MA27454A1 - Remedes ou produits preventifs pour la frequence urinaire ou l'incontinence urinaire, et derives de morphinane presentant un groupe heterocyclique contenant de l'azote - Google Patents
Remedes ou produits preventifs pour la frequence urinaire ou l'incontinence urinaire, et derives de morphinane presentant un groupe heterocyclique contenant de l'azoteInfo
- Publication number
- MA27454A1 MA27454A1 MA28218A MA28218A MA27454A1 MA 27454 A1 MA27454 A1 MA 27454A1 MA 28218 A MA28218 A MA 28218A MA 28218 A MA28218 A MA 28218A MA 27454 A1 MA27454 A1 MA 27454A1
- Authority
- MA
- Morocco
- Prior art keywords
- diseases
- urinary incontinence
- urinary
- remedies
- heterocyclic group
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 4
- 206010036018 Pollakiuria Diseases 0.000 title abstract 3
- 206010046543 Urinary incontinence Diseases 0.000 title abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 2
- 150000003809 morphinane derivatives Chemical class 0.000 title 1
- 230000003449 preventive effect Effects 0.000 title 1
- 208000022934 urinary frequency Diseases 0.000 title 1
- 230000036318 urination frequency Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- -1 hydroxy, methoxy, acetoxy Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
L'invention fournit un dérivé de morphinane de formule (I) [dans laquelle R1 est un groupe méthyle, cyclopropylméthyle ou similaire ; R2 et R3 sont des radicaux hydroxy, méthoxy, acétoxy ou similaire ; Y et Z sont tous deux des liaisons de valence, -C(=0)- ou similaire ; X est une chaîne carbonée en C2 à C5 (un des atomes de carbone pouvant être substitué par un atome d'azote, d'oxygène ou de soufre) faisant partie de la structure cyclique, ou similaire ; R9 est l'hydrogène ou similaire ; R10 et R11 sont liés de manière à représenter -0-, ou similaire ; et R6 est l'hydrogène ou similaire], ou l'un de ses sels d'addition d'acide acceptables du point de vue pharmaceutique. L'invention fournit également un agent thérapeutique ou prophylactique de la pollakiurie ou de l'incontinence urinaire, comprenant en tant qu'un ingrédient efficace le dérivé de morphinane ou son sel d'addition d'acide acceptable du point de vue pharmaceutique ; une méthode de traitement ou de prophylaxie de maladies, et l'utilisation dans les maladies. Les composés de la présente invention sont utiles en tant qu'un nouvel agent thérapeutique ou prophylactique de la pollakiurie ou de l'incontinence urinaire, sont dépourvus d'effets secondaires, et sont utiles dans la méthode de traitement ou de prophylaxie de maladies et dans l'utilisation dans les maladies.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002295616 | 2002-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27454A1 true MA27454A1 (fr) | 2005-07-01 |
Family
ID=32089217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28218A MA27454A1 (fr) | 2002-10-09 | 2005-04-13 | Remedes ou produits preventifs pour la frequence urinaire ou l'incontinence urinaire, et derives de morphinane presentant un groupe heterocyclique contenant de l'azote |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7320984B2 (fr) |
| EP (1) | EP1555266B1 (fr) |
| JP (1) | JP4016986B2 (fr) |
| KR (1) | KR101060629B1 (fr) |
| CN (1) | CN100537573C (fr) |
| AU (1) | AU2003272944B2 (fr) |
| BR (1) | BR0314754A (fr) |
| CA (1) | CA2501389C (fr) |
| ES (1) | ES2479042T3 (fr) |
| HK (1) | HK1079786B (fr) |
| IL (1) | IL166944A (fr) |
| MA (1) | MA27454A1 (fr) |
| MX (1) | MXPA05003723A (fr) |
| NO (1) | NO20052167L (fr) |
| NZ (1) | NZ539199A (fr) |
| WO (1) | WO2004033457A1 (fr) |
| ZA (1) | ZA200502650B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060177381A1 (en) * | 2002-02-15 | 2006-08-10 | Howard Brooks-Korn | Opiopathies |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| TW200533355A (en) | 2004-03-30 | 2005-10-16 | Toray Industries | Antipruritic agent |
| PE20060723A1 (es) * | 2004-11-04 | 2006-08-29 | Toray Industries | Derivados de morfina como agentes analgesicos |
| JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
| WO2007055184A1 (fr) * | 2005-11-09 | 2007-05-18 | Toray Industries, Inc. | Agent thérapeutique ou prophylactique pour un trouble fonctionnel de l'intestin |
| WO2007072749A1 (fr) * | 2005-12-21 | 2007-06-28 | Toray Industries, Inc. | Agent antitussif |
| ES2627217T3 (es) | 2007-05-21 | 2017-07-27 | Toray Industries, Inc. | Partículas micropulverizadas cristalinas |
