MA33364B1 - Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine - Google Patents

Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine

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Publication number
MA33364B1
MA33364B1 MA34456A MA34456A MA33364B1 MA 33364 B1 MA33364 B1 MA 33364B1 MA 34456 A MA34456 A MA 34456A MA 34456 A MA34456 A MA 34456A MA 33364 B1 MA33364 B1 MA 33364B1
Authority
MA
Morocco
Prior art keywords
neprilysin inhibitors
derivatives
relates
substituted
substituted aminobutyric
Prior art date
Application number
MA34456A
Other languages
English (en)
Inventor
Gary Mark Coppola
Yuki Iwaki
Rajeshri Ganesh Karki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
Robert Sun
Original Assignee
Novartis Ag
Saba & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Saba & Co filed Critical Novartis Ag
Publication of MA33364B1 publication Critical patent/MA33364B1/fr

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Abstract

LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE I' OU UN DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES, DANS LAQUELLE R1, R2, R3, X ET N SONT TELS QUE DÉFINIS DANS LE PRÉSENT DOCUMENT. L'INVENTION CONCERNE ÉGALEMENT UN PROCÉDÉ DE FABRICATION DES COMPOSÉS DE L'INVENTION ET LEURS UTILISATIONS THÉRAPEUTIQUES. LA PRÉSENTE INVENTION CONCERNE ÉGALEMENT UNE COMBINAISON D'AGENTS PHARMACOLOGIQUEMENT ACTIFS ET UNE COMPOSITION PHARMACEUTIQUE.
MA34456A 2009-05-28 2010-05-26 Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine MA33364B1 (fr)

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US18175309P 2009-05-28 2009-05-28
US26314109P 2009-11-20 2009-11-20
US32493810P 2010-04-16 2010-04-16
PCT/EP2010/057213 WO2010136474A2 (fr) 2009-05-28 2010-05-26 Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine

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MA33364B1 true MA33364B1 (fr) 2012-06-01

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AU2012217615B2 (en) 2011-02-17 2016-09-29 Theravance Biopharma R&D Ip, Llc Substituted aminobutyric derivatives as neprilysin inhibitors
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CO6470846A2 (es) 2012-06-29
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EP2435402B1 (fr) 2016-04-13
JP2012528107A (ja) 2012-11-12
CN102448928B (zh) 2014-10-01
TW201100393A (en) 2011-01-01
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US20120252830A1 (en) 2012-10-04
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UY32660A (es) 2010-12-31
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US9603819B2 (en) 2017-03-28
US8263629B2 (en) 2012-09-11
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