MA27054A1 - Formulation de suspension orale stabilisee - Google Patents
Formulation de suspension orale stabiliseeInfo
- Publication number
- MA27054A1 MA27054A1 MA27503A MA27503A MA27054A1 MA 27054 A1 MA27054 A1 MA 27054A1 MA 27503 A MA27503 A MA 27503A MA 27503 A MA27503 A MA 27503A MA 27054 A1 MA27054 A1 MA 27054A1
- Authority
- MA
- Morocco
- Prior art keywords
- oral suspension
- stabilized oral
- suspension formulation
- thixotropic
- agent
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 229940100692 oral suspension Drugs 0.000 title abstract 2
- 230000009974 thixotropic effect Effects 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000375 suspending agent Substances 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
DEPOSANT Société dite: PHARMACIA CORPORATION REVENDICATIONS DE PRIORITES US 6 Août 2001 60/310,372 Voir en annexe le titre de l'invention et le texte de l'abrégé Formulation de suspension orale stabilisée Il est proposé des compositions pharmaceutiques pouvant être administrées par voie orale, comprenant un médicament à faible hydrosolubilité en suspension dans un véhicule liquide aqueux comprenant un agent mouillant, un agent épaississant thixotrope et un agent inorganique de mise en suspension. Les compositions sont thixotrope, substantiellement défloculées, et substantiellement stables physiquement.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31037201P | 2001-08-06 | 2001-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27054A1 true MA27054A1 (fr) | 2004-12-20 |
Family
ID=23202195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA27503A MA27054A1 (fr) | 2001-08-06 | 2004-01-27 | Formulation de suspension orale stabilisee |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20030108575A1 (fr) |
| EP (1) | EP1414409B1 (fr) |
| JP (1) | JP2005500363A (fr) |
| KR (1) | KR20040025740A (fr) |
| CN (1) | CN1287768C (fr) |
| AP (1) | AP1817A (fr) |
| AT (1) | ATE353627T1 (fr) |
| BR (1) | BR0211736A (fr) |
| CA (1) | CA2454173A1 (fr) |
| CO (1) | CO5560559A2 (fr) |
| CY (1) | CY1106548T1 (fr) |
| DE (1) | DE60218175T2 (fr) |
| DK (1) | DK1414409T3 (fr) |
| EA (1) | EA007901B1 (fr) |
| EC (1) | ECSP044974A (fr) |
| ES (1) | ES2280560T3 (fr) |
| GE (1) | GEP20074027B (fr) |
| HR (1) | HRP20040118A2 (fr) |
| IL (1) | IL159551A0 (fr) |
| IS (1) | IS7126A (fr) |
| MA (1) | MA27054A1 (fr) |
| MX (1) | MXPA04001109A (fr) |
| MY (1) | MY135119A (fr) |
| NZ (1) | NZ530844A (fr) |
| OA (1) | OA12646A (fr) |
| PL (1) | PL366382A1 (fr) |
| PT (1) | PT1414409E (fr) |
| SI (1) | SI1414409T1 (fr) |
| TN (1) | TNSN04023A1 (fr) |
| UA (1) | UA80682C2 (fr) |
| WO (1) | WO2003013473A1 (fr) |
| YU (1) | YU7404A (fr) |
| ZA (1) | ZA200400639B (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720061D0 (en) | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| US20040105889A1 (en) * | 2002-12-03 | 2004-06-03 | Elan Pharma International Limited | Low viscosity liquid dosage forms |
| US9101540B2 (en) * | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| US20050036956A1 (en) * | 2003-08-15 | 2005-02-17 | Lin Fei | Non-aqueous liquid tooth whitening composition |
| TR200301552A1 (tr) * | 2003-09-18 | 2005-10-21 | Nobel İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Rofekoksib' in yeni oral farmakolojik formülasyonları. |
| US20050266031A1 (en) * | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US8653145B2 (en) * | 2005-09-22 | 2014-02-18 | Eaton Scientific Systems, Ltd. | Method for alleviating climacteric symptoms |
| MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| US9597289B2 (en) * | 2006-04-26 | 2017-03-21 | Rosemont Pharmaceuticals Ltd. | Liquid oral simvastatin compositions |
| CN100434072C (zh) * | 2006-06-19 | 2008-11-19 | 西安交通大学 | 具有抗炎性作用及改善血液流变性和抑制血栓形成的药物 |
| GB0714670D0 (en) | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| US9119819B2 (en) | 2008-04-30 | 2015-09-01 | Wockhardt Ltd. | Oral liquid compositions of rhein or diacerein |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
