MA26684A1 - Composes antagonistes de recepteurs de 5-ht4 - Google Patents
Composes antagonistes de recepteurs de 5-ht4Info
- Publication number
- MA26684A1 MA26684A1 MA25757A MA25757A MA26684A1 MA 26684 A1 MA26684 A1 MA 26684A1 MA 25757 A MA25757 A MA 25757A MA 25757 A MA25757 A MA 25757A MA 26684 A1 MA26684 A1 MA 26684A1
- Authority
- MA
- Morocco
- Prior art keywords
- receptors
- antagonist compounds
- antagonist
- compounds
- Prior art date
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9974098P | 1998-09-10 | 1998-09-10 | |
| US13846899P | 1999-06-10 | 1999-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26684A1 true MA26684A1 (fr) | 2004-12-20 |
Family
ID=26796436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25757A MA26684A1 (fr) | 1998-09-10 | 1999-09-08 | Composes antagonistes de recepteurs de 5-ht4 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6172062B1 (fr) |
| EP (1) | EP1112270B1 (fr) |
| JP (1) | JP3366323B2 (fr) |
| KR (1) | KR100413150B1 (fr) |
| CN (1) | CN1142161C (fr) |
| AR (1) | AR035153A1 (fr) |
| AT (1) | ATE357443T1 (fr) |
| AU (1) | AU758807B2 (fr) |
| BR (1) | BRPI9913542B8 (fr) |
| CA (1) | CA2340952C (fr) |
| CO (1) | CO5130016A1 (fr) |
| DE (1) | DE69935600T2 (fr) |
| ES (1) | ES2283132T3 (fr) |
| MA (1) | MA26684A1 (fr) |
| PE (1) | PE20001029A1 (fr) |
| TR (1) | TR200100698T2 (fr) |
| WO (1) | WO2000015636A1 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9310582D0 (en) * | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
| TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| US6559169B2 (en) | 2001-04-24 | 2003-05-06 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
| US7041683B2 (en) | 2001-04-24 | 2006-05-09 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan |
| US7089924B2 (en) * | 2001-12-14 | 2006-08-15 | Diamond Innovations, Inc. | Granite slabs cut with frame saw employing blades with diamond-containing segments and method of cutting thereof |
| CA2528642C (fr) * | 2003-06-19 | 2011-12-13 | Janssen Pharmaceutica N.V. | 4-(aminomethyl)-piperidine benzamides substitues par des heterocycles, utilises comme antagonistes des recepteurs 5ht<sb>4 </sb> |
| JP4916878B2 (ja) * | 2003-06-19 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ５ｈｔ４−拮抗薬としてのアミノスルホニル置換４−（アミノメチル）−ピペリジンベンズアミド |
| ATE486865T1 (de) * | 2003-06-19 | 2010-11-15 | Janssen Pharmaceutica Nv | Hydroxycarbonylphenyl substituierte 4- (aminomethyl)-piperidinbenzamide als 5ht4- antagonisten |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| DE602005016446D1 (de) | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
| JP5042028B2 (ja) * | 2004-11-05 | 2012-10-03 | セラヴァンス， インコーポレーテッド | キノリノン−カルボキサミド化合物 |
| KR20070091665A (ko) * | 2004-12-22 | 2007-09-11 | 세라밴스 인코포레이티드 | 인다졸－카르복사미드 화합물 |
| CN101137648A (zh) * | 2005-03-01 | 2008-03-05 | 惠氏公司 | 结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐 |
| WO2006094063A1 (fr) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Composes de quinolinone en tant qu’agonistes des recepteurs de 5-ht4 |
| US20110052562A1 (en) * | 2007-12-19 | 2011-03-03 | The Scripps Research Institute | Benzimidazoles and analogs as rho kinase inhibitors |
| WO2009079009A1 (fr) * | 2007-12-19 | 2009-06-25 | Yangbo Feng | Anilides et analogues utilisés comme inhibiteurs de la rho kinase |
| JP2011507848A (ja) * | 2007-12-21 | 2011-03-10 | ザ スクリプス リサーチ インスティチュート | Ｒｈｏキナーゼインヒビターとしてのベンゾピランおよびアナログ |
| JP2012526133A (ja) | 2009-05-05 | 2012-10-25 | ベイポジェニックス インコーポレイテッド | 炎症を低減させるための新規揮発性麻酔薬製剤およびその使用法 |
| US8476221B2 (en) | 2011-03-18 | 2013-07-02 | Halimed Pharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders |
| MA41629A (fr) | 2015-03-04 | 2018-01-09 | Center For Human Reproduction | Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité |
| WO2018026764A1 (fr) | 2016-08-01 | 2018-02-08 | University Of Rochester | Nanoparticules pour la libération contrôlée d'agents anti-biofilm et procédés d'utilisation |
| ES2986149T3 (es) | 2018-10-09 | 2024-11-08 | Univ Rochester | Tratamiento de trastornos vulvovaginales |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374637A (en) | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| GB9005014D0 (en) | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| NZ243993A (en) * | 1991-08-20 | 1994-10-26 | Smithkline Beecham Plc | Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity |
| US5580885A (en) | 1991-09-12 | 1996-12-03 | Smithkline Beecham P.L.C. | 5-HT4 receptor antagonists |
| AU667874B2 (en) * | 1992-02-06 | 1996-04-18 | Smithkline Beecham Plc | Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists |
