BRPI0709960B8 - anticorpo monoclonal do tipo igg1 ou igg3 humana glicosilado, seu uso e método de produção e composição farmacêutica - Google Patents
anticorpo monoclonal do tipo igg1 ou igg3 humana glicosilado, seu uso e método de produção e composição farmacêuticaInfo
- Publication number
- BRPI0709960B8 BRPI0709960B8 BRPI0709960A BRPI0709960A BRPI0709960B8 BR PI0709960 B8 BRPI0709960 B8 BR PI0709960B8 BR PI0709960 A BRPI0709960 A BR PI0709960A BR PI0709960 A BRPI0709960 A BR PI0709960A BR PI0709960 B8 BRPI0709960 B8 BR PI0709960B8
- Authority
- BR
- Brazil
- Prior art keywords
- human igg1
- production
- pharmaceutical composition
- monoclonal antibody
- glycosylated human
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
anticorpos glicosilados. a presente invenção refere-se a um anticorpo do tipo igg1 ou lgg3 humana, sendo glicosilado com uma cadeia de açúcar em asn297, sendo o dito anticorpo distinguido pelo fato de que a quantidade de fucose na dita cadeia de açúcar é pelo menos 99%, e além disso, a quantidade de ngna é 1% ou menos e/ou a quantidade de alfa-1 ,3-galactose do terminal n é 1% ou menos, e os usos dos mesmos.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06007565 | 2006-04-11 | ||
| EP06007565.2 | 2006-04-11 | ||
| EP06016203 | 2006-08-03 | ||
| EP06016203.9 | 2006-08-03 | ||
| US06016203.9 | 2006-08-03 | ||
| PCT/EP2007/003164 WO2007115813A1 (en) | 2006-04-11 | 2007-04-10 | Glycosylated antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0709960A2 BRPI0709960A2 (pt) | 2011-08-02 |
| BRPI0709960B1 BRPI0709960B1 (pt) | 2019-10-15 |
| BRPI0709960B8 true BRPI0709960B8 (pt) | 2021-05-25 |
Family
ID=38039138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0709960A BRPI0709960B8 (pt) | 2006-04-11 | 2007-04-10 | anticorpo monoclonal do tipo igg1 ou igg3 humana glicosilado, seu uso e método de produção e composição farmacêutica |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US7846724B2 (pt) |
| EP (2) | EP2007809B2 (pt) |
| JP (2) | JP5078990B2 (pt) |
| KR (2) | KR101256257B1 (pt) |
| CN (1) | CN103864923A (pt) |
| AR (1) | AR060386A1 (pt) |
| AU (1) | AU2007236198B2 (pt) |
| BR (1) | BRPI0709960B8 (pt) |
| CA (3) | CA3128738A1 (pt) |
| CR (1) | CR10300A (pt) |
| EC (1) | ECSP088814A (pt) |
| ES (1) | ES2395136T5 (pt) |
| IL (5) | IL301499B2 (pt) |
| MA (1) | MA30383B1 (pt) |
| MX (1) | MX2008012953A (pt) |
| NO (1) | NO20083948L (pt) |
| NZ (1) | NZ571277A (pt) |
| RU (1) | RU2008144293A (pt) |
| WO (1) | WO2007115813A1 (pt) |
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| RU2342159C2 (ru) | 2004-07-16 | 2008-12-27 | Пфайзер Продактс Инк. | Комбинированная терапия негематологических злокачественных опухолей с использованием анти-igf-1r-антитела |
| FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| US7432359B2 (en) * | 2004-09-06 | 2008-10-07 | Kirin Pharma Kabushiki Kaisha | Anti-A33 antibody |
| ES2417147T3 (es) | 2005-10-21 | 2013-08-06 | Revo Biologics, Inc. | Anticuerpos con actividad de citotoxicidad celular dependiente de anticuerpos mejorada, métodos para su producción y uso |
| JP2009515552A (ja) | 2005-11-17 | 2009-04-16 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | α４β７インテグリン反応性ヒト化免疫グロブリン |
| US7612178B2 (en) * | 2006-03-28 | 2009-11-03 | Biogen Idec Ma Inc | Anti-IGF-1R antibodies and uses thereof |
| US20080014203A1 (en) * | 2006-04-11 | 2008-01-17 | Silke Hansen | Antibodies against insulin-like growth factor I receptor and uses thereof |
| US7846724B2 (en) * | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| AR095863A1 (es) | 2013-04-16 | 2015-11-18 | Genentech Inc | Variantes de pertuzumab, su evaluación, método de tratamiento, método de preparación y artículo de fabricación |
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