MA30383B1 - Anticorps glycosyles - Google Patents

Anticorps glycosyles

Info

Publication number
MA30383B1
MA30383B1 MA31310A MA31310A MA30383B1 MA 30383 B1 MA30383 B1 MA 30383B1 MA 31310 A MA31310 A MA 31310A MA 31310 A MA31310 A MA 31310A MA 30383 B1 MA30383 B1 MA 30383B1
Authority
MA
Morocco
Prior art keywords
less
sugar chain
glycosyl
antibodies
sugar
Prior art date
Application number
MA31310A
Other languages
English (en)
Inventor
Silke Hansen
Klaus-Peter Kuenkele
Dietmar Reusch
Ralf Schumacher
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38039138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30383(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA30383B1 publication Critical patent/MA30383B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'INVENTION CONCERNE UN ANTICORPS HUMAIN DE TYPE IGGL OU IGG3, GLYCOSYLÉ PAR UNE CHAÎNE DE SUCRE EN POSITION ASN297, LEDIT ANTICORPS ÉTANT CARACTÉRISÉ EN CE QUE LA QUANTITÉ DE FUCOSE DANS LADITE CHAÎNE DE SUCRE EST D'AU MOINS 99 %. DE PLUS, LA QUANTITÉ DE NGNA REPRÉSENTE 1 % OU MOINS ET/OU LA QUANTITÉ D'ALPHA-1,3-GALACTOSE N-TERMINAL REPRÉSENTE 1 % OU MOINS. L'INVENTION CONCERNE ÉGALEMENT LES UTILISATIONS DUDIT ANTICORPS.
MA31310A 2006-04-11 2008-10-20 Anticorps glycosyles MA30383B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06007565 2006-04-11
EP06016203 2006-08-03

Publications (1)

Publication Number Publication Date
MA30383B1 true MA30383B1 (fr) 2009-05-04

Family

ID=38039138

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31310A MA30383B1 (fr) 2006-04-11 2008-10-20 Anticorps glycosyles

Country Status (19)