| US5852014A (en) | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5998409A (en) | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
| ATE266033T1 (de) * | 1992-03-12 | 2004-05-15 | Smithkline Beecham Plc | N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h- 1,3 oxazino 3,2-a indol-10-carboxamid oder ein pharmazeutisch annehmbares salz davon |
| GB9219163D0 (en) | 1992-09-10 | 1992-10-28 | Smithkline Beecham Plc | Pharmaceuticals |
| MX9306311A (es) * | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
| EP0664805A1 (fr) | 1992-10-13 | 1995-08-02 | Smithkline Beecham Plc | Esters ou amides heterocycliques utilises comme antagonistes de recepteur de 5-ht 4? |
| US5705498A (en) | 1992-11-05 | 1998-01-06 | Smithkline Beecham Plc. | Piperidine derivatives as 5-HT4 receptor antagonists |
| US5472866A (en) | 1992-12-24 | 1995-12-05 | Synaptic Pharmaceutical Corporation | DNA encoding 5-HT4A serotonin receptors |
| GB9301660D0 (en) * | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9310582D0 (en) | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
| HUT74870A (en) * | 1993-05-26 | 1997-02-28 | Syntex Inc | Process for producing 1-phenylalkanone 5-ht4 receptor ligands and pharmaceutical compositions containing them |
| GB9312348D0 (en) * | 1993-06-16 | 1993-07-28 | Smithkline Beecham Plc | Pharmaceuticals |
| DE4327595A1 (de) | 1993-08-17 | 1995-02-23 | Hoechst Ag | Zusammensetzungen mit verbesserten elektrostatischen Eigenschaften enthaltend aromatische Polyamide, daraus hergestellte geformte Gebilde sowie deren Verwendung und Verfahren zu ihrer Herstellung |
| AU3192295A (en) * | 1994-08-11 | 1996-03-07 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted amine derivative and medicinal composition containing the same |
| US5654320A (en) | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
| IL117438A (en) | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
| JPH09241241A (ja) * | 1996-03-08 | 1997-09-16 | Roussel Morishita Kk | Ｎ−（１−置換−４−ピペリジル）ベンズアミド誘導体 |
| JPH111472A (ja) * | 1996-04-30 | 1999-01-06 | Dainippon Pharmaceut Co Ltd | ベンズアミド誘導体及びそれを含有する医薬組成物 |
| JP2001506995A (ja) * | 1996-12-19 | 2001-05-29 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Ｎ−ピペラジン−１−イルフェニル−ベンズアミド誘導体 |
| US6069152A (en) | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| FR2771741B1 (fr) * | 1997-11-28 | 2001-07-13 | Inst Nat Sante Rech Med | Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage |
-
1999
- 1999-09-01 CA CA002340952A patent/CA2340952C/fr not_active Expired - Lifetime
- 1999-09-01 KR KR10-2001-7003098A patent/KR100413150B1/ko not_active Expired - Lifetime
- 1999-09-01 CN CNB998104213A patent/CN1142161C/zh not_active Expired - Lifetime
- 1999-09-01 AU AU58572/99A patent/AU758807B2/en not_active Expired
- 1999-09-01 EP EP99946076A patent/EP1112270B1/fr not_active Expired - Lifetime
- 1999-09-01 ES ES99946076T patent/ES2283132T3/es not_active Expired - Lifetime
- 1999-09-01 TR TR2001/00698T patent/TR200100698T2/xx unknown
- 1999-09-01 DE DE69935600T patent/DE69935600T2/de not_active Expired - Lifetime
- 1999-09-01 JP JP2000570174A patent/JP3366323B2/ja not_active Expired - Lifetime
- 1999-09-01 AT AT99946076T patent/ATE357443T1/de active
- 1999-09-01 WO PCT/EP1999/006402 patent/WO2000015636A1/fr not_active Ceased
- 1999-09-01 BR BRPI9913542A patent/BRPI9913542B8/pt not_active IP Right Cessation
- 1999-09-02 US US09/392,195 patent/US6172062B1/en not_active Expired - Lifetime
- 1999-09-06 CO CO99056122A patent/CO5130016A1/es unknown
- 1999-09-07 PE PE1999000897A patent/PE20001029A1/es not_active Application Discontinuation
- 1999-09-08 MA MA25757A patent/MA26684A1/fr unknown
- 1999-09-08 AR ARP990104517A patent/AR035153A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5857299A (en) | 2000-04-03 |
| EP1112270B1 (fr) | 2007-03-21 |
| JP2002524561A (ja) | 2002-08-06 |
| EP1112270A1 (fr) | 2001-07-04 |
| CN1142161C (zh) | 2004-03-17 |
| AR035153A1 (es) | 2004-05-05 |
| CA2340952C (fr) | 2009-12-08 |
| KR20010085777A (ko) | 2001-09-07 |
| JP3366323B2 (ja) | 2003-01-14 |
| DE69935600D1 (de) | 2007-05-03 |
| CA2340952A1 (fr) | 2000-03-23 |
| TR200100698T2 (tr) | 2001-07-23 |
| DE69935600T2 (de) | 2007-12-06 |
| PE20001029A1 (es) | 2000-10-12 |
| BRPI9913542B1 (pt) | 2016-04-19 |
| AU758807B2 (en) | 2003-03-27 |
| KR100413150B1 (ko) | 2003-12-31 |
| ATE357443T1 (de) | 2007-04-15 |
| WO2000015636A1 (fr) | 2000-03-23 |
| ES2283132T3 (es) | 2007-10-16 |
| CO5130016A1 (es) | 2002-02-27 |
| BRPI9913542B8 (pt) | 2021-05-25 |
| US6172062B1 (en) | 2001-01-09 |
| CN1315950A (zh) | 2001-10-03 |
| BR9913542A (pt) | 2001-06-05 |
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