MA30967B1 - Sels et formes cristallines de 2-methyl-2-methyl-2-[4-(3-methyl-2-oxo-8-quinolein-3-yl-2,3-dihydro-imidazo[4,5-c]quinolein-1-yl) - phenyl]-propionitrile. - Google Patents

Sels et formes cristallines de 2-methyl-2-methyl-2-[4-(3-methyl-2-oxo-8-quinolein-3-yl-2,3-dihydro-imidazo[4,5-c]quinolein-1-yl) - phenyl]-propionitrile.

Info

Publication number
MA30967B1
MA30967B1 MA31947A MA31947A MA30967B1 MA 30967 B1 MA30967 B1 MA 30967B1 MA 31947 A MA31947 A MA 31947A MA 31947 A MA31947 A MA 31947A MA 30967 B1 MA30967 B1 MA 30967B1
Authority
MA
Morocco
Prior art keywords
methyl
propionitrile
imidazo
quinoline
dihydro
Prior art date
Application number
MA31947A
Other languages
English (en)
Inventor
Frank Stowasser
Markus Baenziger
Sudhakar Devidasrao Garad
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39345299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30967(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30967B1 publication Critical patent/MA30967B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE DES FORMES CRISTALLINES PARTICULIÈRES DE 2-MÉTHYL-2-[4-(3-MÉTHYL-2-OXO-8-QUINOLÉIN-3-YL-2,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLÉIN-1-YL)- PHÉNYL]-PROPIONITRILE, LEURS HYDRATES ET SOLVATES, LEURS SELS ET HYDRATES ET SOLVATES DE SES SELS, CERTAINS PROCÉDÉS POUR LEUR PRÉPARATION, LES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES FORMES CRISTALLINES, ET LEUR UTILISATION DANS DES PROCÉDÉS DIAGNOSTIQUES OU, DE PRÉFÉRENCE, POUR LE TRAITEMENT THÉRAPEUTIQUE D'ANIMAUX À SANG CHAUD, SPÉCIALEMENT DES ÊTRES HUMAINS, ET LEUR UTILISATION COMME INTERMÉDIAIRE OU POUR LA PRÉPARATION DE PRÉPARATIONS PHARMACEUTIQUES POUR UNE UTILISATION DANS DES PROCÉDÉS DIAGNOSTIQUES OU, DE PRÉFÉRENCE, POUR LE TRAITEMENT THÉRAPEUTIQUE D'ANIMAUX À SANG CHAUD, SPÉCIALEMENT DES ÊTRES HUMAINS.
MA31947A 2006-11-20 2009-06-03 Sels et formes cristallines de 2-methyl-2-methyl-2-[4-(3-methyl-2-oxo-8-quinolein-3-yl-2,3-dihydro-imidazo[4,5-c]quinolein-1-yl) - phenyl]-propionitrile. MA30967B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86648306P 2006-11-20 2006-11-20

Publications (1)

Publication Number Publication Date
MA30967B1 true MA30967B1 (fr) 2009-12-01

Family

ID=39345299

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31947A MA30967B1 (fr) 2006-11-20 2009-06-03 Sels et formes cristallines de 2-methyl-2-methyl-2-[4-(3-methyl-2-oxo-8-quinolein-3-yl-2,3-dihydro-imidazo[4,5-c]quinolein-1-yl) - phenyl]-propionitrile.

Country Status (35)

