MA29810B1 - 4-oxy-n-[1,3,4]-thiadiazol-2-yl-benzènesulfonamides, procédés pour leur préparation et leur utilisation en tant que produits pharmaceutiques - Google Patents

4-oxy-n-[1,3,4]-thiadiazol-2-yl-benzènesulfonamides, procédés pour leur préparation et leur utilisation en tant que produits pharmaceutiques

Info

Publication number
MA29810B1
MA29810B1 MA30788A MA30788A MA29810B1 MA 29810 B1 MA29810 B1 MA 29810B1 MA 30788 A MA30788 A MA 30788A MA 30788 A MA30788 A MA 30788A MA 29810 B1 MA29810 B1 MA 29810B1
Authority
MA
Morocco
Prior art keywords
thiadiazol
oxy
processes
preparation
benzenesulfonamides
Prior art date
Application number
MA30788A
Other languages
English (en)
Inventor
Stefanie Keil
Karl Schoenafinger
Matthias Urmann
Maike Glien
Wolfgang Wendler
Hans-Ludwig Schaefer
Eugen Falk
Hans Matter
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA29810B1 publication Critical patent/MA29810B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE LES 4-OXY-N-[1,3,4]-THIADIAZOL-2-YL-BENZÈNE SULFONAMIDES AINSI QUE LEURS SELS PHYSIOLOGIQUEMENT ACCEPTABLES ET LEURS DÉRIVÉS PHYSIOLOGIQUEMENT FONCTIONNELS PRÉSENTANT UNE ACTIVITÉ AGONISTE VIS-À-VIS DE PPARALPHA, PPARDELTA ET PPARGAMMA. L¿INVENTION CONCERNE DES COMPOSÉS DE FORMULE (I), LES RADICAUX ÉTANT TELS QUE DÉFINIS, AINSI QUE LEURS SELS PHYSIOLOGIQUEMENT ACCEPTABLES ET DES PROCÉDÉS POUR LEUR PRÉPARATION. LES COMPOSÉS CONVIENNENT POUR LE TRAITEMENT ET/OU LA PRÉVENTION DES PATHOLOGIES LIÉES AU MÉTABOLISME DES ACIDES GRAS ET À L¿UTILISATION DU GLUCOSE, AINSI QUE DES PATHOLOGIES LIÉES À LA RÉSISTANCE À L¿INSULINE ET À LA DÉMYÉLINISATION ET D¿AUTRES MALADIES NEURODÉGÉNÉRATIVES DU SYSTÈME NERVEUX CENTRAL ET PÉRIPHÉRIQUE.
MA30788A 2005-10-06 2008-03-31 4-oxy-n-[1,3,4]-thiadiazol-2-yl-benzènesulfonamides, procédés pour leur préparation et leur utilisation en tant que produits pharmaceutiques MA29810B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05021786 2005-10-06

Publications (1)

Publication Number Publication Date
MA29810B1 true MA29810B1 (fr) 2008-09-01

Family

ID=35455941

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30788A MA29810B1 (fr) 2005-10-06 2008-03-31 4-oxy-n-[1,3,4]-thiadiazol-2-yl-benzènesulfonamides, procédés pour leur préparation et leur utilisation en tant que produits pharmaceutiques

Country Status (15)

Country Link
US (1) US7910612B2 (fr)
EP (1) EP1937658A1 (fr)
JP (1) JP2009510144A (fr)
KR (1) KR20080053931A (fr)
CN (1) CN101277940A (fr)
AR (1) AR056121A1 (fr)
AU (1) AU2006299085A1 (fr)
CA (1) CA2624726A1 (fr)
IL (1) IL190460A0 (fr)
MA (1) MA29810B1 (fr)
NO (1) NO20081682L (fr)
RU (1) RU2008113210A (fr)
TW (1) TW200804324A (fr)
WO (1) WO2007039171A1 (fr)
ZA (1) ZA200801988B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100101165A (ko) 2007-12-26 2010-09-16 사노피-아벤티스 사이클릭 피리딜­ｎ­（１,３,４）­티아디아졸­２­일-벤젠 설폰아미드, 이들의 제조방법 및 약제로서의 이들의 용도
CA2747419C (fr) * 2009-01-12 2014-07-08 Icagen, Inc. Derives sulfonamides
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
JP5872552B2 (ja) 2010-07-09 2016-03-01 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化学化合物
WO2012122368A1 (fr) * 2011-03-08 2012-09-13 The Regents Of The University Of California Composés de liaison à la désoxycytidine kinase
WO2017201468A1 (fr) 2016-05-20 2017-11-23 Xenon Pharmaceuticals Inc. Composés benzènesulfonamides et leur utilisation en tant qu'agents thérapeutiques
WO2017202376A1 (fr) * 2016-05-26 2017-11-30 南京明德新药研发股份有限公司 Dérivé de sulfamide
EP3551626B1 (fr) 2016-12-09 2023-10-25 Xenon Pharmaceuticals Inc. Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
AU2019285184B2 (en) 2018-06-13 2023-11-16 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
US10981905B2 (en) 2018-08-31 2021-04-20 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
MA53488A (fr) 2018-08-31 2021-12-08 Xenon Pharmaceuticals Inc Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
PE20231656A1 (es) 2020-11-02 2023-10-17 Trethera Corp Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS44204A (sr) * 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
US7173030B2 (en) * 2003-05-21 2007-02-06 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
AU2004240885A1 (en) * 2003-05-21 2004-12-02 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I
CA2531418A1 (fr) * 2003-07-08 2005-01-20 Novartis Ag Composes benzenesulfonylamino, et compositions pharmaceutiques contenant ces composes
US7507832B2 (en) * 2003-12-22 2009-03-24 Eli Lilly And Company Triazole PPAR modulators

Also Published As

Publication number Publication date
RU2008113210A (ru) 2009-10-10
CN101277940A (zh) 2008-10-01
AU2006299085A1 (en) 2007-04-12
CA2624726A1 (fr) 2007-04-12
NO20081682L (no) 2008-05-06
EP1937658A1 (fr) 2008-07-02
TW200804324A (en) 2008-01-16
AR056121A1 (es) 2007-09-19
US7910612B2 (en) 2011-03-22
ZA200801988B (en) 2008-12-31
WO2007039171A1 (fr) 2007-04-12
US20090012131A1 (en) 2009-01-08
KR20080053931A (ko) 2008-06-16
JP2009510144A (ja) 2009-03-12
IL190460A0 (en) 2008-11-03

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