Country Link
US (5) US7846724B2 (fr)
EP (2) EP2248831A1 (fr)
JP (2) JP5078990B2 (fr)
KR (2) KR101275452B1 (fr)
CN (1) CN103864923A (fr)
AR (1) AR060386A1 (fr)
AU (1) AU2007236198B2 (fr)
BR (1) BRPI0709960B8 (fr)
CA (3) CA2647288C (fr)
CR (1) CR10300A (fr)
EC (1) ECSP088814A (fr)
ES (1) ES2395136T5 (fr)
IL (5) IL321119A (fr)
MA (1) MA30383B1 (fr)
MX (1) MX2008012953A (fr)
NO (1) NO20083948L (fr)
NZ (1) NZ571277A (fr)
RU (1) RU2008144293A (fr)
WO (1) WO2007115813A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846724B2 (en) * 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
PL3199180T3 (pl) 2007-03-08 2022-08-08 Humanigen, Inc. Przeciwciała przeciwko epha3 do leczenia guzów litych
KR101030978B1 (ko) * 2008-07-10 2011-04-28 (주) 에이프로젠 동물세포용 재조합 발현벡터
KR20110119702A (ko) 2009-01-22 2011-11-02 모멘타 파머슈티컬스 인코포레이티드 Ｃｈｏ 세포에서 유도된 글리코단백질 생성물에서의 갈락토오스-알파-1,3-갈락토오스-함유 ｎ-글리칸
AU2010221159B2 (en) 2009-03-06 2015-11-26 Humanigen, Inc. Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
DK3622815T3 (da) 2009-07-08 2023-06-26 Kymab Ltd Gnavermodeller og terapeutiske molekyler
CA2777068C (fr) 2009-10-14 2020-05-26 Humanigen, Inc. Anticorps anti-epha3
SI2493922T1 (sl) * 2009-10-26 2017-06-30 F. Hoffmann-La Roche Ag Postopek za proizvodnjo glikoziliranega imunoglobulina
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
KR101895398B1 (ko) 2011-04-28 2018-10-25 삼성전자 주식회사 산화물 층의 형성 방법 및 이를 포함하는 반도체 소자의 제조 방법
CN104168913A (zh) * 2011-08-10 2014-11-26 法国化学与生物科技实验室 高半乳糖基化抗体
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
CN104011080B (zh) * 2011-12-22 2017-10-20 弗·哈夫曼-拉罗切有限公司 用于真核细胞的全长抗体展示系统及其用途
WO2013158273A1 (fr) 2012-04-20 2013-10-24 Abbvie Inc. Procédés de modulation de la distribution de variant de lysine c-terminal
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (fr) 2012-04-20 2013-10-24 Abbvie Inc. Procédés de purification de protéines pour réduire des espèces acides
US20140004131A1 (en) 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
EP3594230A1 (fr) 2013-02-13 2020-01-15 Laboratoire Français du Fractionnement et des Biotechnologies Anticorps anti-tnf alpha hautement galactosylés et leurs utilisations
US9701753B2 (en) 2013-03-11 2017-07-11 Genzyme Corporation Hyperglycosylated binding polypeptides
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
SG11201600067YA (en) * 2013-07-23 2016-02-26 Biocon Ltd Methods for controlling fucosylation levels in proteins
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
WO2015143091A1 (fr) 2014-03-19 2015-09-24 Genzyme Corporation Modification de la glyco-ingéniérie de fractions de ciblage spécifique à un site
CA3205824A1 (fr) 2014-10-09 2016-04-14 Genzyme Corporation Conjugues medicament-anticorps modifies par glycane
SG11201708804WA (en) 2015-05-07 2017-11-29 Agenus Inc Anti-ox40 antibodies and methods of use thereof
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
US20170073399A1 (en) * 2015-09-11 2017-03-16 Alexion Pharmaceuticals, Inc. Recombinant glycosylated eculizumab and eculizumab variants
