MA26684A1 - Composes antagonistes de recepteurs de 5-ht4 - Google Patents

Composes antagonistes de recepteurs de 5-ht4

Info

Publication number
MA26684A1
MA26684A1 MA25757A MA25757A MA26684A1 MA 26684 A1 MA26684 A1 MA 26684A1 MA 25757 A MA25757 A MA 25757A MA 25757 A MA25757 A MA 25757A MA 26684 A1 MA26684 A1 MA 26684A1
Authority
MA
Morocco
Prior art keywords
receptors
antagonist compounds
antagonist
compounds
Prior art date
Application number
MA25757A
Other languages
English (en)
Inventor
Douglas Clark Robin
Jahangir Alam
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26684A1 publication Critical patent/MA26684A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
MA25757A 1998-09-10 1999-09-08 Composes antagonistes de recepteurs de 5-ht4 MA26684A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9974098P 1998-09-10 1998-09-10
US13846899P 1999-06-10 1999-06-10

Publications (1)

Publication Number Publication Date
MA26684A1 true MA26684A1 (fr) 2004-12-20

Family

ID=26796436

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25757A MA26684A1 (fr) 1998-09-10 1999-09-08 Composes antagonistes de recepteurs de 5-ht4

Country Status (17)

Country Link
US (1) US6172062B1 (fr)
EP (1) EP1112270B1 (fr)
JP (1) JP3366323B2 (fr)
KR (1) KR100413150B1 (fr)
CN (1) CN1142161C (fr)
AR (1) AR035153A1 (fr)
AT (1) ATE357443T1 (fr)
AU (1) AU758807B2 (fr)
BR (1) BRPI9913542B8 (fr)
CA (1) CA2340952C (fr)
CO (1) CO5130016A1 (fr)
DE (1) DE69935600T2 (fr)
ES (1) ES2283132T3 (fr)
MA (1) MA26684A1 (fr)
PE (1) PE20001029A1 (fr)
TR (1) TR200100698T2 (fr)
WO (1) WO2000015636A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
EP1381600A1 (fr) * 2001-04-24 2004-01-21 Wyeth, A Corporation of the State of Delaware Derives azaheterocyclylmethyle antidepresseurs de 2,3-dihydro-1,4-benzodioxane
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US7089924B2 (en) * 2001-12-14 2006-08-15 Diamond Innovations, Inc. Granite slabs cut with frame saw employing blades with diamond-containing segments and method of cutting thereof
JP4688798B2 (ja) * 2003-06-19 2011-05-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−アンタゴニストとしてのヒドロキシカルボニルフェニル置換４−（アミノメチル）−ピペリジンベンズアミド
EP1638961B1 (fr) * 2003-06-19 2009-11-18 Janssen Pharmaceutica N.V. 4-(aminomethyl)-piperidine benzamides substitues par des heterocycles, utilises comme antagonistes des recepteurs 5ht4
EP1641783B1 (fr) * 2003-06-19 2012-03-28 Janssen Pharmaceutica NV Aminosulfonyle substitue 4-(aminomethyle)-piperidine benzamides utilise comme 5ht4-antagonistes
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7399862B2 (en) * 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
WO2006052889A2 (fr) * 2004-11-05 2006-05-18 Theravance, Inc. Composes de quinolinone-carboxamide
CA2588037A1 (fr) * 2004-12-22 2006-06-29 Theravance, Inc. Composes d'indazole-carboxamide
CN101137648A (zh) * 2005-03-01 2008-03-05 惠氏公司 结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
CA2709883A1 (fr) * 2007-12-19 2009-06-25 The Scripps Research Institute Benzimidazoles et analogues comme inhibiteurs de la rho-kinase
WO2009079008A1 (fr) * 2007-12-19 2009-06-25 Yangbo Feng Benzopyranes et analogues utilisés comme inhibiteurs de la rho kinase
US20110038835A1 (en) * 2007-12-21 2011-02-17 The Scripps Research Institute Anilides and analogs as rho kinase inhibitors
EP2427243A4 (fr) 2009-05-05 2012-11-21 Vapogenix Inc Nouvelles formulations d'anesthésiques volatiles et procédés d'utilisation pour réduire l'inflammation
US8476221B2 (en) 2011-03-18 2013-07-02 Halimed Pharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders
