MA30500B1 - Imidazolones et triazolones d'aryle substitues comme inhibiteurs des recepteurs de vasopressine. - Google Patents
Imidazolones et triazolones d'aryle substitues comme inhibiteurs des recepteurs de vasopressine.Info
- Publication number
- MA30500B1 MA30500B1 MA31452A MA31452A MA30500B1 MA 30500 B1 MA30500 B1 MA 30500B1 MA 31452 A MA31452 A MA 31452A MA 31452 A MA31452 A MA 31452A MA 30500 B1 MA30500 B1 MA 30500B1
- Authority
- MA
- Morocco
- Prior art keywords
- docetaxel
- present
- injection
- water
- hpmc
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 8
- 229960003668 docetaxel Drugs 0.000 abstract 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 6
- 239000002202 Polyethylene glycol Substances 0.000 abstract 4
- 238000002347 injection Methods 0.000 abstract 4
- 239000007924 injection Substances 0.000 abstract 4
- 229920001223 polyethylene glycol Polymers 0.000 abstract 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 229920003169 water-soluble polymer Polymers 0.000 abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000003860 storage Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Divulgation de l'invention Problème technique Les présents inventeurs ont réalisé la présente invention en élaborant une composition pharmaceutique pour injection, contenant du docétaxel, qui présente une solubilité et une stabilité améliorées par comparaison avec celles des agents classiques, en combinant du docétaxel hydro-insoluble avec de l'hydroxypropyl-ß-cyclodextrine et un polymère hydrosoluble tel que l'hydroxypropyl méthylcellulose (HPMC), le polyéthylène glycol (PEG) ou la polyvinylpyrrolidone (PVP) dans de l'eau distillée pour améliorer la stabilité du docétaxel dans une solution aqueuse. Par conséquent, il est un objectif de la présente invention de proposer une composition pharmaceutique stable pour injection contenant du docétaxel et un procédé de sa préparation. Solution technique La présente invention se rapporte à une composition pharmaceutique pour injection contenant du docétaxel et présentant une stabilité au stockage supérieure comprenant du docétaxel, de la cyclodextrine et un polymère hydrosoluble tel que l'hydroxypropyl méthylcellulose (HPMC), le polyéthylène glycol (PEG) ou la polyvinylpyrrolidone (PVP). La présente invention concerne également un procédé de préparation d'une composition pharmaceutique pour injection contenant du docétaxel et présentant une stabilité au stockage supérieure, consistant à: 1) mélanger et dissoudre du docétaxel avec de la cyclodextrine et un polymère hydrosoluble choisi à partir d'hydroxypropyl méthylcellulose (HPMC),
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006024024A DE102006024024A1 (de) | 2006-05-23 | 2006-05-23 | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30500B1 true MA30500B1 (fr) | 2009-06-01 |
Family
ID=38353593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31452A MA30500B1 (fr) | 2006-05-23 | 2008-12-05 | Imidazolones et triazolones d'aryle substitues comme inhibiteurs des recepteurs de vasopressine. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8084481B2 (fr) |
| EP (1) | EP2027096B8 (fr) |
| JP (1) | JP5247684B2 (fr) |
| KR (1) | KR101426574B1 (fr) |
| CN (1) | CN101495458B (fr) |
| AR (1) | AR061114A1 (fr) |
| AU (1) | AU2007253572B9 (fr) |
| BR (1) | BRPI0711975A2 (fr) |
| CA (1) | CA2652834C (fr) |
| DE (1) | DE102006024024A1 (fr) |
| DK (1) | DK2027096T3 (fr) |
| DO (1) | DOP2007000102A (fr) |
| EC (1) | ECSP088904A (fr) |
| ES (1) | ES2385606T3 (fr) |
| GT (1) | GT200800250A (fr) |
| HN (1) | HN2008001720A (fr) |
| IL (1) | IL195142A (fr) |
| MA (1) | MA30500B1 (fr) |
| MX (1) | MX2008014797A (fr) |
| PE (1) | PE20080706A1 (fr) |
| PL (1) | PL2027096T3 (fr) |
| PT (1) | PT2027096E (fr) |
| RU (1) | RU2460724C2 (fr) |
| SV (1) | SV2009003098A (fr) |
| TN (1) | TNSN08443A1 (fr) |
| TW (1) | TW200817336A (fr) |
| UY (1) | UY30364A1 (fr) |
| WO (1) | WO2007134862A1 (fr) |