CN109153716A (zh) 2016-01-06 2019-01-04 安口生物公司 调节单克隆抗体组合物中的非岩藻糖基化物类
CN109563161A (zh) 2016-02-03 2019-04-02 安口生物公司 用于提高抗体稳定性的缓冲制剂
US20190270821A1 (en) 2016-09-13 2019-09-05 Humanigen, Inc. Epha3 antibodies for the treatment of pulmonary fibrosis
CN110300599B (zh) 2016-12-07 2024-07-02 艾吉纳斯公司 抗体和其使用方法
CN111108123A (zh) 2017-05-29 2020-05-05 加马玛布斯制药公司 癌症相关的免疫抑制抑制剂
US11306144B2 (en) 2017-08-25 2022-04-19 Five Prime Therapeutics, Inc. B7-H4 antibodies and methods of use thereof
BR112020016986A2 (pt) 2018-02-21 2021-03-02 Five Prime Therapeutics, Inc. formulações de anticorpo contra b7-h4
CA3091161A1 (fr) 2018-02-21 2019-08-29 Five Prime Therapeutics, Inc. Schemas posologiques d'anticorps b7-h4
KR20200144094A (ko) 2018-03-02 2020-12-28 파이브 프라임 테라퓨틱스, 인크. B7-h4 항체 및 이의 사용 방법
US12325737B2 (en) 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
IL307155B2 (en) 2018-05-01 2025-11-01 Amgen Inc Antibodies with modulated glycan profiles
KR20210076025A (ko) 2018-10-15 2021-06-23 파이브 프라임 테라퓨틱스, 인크. 암 병용 요법
CN120192414A (zh) 2019-04-03 2025-06-24 建新公司 具有降低的断裂的抗αβTCR结合多肽
WO2020219868A1 (fr) 2019-04-24 2020-10-29 Regenxbio Inc. Agents thérapeutiques à base d'anticorps entièrement humains à modification post-traductionnelle
HRP20240182T1 (hr) 2020-03-26 2024-04-26 Vanderbilt University Ljudska monoklonska protutijela za teški akutni respiratorni sindrom koronavirusa 2 (sars-cov-2)
CN113512116B (zh) 2020-04-10 2022-09-20 苏州普乐康医药科技有限公司 一种抗igf-1r抗体及其应用
TW202208423A (zh) 2020-05-17 2022-03-01 英商阿斯特捷利康英國股份有限公司 Ｓａｒｓ－ｃｏｖ－２抗體及其選擇和使用方法
US20220041694A1 (en) 2020-08-10 2022-02-10 Astrazeneca Uk Limited Sars-cov-2 antibodies for treatment and prevention of covid-19
WO2022060916A1 (fr) 2020-09-15 2022-03-24 Regenxbio Inc. Anticorps vectorisés pour thérapie antivirale
WO2022060915A1 (fr) 2020-09-15 2022-03-24 Regenxbio Inc. Lanadelumab vectorisé et administration de celui-ci
CA3195967A1 (fr) 2020-10-28 2022-05-05 Xu Wang Anticorps anti-tnf-? vectorises pour indications oculaires
WO2022094157A1 (fr) 2020-10-28 2022-05-05 Regenxbio Inc. Anticorps vectorisés anti-cgrp et anti-récepteur de cgrp et leur administration
US20230390418A1 (en) 2020-10-29 2023-12-07 Regenxbio Inc. Vectorized factor xii antibodies and administration thereof
AU2021369833A1 (en) 2020-10-29 2023-06-08 Regenxbio Inc. Vectorized tnf-alpha antagonists for ocular indications
TW202241943A (zh) 2020-12-29 2022-11-01 美商銳進科斯生物股份有限公司 Tau特異性抗體基因療法組合物、方法及其用途
TW202342095A (zh) 2021-11-05 2023-11-01 英商阿斯特捷利康英國股份有限公司 用於治療和預防ｃｏｖｉｄ—１９之組成物
TW202342510A (zh) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
US20250289871A1 (en) 2022-04-29 2025-09-18 Astrazeneca Uk Limited Sars-cov-2 antibodies and methods of using the same
US20260034246A1 (en) 2022-05-03 2026-02-05 Regenxbio Inc. Vectorized anti-complement antibodies and complement agents and administration thereof
WO2023215807A1 (fr) 2022-05-03 2023-11-09 Regenxbio Inc. INHIBITEURS VECTORISÉS ANTI-TNF-α POUR INDICATIONS OCULAIRES

