MA27012A1 - Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2 - Google Patents

Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2

Info

Publication number
MA27012A1
MA27012A1 MA27346A MA27346A MA27012A1 MA 27012 A1 MA27012 A1 MA 27012A1 MA 27346 A MA27346 A MA 27346A MA 27346 A MA27346 A MA 27346A MA 27012 A1 MA27012 A1 MA 27012A1
Authority
MA
Morocco
Prior art keywords
mglur2
diazepin
agonists
benzo
dihydro
Prior art date
Application number
MA27346A
Other languages
English (en)
Inventor
Geo Adam
Erwin Goetschi
Vincent Mutel
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27012A1 publication Critical patent/MA27012A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA27346A 2001-04-12 2003-10-08 Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2 MA27012A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01109125 2001-04-12

Publications (1)

Publication Number Publication Date
MA27012A1 true MA27012A1 (fr) 2004-12-20

Family

ID=8177126

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27346A MA27012A1 (fr) 2001-04-12 2003-10-08 Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2

Country Status (37)

Country Link
US (1) US6544985B2 (fr)
EP (1) EP1379511B1 (fr)
JP (1) JP4071115B2 (fr)
KR (1) KR100566171B1 (fr)
CN (1) CN1264825C (fr)
AR (1) AR035816A1 (fr)
AT (1) ATE299868T1 (fr)
AU (1) AU2002312788B2 (fr)
BG (1) BG108254A (fr)
BR (1) BR0208891A (fr)
CA (1) CA2442557C (fr)
CZ (1) CZ20033003A3 (fr)
DE (1) DE60205100T2 (fr)
DK (1) DK1379511T3 (fr)
EC (1) ECSP034797A (fr)
ES (1) ES2246012T3 (fr)
GT (1) GT200200073A (fr)
HR (1) HRP20030792A2 (fr)
HU (1) HUP0400851A3 (fr)
IL (2) IL157873A0 (fr)
JO (1) JO2285B1 (fr)
MA (1) MA27012A1 (fr)
MX (1) MXPA03009311A (fr)
MY (1) MY140271A (fr)
NO (1) NO20034576L (fr)
NZ (1) NZ528315A (fr)
PA (1) PA8543301A1 (fr)
PE (1) PE20021041A1 (fr)
PL (1) PL367064A1 (fr)
PT (1) PT1379511E (fr)
RU (1) RU2263112C2 (fr)
SI (1) SI1379511T1 (fr)
SK (1) SK13682003A3 (fr)
UY (1) UY27258A1 (fr)
WO (1) WO2002083652A1 (fr)
YU (1) YU79003A (fr)
ZA (1) ZA200307243B (fr)

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ATE374030T1 (de) * 2003-07-25 2007-10-15 Hoffmann La Roche Kombination eines mglur2 antagonists und eines ache inhibitors zur behandlung von akuten und/oder chronischen neurologischen krankheiten
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PL1761541T3 (pl) * 2004-06-21 2008-06-30 Hoffmann La Roche Pochodne pirazolopirymidyny
CA2597608C (fr) * 2005-02-11 2013-12-24 F. Hoffmann-La Roche Ag Derives de pyrazolopyrimidine en tant qu'antagonistes de mglur2
ATE460417T1 (de) 2005-03-23 2010-03-15 Hoffmann La Roche Acetylenylpyrazolopyrimidinderivate als mglur2- antagonsten
ES2567133T3 (es) * 2005-06-23 2016-04-20 Array Biopharma, Inc. Proceso para preparar compuestos de benzoimidazol
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HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
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ATE250039T1 (de) * 1999-10-15 2003-10-15 Hoffmann La Roche Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
ATE261945T1 (de) * 1999-10-15 2004-04-15 Hoffmann La Roche Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten

Also Published As

Publication number Publication date
IL157873A0 (en) 2004-03-28
JO2285B1 (en) 2005-09-12
HRP20030792A2 (en) 2005-10-31
PE20021041A1 (es) 2002-11-19
AR035816A1 (es) 2004-07-14
US6544985B2 (en) 2003-04-08
WO2002083652A1 (fr) 2002-10-24
HK1068888A1 (en) 2005-05-06
UY27258A1 (es) 2002-10-31
EP1379511A1 (fr) 2004-01-14
BR0208891A (pt) 2004-04-20
SI1379511T1 (en) 2005-10-31
MY140271A (en) 2009-12-31
CN1535266A (zh) 2004-10-06
KR100566171B1 (ko) 2006-03-29
SK13682003A3 (sk) 2004-07-07
RU2003130637A (ru) 2005-04-10
CA2442557C (fr) 2008-12-23
EP1379511B1 (fr) 2005-07-20
GT200200073A (es) 2002-11-07
KR20030087076A (ko) 2003-11-12
MXPA03009311A (es) 2004-02-12
JP2004529925A (ja) 2004-09-30
US20020193367A1 (en) 2002-12-19
CZ20033003A3 (cs) 2004-05-12
ES2246012T3 (es) 2006-02-01
AU2002312788B2 (en) 2005-11-10
PA8543301A1 (es) 2003-01-24
NZ528315A (en) 2005-04-29
RU2263112C2 (ru) 2005-10-27
DE60205100D1 (de) 2005-08-25
BG108254A (bg) 2004-09-30
ECSP034797A (es) 2003-12-01
DE60205100T2 (de) 2006-06-01
PT1379511E (pt) 2005-10-31
DK1379511T3 (da) 2005-11-07
HUP0400851A3 (en) 2010-03-29
IL157873A (en) 2008-11-26
CN1264825C (zh) 2006-07-19
JP4071115B2 (ja) 2008-04-02
PL367064A1 (en) 2005-02-21
YU79003A (sh) 2006-05-25
CA2442557A1 (fr) 2002-10-24
NO20034576L (no) 2003-11-12
HUP0400851A2 (hu) 2004-07-28
ZA200307243B (en) 2004-12-16
ATE299868T1 (de) 2005-08-15
NO20034576D0 (no) 2003-10-10

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