BRPI9913542B8 - derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos - Google Patents

derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos

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Publication number
BRPI9913542B8
BRPI9913542B8 BRPI9913542A BR9913542A BRPI9913542B8 BR PI9913542 B8 BRPI9913542 B8 BR PI9913542B8 BR PI9913542 A BRPI9913542 A BR PI9913542A BR 9913542 A BR9913542 A BR 9913542A BR PI9913542 B8 BRPI9913542 B8 BR PI9913542B8
Authority
BR
Brazil
Prior art keywords
dihydrobenzodioxine
derivatives
receptor antagonists
preparation
well
Prior art date
Application number
BRPI9913542A
Other languages
English (en)
Other versions
BRPI9913542B1 (pt
BR9913542A (pt
Inventor
Jahangir Alam
Douglas Clark Robin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9913542A publication Critical patent/BR9913542A/pt
Publication of BRPI9913542B1 publication Critical patent/BRPI9913542B1/pt
Publication of BRPI9913542B8 publication Critical patent/BRPI9913542B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

patente de invenção: <b>"derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht~ 4~"<d>. a presente invenção se refere a certos compostos antagonistas do receptor 5-ht~ 4~ representado pela fórmula (i), onde z é representado pela fórmula (a) ou (b), em que r¹, r², r³, r^ 4^ e r^ 5^ e os outros substituintes são como definidos no relatório descritivo e como isômeros individuais, mistura racêmica ou não racêmica de isômeros e sais ou hidratos farmaceuticamente aceitáveis dos mesmos. a invenção se refere ainda a composições farmacêuticas contendo tais compostos e ao seu uso como agentes terapêuticos.
BRPI9913542A 1998-09-10 1999-09-01 derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos BRPI9913542B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9974098P 1998-09-10 1998-09-10
US13846899P 1999-06-10 1999-06-10
PCT/EP1999/006402 WO2000015636A1 (en) 1998-09-10 1999-09-01 Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists

Publications (3)

Publication Number Publication Date
BR9913542A BR9913542A (pt) 2001-06-05
BRPI9913542B1 BRPI9913542B1 (pt) 2016-04-19
BRPI9913542B8 true BRPI9913542B8 (pt) 2021-05-25

Family

ID=26796436

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9913542A BRPI9913542B8 (pt) 1998-09-10 1999-09-01 derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos

Country Status (17)

Country Link
US (1) US6172062B1 (pt)
EP (1) EP1112270B1 (pt)
JP (1) JP3366323B2 (pt)
KR (1) KR100413150B1 (pt)
CN (1) CN1142161C (pt)
AR (1) AR035153A1 (pt)
AT (1) ATE357443T1 (pt)
AU (1) AU758807B2 (pt)
BR (1) BRPI9913542B8 (pt)
CA (1) CA2340952C (pt)
CO (1) CO5130016A1 (pt)
DE (1) DE69935600T2 (pt)
ES (1) ES2283132T3 (pt)
MA (1) MA26684A1 (pt)
PE (1) PE20001029A1 (pt)
TR (1) TR200100698T2 (pt)
WO (1) WO2000015636A1 (pt)

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TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
EP1381600A1 (en) * 2001-04-24 2004-01-21 Wyeth, A Corporation of the State of Delaware Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
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EP1638961B1 (en) * 2003-06-19 2009-11-18 Janssen Pharmaceutica N.V. Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
EP1641783B1 (en) * 2003-06-19 2012-03-28 Janssen Pharmaceutica NV Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7399862B2 (en) * 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
WO2006052889A2 (en) * 2004-11-05 2006-05-18 Theravance, Inc. Quinolinone-carboxamide compounds
CA2588037A1 (en) * 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
CN101137648A (zh) * 2005-03-01 2008-03-05 惠氏公司 结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐
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WO2009079008A1 (en) * 2007-12-19 2009-06-25 Yangbo Feng Benzopyrans and analogs as rho kinase inhibitors
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MA41629A (fr) 2015-03-04 2018-01-09 Center For Human Reproduction Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité
US20210330599A1 (en) 2016-08-01 2021-10-28 University Of Rochester Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use
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Also Published As

Publication number Publication date
MA26684A1 (fr) 2004-12-20
AU5857299A (en) 2000-04-03
WO2000015636A1 (en) 2000-03-23
DE69935600D1 (de) 2007-05-03
JP2002524561A (ja) 2002-08-06
PE20001029A1 (es) 2000-10-12
KR100413150B1 (ko) 2003-12-31
ES2283132T3 (es) 2007-10-16
DE69935600T2 (de) 2007-12-06
CA2340952A1 (en) 2000-03-23
EP1112270B1 (en) 2007-03-21
ATE357443T1 (de) 2007-04-15
JP3366323B2 (ja) 2003-01-14
AR035153A1 (es) 2004-05-05
TR200100698T2 (tr) 2001-07-23
CA2340952C (en) 2009-12-08
CO5130016A1 (es) 2002-02-27
BRPI9913542B1 (pt) 2016-04-19
BR9913542A (pt) 2001-06-05
AU758807B2 (en) 2003-03-27
KR20010085777A (ko) 2001-09-07
CN1142161C (zh) 2004-03-17
CN1315950A (zh) 2001-10-03
US6172062B1 (en) 2001-01-09
EP1112270A1 (en) 2001-07-04

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