MA30084B1 - Triazolopyridazines en tant que modulateurs de la tyrosine kinase - Google Patents

Triazolopyridazines en tant que modulateurs de la tyrosine kinase

Info

Publication number
MA30084B1
MA30084B1 MA31070A MA31070A MA30084B1 MA 30084 B1 MA30084 B1 MA 30084B1 MA 31070 A MA31070 A MA 31070A MA 31070 A MA31070 A MA 31070A MA 30084 B1 MA30084 B1 MA 30084B1
Authority
MA
Morocco
Prior art keywords
compounds
modulators
tyrosine kinase
present
met
Prior art date
Application number
MA31070A
Other languages
English (en)
Inventor
Tianbao Lu
Richard Alexander
Richard W Connors
Maxwell D Cummings
Robert A Galemmo
Heather Rae Hufnagel
Dana L Johnson
Ehab Khalil
Kristi A Leonard
Thomas P Markotan
Anna C Maroney
Jan L Sechler
Jeremy M Travins
Robert W Tuman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37964498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30084(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA30084B1 publication Critical patent/MA30084B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des composés de triazolopyridazine de formule (I), dans laquelle: R1, R5, R6, R7, R8, et A sont tels que définis dans la description, l'utilisation de tels composés en tant que modulateurs de la protéine tyrosine kinase, notamment des inhibiteurs de c-Met, et l'utilisation de tels composés pour la réduction ou l'inhibition de l'activité kinase de c-Met dans une cellule ou chez un sujet, et l'utilisation de tels composés pour la prévention ou le traitement chez un sujet d'un trouble et/ou des troubles de prolifération cellulaire apparentés à c-Met. La présente invention concerne également des compositions pharmaceutiques comportant les composés de la présente invention et des procédés pour le traitement de pathologies telles que le cancer et d'autres troubles de prolifération cellulaire.
MA31070A 2005-12-21 2008-06-20 Triazolopyridazines en tant que modulateurs de la tyrosine kinase MA30084B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75263405P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
MA30084B1 true MA30084B1 (fr) 2008-12-01

Family

ID=37964498

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31070A MA30084B1 (fr) 2005-12-21 2008-06-20 Triazolopyridazines en tant que modulateurs de la tyrosine kinase

Country Status (40)

Country Link
US (2) US8030305B2 (fr)
EP (1) EP1966214B9 (fr)
JP (1) JP5292102B2 (fr)
KR (1) KR101412675B1 (fr)
CN (1) CN101374843B (fr)
AP (1) AP3433A (fr)
AR (1) AR058703A1 (fr)
AU (1) AU2006331912B2 (fr)
BR (1) BRPI0620292B1 (fr)
CA (1) CA2634721C (fr)
CR (1) CR10170A (fr)
CY (1) CY1118846T1 (fr)
DK (1) DK1966214T3 (fr)
EA (1) EA015754B1 (fr)
EC (1) ECSP088573A (fr)
ES (1) ES2612377T3 (fr)
GT (1) GT200800105A (fr)
HN (1) HN2008000931A (fr)
HR (1) HRP20170103T1 (fr)
HU (1) HUE030390T2 (fr)
IL (1) IL192108A (fr)
LT (1) LT1966214T (fr)
MA (1) MA30084B1 (fr)
ME (1) ME02736B (fr)
MX (1) MX2008008277A (fr)
MY (1) MY159523A (fr)
NI (1) NI200800179A (fr)
NO (1) NO340958B1 (fr)
NZ (1) NZ568807A (fr)
PE (2) PE20070752A1 (fr)
PL (1) PL1966214T3 (fr)
PT (1) PT1966214T (fr)
RS (1) RS55630B1 (fr)
SV (1) SV2008002963A (fr)
TN (1) TNSN08278A1 (fr)
TW (1) TWI399378B (fr)
UA (1) UA98297C2 (fr)
UY (1) UY30041A1 (fr)
WO (1) WO2007075567A1 (fr)
ZA (1) ZA200806277B (fr)

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US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
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TNSN99006A1 (fr) 4-(2-ceto-1-benzimidazolinyl) piperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
MA30207B1 (fr) Modulateurs des recepteurs de la progesterone a base d'indole sulfonamide
MA30232B1 (fr) Inhibiteurs de kinase bases sur l'hydantoine
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MA47447B1 (fr) 2-hétéroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides pour le traitement du cancer
MA26723A1 (fr) Acides oxamiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA30539B1 (fr) Derives de piperazinyle utiles dans le traitement de maladies induites par le recepteur gpr38.
MA27937A1 (fr) Dérivés d'indazole 3, 5-disubstitués, compositions pharmaceutiques, et méthodes de médiation ou d'inhibition de la prolifération cellulaire
MA32684B1 (fr) Dérivés de picolinamide en tant qu'inhibiteurs de kinase
MA34474B1 (fr) Agonistes de gpr40
MA31311B1 (fr) Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p)
MA31260B1 (fr) 3-imidazolyl-indoles pour le traitement de maladies proliferatives
TNSN97198A1 (fr) Derives de 6-phenylpyridyl-2- amine et compositions pharmaceutiques les contenant
MA30333B1 (fr) Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete.
MA31683B1 (fr) Composes et procedes pour moduler fxr
MA31027B1 (fr) INHIBITEURS DE L'ACTIVITE Akt
TN2009000138A1 (fr) Biaryl-ether-urees
TNSN99172A1 (fr) 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
BRPI0515532A (pt) composto, composição farmacêutica, métodos de inibir a ligação de ligandos endógenos ao receptor de crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor de crt-2 e de preparar um composto, e, kit
TNSN05298A1 (fr) Derives de pyrazolo-quinazoline, procede pour leur preparation et leur utilisation comme inhibiteurs de kinases