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005330A1 (fr) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Procede pour ameliorer la stabilite des glycoproteines
US5202238A (en) * 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) * 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5650508A (en) * 1991-12-27 1997-07-22 Georgia Tech Research Corporation Peptide ketoamides
DK0752248T3 (da) 1992-11-13 2000-11-13 Idec Pharma Corp Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
US6025145A (en) 1993-11-23 2000-02-15 Genentech, Inc. Kinase receptor activation assay
EP0852951A1 (fr) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Compositions pharmaceutiques stables, lyophilisées d'anticorps monoclonaux ou polyclonaux
ATE375365T1 (de) 1998-04-02 2007-10-15 Genentech Inc Antikörper varianten und fragmente davon
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
CA2704600C (fr) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. Methode de production d'anticorps avec activite adcc accrue
EP1212422B1 (fr) 1999-08-24 2007-02-21 Medarex, Inc. Anticorps contre l'antigene ctla-4 humain et utilisation
US20030165502A1 (en) * 2000-06-13 2003-09-04 City Of Hope Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth
ME00502B (me) 2001-01-05 2011-10-10 Amgen Fremont Inc Antitjela za insulinu sličan receptor faktora i rasta
SI1461359T1 (sl) 2002-01-18 2007-06-30 Pf Medicament Nova anti IGF-IR protitelesa in njihova uporaba
US7553485B2 (en) * 2002-01-18 2009-06-30 Pierre Fabre Medicament Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
US7241444B2 (en) * 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
EP1506286B1 (fr) 2002-05-24 2014-03-19 Merck Sharp & Dohme Corp. Anticorps anti-igfr humain neutralisant
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
US6819599B2 (en) * 2002-08-01 2004-11-16 Micron Technology, Inc. Programmable DQS preamble
US20040209930A1 (en) 2002-10-02 2004-10-21 Carboni Joan M. Synergistic methods and compositions for treating cancer
EP2248892B1 (fr) 2003-01-22 2015-04-22 Roche Glycart AG Constructions à fusion et utilisation associée pour produire des anticorps avec un récepteur FC liant l'affinité et fonction effectrice
PL378812A1 (pl) 2003-02-13 2006-05-29 Pfizer Products Inc. Zastosowania przeciwciał przeciw receptorowi insulinopodobnego czynnika wzrostowego I
JP2007528201A (ja) 2003-03-14 2007-10-11 ファルマシア・コーポレーション 癌治療のためのｉｇｆ−ｉ受容体に対する抗体
ES2383014T3 (es) 2003-04-02 2012-06-15 F. Hoffmann-La Roche Ag Anticuerpos contra el factor I de crecimiento similar a insulina y usos de los mismos
CA2524305C (fr) 2003-05-01 2015-12-08 Imclone Systems Incorporated Anticorps entierement humains diriges contre le recepteur du facteur de croissance 1 de type insuline
AR046071A1 (es) 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
DE602004029581D1 (de) 2003-08-13 2010-11-25 Pfizer Prod Inc Modifizierte humane igf-1r antikörper
AR045614A1 (es) 2003-09-10 2005-11-02 Hoffmann La Roche Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos
FR2861080B1 (fr) † 2003-10-20 2006-02-17 Lab Francais Du Fractionnement Anticorps presentant un taux de fucose et de galactose optimise
WO2005058967A2 (fr) 2003-12-16 2005-06-30 Pierre Fabre Medicament Nouveau recepteur hybride anti-insuline/igf-i ou recepteur hybride anti-insuline/igf-i et anticorps igf-ir et applications
WO2005082415A2 (fr) 2004-02-25 2005-09-09 Dana Farber Cancer Institute, Inc. Procedes d'inhibition de croissance de cellules tumorales
AU2005247303A1 (en) † 2004-04-16 2005-12-08 Genentech, Inc. Treatment of polychondritis and mononeuritis multiplex with anti-CD20 antibodies
KR20080019733A (ko) 2004-07-16 2008-03-04 화이자 프로덕츠 인코포레이티드 항-아이지에프-1알 항체를 사용하는 비-혈액학적악성종양에 대한 조합 치료
FR2873699B1 (fr) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
US7432359B2 (en) * 2004-09-06 2008-10-07 Kirin Pharma Kabushiki Kaisha Anti-A33 antibody
KR20140133958A (ko) 2005-10-21 2014-11-20 엘에프비 유에스에이, 인크. 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법
EP1948691A1 (fr) 2005-11-17 2008-07-30 Millennium Pharmaceuticals, Inc. IMMUNOGLOBULINE HUMANISEE REACTIVE AVEC L INTEGRINE a4ß7
AU2007245164A1 (en) * 2006-03-28 2007-11-08 Biogen Idec Ma Inc. Anti-IGF-IR antibodies and uses thereof
US7846724B2 (en) * 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
US20080014203A1 (en) 2006-04-11 2008-01-17 Silke Hansen Antibodies against insulin-like growth factor I receptor and uses thereof
MX368259B (es) 2013-04-16 2019-09-25 Genentech Inc Variantes de pertuzumab y su evaluacion.

