MA29775B1 - Derives de pyrazolone - Google Patents

Derives de pyrazolone

Info

Publication number
MA29775B1
MA29775B1 MA30744A MA30744A MA29775B1 MA 29775 B1 MA29775 B1 MA 29775B1 MA 30744 A MA30744 A MA 30744A MA 30744 A MA30744 A MA 30744A MA 29775 B1 MA29775 B1 MA 29775B1
Authority
MA
Morocco
Prior art keywords
pyrazolone derivatives
pyrazolone
esters
formula
pharmaceutically acceptable
Prior art date
Application number
MA30744A
Other languages
English (en)
Inventor
Kurt Amrein
Daniel Hunziker
Bernd Kuhn
Alexander V Mayweg
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29775B1 publication Critical patent/MA29775B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dérivés de pyrazolone Des composés de formule (I) ainsi que leurs sels et esters pharmaceutiquement acceptables, formule dans laquelle R1 à R4 répondent aux définitions indiquées dans la revendication 1, peuvent être utilisés sous forme de compositions pharmaceutiques.
MA30744A 2005-08-31 2008-03-14 Derives de pyrazolone MA29775B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107970 2005-08-31

Publications (1)

Publication Number Publication Date
MA29775B1 true MA29775B1 (fr) 2008-09-01

Family

ID=37729936

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30744A MA29775B1 (fr) 2005-08-31 2008-03-14 Derives de pyrazolone

Country Status (22)

Country Link
US (1) US7652057B2 (fr)
EP (1) EP1924562A2 (fr)
JP (1) JP5073664B2 (fr)
KR (1) KR100982088B1 (fr)
CN (1) CN101243050B (fr)
AR (1) AR055145A1 (fr)
AU (1) AU2006286646B2 (fr)
BR (1) BRPI0615039A2 (fr)
CA (1) CA2618840C (fr)
CR (1) CR9703A (fr)
EC (1) ECSP088229A (fr)
IL (1) IL189186A0 (fr)
MA (1) MA29775B1 (fr)
MX (1) MX2008002583A (fr)
MY (1) MY145464A (fr)
NO (1) NO20080554L (fr)
NZ (1) NZ565536A (fr)
RU (1) RU2407737C2 (fr)
TW (1) TWI332949B (fr)
UA (1) UA90742C2 (fr)
WO (1) WO2007025880A2 (fr)
ZA (1) ZA200801444B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9428467B2 (en) 2008-11-20 2016-08-30 Northwestern University Selective calcium channel antagonists
US10167263B2 (en) * 2008-11-20 2019-01-01 Northwestern University Treatment of amyotrophic lateral sclerosis
US9145424B2 (en) 2008-11-20 2015-09-29 Northwestern University Treatment of amyotrophic lateral sclerosis
SG176100A1 (en) * 2009-05-22 2011-12-29 Abbott Lab Modulators of 5-ht receptors and methods of use thereof
WO2011051958A1 (fr) 2009-10-30 2011-05-05 E.I. Du Pont De Nemours And Company Pyrazolones fongicides
KR101770979B1 (ko) * 2010-05-21 2017-08-24 애브비 인코포레이티드 5­ｈｔ 수용체의 조절제 및 이의 사용방법
EP2881387A1 (fr) 2013-12-09 2015-06-10 Basf Se Composés pyrazolone à activité herbicide
EP2881388A1 (fr) 2013-12-09 2015-06-10 Basf Se Composés pyrazolone à activité herbicide
EP3235813A1 (fr) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Dérivés aza-tétra-cycliques
WO2019048988A1 (fr) 2017-09-08 2019-03-14 Pi Industries Ltd. Nouveaux composés hétérocycliques fongicides
CA3073637A1 (fr) 2017-09-08 2019-03-14 Pi Industries Ltd Nouveaux composes heterocycliques fongicides
CA3136838A1 (fr) * 2019-04-17 2020-10-22 Pontificia Universidad Catolica De Chile Derives d'adamantyloxadiazoles et leurs solvates, hydrates et sels pharmaceutiquement acceptables, composition pharmaceutique les comprenant, procede de synthese, utiles en tant q u'inhibiteurs efficaces et selectifs de l'activite reductase de l'enzyme 11-beta deshydrogenase de type 1 (11s-hsd1)
CN113527207B (zh) * 2020-04-22 2023-06-06 常州强力电子新材料股份有限公司 乙氧基/丙氧基改性的吡唑啉有机物、其应用、光固化组合物及光刻胶
CN112375072B (zh) * 2020-09-28 2021-05-28 上海长征富民金山制药有限公司 吡唑啉酮衍生物、注射剂及其用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731473A (en) * 1956-01-17 New pyrazolone derivatives
DE668628C (de) * 1935-12-08 1938-12-07 Beiersdorf & Co A G P Verfahren zur Darstellung von Alkyl- und Aralkylabkoemmlingen der 3,4-Cyclotetramethylen-1-aryl-5-pyrazolone
JPS609752B2 (ja) * 1979-11-09 1985-03-12 東邦新薬株式会社 新規な２−アセトキシベンズアミド誘導体、その製法及びそれを有効成分とする医薬
DE4415484A1 (de) 1994-05-03 1995-11-09 Basf Ag Verfahren zur Herstellung von 1-(Het)aryl-3-hydroxy-pyrazolen
US5663365A (en) 1996-10-29 1997-09-02 Japan Hydrazine Co., Ltd. Process for the preparation of pyrazolones
ATE219044T1 (de) 1997-04-10 2002-06-15 Pfizer Fluorosubstituierte adamantan-derivate
TW536387B (en) 1998-04-23 2003-06-11 Sumitomo Chemical Co Pyrazolinone compound
ATE264337T1 (de) * 1999-08-31 2004-04-15 Kissei Pharmaceutical Glucopyranosyloxypyrazol-derivate, diese enthaltende arzneimittel und zwischenprodukte zu deren herstellung
PL209375B1 (pl) * 2000-12-28 2011-08-31 Kissei Pharmaceutical Pochodne glukopiranozyloksypirazolu, kompozycja farmaceutyczna zawierająca takie pochodne i zastosowanie tych pochodnych do wytwarzania kompozycji farmaceutycznej
PL213095B1 (pl) * 2002-08-08 2013-01-31 Kissei Pharmaceutical Pochodna pirazolu, kompozycja farmaceutyczna, srodek do leczenia lub hamowania choroby i zastosowanie pochodnej pirazolu
US7368578B2 (en) * 2002-09-10 2008-05-06 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
PL377426A1 (pl) 2002-12-19 2006-02-06 Bristol-Myers Squibb Company Podstawione tricykliczne gamma-karboliny jako agoniści i antagoniści receptora serotoninowego
GB0306718D0 (en) * 2003-03-24 2003-04-30 Sterix Ltd Compound
US7659408B2 (en) * 2003-08-07 2010-02-09 Merck Sharp & Dhome Corp. Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
GB2637773A (en) * 2024-02-05 2025-08-06 Nokia Technologies Oy Access traffic steering, switching, splitting (ATSSS) between access paths

