MA29772B1 - Benzimidazoles substitues et procedes de preparation - Google Patents

Benzimidazoles substitues et procedes de preparation

Info

Publication number
MA29772B1
MA29772B1 MA30738A MA30738A MA29772B1 MA 29772 B1 MA29772 B1 MA 29772B1 MA 30738 A MA30738 A MA 30738A MA 30738 A MA30738 A MA 30738A MA 29772 B1 MA29772 B1 MA 29772B1
Authority
MA
Morocco
Prior art keywords
preparation
methods
substituted benzimidazoles
formula
benzimidazoles
Prior art date
Application number
MA30738A
Other languages
English (en)
Inventor
Martin Dimitroff
Bridget R Miller
Brady S Stillwell
David A Siesel
Tyson Swiftney
Brian Diaz
Danlin Gu
Dyck Jonathan P Van
David Ryckman
Daniel J Poon
Teresa E Pick
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA29772B1 publication Critical patent/MA29772B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des procédés de préparation de nouveaux composés benzimidazoles substitués de formule (I) utiles pour le traitement de troubles à médiation par kinase, où R1, R2, R3, R4, a, b, et c sont définis au sein de la formule (I).
MA30738A 2005-08-30 2008-03-11 Benzimidazoles substitues et procedes de preparation MA29772B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71253905P 2005-08-30 2005-08-30
US71310805P 2005-08-30 2005-08-30
US73159105P 2005-10-27 2005-10-27
US77468406P 2006-02-17 2006-02-17

Publications (1)

Publication Number Publication Date
MA29772B1 true MA29772B1 (fr) 2008-09-01

Family

ID=37434025

Family Applications (2)

Application Number Title Priority Date Filing Date
MA30738A MA29772B1 (fr) 2005-08-30 2008-03-11 Benzimidazoles substitues et procedes de preparation
MA30737A MA29915B1 (fr) 2005-08-30 2008-03-11 Benzimidazoles substitues utilises en tant qu'inhibiteurs de kinases

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA30737A MA29915B1 (fr) 2005-08-30 2008-03-11 Benzimidazoles substitues utilises en tant qu'inhibiteurs de kinases

Country Status (36)

Country Link
US (6) US20070049622A1 (fr)
EP (2) EP1924577B1 (fr)
JP (4) JP5210867B2 (fr)
KR (2) KR20080039965A (fr)
AR (2) AR055622A1 (fr)
AT (2) ATE503751T1 (fr)
AU (2) AU2006287688B2 (fr)
BR (2) BRPI0615314A2 (fr)
CA (2) CA2620472C (fr)
CR (1) CR9716A (fr)
CU (1) CU23784B7 (fr)
CY (2) CY1111871T1 (fr)
DE (1) DE602006021036D1 (fr)
DK (2) DK1926722T3 (fr)
EA (1) EA014230B1 (fr)
EC (2) ECSP088210A (fr)
ES (1) ES2374451T3 (fr)
GE (1) GEP20105004B (fr)
GT (1) GT200600394A (fr)
HN (1) HN2008000317A (fr)
HR (2) HRP20110312T1 (fr)
IL (2) IL189080A (fr)
MA (2) MA29772B1 (fr)
MY (2) MY148694A (fr)
NI (1) NI200800060A (fr)
NO (1) NO20081476L (fr)
NZ (2) NZ565451A (fr)
PE (2) PE20070335A1 (fr)
PL (2) PL1924577T3 (fr)
PT (2) PT1924577E (fr)
RS (1) RS52099B (fr)
SI (2) SI1924577T1 (fr)
SM (1) SMAP200800022A (fr)
TN (2) TNSN08088A1 (fr)
TW (2) TW200804345A (fr)
WO (2) WO2007030377A1 (fr)

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WO2005073224A2 (fr) 2004-01-23 2005-08-11 Amgen Inc Composes et methodes d'utilisation de ces derniers
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