LV10860B - Method for producing of phenylalkylamines - Google Patents

Method for producing of phenylalkylamines Download PDF

Info

Publication number: LV10860B
Authority: LV; Latvia
Prior art keywords: carbon atoms; general formula; phenyl; alkyl; formula
Prior art date: 1986-09-25

Application number

LVP-93-650A

Other languages

English (en)

Latvian (lv)

Other versions

LV10860A (lv

Inventor

Knoll Jozsef

Simay Antal

Szinnyei Eva

Somfai Eva

Tirik Zoltan

Mozsolits Karoly

Bergmann Janos

Original Assignee

Chinoin Gyegyszer S Vegy Szeti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-25

Filing date

1993-06-22

Publication date

1996-04-20

1993-06-22 Application filed by Chinoin Gyegyszer S Vegy Szeti filed Critical Chinoin Gyegyszer S Vegy Szeti

1995-10-20 Publication of LV10860A publication Critical patent/LV10860A/xx

1996-04-20 Publication of LV10860B publication Critical patent/LV10860B/lv

Links

238000004519 manufacturing process Methods 0.000 title claims 2
125000004432 carbon atom Chemical group C* 0.000 claims abstract 21
125000000217 alkyl group Chemical group 0.000 claims abstract 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 6
150000001875 compounds Chemical class 0.000 claims abstract 5
125000000753 cycloalkyl group Chemical group 0.000 claims abstract 5
125000005843 halogen group Chemical group 0.000 claims abstract 4
238000000034 method Methods 0.000 claims abstract 4
125000003545 alkoxy group Chemical group 0.000 claims abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
229910052736 halogen Inorganic materials 0.000 claims abstract 2
125000003884 phenylalkyl group Chemical group 0.000 claims abstract 2
150000001412 amines Chemical class 0.000 claims 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
239000011230 binding agent Substances 0.000 claims 1
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
150000007529 inorganic bases Chemical class 0.000 claims 1
230000003993 interaction Effects 0.000 claims 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
150000007530 organic bases Chemical class 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
125000002130 sulfonic acid ester group Chemical group 0.000 claims 1
230000000694 effects Effects 0.000 abstract 3
230000014759 maintenance of location Effects 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
150000003943 catecholamines Chemical class 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000003368 psychostimulant agent Substances 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
239000000021 stimulant Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
239000011800 void material Substances 0.000 abstract 1
101150115538 nero gene Proteins 0.000 description 2
WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 1
241001669680 Dormitator maculatus Species 0.000 description 1
101150096418 Mepe gene Proteins 0.000 description 1
101100066898 Mus musculus Flna gene Proteins 0.000 description 1
101100366940 Mus musculus Stom gene Proteins 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
235000009470 Theobroma cacao Nutrition 0.000 description 1
244000240602 cacao Species 0.000 description 1
238000001727 in vivo Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
External Artificial Organs (AREA)

LVP-93-650A 1986-09-25 1993-06-22 Method for producing of phenylalkylamines LV10860B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU864101A HU207280B (en)	1986-09-25	1986-09-25	Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them
PCT/HU1987/000040 WO1988002254A1 (en)	1986-09-25	1987-09-25	New psychostimulant agent

Publications (2)

Publication Number	Publication Date
LV10860A LV10860A (lv)	1995-10-20
LV10860B true LV10860B (en)	1996-04-20

Family

ID=10966901

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LVP-93-650A LV10860B (en)	1986-09-25	1993-06-22	Method for producing of phenylalkylamines
LVP-93-651A LV10709B (en)	1986-09-25	1993-06-22	Method for preparation of phenylalkylamines

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-651A LV10709B (en)	1986-09-25	1993-06-22	Method for preparation of phenylalkylamines

Country Status (21)

Country	Link
US (1)	US5075338A (de)
EP (1)	EP0284621B1 (de)
KR (1)	KR880701545A (de)
AT (1)	ATE117204T1 (de)
CS (1)	CS277418B6 (de)
DD (1)	DD262226A5 (de)
DE (1)	DE3751006T2 (de)
DK (1)	DK282488D0 (de)
ES (1)	ES2007411A6 (de)
FI (1)	FI882474A0 (de)
GE (1)	GEP19960656B (de)
HU (1)	HU207280B (de)
IL (1)	IL83905A (de)
LT (2)	LT3530B (de)
LV (2)	LV10860B (de)
PL (1)	PL151642B1 (de)
PT (1)	PT85799B (de)
RU (1)	RU2007384C1 (de)
SU (1)	SU1746882A3 (de)
UA (3)	UA11100A (de)
WO (1)	WO1988002254A1 (de)

