BRPI0620408B8 - derivados de pirimidinil aril uréia sendo inibidores de fgf, seus usos, e preparação farmacêutica - Google Patents

derivados de pirimidinil aril uréia sendo inibidores de fgf, seus usos, e preparação farmacêutica

Info

Publication number
BRPI0620408B8
BRPI0620408B8 BRPI0620408A BRPI0620408A BRPI0620408B8 BR PI0620408 B8 BRPI0620408 B8 BR PI0620408B8 BR PI0620408 A BRPI0620408 A BR PI0620408A BR PI0620408 A BRPI0620408 A BR PI0620408A BR PI0620408 B8 BRPI0620408 B8 BR PI0620408B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical preparation
urea derivatives
aryl urea
fgf inhibitors
pyrimidinyl
Prior art date
Application number
BRPI0620408A
Other languages
English (en)
Inventor
Bold Guido
Furet Pascal
Guagnano Vito
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0620408A2 publication Critical patent/BRPI0620408A2/pt
Publication of BRPI0620408B1 publication Critical patent/BRPI0620408B1/pt
Publication of BRPI0620408B8 publication Critical patent/BRPI0620408B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

compostos derivados de pirimidinil aril uréia sendo inibidores de fgf, uso dos mesmos, preparação farmacêutica e método para a sua fabricação. a invenção refere-se a heteroaril aril uréias da fórmula ia, em que os radicais e símbolos têm os significados como aqui definido, o uso de tais compostos no tratamento de doenças dependentes de proteína cina-se; às preparações farmacêuticas compreendendo a referidas heteroaril aril uréias, aos processos para a fabricação de tais novos compostos e aos métodos de tratamento compreendendo o uso de tais heteroaril aril uréias.
BRPI0620408A 2005-12-21 2006-12-20 derivados de pirimidinil aril uréia sendo inibidores de fgf, seus usos, e preparação farmacêutica BRPI0620408B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75271105P 2005-12-21 2005-12-21
US60/752,71 2005-12-21
US60/752,711 2005-12-21
PCT/EP2006/070046 WO2007071752A2 (en) 2005-12-21 2006-12-20 Pyrimidinyl aryl urea derivatives being fgf inhibitors

Publications (3)

Publication Number Publication Date
BRPI0620408A2 BRPI0620408A2 (pt) 2011-11-08
BRPI0620408B1 BRPI0620408B1 (pt) 2020-09-15
BRPI0620408B8 true BRPI0620408B8 (pt) 2021-05-25

Family

ID=37946774

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0620408A BRPI0620408B8 (pt) 2005-12-21 2006-12-20 derivados de pirimidinil aril uréia sendo inibidores de fgf, seus usos, e preparação farmacêutica

Country Status (22)

Country Link
US (2) US8293746B2 (pt)
EP (1) EP1976847B1 (pt)
JP (1) JP5153645B2 (pt)
KR (1) KR101406956B1 (pt)
CN (1) CN101336237B (pt)
AU (1) AU2006326989B2 (pt)
BR (1) BRPI0620408B8 (pt)
CA (1) CA2634047C (pt)
CR (1) CR10072A (pt)
EA (1) EA016438B1 (pt)
EC (1) ECSP088561A (pt)
GE (1) GEP20105074B (pt)
HN (1) HN2008000949A (pt)
IL (1) IL192093A0 (pt)
MA (1) MA30063B1 (pt)
ME (2) MEP3808A (pt)
NO (1) NO20083214L (pt)
SM (1) SMP200800041B (pt)
SV (1) SV2008002967A (pt)
TN (1) TNSN08276A1 (pt)
WO (1) WO2007071752A2 (pt)
ZA (1) ZA200805092B (pt)

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Also Published As

Publication number Publication date
IL192093A0 (en) 2008-12-29
BRPI0620408B1 (pt) 2020-09-15
JP5153645B2 (ja) 2013-02-27
SMP200800041B (it) 2009-07-14
US8759517B2 (en) 2014-06-24
MEP3808A (xx) 2010-02-10
JP2009520768A (ja) 2009-05-28
WO2007071752A3 (en) 2007-11-08
BRPI0620408A2 (pt) 2011-11-08
KR20080090439A (ko) 2008-10-08
EP1976847A2 (en) 2008-10-08
TNSN08276A1 (en) 2009-10-30
SMAP200800041A (it) 2008-07-23
ZA200805092B (en) 2009-09-30
HN2008000949A (es) 2010-11-11
EA200801565A1 (ru) 2008-12-30
WO2007071752A2 (en) 2007-06-28
US8293746B2 (en) 2012-10-23
CN101336237A (zh) 2008-12-31
US20080312248A1 (en) 2008-12-18
MA30063B1 (fr) 2008-12-01
ECSP088561A (es) 2008-07-30
CA2634047A1 (en) 2007-06-28
AU2006326989A1 (en) 2007-06-28
EP1976847B1 (en) 2015-06-17
ME00011A (me) 2009-02-10
CR10072A (es) 2008-08-25
NO20083214L (no) 2008-09-01
GEP20105074B (en) 2010-09-10
EA016438B1 (ru) 2012-05-30
KR101406956B1 (ko) 2014-06-13
CN101336237B (zh) 2015-09-30
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