| ZA (1) | ZA200809860B (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006024024A1 (de) * | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| EA201170549A1 (ru) * | 2008-10-10 | 2012-01-30 | Янссен Фармацевтика Нв | Комбинированная терапия с использованием блокаторов рецепторов ангиотензина и антагонистов рецепторов вазопрессина |
| DE102008060967A1 (de) * | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| DE102009013642A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylalaninderivate und deren Verwendung |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| DE102009028929A1 (de) * | 2009-08-27 | 2011-07-07 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Heterocyclisch-substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| ES2635340T3 (es) * | 2010-02-27 | 2017-10-03 | Bayer Intellectual Property Gmbh | Ariltriazolonas ligadas a bis-arilo y su uso |
| EP4137137A1 (fr) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Inhibiteurs et satiogènes de recyclage d'acide biliaire pour le traitement du diabète, de l'obésité et d'états gastro-intestinaux inflammatoires |
| DE102010040187A1 (de) * | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
| DE102010040924A1 (de) * | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
| HRP20150462T1 (hr) * | 2010-10-01 | 2015-07-17 | Taisho Pharmaceutical Co., Ltd | Derivat 1,2,4-triazolona |
| CN102260154A (zh) * | 2011-06-10 | 2011-11-30 | 南通职业大学 | 一种医药中间体α-溴代对氯苯丙酮的制备方法 |
| CN102875499B (zh) * | 2011-07-12 | 2015-08-19 | 天津药明康德新药开发有限公司 | 3-氨甲基氧杂环丁烷及其有机酸盐的制备方法 |
| AR087342A1 (es) * | 2011-07-29 | 2014-03-19 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y sus usos |
| SI2772482T1 (sl) * | 2011-10-27 | 2016-06-30 | Taisho Pharmaceutical Co., Ltd. | Derivat azola |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| EA038594B1 (ru) | 2011-10-28 | 2021-09-21 | Шайр Хьюман Дженетик Терапис, Инк. | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
| KR20160002773A (ko) | 2013-03-15 | 2016-01-08 | 루메나 파마수티컬즈, 인코포레이티드 | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| JP6387669B2 (ja) * | 2013-04-26 | 2018-09-12 | 大正製薬株式会社 | アゾール誘導体を含有する医薬 |
| WO2016010610A2 (fr) * | 2014-07-18 | 2016-01-21 | Ohio University | Compositions d'imidazole et de thiazole permettant de modifier la signalisation biologique |
| US20170313665A1 (en) | 2014-11-03 | 2017-11-02 | Bayer Pharma Aktiengesellschaft | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof |
| GB201504763D0 (en) * | 2015-03-20 | 2015-05-06 | Mironid Ltd | Compounds and uses |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| WO2017191117A1 (fr) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Antagonistes du récepteur v1a destinés à une utilisation dans le traitement de maladies rénales |
| EP3452457B1 (fr) * | 2016-05-03 | 2020-03-18 | Bayer Pharma Aktiengesellschaft | Dérivés de phényltriazole à substitution oxoalkyle et utilisations associées |
| WO2019141575A1 (fr) | 2018-01-16 | 2019-07-25 | Bayer Aktiengesellschaft | Assistance dans le cadre du traitement de l'insuffisance cardiaque |
| EP4424363B1 (fr) | 2019-02-12 | 2026-04-29 | Mirum Pharmaceuticals, Inc. | Procédés pour augmenter la croissance chez des sujets pédiatriques présentant une maladie hépatique cholestatique |
| WO2021127459A1 (fr) * | 2019-12-20 | 2021-06-24 | Blackthorn Therapeutics, Inc. | Modulateurs du récepteur gpr139 |
| US12569481B2 (en) | 2020-06-12 | 2026-03-10 | Vanderbilt University | Methods of treatment for gastrointestinal motility disorders |
| US20250000093A1 (en) | 2021-09-20 | 2025-01-02 | Basf Se | Heterocyclic compounds for the control of invertebrate pests |
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| DE19929348A1 (de) | 1999-06-26 | 2000-12-28 | Bayer Ag | Verfahren zur Herstellung von 2-Heterocyclylmethyl-benzoesäurederivaten |