MA41629A (fr) 2015-03-04 2018-01-09 Center For Human Reproduction Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité
US20210330599A1 (en) 2016-08-01 2021-10-28 University Of Rochester Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use
US20220040136A1 (en) 2018-10-09 2022-02-10 University Of Rochester Treatment of vulvovaginal disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374637A (en) 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
CA2116024A1 (fr) * 1991-08-20 1993-03-04 Francis David King Antagonistes des recepteurs 5-ht4
CA2118812C (fr) * 1991-09-12 2006-01-17 Francis David King Antagonistes des recepteur a 5-ht4
EP0625149A1 (fr) * 1992-02-06 1994-11-23 Smithkline Beecham Plc Derives de benzopyrane, de benzothiopyrane et de coumarone utilises comme antagonistes du recepteur 5-ht4
RU2104279C1 (ru) * 1992-03-12 1998-02-10 Смитклайн Бичам Плс Конденсированное индольное производное или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность антагониста 5-нт*004-рецептора
US5998409A (en) 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
US5852014A (en) 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AU5150393A (en) * 1992-10-13 1994-05-09 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists
NZ257545A (en) * 1992-11-05 1997-01-29 Smithkline Beecham Plc Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
US5472866A (en) 1992-12-24 1995-12-05 Synaptic Pharmaceutical Corporation DNA encoding 5-HT4A serotonin receptors
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
HUT74870A (en) * 1993-05-26 1997-02-28 Syntex Inc Process for producing 1-phenylalkanone 5-ht4 receptor ligands and pharmaceutical compositions containing them
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
DE4327595A1 (de) 1993-08-17 1995-02-23 Hoechst Ag Zusammensetzungen mit verbesserten elektrostatischen Eigenschaften enthaltend aromatische Polyamide, daraus hergestellte geformte Gebilde sowie deren Verwendung und Verfahren zu ihrer Herstellung
WO1996005166A1 (fr) * 1994-08-11 1996-02-22 Yamanouchi Pharmaceutical Co., Ltd. Derive d'amine substitue et composition medicamenteuse le contenant
IL117438A (en) 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5654320A (en) 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
JPH09241241A (ja) * 1996-03-08 1997-09-16 Roussel Morishita Kk Ｎ−（１−置換−４−ピペリジル）ベンズアミド誘導体
JPH111472A (ja) * 1996-04-30 1999-01-06 Dainippon Pharmaceut Co Ltd ベンズアミド誘導体及びそれを含有する医薬組成物
CA2274055A1 (fr) * 1996-12-19 1998-06-25 Smithkline Beecham P.L.C. Derives du n-piperazine-1-ylphenyl-benzamide
US6069152A (en) 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
FR2771741B1 (fr) * 1997-11-28 2001-07-13 Inst Nat Sante Rech Med Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage

Also Published As

Publication number Publication date
AU5857299A (en) 2000-04-03
WO2000015636A1 (fr) 2000-03-23
DE69935600D1 (de) 2007-05-03
JP2002524561A (ja) 2002-08-06
PE20001029A1 (es) 2000-10-12
KR100413150B1 (ko) 2003-12-31
ES2283132T3 (es) 2007-10-16
DE69935600T2 (de) 2007-12-06
CA2340952A1 (fr) 2000-03-23
EP1112270B1 (fr) 2007-03-21
ATE357443T1 (de) 2007-04-15
JP3366323B2 (ja) 2003-01-14
AR035153A1 (es) 2004-05-05
TR200100698T2 (tr) 2001-07-23
CA2340952C (fr) 2009-12-08
CO5130016A1 (es) 2002-02-27
BRPI9913542B1 (pt) 2016-04-19
BR9913542A (pt) 2001-06-05
AU758807B2 (en) 2003-03-27
KR20010085777A (ko) 2001-09-07
CN1142161C (zh) 2004-03-17
CN1315950A (zh) 2001-10-03
US6172062B1 (en) 2001-01-09
EP1112270A1 (fr) 2001-07-04
BRPI9913542B8 (pt) 2021-05-25

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