MA29858B1 - Derives de carbamoylbenzotriazole en tant qu'inhibiteurs de lipases et phospholipases - Google Patents

Derives de carbamoylbenzotriazole en tant qu'inhibiteurs de lipases et phospholipases

Info

Publication number
MA29858B1
MA29858B1 MA30825A MA30825A MA29858B1 MA 29858 B1 MA29858 B1 MA 29858B1 MA 30825 A MA30825 A MA 30825A MA 30825 A MA30825 A MA 30825A MA 29858 B1 MA29858 B1 MA 29858B1
Authority
MA
Morocco
Prior art keywords
phospholipases
lipases
inhibitors
derivatives
carbamoylbenzotriazole
Prior art date
Application number
MA30825A
Other languages
English (en)
Inventor
Stefan Petry
Gerhard Zoller
Norbert Tennagels
Guenter Mueller
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA29858B1 publication Critical patent/MA29858B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des dérivés benzotriazol de formule générale (I), présentant les significations mentionnées dans la description, leurs sels pharmaceutiquement acceptables et leur utilisation comme médicaments.
MA30825A 2005-10-19 2008-04-08 Derives de carbamoylbenzotriazole en tant qu'inhibiteurs de lipases et phospholipases MA29858B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005049953A DE102005049953A1 (de) 2005-10-19 2005-10-19 Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number Publication Date
MA29858B1 true MA29858B1 (fr) 2008-10-03

Family

ID=37667178

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30825A MA29858B1 (fr) 2005-10-19 2008-04-08 Derives de carbamoylbenzotriazole en tant qu'inhibiteurs de lipases et phospholipases

Country Status (26)

Country Link
US (2) US7897625B2 (fr)
EP (1) EP1940807B1 (fr)
JP (1) JP2009512650A (fr)
KR (1) KR20080063474A (fr)
CN (1) CN101291918A (fr)
AR (1) AR057554A1 (fr)
AU (1) AU2006303552A1 (fr)
BR (1) BRPI0617613A2 (fr)
CA (1) CA2625722A1 (fr)
CR (1) CR9850A (fr)
DE (1) DE102005049953A1 (fr)
DO (1) DOP2006000226A (fr)
EC (1) ECSP088377A (fr)
GT (1) GT200600463A (fr)
HN (1) HN2006035238A (fr)
IL (1) IL190714A0 (fr)
MA (1) MA29858B1 (fr)
NO (1) NO20081942L (fr)
NZ (1) NZ567573A (fr)
PE (1) PE20070724A1 (fr)
RU (1) RU2430096C2 (fr)
TN (1) TNSN08177A1 (fr)
TW (1) TW200730513A (fr)
UY (1) UY29872A1 (fr)
WO (1) WO2007045393A1 (fr)
ZA (1) ZA200802370B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009003761A (es) * 2006-10-04 2009-06-30 Schering Corp Derivados biciclicos y triciclicos como antagonistas del receptor de trombina.
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
WO2010003624A2 (fr) 2008-07-09 2010-01-14 Sanofi-Aventis Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation
WO2010044441A1 (fr) 2008-10-17 2010-04-22 塩野義製薬株式会社 Dérivé amide d'acide acétique ayant une activité inhibitrice d'une lipase endothéliale vasculaire
AU2009330821B2 (en) * 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
WO2011022312A1 (fr) * 2009-08-20 2011-02-24 Merck Sharp & Dohme Corp. Dérivés d’éther de benzotriazole
CA2784710A1 (fr) 2009-12-15 2011-06-23 Shionogi & Co., Ltd. Derive d'oxadiazole ayant une activite d'inhibition de la lipase endotheliale
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
WO2012047580A1 (fr) * 2010-09-27 2012-04-12 Janssen Pharmaceutica Nv Dérivés alpha-cétoamide utiles comme inhibiteurs de lipase endothéliale
ES2694829T3 (es) * 2013-02-25 2018-12-27 Aurigene Discovery Technologies Limited Derivados de benzotriazol trisustituido como inhibidores de dihidroorotato oxigenasa
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2553987C1 (ru) * 2013-12-26 2015-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения
CN104292172B (zh) * 2014-09-12 2016-08-17 浙江理工大学 一种苯并三氮唑类衍生物及其制备方法
CA3060390A1 (fr) * 2017-04-24 2018-11-01 Aurigene Discovery Technologies Limited Methodes d'utilisation de derives de benzotriazole trisubstitues en tant qu'inhibiteurs de dihydroorotate oxygenase
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
CA3091792A1 (fr) 2018-02-20 2019-08-29 Agios Pharmaceuticals, Inc. Procedes d'utilisation de derives de benzotriazole trisubstitues

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1035188A (fr) * 1974-08-15 1978-07-25 Eastman Kodak Company Substances retardatrices de developpement partiel
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CA1126999A (fr) 1978-10-20 1982-07-06 Michael J. Simons Utilisation de derives de l'azole a groupe carbomoyl disubstitue en n,n, sur de l'azote cyclique, comme precurseurs pour la retenue du developpement dans des elements photographiques
JPS6239573A (ja) * 1985-08-13 1987-02-20 Sumitomo Chem Co Ltd シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤
US6372421B1 (en) * 2000-06-13 2002-04-16 Eastman Kodak Company Photothermographic imaging element having improved contrast and methods of image formation
US6440648B1 (en) * 2000-06-13 2002-08-27 Eastman Kodak Company Color photographic element having improved contrast and compatibility with both dry and conventional processing
BR0209334A (pt) 2001-05-05 2004-06-15 Smithkline Beecham Plc Aminas n-aroil cìclicas
BR0214967A (pt) 2001-12-14 2005-05-10 Novo Nordisk As Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente
DE10247680B4 (de) * 2002-10-12 2005-09-01 Aventis Pharma Deutschland Gmbh Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
EP1610779B1 (fr) * 2003-03-31 2009-09-09 Eli Lilly And Company Utilisation de derives amides d'acide 3-oxo-1,3-dihydro-indazole-2-carboxylique comme inhibiteurs de la phospholipase

Also Published As

Publication number Publication date
NO20081942L (no) 2008-04-23
PE20070724A1 (es) 2007-08-07
KR20080063474A (ko) 2008-07-04
EP1940807B1 (fr) 2015-06-17
RU2008119460A (ru) 2009-11-27
JP2009512650A (ja) 2009-03-26
CR9850A (es) 2008-06-18
AR057554A1 (es) 2007-12-05
US7897625B2 (en) 2011-03-01
US20080287503A1 (en) 2008-11-20
IL190714A0 (en) 2008-11-03
WO2007045393A1 (fr) 2007-04-26
UY29872A1 (es) 2007-05-31
US20110118321A1 (en) 2011-05-19
RU2430096C2 (ru) 2011-09-27
AU2006303552A1 (en) 2007-04-26
CA2625722A1 (fr) 2007-04-26
TNSN08177A1 (en) 2009-10-30
HN2006035238A (es) 2010-05-24
ZA200802370B (en) 2008-12-31
DOP2006000226A (es) 2007-05-15
NZ567573A (en) 2010-06-25
BRPI0617613A2 (pt) 2011-08-02
EP1940807A1 (fr) 2008-07-09
CN101291918A (zh) 2008-10-22
TW200730513A (en) 2007-08-16
GT200600463A (es) 2007-05-21
DE102005049953A1 (de) 2007-04-26
ECSP088377A (es) 2008-05-30

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