| AU2008254039B2 (en) * | 2007-05-21 | 2013-10-24 | Toray Industries, Inc. | Method for producing pharmaceutical tablet |
| AU2008283929B2 (en) | 2007-08-06 | 2013-10-10 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| PL2712622T3 (pl) * | 2008-05-21 | 2017-01-31 | Ferring B.V. | Ulegająca rozpadowi w ustach desmopresyna do zwiększania początkowego okresu snu niezakłócanego przez nokturię |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| CA2740476C (fr) * | 2008-10-24 | 2016-04-05 | Toray Industries, Inc. | Comprime stable contenant un derive de 4,5-epoxymorphinane |
| WO2010083384A2 (fr) * | 2009-01-16 | 2010-07-22 | Virginia Commonwealth University | Antagonistes non peptidiques, puissants et sélectifs des récepteurs opioïdes mu |
| US8623888B2 (en) * | 2009-07-15 | 2014-01-07 | Mallinckrodt Llc | 3-oxy-hydromorphone derivatives |
| EP2580201B1 (fr) | 2010-06-11 | 2017-08-02 | Rhodes Technologies | Procédés catalysés par métal de transition pour la préparation de composés de n-allyle et utilisation de ceux-ci |
| US10988481B2 (en) | 2016-05-19 | 2021-04-27 | Virginia Commonwealth University | Potent and selective mu opioid receptor modulators |
| DK3761982T3 (da) | 2018-03-08 | 2025-01-02 | Victoria Link Ltd | Anvendelse af nalfurafin til behandling af demyeliniserende sygdomme |
| CN109970747B (zh) * | 2019-05-05 | 2020-07-24 | 潍坊科技学院 | 一种制备10α-羟基纳呋拉啡的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3318884A (en) * | 1965-07-21 | 1967-05-09 | American Cyanamid Co | Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives |
| ES2121988T3 (es) | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| NZ268969A (en) | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| AU5090796A (en) | 1995-03-03 | 1996-09-23 | Algos Pharmaceutical Corporation | Use of dextromethorphan or dextrorphan for the treatment of urinary incontinence |
| AU6020300A (en) | 1999-07-19 | 2001-02-05 | Toray Industries, Inc. | Remedies or preventives for frequent urination or urinary incontinence |
| WO2002080918A1 (fr) | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
-
2003
- 2003-10-08 BR BR0314754-1A patent/BR0314754A/pt not_active Application Discontinuation
- 2003-10-08 ES ES03754030.9T patent/ES2479042T3/es not_active Expired - Lifetime
- 2003-10-08 HK HK05112093.6A patent/HK1079786B/zh not_active IP Right Cessation
- 2003-10-08 AU AU2003272944A patent/AU2003272944B2/en not_active Ceased
- 2003-10-08 WO PCT/JP2003/012890 patent/WO2004033457A1/fr not_active Ceased
- 2003-10-08 MX MXPA05003723A patent/MXPA05003723A/es active IP Right Grant
- 2003-10-08 KR KR1020057006096A patent/KR101060629B1/ko not_active Expired - Fee Related
- 2003-10-08 JP JP2004542845A patent/JP4016986B2/ja not_active Expired - Fee Related
- 2003-10-08 NZ NZ539199A patent/NZ539199A/en not_active IP Right Cessation
- 2003-10-08 US US10/530,664 patent/US7320984B2/en not_active Expired - Fee Related
- 2003-10-08 CA CA2501389A patent/CA2501389C/fr not_active Expired - Fee Related
- 2003-10-08 EP EP03754030.9A patent/EP1555266B1/fr not_active Expired - Lifetime
- 2003-10-08 CN CNB2003801009713A patent/CN100537573C/zh not_active Expired - Fee Related
-
2005
- 2005-02-16 IL IL166944A patent/IL166944A/en not_active IP Right Cessation
- 2005-04-01 ZA ZA200502650A patent/ZA200502650B/en unknown
- 2005-04-13 MA MA28218A patent/MA27454A1/fr unknown
- 2005-05-03 NO NO20052167A patent/NO20052167L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL166944A (en) | 2010-11-30 |
| NO20052167L (no) | 2005-06-16 |
| KR101060629B1 (ko) | 2011-08-31 |
| US20060040970A1 (en) | 2006-02-23 |
| MXPA05003723A (es) | 2005-09-30 |
| EP1555266B1 (fr) | 2014-05-21 |
| JPWO2004033457A1 (ja) | 2006-04-27 |
| WO2004033457A1 (fr) | 2004-04-22 |
| JP4016986B2 (ja) | 2007-12-05 |
| CA2501389C (fr) | 2013-01-08 |
| AU2003272944A1 (en) | 2004-05-04 |
| NZ539199A (en) | 2008-09-26 |
| AU2003272944B2 (en) | 2009-11-12 |
| EP1555266A4 (fr) | 2006-12-06 |
| CN1703415A (zh) | 2005-11-30 |
| US7320984B2 (en) | 2008-01-22 |
| HK1079786A1 (zh) | 2006-04-13 |
| HK1079786B (zh) | 2010-03-12 |
| ZA200502650B (en) | 2006-06-28 |
| KR20050056232A (ko) | 2005-06-14 |
| CN100537573C (zh) | 2009-09-09 |
| BR0314754A (pt) | 2005-07-26 |
| CA2501389A1 (fr) | 2004-04-22 |
| EP1555266A1 (fr) | 2005-07-20 |
| ES2479042T3 (es) | 2014-07-23 |
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