| WO2011107855A2 (fr) | 2010-03-04 | 2011-09-09 | Torrent Pharmaceuticals Limited | Forme dosifiée sous forme de suspension liquide à libération prolongée pour une administration par voie orale |
| PT2544532T (pt) | 2010-03-12 | 2017-06-02 | Monsanto Technology Llc | Composições de gel agroquímicas |
| JO3587B1 (ar) * | 2010-06-02 | 2020-07-05 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم |
| EP2462922A1 (fr) * | 2010-12-10 | 2012-06-13 | Bioprojet | Nouvelle forme d'administration pour inhibiteurs de l'enképhalinase |
| CA2824433C (fr) * | 2011-01-18 | 2019-11-12 | Senju Pharmaceutical Co., Ltd. | Composition liquide aqueuse de bromfenac qui est efficace comme conservateur |
| CN113842362A (zh) | 2012-11-14 | 2021-12-28 | 格雷斯公司 | 含有生物活性材料与无序无机氧化物的组合物 |
| AU2016270504A1 (en) * | 2015-05-29 | 2017-12-14 | Codadose Incorporated | Liquid formulations of celecoxib for oral administration |
| EP4353311A3 (fr) | 2015-07-20 | 2024-07-17 | The Brigham and Women's Hospital, Inc. | Compositions d'extraction par cisaillement utilisees comme agent embolique intravasculaire |
| CN105902409B (zh) * | 2016-05-13 | 2019-03-05 | 广东龙湖科技股份有限公司 | 一种温和且具有触变性的牙膏 |
| MX2019004222A (es) * | 2016-10-19 | 2019-06-10 | Signpath Pharma Inc | Efecto protector de dmpc, dmpg, dmpc/dmpg, lysopg y lysopc contra farmacos que provocan canalopatias. |
| WO2019070818A2 (fr) * | 2017-10-04 | 2019-04-11 | Panacea Biomatx, Inc. | Suspensions de produits pharmaceutiques encapsulés et leurs procédés de fabrication et d'utilisation |
| CN112402376A (zh) * | 2019-08-22 | 2021-02-26 | 上海上药信谊药厂有限公司 | 一种结肠靶向的柳氮磺吡啶口服混悬剂及其制备方法 |
| CN117883379A (zh) * | 2021-02-12 | 2024-04-16 | 浙江贝灵生物医药有限公司 | 一种口服碱性溶媒组合物及其制备方法与应用 |
| WO2022185338A1 (fr) * | 2021-03-05 | 2022-09-09 | Alkem Laboratories Limited | Suspension orale stable de célécoxib et son procédé de préparation |
| KR20240161261A (ko) | 2023-05-04 | 2024-11-12 | 주식회사 퍼슨 | 성상 안정성이 우수한 현탁액 조성물 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684666A (en) * | 1986-08-19 | 1987-08-04 | Haas Pharmaceuticals, Inc. | Stabilized liquid analgesic compositions |
| AU639004B2 (en) * | 1989-06-13 | 1993-07-15 | Abbott Laboratories | Anhydrous oil-based liquid suspension for delivering a medicament |
| US5112604A (en) * | 1989-09-01 | 1992-05-12 | Riker Laboratories, Inc. | Oral suspension formulation |
| US5616458A (en) * | 1990-03-14 | 1997-04-01 | Board Of Regents, University Of Tx System | Tripterygium wilfordii hook F extracts and components, and uses thereof |
| US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
| US5543297A (en) * | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
| US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
| US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
| US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5434178A (en) * | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
| DE69422306T4 (de) * | 1993-11-30 | 2000-09-07 | G.D. Searle & Co., Chicago | Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen |
| US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
| US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
| WO1995030652A1 (fr) * | 1994-05-04 | 1995-11-16 | G.D. Searle & Co. | Spirodienes substitues utilises pour le traitement d'inflammations |
| US5418254A (en) * | 1994-05-04 | 1995-05-23 | G. D. Searle & Co. | Substituted cyclopentadienyl compounds for the treatment of inflammation |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
| AU3201095A (en) * | 1994-07-27 | 1996-02-22 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
| US5521213A (en) * | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5420343A (en) * | 1994-08-31 | 1995-05-30 | G. D. Searle & Co. | Derivatives of aromatic cyclic alkylethers |
| US5585504A (en) * | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5696143A (en) * | 1994-09-20 | 1997-12-09 | Talley; John J. | Benz G! indazolyl derivatives for the treatment of inflammation |
| US5849943A (en) * | 1994-10-27 | 1998-12-15 | Merck Frosst Canada, Inc. | Stilbene derivatives useful as cyclooxygenase-2 inhibitors |