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US5430044A (en) *	1987-02-06	1995-07-04	Fisons Corporation	Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties
ATE135206T1 (de) *	1988-08-12	1996-03-15	Astra Ab	Arylalkylamine und -amide mit krampflösender und nervenschützender wirkung
AU641394B2 (en) *	1989-06-02	1993-09-23	John Wyeth & Brother Limited	Amines
US6011068A (en) *	1991-08-23	2000-01-04	Nps Pharmaceuticals, Inc.	Calcium receptor-active molecules
US6313146B1 (en)	1991-08-23	2001-11-06	Nps Pharmaceuticals, Inc.	Calcium receptor-active molecules
US6001884A (en) *	1991-08-23	1999-12-14	Nps Pharmaceuticals, Inc.	Calcium receptor-active molecules
HUT63579A (en) *	1991-12-20	1993-09-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing double-phase pharmaceutical compositions suitable for treating diseases occurring during neurodegenerative processes
ES2285707T3 (es)	1994-10-21	2007-11-16	Nps Pharmaceuticals, Inc.	Compuestos activos frente al receptor de calcio.
US6319954B1 (en)	1995-01-13	2001-11-20	Somerset Pharmaceuticals, Inc.	S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions
US6033682A (en)	1995-01-13	2000-03-07	Somerset Pharmaceuticals, Inc.	S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions
US6348208B1 (en) *	1995-01-13	2002-02-19	Somerset Pharmaceuticals, Inc.	Methods and pharmaceutical compositions employing desmethylselegiline
US6299901B1 (en)	1995-01-13	2001-10-09	Somerset Pharmaceuticals, Inc.	Methods and pharmaceutical compositions employing desmethylselegiline
US6316022B1 (en)	1995-06-07	2001-11-13	Noven Pharmaceuticals, Inc.	Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
CA2223588C (en) *	1995-06-07	2004-01-06	Noven Pharmaceuticals, Inc.	Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
WO1997041090A1 (en)	1996-05-01	1997-11-06	Nps Pharmaceuticals, Inc.	Inorganic ion receptor-active compounds
PT957080E (pt) *	1997-08-07	2006-10-31	Fujimoto Brothers Co Ltd	Novos derivados de etilamina
JP4499208B2 (ja) *	1998-10-29	2010-07-07	株式会社フジモト・コーポレーション	新規な光学活性アミノペンタン誘導体
US20050059743A1 (en) *	2000-11-01	2005-03-17	Sention, Inc.	Methods for treating mild cognitive impairment and alzheimer's disease
US20030232890A1 (en) *	2000-11-01	2003-12-18	Sention, Inc.	Methods for treating an impairment in memory consolidation
US20070117869A1 (en) *	2000-11-01	2007-05-24	Cognition Pharmaceuticals Llc	Methods for treating coginitive impairment and improving cognition
US7619005B2 (en) *	2000-11-01	2009-11-17	Cognition Pharmaceuticals Llc	Methods for treating cognitive impairment in humans with Multiple Sclerosis
WO2002039998A2 (en) *	2000-11-01	2002-05-23	Sention, Inc.	Methods and compositions for regulating memory consolidation
WO2005000203A2 (en)	2001-10-31	2005-01-06	Sention, Inc.	Methods for treating cognitive impairment and improving cognition
US20030119884A1 (en) *	2000-11-01	2003-06-26	Epstein Mel H.	Methods and compositions for regulating memory consolidation
ES2314056T3 (es) *	2001-05-02	2009-03-16	Blanchette Rockefeller Neurosciences Institute	Activadores de la anhidrasa carbonica para mejorar el aprendizaje y la memoria.
EP1935414A3 (de) *	2001-05-02	2010-08-18	Blanchette Rockefeller Neurosciences Institute	Kohlenstoffanhydrase-Aktivatoren zur Erhöhung der Auffassungsgabe und der Merkfähigkeit
TW201206425A (en)	2004-05-18	2012-02-16	Brni Neurosciences Inst	Treatment of depressive disorders
EP2419400A1 (de)	2009-04-15	2012-02-22	Research Triangle Institute	Monoaminwiederaufnahmehemmer
RU2731102C2 (ru)	2014-12-05	2020-08-28	Земмельвайс Юнивёрсити	Арилалкиламиновые соединения для применения для профилактики или лечения рака

