MA26963A1 - Composes derives de benzothiophene, procede de leur preparation et leur utilisation. - Google Patents

Composes derives de benzothiophene, procede de leur preparation et leur utilisation.

Info

Publication number
MA26963A1
MA26963A1 MA27164A MA27164A MA26963A1 MA 26963 A1 MA26963 A1 MA 26963A1 MA 27164 A MA27164 A MA 27164A MA 27164 A MA27164 A MA 27164A MA 26963 A1 MA26963 A1 MA 26963A1
Authority
MA
Morocco
Prior art keywords
preparation
benzothiophene
compounds derived
present
medicament
Prior art date
Application number
MA27164A
Other languages
English (en)
Inventor
Castillo Nieto Juan Carlos Del
Aldaz Berta Esperanza Lasheras
Vega Antonio Monge
Mancini Marisabel Mourelle
Rio Zambrana Joaquin Del
Original Assignee
Vita Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Lab filed Critical Vita Lab
Publication of MA26963A1 publication Critical patent/MA26963A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thin Film Transistor (AREA)

Abstract

COMPOSES DERIVES DE BENZOTHIOPHENE, PROCEDE DE LEUR PREPARATION ET LEUR UTILISATION La présente invention fournit de nouveaux dérivés de benzothiophène de la formule générale (I) et un procédé pour les préparer, les compositions correspondantes et leur utilisation pour la fabrication d'un médicament pour le traitement d'affections neurologiques. Ces nouveaux composés se comportent comme des inhibiteurs de recapture de la sérotonine et présentent une haute affinité pour le récepteur 5-HT1A.
MA27164A 2000-11-29 2003-05-19 Composes derives de benzothiophene, procede de leur preparation et leur utilisation. MA26963A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002914A ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.

Publications (1)

Publication Number Publication Date
MA26963A1 true MA26963A1 (fr) 2004-12-20

Family

ID=8495887

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27164A MA26963A1 (fr) 2000-11-29 2003-05-19 Composes derives de benzothiophene, procede de leur preparation et leur utilisation.

Country Status (35)

Country Link
US (1) US20040034219A1 (fr)
EP (1) EP1337528B1 (fr)
JP (1) JP2004514719A (fr)
KR (1) KR20030066689A (fr)
CN (1) CN1478088A (fr)
AP (1) AP2003002801A0 (fr)
AR (1) AR034009A1 (fr)
AT (1) ATE272634T1 (fr)
AU (1) AU2002215157A1 (fr)
BG (1) BG107851A (fr)
BR (1) BR0115708A (fr)
CA (1) CA2429892A1 (fr)
CZ (1) CZ20031398A3 (fr)
DE (1) DE60104717T2 (fr)
EA (1) EA200300519A1 (fr)
EE (1) EE200300245A (fr)
ES (2) ES2188344B1 (fr)
GE (1) GEP20043366B (fr)
HR (1) HRP20030407A2 (fr)
HU (1) HUP0303568A3 (fr)
IL (1) IL155966A0 (fr)
IS (1) IS6824A (fr)
MA (1) MA26963A1 (fr)
MX (1) MXPA03004875A (fr)
NO (1) NO20032332L (fr)
NZ (1) NZ525950A (fr)
OA (1) OA12536A (fr)
PE (1) PE20020692A1 (fr)
PL (1) PL362982A1 (fr)
PT (1) PT1337528E (fr)
SI (1) SI1337528T1 (fr)
SK (1) SK6202003A3 (fr)
TR (1) TR200402779T4 (fr)
WO (1) WO2002044170A2 (fr)
ZA (1) ZA200303858B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2323451T7 (es) 2001-07-20 2011-08-01 Psychogenics Inc. Tratamiento para el trastorno de hiperactividad con deficit de atencion.
RU2309154C9 (ru) 2002-03-27 2016-09-27 Глэксо Груп Лимитед 3-фенилсульфонил-8-пиперазин-1-ил-хинолины, обладающие аффинностью к 5-нт6 рецептору, способы их получения (варианты)
JP2006516977A (ja) 2003-01-13 2006-07-13 ダイノゲン ファーマシューティカルズ，インコーポレイテッド 悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
DE602004000260T2 (de) 2003-07-22 2006-08-24 Arena Pharmaceuticals, Inc., San Diego Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
US7881267B2 (en) * 2004-06-04 2011-02-01 Hewlett-Packard Development Company, L.P. Portable computing device for wireless communications and method of operation
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
EP2508177A1 (fr) 2007-12-12 2012-10-10 Glaxo Group Limited Associations contenant de la 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
CN101619056B (zh) 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
WO2015014256A1 (fr) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryle substitués et procédés d'utilisation
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
US10022355B2 (en) 2015-06-12 2018-07-17 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder
BR112018000728A2 (pt) 2015-07-15 2018-09-04 Axovant Sciences Gmbh resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
US5658909A (en) * 1994-11-17 1997-08-19 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.

Also Published As

Publication number Publication date
ZA200303858B (en) 2004-05-19
HUP0303568A3 (en) 2005-02-28
MXPA03004875A (es) 2005-02-14
EA200300519A1 (ru) 2003-12-25
TR200402779T4 (tr) 2004-11-22
CA2429892A1 (fr) 2002-06-06
CN1478088A (zh) 2004-02-25
PE20020692A1 (es) 2002-09-02
EP1337528B1 (fr) 2004-08-04
KR20030066689A (ko) 2003-08-09
PT1337528E (pt) 2004-11-30
CZ20031398A3 (cs) 2004-01-14
WO2002044170A2 (fr) 2002-06-06
DE60104717T2 (de) 2006-04-06
US20040034219A1 (en) 2004-02-19
ES2188344B1 (es) 2004-09-16
ES2225623T3 (es) 2005-03-16
OA12536A (en) 2006-06-05
GEP20043366B (en) 2004-04-13
ATE272634T1 (de) 2004-08-15
PL362982A1 (en) 2004-11-02
ES2188344A1 (es) 2003-06-16
DE60104717D1 (de) 2004-09-09
IL155966A0 (en) 2003-12-23
AR034009A1 (es) 2004-01-21
JP2004514719A (ja) 2004-05-20
BG107851A (bg) 2004-06-30
AU2002215157A1 (en) 2002-06-11
NO20032332D0 (no) 2003-05-22
SK6202003A3 (en) 2004-05-04
NO20032332L (no) 2003-05-22
SI1337528T1 (en) 2005-02-28
BR0115708A (pt) 2004-02-03
WO2002044170A3 (fr) 2002-09-06
HUP0303568A2 (hu) 2004-03-01
EP1337528A2 (fr) 2003-08-27
HRP20030407A2 (en) 2004-08-31
EE200300245A (et) 2003-08-15
AP2003002801A0 (en) 2003-06-30
IS6824A (is) 2003-05-22
NZ525950A (en) 2004-11-26

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