| US5739166A (en) * | 1994-11-29 | 1998-04-14 | G.D. Searle & Co. | Substituted terphenyl compounds for the treatment of inflammation |
| JP2636819B2 (ja) * | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
| JP3181190B2 (ja) * | 1994-12-20 | 2001-07-03 | 日本たばこ産業株式会社 | オキサゾール誘導体 |
| US5552422A (en) * | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| AU4479096A (en) * | 1995-01-31 | 1996-08-21 | Merck Frosst Canada Inc. | 5-methanesulfonamido-3h-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2 |
| US5596008A (en) * | 1995-02-10 | 1997-01-21 | G. D. Searle & Co. | 3,4-Diaryl substituted pyridines for the treatment of inflammation |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
| EP0828717B1 (fr) * | 1995-05-25 | 2002-09-04 | G.D. SEARLE & CO. | Procede de preparation de 3-haloalkyl-1h-pyrazoles |
| US5643933A (en) * | 1995-06-02 | 1997-07-01 | G. D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US5739143A (en) * | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
| IL118544A (en) * | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
| GB9514518D0 (en) * | 1995-07-15 | 1995-09-13 | Sod Conseils Rech Applic | Guanidine salt inhibitors of NO synthase and cyclooxygenase |
| JPH0977664A (ja) * | 1995-09-13 | 1997-03-25 | Yakult Honsha Co Ltd | シクロオキシゲナーゼ−2特異的阻害剤及び抗炎症剤 |
| US5756529A (en) * | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| US5981576A (en) * | 1995-10-13 | 1999-11-09 | Merck Frosst Canada, Inc. | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors |
| US6020343A (en) * | 1995-10-13 | 2000-02-01 | Merck Frosst Canada, Inc. | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors |
| US6057319A (en) * | 1995-10-30 | 2000-05-02 | Merck Frosst Canada & Co. | 3,4-Diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors |
| PL187516B1 (pl) * | 1996-01-11 | 2004-07-30 | Smithkline Beecham Corp | Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki |
| ZA97175B (en) * | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
| US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US5789413A (en) * | 1996-02-01 | 1998-08-04 | Merck Frosst Canada, Inc. | Alkylated styrenes as prodrugs to COX-2 inhibitors |
| GB9607503D0 (en) * | 1996-04-11 | 1996-06-12 | Merck Frosst Canada Inc | Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors |
| US5807873A (en) * | 1996-04-04 | 1998-09-15 | Laboratories Upsa | Diarylmethylidenefuran derivatives and their uses in therapeutics |
| ATE233743T1 (de) * | 1996-04-12 | 2003-03-15 | Searle & Co | N-((4-(5-methyl-3-phenylisoxazol-4- yl)phenyl)sulphonylpropylamid und sein natriumsalz als pro-pharmakon von cox-2 inhibitoren |
| US5922742A (en) * | 1996-04-23 | 1999-07-13 | Merck Frosst Canada | Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors |
| US5883267A (en) * | 1996-05-31 | 1999-03-16 | Merck & Co., Inc. | Process for making phenyl heterocycles useful as cox-2 inhibitors |
| WO1997046532A1 (fr) * | 1996-06-03 | 1997-12-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2-benzyl-4-sulfonyl-4h-isoquinoline-1,3-diones et leur utilisation comme agents anti-inflammatoires |
| US5677318A (en) * | 1996-07-11 | 1997-10-14 | Merck Frosst Canada, Inc. | Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents |
| US5861419A (en) * | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| US5776967A (en) * | 1996-07-26 | 1998-07-07 | American Home Products Corporation | Pyranoindole inhibitors of COX--2 |
| FR2751966B1 (fr) * | 1996-08-01 | 1998-10-30 | Union Pharma Scient Appl | Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique |
| FR2751964B1 (fr) * | 1996-08-01 | 1998-10-30 | Union Pharma Scient Appl | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutique |
| US5830911A (en) * | 1996-08-14 | 1998-11-03 | American Home Products Corporation | Pyranoindole and tetrahydrocarbazole inhibitors of COX-2 |
| US6005000A (en) * | 1996-08-22 | 1999-12-21 | Oxis International, Inc. | 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor |
| FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