Family Cites Families (16)

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Publication number	Priority date	Publication date	Assignee	Title
US485926A (en)		1892-11-08		Field
DE767263C (de) *	1937-10-03	1952-03-31	Theodor H Temmler	Verfahren zur Herstellung von ª-Aralkylaminen
DE893341C (de) *	1950-08-23	1953-10-15	Troponwerke Dinklage & Co	Verfahren zur Herstellung von N-Aralkyl-ª-phenyl-isopropylaminen
US2797242A (en) *	1953-08-11	1957-06-25	Parke Davis & Co	Substituted alpha-benzylphenethylamines and methods for producing the same
DE227447C (de)	1955-03-23	1910-10-21
DE1210873B (de) *	1959-03-18	1966-02-17	Hoffmann La Roche	Verfahren zur Herstellung von Halogenalkylaminen
US3044932A (en) *	1960-02-24	1962-07-17	Upjohn Co	Appetite suppressant drugs
DE1133395B (de) *	1960-11-12	1962-07-19	Hoechst Ag	Verfahren zur Herstellung von herz- und kreislaufwirksamen Phenylalkylaminen
DE1227447B (de) *	1962-03-30	1966-10-27	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur Herstellung von Phenylisopropylaminen
GB1031425A (en) *	1962-03-30	1966-06-02	Chinoin Gyogyszer Es Vegyeszet	New aralkylamines and their preparation
FR1478311A (fr) *	1963-10-18	1967-04-28	Koninklijke Pharma Fab Nv	Procédé de préparation d'aminoalcanes et produits en résultant
GB1218135A (en) *	1967-07-28	1971-01-06	Abbott Lab	Substituted phenethylamine derivatives
DE2143204C3 (de) *	1971-08-28	1979-09-27	Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt	N-Fluoralkyl-phenylisopropylamin-Derivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis
US4025624A (en) *	1975-11-18	1977-05-24	A. H. Robins Company, Incorporated	Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
US4404222A (en) *	1980-08-25	1983-09-13	American Cyanamid Company	Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby
DD145599A1 (de) *	1979-08-23	1980-12-24	Roswitha Toepfer	Mittel zur regulierung des pflanzenwachstums

1986
- 1986-09-25 HU HU864101A patent/HU207280B/hu not_active IP Right Cessation
1987
- 1987-09-15 IL IL83905A patent/IL83905A/xx not_active IP Right Cessation
- 1987-09-21 DD DD87307094A patent/DD262226A5/de not_active IP Right Cessation
- 1987-09-23 ES ES8702717A patent/ES2007411A6/es not_active Expired
- 1987-09-25 DE DE3751006T patent/DE3751006T2/de not_active Expired - Fee Related
- 1987-09-25 UA UA4355858A patent/UA11100A/uk unknown
- 1987-09-25 PL PL1987267913A patent/PL151642B1/pl unknown
- 1987-09-25 UA UA4742460A patent/UA19171A/uk unknown
- 1987-09-25 CS CS876898A patent/CS277418B6/cs unknown
- 1987-09-25 WO PCT/HU1987/000040 patent/WO1988002254A1/en not_active Ceased
- 1987-09-25 EP EP87906316A patent/EP0284621B1/de not_active Expired - Lifetime
- 1987-09-25 AT AT87906316T patent/ATE117204T1/de not_active IP Right Cessation
- 1987-09-25 PT PT85799A patent/PT85799B/pt not_active IP Right Cessation
1988
- 1988-05-24 DK DK282488A patent/DK282488D0/da not_active Application Discontinuation
- 1988-05-24 SU SU884355858A patent/SU1746882A3/ru active
- 1988-05-24 KR KR1019880700574A patent/KR880701545A/ko not_active Ceased
- 1988-05-25 FI FI882474A patent/FI882474A0/fi not_active IP Right Cessation
1989
- 1989-10-11 US US07/420,058 patent/US5075338A/en not_active Expired - Fee Related
- 1989-11-23 RU SU894742460A patent/RU2007384C1/ru active
1990
- 1990-09-10 UA UA4830945A patent/UA19808A/uk unknown
1993
- 1993-06-22 LV LVP-93-650A patent/LV10860B/lv unknown
- 1993-06-22 LV LVP-93-651A patent/LV10709B/lv unknown
- 1993-08-12 GE GEAP19931393A patent/GEP19960656B/en unknown
- 1993-08-19 LT LTIP878A patent/LT3530B/lt not_active IP Right Cessation
- 1993-08-19 LT LTIP879A patent/LT3531B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
LV10709A (lv)	1995-06-20
KR880701545A (ko)	1988-11-03
PT85799B (pt)	1990-08-31
UA19808A (uk)	1997-12-25
IL83905A (en)	1993-07-08
ES2007411A6 (es)	1989-06-16
PT85799A (en)	1987-10-01
CS277418B6 (en)	1993-03-17
HUT45962A (en)	1988-09-28
LT3530B (en)	1995-11-27
LV10709B (en)	1995-12-20
EP0284621A1 (de)	1988-10-05
FI882474A7 (fi)	1988-05-25
DE3751006T2 (de)	1995-05-24
CS689887A3 (en)	1992-08-12
DE3751006D1 (de)	1995-03-02
RU2007384C1 (ru)	1994-02-15
DK282488A (da)	1988-05-24
PL267913A1 (en)	1989-03-06
PL151642B1 (en)	1990-09-28
LTIP878A (en)	1995-03-27
US5075338A (en)	1991-12-24
UA19171A (uk)	1997-12-25
ATE117204T1 (de)	1995-02-15
DD262226A5 (de)	1988-11-23
GEP19960656B (en)	1996-12-24
FI882474A0 (fi)	1988-05-25
UA11100A (uk)	1996-12-25
WO1988002254A1 (en)	1988-04-07
DK282488D0 (da)	1988-05-24
LTIP879A (en)	1995-03-27
EP0284621B1 (de)	1995-01-18
HU207280B (en)	1993-03-29
SU1746882A3 (ru)	1992-07-07
LT3531B (en)	1995-11-27
LV10860A (lv)	1995-10-20

