MA27570A1 - 2-(1h-indazole-6-ylamino)-benzamides en tant qu'inhibiteurs de proteine-kinases, utiles pour le traitement de maladies ophtalmiques - Google Patents

2-(1h-indazole-6-ylamino)-benzamides en tant qu'inhibiteurs de proteine-kinases, utiles pour le traitement de maladies ophtalmiques

Info

Publication number
MA27570A1
MA27570A1 MA28348A MA28348A MA27570A1 MA 27570 A1 MA27570 A1 MA 27570A1 MA 28348 A MA28348 A MA 28348A MA 28348 A MA28348 A MA 28348A MA 27570 A1 MA27570 A1 MA 27570A1
Authority
MA
Morocco
Prior art keywords
ophthalmic diseases
indazole
compounds
benzamides
ylamino
Prior art date
Application number
MA28348A
Other languages
English (en)
Inventor
Allen John Borchardt
Robert Steven Kania
Cynthia Louise Palmer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA27570A1 publication Critical patent/MA27570A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-(lH-indazole-6-ylamino)-benzamides en tant qu'inhibiteurs de protéine-kinases, utiles pour le traitement de maladies ophtalmiques Des composés d'indazole qui modulent et/ou inhibent les maladies ophtalmiques et l'activité de certaines protéine-kinases sont décrits. Ces composés et les compositions pharmaceutiques qui les contiennent sont capables d'être des médiateurs de la transduction du signal de tyrosine-kinase et, de ce fait, des modulateurs et/ou des inhibiteurs d'une prolifération cellulaire indésirable. L'invention concerne aussi l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant ces composés, et des méthodes de traitement de maladies ophtalmiques et du cancer ainsi que d'autres pathologies accompagnées d'angiogenèse et/ou de prolifération cellulaire indésirables, telles que rétinopathie diabétique, glaucome néovasculaire, polyarthrite rhumatoïde ou psoriasis, par l'administration de quantités efficaces des composés en question.
MA28348A 2002-12-19 2005-06-17 2-(1h-indazole-6-ylamino)-benzamides en tant qu'inhibiteurs de proteine-kinases, utiles pour le traitement de maladies ophtalmiques MA27570A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43490202P 2002-12-19 2002-12-19

Publications (1)

Publication Number Publication Date
MA27570A1 true MA27570A1 (fr) 2005-10-03

Family

ID=32682122

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28348A MA27570A1 (fr) 2002-12-19 2005-06-17 2-(1h-indazole-6-ylamino)-benzamides en tant qu'inhibiteurs de proteine-kinases, utiles pour le traitement de maladies ophtalmiques

Country Status (37)

Country Link
US (2) US7053107B2 (fr)
EP (1) EP1585743B1 (fr)
JP (1) JP3814285B2 (fr)
KR (1) KR100730267B1 (fr)
CN (1) CN1747950A (fr)
AP (1) AP2005003341A0 (fr)
AR (1) AR042510A1 (fr)
AT (1) ATE362928T1 (fr)
AU (1) AU2003286321A1 (fr)
BR (1) BR0317548A (fr)
CA (1) CA2510850A1 (fr)
CO (1) CO5580767A2 (fr)
CR (1) CR7882A (fr)
DE (1) DE60314013T2 (fr)
DK (1) DK1585743T3 (fr)
EA (1) EA008501B1 (fr)
EC (1) ECSP055858A (fr)
GT (1) GT200300294A (fr)
HR (1) HRP20050559A2 (fr)
IS (1) IS7859A (fr)
MA (1) MA27570A1 (fr)
MX (1) MXPA05006676A (fr)
NL (1) NL1025073C2 (fr)
NO (1) NO20053486L (fr)
NZ (1) NZ540340A (fr)
OA (1) OA12977A (fr)
PA (1) PA8592901A1 (fr)
PE (1) PE20041006A1 (fr)
PL (1) PL377713A1 (fr)
PT (1) PT1585743E (fr)
RS (1) RS20050430A (fr)
SI (1) SI1585743T1 (fr)
TN (1) TNSN05164A1 (fr)
TW (1) TW200424193A (fr)
UY (1) UY28130A1 (fr)
WO (1) WO2004056806A1 (fr)
ZA (1) ZA200504339B (fr)

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EP1585743A1 (fr) 2005-10-19
CA2510850A1 (fr) 2004-07-08
RS20050430A (sr) 2007-08-03
PE20041006A1 (es) 2004-12-24
MXPA05006676A (es) 2005-08-16
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EP1585743B1 (fr) 2007-05-23
JP2006515589A (ja) 2006-06-01
KR100730267B1 (ko) 2007-06-20
AU2003286321A1 (en) 2004-07-14
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AP2005003341A0 (en) 2005-06-30
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