| US5972950A (en) * | 1996-10-08 | 1999-10-26 | Laboratories Upsa | 1,2-diarylmethylene derivatives, their methods of preparation and their uses in therapeutics |
| US5681842A (en) * | 1996-11-08 | 1997-10-28 | Abbott Laboratories | Prostaglandin synthase-2 inhibitors |
| US5869524A (en) * | 1996-11-12 | 1999-02-09 | American Home Products Corporation | Indene inhibitors of COX-2 |
| US6096753A (en) * | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
| PT946507E (pt) * | 1996-12-10 | 2004-02-27 | Searle & Co | Compostos de pirrolilo substituidos para o tratamento da inflamacao |
| US5973191A (en) * | 1996-12-30 | 1999-10-26 | Vanderbilt University | Selective inhibitors of prostaglandin endoperoxide synthase-2 |
| US5929076A (en) * | 1997-01-10 | 1999-07-27 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
| US5783597A (en) * | 1997-03-04 | 1998-07-21 | Ortho Pharmaceutical Corporation | 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use |
| US6004960A (en) * | 1997-03-14 | 1999-12-21 | Merck Frosst Canada, Inc. | Pyridazinones as inhibitors of cyclooxygenase-2 |
| US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| US6046217A (en) * | 1997-09-12 | 2000-04-04 | Merck Frosst Canada & Co. | 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2 |
| US6040450A (en) * | 1997-09-25 | 2000-03-21 | Merck & Co., Inc. | Process for making diaryl pyridines useful as cox-2-inhibitors |
| FR2769311B1 (fr) * | 1997-10-07 | 1999-12-24 | Union Pharma Scient Appl | Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique |
| US6133292A (en) * | 1997-10-30 | 2000-10-17 | Merck Frosst Canada & Co. | Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxygenase-2-inhibitors |
| US6020347A (en) * | 1997-11-18 | 2000-02-01 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| FR2771412B1 (fr) * | 1997-11-26 | 2000-04-28 | Adir | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| RS49945B (sr) * | 1998-04-24 | 2008-09-29 | Merck & Co.Inc., | Postupak za sintetizovanje inhibitora cox-2 |
| US6077869A (en) * | 1998-10-29 | 2000-06-20 | Ortho-Mcneil Pharmaceutical, Inc. | Aryl phenylhydrazides as selective COX-2 inhibitors for treatment of inflammation |
| SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
| US6077868A (en) * | 1999-07-20 | 2000-06-20 | Wisconsin Alumni Research Foundation | Selective inhibition of cyclooxygenase-2 |
| US6083969A (en) * | 1999-10-20 | 2000-07-04 | Ortho-Mcneil Pharaceutical, Inc. | 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents |
| AU2298301A (en) * | 1999-10-20 | 2001-05-08 | Board Of Trustees Of Southern Illinois University, The | Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators |
| KR100793668B1 (ko) * | 1999-12-08 | 2008-01-10 | 파마시아 코포레이션 | 강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브 |
| CA2406226A1 (fr) * | 2000-04-18 | 2001-10-25 | Pharmacia Corporation | Formulation a effet therapeutique rapide contenant un inhibiteur selectif de la cyclooxygenase-2 |
| AU2001282886A1 (en) * | 2000-07-13 | 2002-01-30 | Pharmacia Corporation | Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain |
| GB0617119D0 (en) * | 2006-08-31 | 2006-10-11 | Renovo Ltd | Method of prognosis |
-
2002
- 2002-05-08 UA UA2004020879A patent/UA80682C2/uk unknown
- 2002-08-05 CN CNB02815522XA patent/CN1287768C/zh not_active Expired - Fee Related
- 2002-08-05 EA EA200400148A patent/EA007901B1/ru not_active IP Right Cessation
- 2002-08-05 AT AT02756952T patent/ATE353627T1/de not_active IP Right Cessation
- 2002-08-05 AP APAP/P/2004/002969A patent/AP1817A/en active
- 2002-08-05 SI SI200230516T patent/SI1414409T1/sl unknown
- 2002-08-05 PT PT02756952T patent/PT1414409E/pt unknown
- 2002-08-05 GE GE5420A patent/GEP20074027B/en unknown
- 2002-08-05 DK DK02756952T patent/DK1414409T3/da active
- 2002-08-05 ES ES02756952T patent/ES2280560T3/es not_active Expired - Lifetime
- 2002-08-05 IL IL15955102A patent/IL159551A0/xx unknown
- 2002-08-05 KR KR10-2004-7001860A patent/KR20040025740A/ko not_active Ceased
- 2002-08-05 JP JP2003518483A patent/JP2005500363A/ja active Pending
- 2002-08-05 HR HR20040118A patent/HRP20040118A2/hr not_active Application Discontinuation
