date
LV10685A LV10685A (lv)	1995-06-20
LV10685B true LV10685B (en)	1995-12-20

Family

ID=23564195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-1079A LV10685B (en)	1989-08-18	1993-09-22	Device for transdermal administration of dexamedethomidine

Country Status (25)

Country	Link
US (1)	US5124157A (pl)
EP (1)	EP0413487B1 (pl)
JP (1)	JP3043064B2 (pl)
CN (1)	CN1035922C (pl)
AT (1)	ATE122899T1 (pl)
AU (1)	AU639015B2 (pl)
BG (1)	BG95935A (pl)
CA (1)	CA2064687C (pl)
DD (1)	DD297066A5 (pl)
DE (1)	DE69019628T2 (pl)
DK (1)	DK0413487T3 (pl)
ES (1)	ES2072397T3 (pl)
FI (1)	FI100857B (pl)
HU (1)	HUT64223A (pl)
IE (1)	IE67127B1 (pl)
LT (1)	LT3753B (pl)
LV (1)	LV10685B (pl)
NO (1)	NO300408B1 (pl)
NZ (1)	NZ234749A (pl)
PL (1)	PL165023B1 (pl)
PT (1)	PT95002B (pl)
RU (1)	RU2098083C1 (pl)
UA (1)	UA26988C2 (pl)
WO (1)	WO1991002505A1 (pl)
ZA (1)	ZA906539B (pl)