Also Published As

Publication number Publication date
CN103864923A (zh) 2014-06-18
IL301499B1 (en) 2025-08-01
US11673958B2 (en) 2023-06-13
KR101275452B1 (ko) 2013-06-17
JP5078990B2 (ja) 2012-11-21
NZ571277A (en) 2011-12-22
US12559561B2 (en) 2026-02-24
US8703919B2 (en) 2014-04-22
AU2007236198A1 (en) 2007-10-18
IL194165A0 (en) 2011-08-01
ES2395136T3 (es) 2013-02-08
CA2849203C (fr) 2020-12-15
US20100322927A1 (en) 2010-12-23
BRPI0709960A2 (pt) 2011-08-02
KR101256257B1 (ko) 2013-04-22
EP2248831A1 (fr) 2010-11-10
CA3128738A1 (fr) 2007-10-18
WO2007115813A1 (fr) 2007-10-18
CA2647288A1 (fr) 2007-10-18
US7846724B2 (en) 2010-12-07
JP2012254996A (ja) 2012-12-27
US20070248600A1 (en) 2007-10-25
US20140193404A1 (en) 2014-07-10
EP2007809B1 (fr) 2012-09-12
IL269201A (en) 2019-11-28
US20230227564A1 (en) 2023-07-20
AR060386A1 (es) 2008-06-11
NO20083948L (no) 2008-11-06
US20120128664A1 (en) 2012-05-24
CR10300A (es) 2008-10-29
EP2007809A1 (fr) 2008-12-31
RU2008144293A (ru) 2010-05-20
BRPI0709960B8 (pt) 2021-05-25
ES2395136T5 (es) 2019-02-12
ECSP088814A (es) 2008-11-27
IL301499B2 (en) 2025-12-01
EP2007809B2 (fr) 2018-09-12
AU2007236198B2 (en) 2012-11-08
MX2008012953A (es) 2008-10-15
KR20080106342A (ko) 2008-12-04
BRPI0709960B1 (pt) 2019-10-15
CA2647288C (fr) 2021-10-26
CA2849203A1 (fr) 2007-10-18
IL301499A (en) 2023-05-01
IL321119A (en) 2025-07-01
KR20120028397A (ko) 2012-03-22
IL233150A0 (en) 2014-07-31
JP2009533366A (ja) 2009-09-17

Similar Documents

Publication Publication Date Title
MA30383B1 (fr) Anticorps glycosyles
MA31066B1 (fr) Anticorps contre le recepteur du facteur de croissance i de type insuline et leurs utilisations
NO20084082L (no) Antistoffer mot insulin-like vekstfaktor 1 reseptorer og deres anvendelse
Radaev et al. Recognition of IgG by Fcγ receptor: the role of Fc glycosylation and the binding of peptide inhibitors
EA200970416A1 (ru) Полипептиды с усиленными противовоспалительными и сниженными цитотоксическими свойствами и способы, относящиеся к ним
PE20100251A1 (es) Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina
UA102667C2 (uk) Людське нейтралізуюче антитіло проти в7rp1
TNSN07398A1 (fr) Anticorps contre la p-cadherine
WO2008006554A3 (fr) Anticorps modifiés
WO2008057634A3 (fr) Polypeptides ayant des propriétés antiinflammatoires accrues et cytotoxiques réduites et procédés associés
WO2018056821A8 (fr) Molécules de liaison qui modulent une activité biologique exprimée par une cellule
WO2008097817A3 (fr) Complexes d'antigènes multivariables et d'un anticorps monoclonal humanisé cible
PE20081899A1 (es) Anticuerpos anti-ige
IL172321A (en) Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof
WO1998057994A3 (fr) Anticorps opsoniques, monoclonaux protecteurs, et chimeres specifiques a l'acide lipoteichoique des bacteries gram positif
ATE517922T1 (de) Stabilisierte einzel-domänen-antikörper in einer pharmazeutischen zusammensetzung ausgestaltet für inhalation
ATE442860T1 (de) Mikropartikel mit cd28-spezifischen monoklonalen antikoerpern
PE20080187A1 (es) Agonistas receptores de eritropoietina
WO2004046188A3 (fr) Anticorps anti-ras activee
Nimmerjahn et al. Sweet rules: linking glycosylation to antibody function
WO2006004950A3 (fr) Anticorps monoclonal 31.1 humanise utilise en tant qu'agent anticancereux
WO2009108168A3 (fr) Glycoconjugués de nanoparticules d’or permettant de générer une igg correspondant au glucide
TH96999A (th) แอนตี้บอดี้ที่ถูกไกลโคซิเลท
FR3138502B3 (fr) Dispositif lumineux pour véhicule comprenant un boîtier et une glace de fermeture
FR3146154B1 (fr) Elément de châssis pour la réalisation d’un espace de vie tel qu’une pergola et étrier de renfort pour un tel élément de châssis