Country Link
US (2) US8436177B2 (fr)
EP (2) EP2094700B1 (fr)
JP (2) JP5562033B2 (fr)
KR (3) KR20140091718A (fr)
CN (5) CN109970735A (fr)
AR (1) AR064256A1 (fr)
AU (1) AU2007323820B2 (fr)
BR (1) BRPI0719112A2 (fr)
CA (1) CA2669199C (fr)
CL (1) CL2007003316A1 (fr)
CO (1) CO6382134A2 (fr)
CR (1) CR10757A (fr)
DO (1) DOP2009000116A (fr)
EA (1) EA015677B1 (fr)
EC (1) ECSP099340A (fr)
GE (1) GEP20125436B (fr)
GT (1) GT200900133A (fr)
HR (1) HRP20140627T1 (fr)
IL (2) IL198467A (fr)
JO (1) JO2903B1 (fr)
MA (1) MA30967B1 (fr)
MX (1) MX2009005360A (fr)
MY (1) MY150216A (fr)
NI (1) NI200900091A (fr)
NO (1) NO20092227L (fr)
NZ (1) NZ576357A (fr)
PE (2) PE20081780A1 (fr)
PH (1) PH12013502100A1 (fr)
RS (1) RS53335B (fr)
SM (1) SMP200900041B (fr)
TN (1) TN2009000191A1 (fr)
TW (2) TW201402567A (fr)
UA (1) UA98473C2 (fr)
UY (1) UY30728A1 (fr)
WO (1) WO2008064093A2 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0906473A8 (pt) 2008-01-04 2016-02-10 Intellikine Inc Certas entidades químicas, composições e métodos
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2474323A3 (fr) * 2008-03-26 2012-10-10 Novartis AG Dérivés d'imidazoquinoline et de pyrimidine en tant que modulateurs puissants de processus angiogènes à commande VEGF
WO2010036380A1 (fr) 2008-09-26 2010-04-01 Intellikine, Inc. Inhibiteurs hétérocycliques de kinases
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
MA33332B1 (fr) 2009-06-04 2012-06-01 Novartis Ag Dérivés de la 1h-imidazo[4,5-c]quinolinone
BR112012019459A2 (pt) 2010-02-03 2017-10-17 Signal Pharm Llc identificação de mutação de lkb1 como um biomarcador preditivo para sensibilidade para inibidores de tor quinase.
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ， インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
DE102010035744A1 (de) * 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
WO2012064973A2 (fr) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et utilisations de ceux-ci
EP3238722B1 (fr) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Formes solides d'isoquinolinones
EP2734520B1 (fr) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PE20141371A1 (es) 2011-08-29 2014-10-13 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos
CA2848065A1 (fr) * 2011-09-30 2013-04-04 Dana-Farber Cancer Institute, Inc. Procede de traitement du carcinome mucoepidermoide
CN103467482B (zh) 2012-04-10 2017-05-10 上海璎黎药业有限公司 稠合嘧啶类化合物，其制备方法，中间体，组合物和应用
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9913844B2 (en) * 2013-03-21 2018-03-13 Novartis Ag Combination therapy
HK1221168A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法
JP6382946B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
WO2014172425A1 (fr) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Traitement du cancer par des dihydropyrazino-pyrazines
WO2014172436A1 (fr) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Polythérapie comprenant un inhibiteur de kinase tor et un composé de quinazolinone substitué en 5 pour le traitement du cancer
EP3549940A1 (fr) 2013-04-17 2019-10-09 Signal Pharmaceuticals, LLC Formulations pharmaceutiques associés à 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
MY189663A (en) 2013-04-17 2022-02-23 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
CA2908742C (fr) 2013-04-17 2021-06-01 Signal Pharmaceuticals, Llc Polytherapie comprenant un inhibiteur de la kinase tor et un analogue de la cytidine pour le traitement du cancer
CN107474051B (zh) 2013-05-29 2020-10-30 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
JP6441910B2 (ja) 2013-09-30 2018-12-19 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合ピリミジン化合物、中間体、その調製方法、組成物及び使用
