MA29775B1 - Derives de pyrazolone - Google Patents

Derives de pyrazolone

Info

Publication number
MA29775B1
MA29775B1 MA30744A MA30744A MA29775B1 MA 29775 B1 MA29775 B1 MA 29775B1 MA 30744 A MA30744 A MA 30744A MA 30744 A MA30744 A MA 30744A MA 29775 B1 MA29775 B1 MA 29775B1
Authority
MA
Morocco
Prior art keywords
pyrazolone derivatives
pyrazolone
esters
formula
pharmaceutically acceptable
Prior art date
Application number
MA30744A
Other languages
English (en)
Inventor
Kurt Amrein
Daniel Hunziker
Bernd Kuhn
Alexander V Mayweg
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29775B1 publication Critical patent/MA29775B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dérivés de pyrazolone Des composés de formule (I) ainsi que leurs sels et esters pharmaceutiquement acceptables, formule dans laquelle R1 à R4 répondent aux définitions indiquées dans la revendication 1, peuvent être utilisés sous forme de compositions pharmaceutiques.
MA30744A 2005-08-31 2008-03-14 Derives de pyrazolone MA29775B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107970 2005-08-31

Publications (1)

Publication Number Publication Date
MA29775B1 true MA29775B1 (fr) 2008-09-01

Family

ID=37729936

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30744A MA29775B1 (fr) 2005-08-31 2008-03-14 Derives de pyrazolone

Country Status (22)

Country Link
US (1) US7652057B2 (fr)
EP (1) EP1924562A2 (fr)
JP (1) JP5073664B2 (fr)
KR (1) KR100982088B1 (fr)
CN (1) CN101243050B (fr)
AR (1) AR055145A1 (fr)
AU (1) AU2006286646B2 (fr)
BR (1) BRPI0615039A2 (fr)
CA (1) CA2618840C (fr)
CR (1) CR9703A (fr)
EC (1) ECSP088229A (fr)
IL (1) IL189186A0 (fr)
MA (1) MA29775B1 (fr)
MX (1) MX2008002583A (fr)
MY (1) MY145464A (fr)
NO (1) NO20080554L (fr)
NZ (1) NZ565536A (fr)
RU (1) RU2407737C2 (fr)
TW (1) TWI332949B (fr)
UA (1) UA90742C2 (fr)
WO (1) WO2007025880A2 (fr)
ZA (1) ZA200801444B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9428467B2 (en) 2008-11-20 2016-08-30 Northwestern University Selective calcium channel antagonists
US9145424B2 (en) 2008-11-20 2015-09-29 Northwestern University Treatment of amyotrophic lateral sclerosis
EP2367798B1 (fr) * 2008-11-20 2018-02-28 Northwestern University Dérivés pyrazolone utiles dans le traitement de la sclérose latérale amyotrophique
EP2641907B1 (fr) 2009-05-22 2015-01-28 AbbVie Inc. Preparation des modulateurs de récepteurs 5-HT
WO2011051958A1 (fr) 2009-10-30 2011-05-05 E.I. Du Pont De Nemours And Company Pyrazolones fongicides
RU2015140748A (ru) * 2010-05-21 2018-12-26 Эббви Инк. Модуляторы 5-нт рецепторов и способы их применения
EP2881388A1 (fr) 2013-12-09 2015-06-10 Basf Se Composés pyrazolone à activité herbicide
EP2881387A1 (fr) 2013-12-09 2015-06-10 Basf Se Composés pyrazolone à activité herbicide
EP3235813A1 (fr) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Dérivés aza-tétra-cycliques
JP2020533303A (ja) 2017-09-08 2020-11-19 ピーアイ インダストリーズ リミテッドＰｉ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ 新規な殺菌性複素環化合物
WO2019048988A1 (fr) 2017-09-08 2019-03-14 Pi Industries Ltd. Nouveaux composés hétérocycliques fongicides
KR102783746B1 (ko) * 2019-04-17 2025-03-18 폰티피씨아 유니베르시다드 까똘리까 데 칠레 효소 11-베타 탈수소효소 유형 1(11β-HSD1)의 환원효소 활성의 효과적이고 선택적인 저해제로 사용되기에 적합한 아다만틸 옥사디아졸의 유도체 및 그 약학적으로 허용가능한 용매화물, 수화물 및 염, 이를 포함하는 약학적 조성물, 합성 방법
CN113527207B (zh) * 2020-04-22 2023-06-06 常州强力电子新材料股份有限公司 乙氧基/丙氧基改性的吡唑啉有机物、其应用、光固化组合物及光刻胶
CN112375072B (zh) * 2020-09-28 2021-05-28 上海长征富民金山制药有限公司 吡唑啉酮衍生物、注射剂及其用途