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US5591767A (en) *	1993-01-25	1997-01-07	Pharmetrix Corporation	Liquid reservoir transdermal patch for the administration of ketorolac
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US5536263A (en) *	1994-03-30	1996-07-16	Lectec Corporation	Non-occulusive adhesive patch for applying medication to the skin
US5635203A (en) *	1994-09-29	1997-06-03	Alza Corporation	Transdermal device having decreased delamination
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GB9614098D0 (en)	1996-07-05	1996-09-04	Orion Yhtymae Oy	Transdermal delivery of levosimendan
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US6716867B1 (en)	1998-04-01	2004-04-06	Orion Corporation	Use of dexmedetomidine for ICU sedation
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US8211462B2 (en) *	2002-07-30	2012-07-03	Ucb Pharma Gmbh	Hot-melt TTS for administering rotigotine
US8246979B2 (en)	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system for the administration of rotigotine
US8246980B2 (en) *	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system
IL152574A (en)	2002-10-31	2009-09-22	Transpharma Medical Ltd	A system for passing through the skin of dry items or dried medicines
US8133505B2 (en)	2002-10-31	2012-03-13	Transpharma Medical Ltd.	Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en)	2002-10-31	2010-02-16	Transpharma Medical Ltd.	Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en)	2002-10-31	2008-06-03	Transpharma Medical Ltd.	Transdermal delivery system for dried particulate or lyophilized medications
ES2239196T3 (es) *	2002-12-02	2005-09-16	Schwarz Pharma Ag	Suministro iontoforetico de rotigotina para el tratamiento de la enfermedad de parkinson.
DE10261696A1 (de) *	2002-12-30	2004-07-15	Schwarz Pharma Ag	Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE102006054733A1 (de) *	2006-11-21	2008-05-29	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
US20090291127A1 (en) *	2008-05-21	2009-11-26	Jianye Wen	Transdermal anti-dementia active agent formulations and methods for using the same
US7795263B2 (en) *	2008-07-08	2010-09-14	Wildlife Laboratories, Inc.	Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
SG175979A1 (en) *	2009-05-15	2011-12-29	Recro Pharma Inc	Sublingual dexmedetomidine compositions and methods of use thereof
US20130072532A1 (en) *	2010-01-08	2013-03-21	Recro Pharma, Inc.	Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en)	2011-10-14	2013-04-18	Hospira, Inc.	Methods of treating pediatric patients using dexmedetomidine
WO2013090278A2 (en)	2011-12-11	2013-06-20	Recro Pharma, Inc.	Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en)	2012-01-04	2012-08-14	Hospira, Inc.	Dexmedetomidine premix formulation
WO2013173317A1 (en) *	2012-05-14	2013-11-21	Prospire, Llc	TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS
KR101948779B1 (ko) *	2013-10-07	2019-05-21	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
US20150098982A1 (en) *	2013-10-07	2015-04-09	Teikoku Pharma Usa, Inc.	Methods and Compositions for Managing Pain Comprising Dexmedetomidine Transdermal Compositions
KR101881791B1 (ko) *	2013-10-07	2018-07-25	테이코쿠 팔마 유에스에이, 인코포레이티드	비진정성 덱스메데토미딘 경피 조성물을 사용하여 금단 증후군을 치료하기 위한 방법 및 조성물
CA2924233C (en) *	2013-10-07	2018-10-23	Teikoku Pharma Usa, Inc.	Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
CA2924236C (en) *	2013-10-07	2020-01-07	Teikoku Pharma Usa, Inc.	Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
US9974754B2 (en)	2013-12-18	2018-05-22	Maruishi Pharmaceutical Co., Ltd.	Hydrous adhesive patch
US9717796B1 (en)	2016-04-20	2017-08-01	Slypharma, Llc	Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
BR112019007325A2 (pt) *	2016-10-18	2019-07-02	Lts Lohmann Therapie Systeme Ag	sistema terapêutico tópico de duas camadas
BR112019006955A2 (pt)	2016-10-31	2019-07-02	Teikoku Pharma Usa Inc	métodos de controle da dor usando dispositivos de distribuição transdérmica de dexmedetomidina
US20190350840A1 (en) *	2016-12-26	2019-11-21	Hisamitsu Pharmaceutical Co., Inc.	Microneedle device
KR102437993B1 (ko)	2018-06-26	2022-08-29	히사미쓰 세이야꾸 가부시키가이샤	마이크로 니들 디바이스 및 그것을 제조하는 방법
US11160791B2 (en)	2018-11-01	2021-11-02	Medefil, Inc.	Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN111346072B (zh) *	2018-12-21	2022-05-27	宜昌人福药业有限责任公司	一种透皮给药的药物组合物及其制备方法
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1989
- 1989-08-18 US US07/395,717 patent/US5124157A/en not_active Expired - Fee Related
1990
- 1990-08-01 NZ NZ234749A patent/NZ234749A/en unknown
- 1990-08-06 DK DK90308637.9T patent/DK0413487T3/da active
- 1990-08-06 DE DE69019628T patent/DE69019628T2/de not_active Expired - Fee Related
- 1990-08-06 ES ES90308637T patent/ES2072397T3/es not_active Expired - Lifetime
- 1990-08-06 AT AT90308637T patent/ATE122899T1/de not_active IP Right Cessation
- 1990-08-06 EP EP90308637A patent/EP0413487B1/en not_active Expired - Lifetime
- 1990-08-08 DD DD90343324A patent/DD297066A5/de not_active IP Right Cessation
- 1990-08-14 JP JP2511906A patent/JP3043064B2/ja not_active Expired - Lifetime
- 1990-08-14 CA CA002064687A patent/CA2064687C/en not_active Expired - Fee Related
- 1990-08-14 PT PT95002A patent/PT95002B/pt active IP Right Grant
- 1990-08-14 WO PCT/US1990/004575 patent/WO1991002505A1/en not_active Ceased
- 1990-08-14 HU HU9200517A patent/HUT64223A/hu unknown
- 1990-08-14 AU AU61834/90A patent/AU639015B2/en not_active Expired
- 1990-08-14 UA UA93004242A patent/UA26988C2/uk unknown
- 1990-08-14 RU SU925011651A patent/RU2098083C1/ru active
- 1990-08-17 CN CN90107099A patent/CN1035922C/zh not_active Expired - Lifetime
- 1990-08-17 ZA ZA906539A patent/ZA906539B/xx unknown
- 1990-08-17 IE IE299390A patent/IE67127B1/en not_active IP Right Cessation
- 1990-08-17 PL PL90286525A patent/PL165023B1/pl unknown
1992
- 1992-02-10 NO NO920521A patent/NO300408B1/no unknown
- 1992-02-11 FI FI920576A patent/FI100857B/fi active
- 1992-02-17 BG BG095935A patent/BG95935A/bg unknown
1993
- 1993-09-22 LV LVP-93-1079A patent/LV10685B/lv unknown
1994
- 1994-01-13 LT LTIP1773A patent/LT3753B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0413487B1 (en)	1995-05-24
ES2072397T3 (es)	1995-07-16
FI100857B (fi)	1998-03-13
PL286525A1 (en)	1991-05-20
UA26988C2 (uk)	2000-02-28
NO300408B1 (no)	1997-05-26
US5124157A (en)	1992-06-23
LV10685A (lv)	1995-06-20
LTIP1773A (en)	1995-07-25
PT95002B (pt)	1997-10-31
DE69019628D1 (de)	1995-06-29
ATE122899T1 (de)	1995-06-15
NO920521L (no)	1992-02-10
CN1035922C (zh)	1997-09-24
CN1049450A (zh)	1991-02-27
LT3753B (en)	1996-03-25
HUT64223A (en)	1993-12-28
WO1991002505A1 (en)	1991-03-07
IE902993A1 (en)	1991-02-27
EP0413487A1 (en)	1991-02-20
PT95002A (pt)	1992-02-28
JP3043064B2 (ja)	2000-05-22
CA2064687A1 (en)	1991-02-19
NO920521D0 (no)	1992-02-10
DE69019628T2 (de)	1995-09-28
ZA906539B (en)	1991-06-26
FI920576A0 (fi)	1992-02-11
JPH05503916A (ja)	1993-06-24
DK0413487T3 (da)	1995-07-17
HU9200517D0 (en)	1992-05-28
AU639015B2 (en)	1993-07-15
AU6183490A (en)	1991-04-03
NZ234749A (en)	1992-03-26
RU2098083C1 (ru)	1997-12-10
CA2064687C (en)	1998-04-21
PL165023B1 (pl)	1994-11-30
IE67127B1 (en)	1996-03-06
DD297066A5 (de)	1992-01-02
BG95935A (bg)	1993-12-24