Publication	Publication Date	Title
LV10860B (en)	1996-04-20	Method for producing of phenylalkylamines
Klayman et al.	1983	2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl) ethyl]-3-thiosemicarbazides as potential antimalarial agents
AU2007317242B2 (en)	2013-08-01	Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto
BR0014116A (pt)	2002-05-21	Uso de um composto, composto, métodos para preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica
HUT59404A (en)	1992-05-28	Heterocyclic compounds
AP2001002307A0 (en)	2001-12-31	B3 adrenergic receptor agonists and uses thereof.
EP0445811A3 (en)	1992-01-15	Nitrogen-containing heterocyclic compounds, their production and use
NO981858L (no)	1998-06-24	Fenyletanolamin-forbindelser anvendelige som <beta>3 agonist, fremgangsmÕte for fremstilling av disse og mellomprodukter i fremstilling av dem
EP1006115A3 (de)	2000-06-28	Imidazopyridinen mit antihypertensiven, cardioprotektiven, anti-ischämischen und antilipolytischen Eigenschaften
CA2318349A1 (en)	1999-07-08	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
CA2128493A1 (en)	1995-01-31	Aminobenzoic acid derivatives
Conrad et al.	1979	Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates
DK57181A (da)	1981-08-14	Fremgangsmaade til fremstilling af 4-substituerede imidazolderivater eller ugiftige farmaceutisk acceptable syreadditionssalte deraf
DK339685D0 (da)	1985-07-25	2-phenylalkyl-3-aminoalkyl-4(3h)-quinazolinoner og fremgangsmaade til fremstilling deraf
US6040314A (en)	2000-03-21	Bicyclic isothiourea derivatives useful in therapy
KR830010072A (ko)	1983-12-26	아미디노 피페리딘 유도체의 제조방법
FI65987C (fi)	1984-08-10	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alkanolaminderivat
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US4202967A (en)	1980-05-13	N,N-pentamethylene derivatives of daunomycin and adriamycin
Lin et al.	1985	Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl) ethoxy] methyl]-5-benzyluracil and its amino analog new potent uridine phosphorylase inhibitors with high water solubility
HUT70480A (en)	1995-10-30	Mono and bis alkylamino-anthracyclines pharmaceutical compns. contg. them and process to prepare the said compds.
MY101862A (en)	1992-01-31	Dry pesticidal compositions
Attaby	1990	Reactions with cyanothioacetamide derivatives: Synthesis of several new pyridine and annelated pyridine derivatives
IE43984B1 (en)	1981-07-15	A 1,4-dihydropyridine-3 5-dicarboxylic acid di-ester derivative, several processes for its preparation,and its use as a coronary therapeutic agent
DE1620044C3 (de)	1974-08-22	Verfahren zur Herstellung von substituierten Aminomethylphosphinsäuren