- 2002-08-05 BR BR0211736-3A patent/BR0211736A/pt not_active IP Right Cessation
- 2002-08-05 PL PL02366382A patent/PL366382A1/xx not_active Application Discontinuation
- 2002-08-05 DE DE60218175T patent/DE60218175T2/de not_active Expired - Fee Related
- 2002-08-05 WO PCT/US2002/024746 patent/WO2003013473A1/fr not_active Ceased
- 2002-08-05 US US10/212,308 patent/US20030108575A1/en not_active Abandoned
- 2002-08-05 YU YU7404A patent/YU7404A/sh unknown
- 2002-08-05 EP EP02756952A patent/EP1414409B1/fr not_active Expired - Lifetime
- 2002-08-05 MX MXPA04001109A patent/MXPA04001109A/es active IP Right Grant
- 2002-08-05 CA CA002454173A patent/CA2454173A1/fr not_active Abandoned
- 2002-08-05 OA OA1200400030A patent/OA12646A/en unknown
- 2002-08-05 NZ NZ530844A patent/NZ530844A/en unknown
- 2002-08-06 MY MYPI20022925A patent/MY135119A/en unknown
-
2004
- 2004-01-26 IS IS7126A patent/IS7126A/is unknown
- 2004-01-27 ZA ZA200400639A patent/ZA200400639B/en unknown
- 2004-01-27 MA MA27503A patent/MA27054A1/fr unknown
- 2004-02-05 TN TNP2004000023A patent/TNSN04023A1/fr unknown
- 2004-02-06 CO CO04009302A patent/CO5560559A2/es not_active Application Discontinuation
- 2004-02-06 EC EC2004004974A patent/ECSP044974A/es unknown
-
2007
- 2007-04-26 CY CY20071100568T patent/CY1106548T1/el unknown
- 2007-12-21 US US11/962,903 patent/US20090081309A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA27054A1 (fr) | Formulation de suspension orale stabilisee | |
| DK1401501T3 (da) | Orale farmaceutiske sammensætninger med modificeret frigivelse af den aktive ingrediens | |
| EP1461031A4 (fr) | Preparations pour une administration par voie orale d'acide cromoglycique | |
| WO2003105800A3 (fr) | Forme galenique, se presentant sous forme de film adherant a la muqueuse, pour l'administration de principes actifs du cannabis | |
| TR200200561T2 (tr) | Mesalazin içeren ve vücut içinde kontrollü bir şekilde salgılanabilen ağızdan alınan farmasötik bileşimler | |
| FR2830447B1 (fr) | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques | |
| DE60232496D1 (de) | Tabletten, die in der mundhöhle schnell zerfallen | |
| HRP20030910A2 (en) | Tartarate salts 5,8,14-triazatetracyclo {10.3.1.0<sup>2,11</sup>.0<sup>4,9</sup>}-hexadeca-2(11), 3,5,7,9-pentaene and pharmaceutical compositions thereof | |
| BR0013157A (pt) | Composições farmacêuticas e nutricionais contendo ácidos graxos essenciais e agentes de abaixamento da homocisteìna | |
| FR08C0004I2 (fr) | Composition orale d' une dose pour une libération prolongée | |
| MXPA05008909A (es) | Formulacion intranasal de rotigotina. | |
| EP1992336A3 (fr) | Forme galénique pour la délivrance colique de principes actifs | |
| FR2808685B1 (fr) | Compositions pharmaceutiques pour administration transdermique d'agents anti-inflammatoires | |
| ITMI20021392A1 (it) | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' | |
| WO2003105767A3 (fr) | Produits parentéraux antifongiques | |
| DK1104289T3 (da) | Hidtil ukendte orale formuleringer for 5-HT4-agonister eller -antagonister | |
| IL161326A0 (en) | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2 (11),3,5,7,9-pentaene and pharmaceutical compositions thereof | |
| HRP20010878B1 (en) | Ziprasidone suspension | |
| MXPA03010054A (es) | Composiciones que comprenden lopinavir y metodos para aumentar la biodisponibilidad de agentes farmaceuticos. | |
| ES2130081B1 (es) | Comprimido de maleato de trimebutina con recubrimiento laminar. | |
| HUP0304085A3 (en) | The citrate salt of 5,8,14-triazatetracyclo(10.3.1.02,11.04,9)-hexadeca-2.(11),3,5,7,9-pentaene and pharmaceutical compositions thereof | |
| EP1993567A4 (fr) | Préparations de gallium administrables per os et leurs méthodes d'utilisation | |
| MXPA03005221A (es) | Composicion farmaceutica de dronedarona para administracion parenteral. | |
| MY138172A (en) | Pharmaceutical compositions based on azetidine derivatives | |
| WO2004069187A3 (fr) | Formulation et administration d'un medicament a l'aide de cyclodextrines cristallines methylees |