Publication	Publication Date	Title
LV10685B (en)	1995-12-20	Device for transdermal administration of dexamedethomidine
US4573995A (en)	1986-03-04	Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
JP2511472B2 (ja)	1996-06-26	速度コントロ―ル接着剤を有する改良された経皮投与デバイス
US5948433A (en)	1999-09-07	Transdermal patch
EP0708627B1 (en)	2000-02-02	Method and device for providing nicotine replacement therapy transdermally/transbuccally
KR950001968B1 (ko)	1995-03-08	펜타닐의 경피투여용 적층 혼성체
US5480648A (en)	1996-01-02	Transdermal prostaglandin composition
JP2650710B2 (ja)	1997-09-03	スクロースエステルを用いる皮膚透過促進剤組成物
JP2758908B2 (ja)	1998-05-28	皮膚透過促進剤としてグリセロールモノオレエートを用いる治療系
IE893455L (en)	1990-05-01	Dosage form having reduced abuse potential
US5217718A (en)	1993-06-08	Method and device for administering dexmedetomidine transdermally
US5186939A (en)	1993-02-16	Laminated composite for transdermal administration of fentanyl
ES2201434T3 (es)	2004-03-16	Sistema terapeutico transdermal para la administracion de hormonas.
AU700418B2 (en)	1999-01-07	Transdermally administrable medicament with ACE inhibitors
CA2312234A1 (en)	1999-05-14	Use of methylnaltrexone and related compounds
DK201300015U1 (en)	2013-02-08	Transdermal therapeutic system for administration of rivastigmine
CN103269698A (zh)	2013-08-28	用于施用活性物质的经皮治疗系统
US6106856A (en)	2000-08-22	Transdermal delivery of calcium channel blockers, such as nifedipine
MXPA04011759A (es)	2005-07-27	Emplasto conteniendo fentanilo.
CA2183544A1 (en)	1995-08-24	Desogestrel-containing transdermal application agent
NL8104929A (nl)	1982-06-01	Anticholinergische preparaten, alsmede de bereiding en de toepassing ervan.
JP2002513753A (ja)	2002-05-14	カンデサルタン投与用経皮治療システム
JPS63307814A (ja)	1988-12-15	疾患治療用貼付剤
JPH07145061A (ja)	1995-06-06	経皮吸収製剤
HUT77085A (hu)	1998-03-02	Ösztradioltartalmú transzdermális terápiás rendszer TTS vízmegkötő adalékokkal és eljárás előállítására