MA28677B1 - N-(2-benzyl) -2-phenylbutanamides modulant le recepteur d'androgene - Google Patents

N-(2-benzyl) -2-phenylbutanamides modulant le recepteur d'androgene

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Publication number
MA28677B1
MA28677B1 MA29551A MA29551A MA28677B1 MA 28677 B1 MA28677 B1 MA 28677B1 MA 29551 A MA29551 A MA 29551A MA 29551 A MA29551 A MA 29551A MA 28677 B1 MA28677 B1 MA 28677B1
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MA
Morocco
Prior art keywords
bone
compounds
androgen receptor
disease
cancer
Prior art date
Application number
MA29551A
Other languages
English (en)
Inventor
Barbara Hanney
Yuntae Kim
Michael R Krout
Robert S Meissner
Helen J Mitchell
Jeffrey Musselman
James J Perkins
Jiabing Wang
Original Assignee
Merck Sharp & Dohme
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Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA28677B1 publication Critical patent/MA28677B1/fr

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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Abstract

EXTRAIT Les composés de la formule développée I sont des modulateurs de récepteur androgène (AR) à sélectivité tissulaire. Ces composés sont utiles dans le renforcement de la tonicité musculaire affaiblie et le traitement des conditions provoquées par la déficience en androgènes ou qui peuvent être améliorées par l'administration d'androgènes. y compris l'ostéoporose. l'ostéopénie. l'ostéoporose induite par les glucocorticoïdes. la parodontopathie. la fracture de l'os, les lésions de l'os à la suite de chirurgie osseuse reconstructive. la sarcopénie. la fragilité, le vieillissement de la peau, l'hypogénitalisme masculin, les symptômes post-ménopausiques chez les femmes, l'athérosclérose, l'hypercholestérolémie. l'hyperlipidémie. l'obésité, l'anémie aplasique et autres troubles hématopoïetiques. l'arthrite inflammatoire et la réparation des articulations, le dépérissement dû au VIH. le cancer de la prostate, l'hyperplasie prostatique bénigne (BPH). l'adiposité abdominale, le syndrome métabolique, le diabète de type II. la cachexie due au cancer, la maladie d'Alzheimer. les dystrophies musculaires, le déficit cognitif. le dysfonctionnement sexuel, les apnées du sommeil, la dépression, l'insuffisance ovarienne prématurée, et les maladies auto-immunes. seuls ou en combinaison avec d'autres agents actifs.
MA29551A 2004-06-07 2006-12-25 N-(2-benzyl) -2-phenylbutanamides modulant le recepteur d'androgene MA28677B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57769804P 2004-06-07 2004-06-07

Publications (1)

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MA28677B1 true MA28677B1 (fr) 2007-06-01

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MA29551A MA28677B1 (fr) 2004-06-07 2006-12-25 N-(2-benzyl) -2-phenylbutanamides modulant le recepteur d'androgene

Country Status (24)

Country Link
US (3) US7268153B2 (fr)
EP (1) EP1755572B1 (fr)
JP (1) JP4881865B2 (fr)
CN (1) CN1976902A (fr)
AR (1) AR049140A1 (fr)
AT (1) ATE545631T1 (fr)
AU (1) AU2005251766B9 (fr)
BR (1) BRPI0511862A (fr)
CA (1) CA2569124C (fr)
CR (1) CR8777A (fr)
EC (1) ECSP067061A (fr)
IL (1) IL179843A0 (fr)
MA (1) MA28677B1 (fr)
MX (1) MXPA06014235A (fr)
MY (1) MY147997A (fr)
NO (1) NO20070085L (fr)
NZ (1) NZ551738A (fr)
PE (1) PE20060401A1 (fr)
RU (1) RU2378255C2 (fr)
SG (1) SG169398A1 (fr)
TW (1) TW200610755A (fr)
UA (1) UA87854C2 (fr)
WO (1) WO2005120477A2 (fr)
ZA (1) ZA200609673B (fr)

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US20090088458A1 (en) * 2005-08-02 2009-04-02 Meissner Robert S N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators
WO2007077510A2 (fr) * 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Antagonistes des récepteurs muscariniques
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US20090197947A1 (en) * 2008-02-01 2009-08-06 The Research Foundation Of State University Of New York Medicaments and methods for lowering plasma lipid levels and screening drugs
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