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US2731473A (en) * 1956-01-17 New pyrazolone derivatives
DE668628C (de) * 1935-12-08 1938-12-07 Beiersdorf & Co A G P Verfahren zur Darstellung von Alkyl- und Aralkylabkoemmlingen der 3,4-Cyclotetramethylen-1-aryl-5-pyrazolone
JPS609752B2 (ja) * 1979-11-09 1985-03-12 東邦新薬株式会社 新規な２−アセトキシベンズアミド誘導体、その製法及びそれを有効成分とする医薬
DE4415484A1 (de) 1994-05-03 1995-11-09 Basf Ag Verfahren zur Herstellung von 1-(Het)aryl-3-hydroxy-pyrazolen
US5663365A (en) 1996-10-29 1997-09-02 Japan Hydrazine Co., Ltd. Process for the preparation of pyrazolones
PT870757E (pt) 1997-04-10 2002-09-30 Pfizer Derivados de adamantano substituidos por fluoro
TW536387B (en) 1998-04-23 2003-06-11 Sumitomo Chemical Co Pyrazolinone compound
UA71994C2 (en) * 1999-08-31 2005-01-17 Kissei Pharmaceutical Glucopyranosyloxypyrazole derivatives, a pharmaceutical composition containing these derivatives and intermediate compounds for the preparation thereof
SI1354888T1 (sl) * 2000-12-28 2009-10-31 Kissei Pharmaceutical Glukopiranoziloksipirazolni derivati in njihova uporaba v zdravilih
US7375087B2 (en) * 2002-08-08 2008-05-20 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
AU2003262023A1 (en) * 2002-09-10 2004-04-30 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
ES2364046T3 (es) 2002-12-19 2011-08-23 Bristol-Myers Squibb Company Gamma-carbolinas tricíclicas sustituidas utilizadas como agonistas y antagonistas de los receptores de la serotonina.
GB0306718D0 (en) * 2003-03-24 2003-04-30 Sterix Ltd Compound
CN1832741A (zh) * 2003-08-07 2006-09-13 默克公司 作为11－β－羟甾类脱氢酶－1抑制剂的吡唑甲酰胺类
GB2637773A (en) * 2024-02-05 2025-08-06 Nokia Technologies Oy Access traffic steering, switching, splitting (ATSSS) between access paths

Also Published As

Publication number Publication date
JP5073664B2 (ja) 2012-11-14
KR100982088B1 (ko) 2010-09-13
AU2006286646A1 (en) 2007-03-08
NO20080554L (no) 2008-03-14
WO2007025880A3 (fr) 2007-05-03
BRPI0615039A2 (pt) 2011-04-26
RU2008111971A (ru) 2009-10-10
IL189186A0 (en) 2008-06-05
CA2618840C (fr) 2011-07-05
TWI332949B (en) 2010-11-11
TW200740764A (en) 2007-11-01
ECSP088229A (es) 2008-03-26
CR9703A (es) 2008-02-20
ZA200801444B (en) 2008-12-31
US20070049574A1 (en) 2007-03-01
AU2006286646B2 (en) 2010-09-23
CA2618840A1 (fr) 2007-03-08
MY145464A (en) 2012-02-15
RU2407737C2 (ru) 2010-12-27
JP2009506089A (ja) 2009-02-12
HK1123295A1 (en) 2009-06-12
KR20080031482A (ko) 2008-04-08
CN101243050A (zh) 2008-08-13
CN101243050B (zh) 2012-07-04
EP1924562A2 (fr) 2008-05-28
MX2008002583A (es) 2008-03-18
WO2007025880A2 (fr) 2007-03-08
AR055145A1 (es) 2007-08-08
UA90742C2 (en) 2010-05-25
US7652057B2 (en) 2010-01-26
NZ565536A (en) 2011-03-31

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