Also Published As

Publication number Publication date
ECSP088229A (es) 2008-03-26
CA2618840A1 (fr) 2007-03-08
AR055145A1 (es) 2007-08-08
NO20080554L (no) 2008-03-14
EP1924562A2 (fr) 2008-05-28
US20070049574A1 (en) 2007-03-01
JP5073664B2 (ja) 2012-11-14
CR9703A (es) 2008-02-20
CN101243050B (zh) 2012-07-04
ZA200801444B (en) 2008-12-31
CA2618840C (fr) 2011-07-05
BRPI0615039A2 (pt) 2011-04-26
HK1123295A1 (en) 2009-06-12
MX2008002583A (es) 2008-03-18
NZ565536A (en) 2011-03-31
TW200740764A (en) 2007-11-01
US7652057B2 (en) 2010-01-26
WO2007025880A2 (fr) 2007-03-08
TWI332949B (en) 2010-11-11
KR100982088B1 (ko) 2010-09-13
MY145464A (en) 2012-02-15
RU2407737C2 (ru) 2010-12-27
AU2006286646A1 (en) 2007-03-08
AU2006286646B2 (en) 2010-09-23
JP2009506089A (ja) 2009-02-12
CN101243050A (zh) 2008-08-13
RU2008111971A (ru) 2009-10-10
IL189186A0 (en) 2008-06-05
KR20080031482A (ko) 2008-04-08
WO2007025880A3 (fr) 2007-05-03
UA90742C2 (en) 2010-05-25

Similar Documents

Publication Publication Date Title
MA29775B1 (fr) Derives de pyrazolone
MA29909B1 (fr) Derives de pyridazine
MA30162B1 (fr) Nouveaux derives de pyrrole a cycles fusionnes
MA29856B1 (fr) Derives de diacylindazole en tant qu'inhibiteurs de lipases et de phospholipases
MA27560A1 (fr) Nouveaux derives de fluorglycoside heterocycliques, produits pharmaceutiques contenant ces composes et leur utilisation
HRP20050663A2 (en) Malonamide derivatives as gamma-secretase inhibitors
MA29857B1 (fr) Derives de triazolopyridine en tant qu'inhibiteurs de lipases et phospholipases
MA31580B1 (fr) Derives de bicyclolactames substitués
MA30717B1 (fr) Derives de pyridin-3-yle en tant qu'agents immunomodulateurs
MA30718B1 (fr) Derives de pyridin-4-yle en tant qu'agents immunomodulateurs.
MA27559A1 (fr) Nouveaux derives de fluorglycoside aromatiques, produits pharmaceutiques contenant ces composes et leur utilisation
MA30231B1 (fr) Derives de benzamides et d'heteroarenes
MEP36508A (en) Triazolopyrazine derivatives useful as anti-cancer agents
MA29858B1 (fr) Derives de carbamoylbenzotriazole en tant qu'inhibiteurs de lipases et phospholipases
EA201490489A1 (ru) Пуриновые производные и их применение в качестве модуляторов толл-подобного рецептора 7
MA30352B1 (fr) Pyridine [3,4-b] pyrazinones
MA31683B1 (fr) Composes et procedes pour moduler fxr
TNSN07476A1 (fr) Derives de n-(pyridine -2- yl) - sulfonamide
MY138252A (en) Azabicyclic-substitud fused-heteroaryl compounds for the treatment of disease
MA33384B1 (fr) Sulfonamides hétérocycliques, leurs utilisations et compositions pharmaceutiques les contenant
MA32563B1 (fr) Dabigatran pour cathétérisme cardiaque de chirurgie percutanée
MA29926B1 (fr) Derives de pyrazine
MA31296B1 (fr) Derives d'imidazolidine carboxamide en tant qu'inhibiteurs de lipase et de phospholipase
MA37886B1 (fr) Nouvelles pyridinones bicycliques
MA27867A1 (fr) Nouveaux derives de 2h-pyridazine-3-one, compositions pharmaceutiques contenant ces derives et procede de preparation de l'ingredient actif.