| US6531142B1 (en) * | 1999-08-18 | 2003-03-11 | The Procter & Gamble Company | Stable, electrostatically sprayable topical compositions |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| WO2002066447A1 (fr) | 2001-02-21 | 2002-08-29 | Ono Pharmaceutical Co., Ltd. | Derives de 4h-1,2,4-triazole-3(2h)-thione tenant lieu d'inhibiteurs de sphingomyelinase |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| US20040071757A1 (en) * | 2001-11-20 | 2004-04-15 | David Rolf | Inhalation antiviral patch |
| EP1606264B1 (fr) * | 2003-03-14 | 2012-05-02 | Merck Sharp & Dohme Corp. | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
| KR20060066141A (ko) | 2003-06-27 | 2006-06-15 | 버글린 코퍼레이션 오브 워싱턴 | 사과 및 연한 코아를 가지거나 피트를 가진 다른 과일들을작은 응력을 가지고 정확하게 코아제거하고슬라이스절단하기 위한 기계 |
| CA2771944A1 (fr) | 2003-07-16 | 2005-01-27 | Teva Women's Health, Inc. | Procedes de traitement hormonal utilisant des posologies contraceptives avec administration continue d'oestrogenes |
| WO2005097112A2 (fr) | 2004-03-08 | 2005-10-20 | Wyeth | Modulateurs de canaux ioniques |
| JP2007527909A (ja) | 2004-03-08 | 2007-10-04 | ワイス | イオンチャンネルモジュレーター |
| EP1722784A4 (fr) | 2004-03-08 | 2009-08-12 | Wyeth Corp | Modulateurs de canal ionique |
| US20070225333A1 (en) | 2004-04-28 | 2007-09-27 | Bryans Justin S | 3-Heterocyclyl-4-Phenyl-Triazole Derivatives as Inhibitors of the Vasopressin Via Receptor |
| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2006117657A1 (fr) | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | Derives de triazolone utilises comme agents anti-inflammatoires |
| DE102006024024A1 (de) * | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| US20080095863A1 (en) * | 2006-10-24 | 2008-04-24 | Alcon Manufacturing Ltd. | 2-pyrrolidone derivatives for preservation of ophthalmic, otic and nasal compositions |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
-
2006
- 2006-05-23 DE DE102006024024A patent/DE102006024024A1/de not_active Withdrawn
-
2007
- 2007-05-21 US US12/301,616 patent/US8084481B2/en not_active Expired - Fee Related
- 2007-05-21 MX MX2008014797A patent/MX2008014797A/es active IP Right Grant
- 2007-05-21 AU AU2007253572A patent/AU2007253572B9/en not_active Ceased
- 2007-05-21 CN CN200780027634.4A patent/CN101495458B/zh not_active Expired - Fee Related
- 2007-05-21 PL PL07725514T patent/PL2027096T3/pl unknown
- 2007-05-21 JP JP2009511411A patent/JP5247684B2/ja not_active Expired - Fee Related
- 2007-05-21 KR KR1020087031086A patent/KR101426574B1/ko not_active Expired - Fee Related
- 2007-05-21 EP EP07725514A patent/EP2027096B8/fr not_active Not-in-force
- 2007-05-21 DK DK07725514.9T patent/DK2027096T3/da active
- 2007-05-21 BR BRPI0711975-5A patent/BRPI0711975A2/pt not_active IP Right Cessation
- 2007-05-21 RU RU2008150598/04A patent/RU2460724C2/ru not_active IP Right Cessation
- 2007-05-21 WO PCT/EP2007/004615 patent/WO2007134862A1/fr not_active Ceased
- 2007-05-21 CA CA2652834A patent/CA2652834C/fr not_active Expired - Fee Related
- 2007-05-22 PE PE2007000627A patent/PE20080706A1/es not_active Application Discontinuation
- 2007-05-22 TW TW096118061A patent/TW200817336A/zh unknown
- 2007-05-23 ES ES07725514T patent/ES2385606T3/es active Active
- 2007-05-23 AR ARP070102236A patent/AR061114A1/es not_active Application Discontinuation
- 2007-05-23 DO DO2007000102A patent/DOP2007000102A/es unknown
- 2007-05-23 PT PT07725514T patent/PT2027096E/pt unknown
- 2007-05-24 UY UY30364A patent/UY30364A1/es not_active Application Discontinuation
-
2008
- 2008-11-06 TN TNP2008000443A patent/TNSN08443A1/en unknown
- 2008-11-06 IL IL195142A patent/IL195142A/en not_active IP Right Cessation
- 2008-11-19 ZA ZA2008/09860A patent/ZA200809860B/en unknown
- 2008-11-20 SV SV2008003098A patent/SV2009003098A/es not_active Application Discontinuation
- 2008-11-20 GT GT200800250A patent/GT200800250A/es unknown
- 2008-11-21 EC EC2008008904A patent/ECSP088904A/es unknown
- 2008-11-21 HN HN2008001720A patent/HN2008001720A/es unknown
- 2008-12-05 MA MA31452A patent/MA30500B1/fr unknown
-
2011
- 2011-12-26 US US13/337,216 patent/US20130005704A1/en not_active Abandoned
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