WO2015051241A1 (fr) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
EP3964507A1 (fr) 2013-10-04 2022-03-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
CN106831722B (zh) 2013-10-16 2019-08-30 上海璎黎药业有限公司 稠合杂环化合物、其制备方法、药物组合物和用途
CN106456628A (zh) 2014-03-19 2017-02-22 无限药品股份有限公司 用于治疗PI3K‑γ介导的障碍的杂环化合物
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
WO2015160975A2 (fr) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Polythérapies
WO2015160880A1 (fr) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Formes solides comprenant 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one, et co-formateur, compositions et procédés d'utilisation de ces dernières
WO2016054491A1 (fr) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
US10576076B2 (en) 2015-05-20 2020-03-03 Novartis Ag Pharmaceutical combination of everolimus with dactolisib
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017161116A1 (fr) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3474856B1 (fr) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Therapies combinées
JP2020500930A (ja) 2016-11-23 2020-01-16 ノバルティス アーゲー エベロリムス、ダクトリシブまたは両方で免疫応答を増強する方法
IL271491B2 (en) 2017-06-22 2023-09-01 Celgene Corp Treatment of carcinoma of the liver characterized by hepatitis b virus infection
WO2019157516A1 (fr) 2018-02-12 2019-08-15 resTORbio, Inc. Polythérapies
CN111187181B (zh) * 2019-11-22 2023-05-05 吉林大学 一种2-(4-氨基苯基)-2-甲基丙腈化合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929624A (en) 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5268376A (en) 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
JP2000119271A (ja) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
AR046845A1 (es) * 2003-11-21 2005-12-28 Novartis Ag Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas
RU2006121646A (ru) * 2003-11-21 2008-01-10 Новартис АГ (CH) Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы
EP1769092A4 (fr) 2004-06-29 2008-08-06 Europ Nickel Plc Lixiviation amelioree de metaux de base
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
KR20090080530A (ko) 2009-07-24
JP2010510240A (ja) 2010-04-02
EP2094700B1 (fr) 2014-04-02
TN2009000191A1 (en) 2010-10-18
KR20140129396A (ko) 2014-11-06
NI200900091A (es) 2010-02-17
IL198467A0 (en) 2010-02-17
NZ576357A (en) 2011-01-28
CN102993202A (zh) 2013-03-27
KR20140091718A (ko) 2014-07-22
PH12013502100A1 (en) 2015-09-21
NO20092227L (no) 2009-08-17
CO6382134A2 (es) 2012-02-15
AU2007323820A1 (en) 2008-05-29
RS53335B (sr) 2014-10-31
TW200827356A (en) 2008-07-01
IL198467A (en) 2014-11-30
EP2364981A1 (fr) 2011-09-14
JP5562033B2 (ja) 2014-07-30
MY150216A (en) 2013-12-13
CN101541793A (zh) 2009-09-23
AR064256A1 (es) 2009-03-25
EA015677B1 (ru) 2011-10-31
JP2013173788A (ja) 2013-09-05
TW201402567A (zh) 2014-01-16
WO2008064093A2 (fr) 2008-05-29
UA98473C2 (ru) 2012-05-25
WO2008064093A3 (fr) 2008-08-14
US20100168153A1 (en) 2010-07-01
UY30728A1 (es) 2008-07-03
IL219877A0 (en) 2012-06-28
DOP2009000116A (es) 2009-05-31
PE20120083A1 (es) 2012-03-01
SMP200900041B (it) 2009-09-07
CN106045993A (zh) 2016-10-26
CR10757A (es) 2009-06-11
HRP20140627T1 (hr) 2014-09-26
TWI417292B (zh) 2013-12-01
GT200900133A (es) 2010-05-21
CA2669199C (fr) 2015-12-29
CN102336752A (zh) 2012-02-01
SMAP200900041A (it) 2009-07-14
PE20081780A1 (es) 2009-01-01
EA200900638A1 (ru) 2009-12-30
US8436177B2 (en) 2013-05-07
JO2903B1 (en) 2015-09-15
CN109970735A (zh) 2019-07-05
AU2007323820B2 (en) 2012-02-23
EP2094700A2 (fr) 2009-09-02
CA2669199A1 (fr) 2008-05-29
CL2007003316A1 (es) 2008-06-27
GEP20125436B (en) 2012-03-26
ECSP099340A (es) 2009-06-30
HK1132739A1 (en) 2010-03-05
MX2009005360A (es) 2009-06-05
US20130289064A1 (en) 2013-10-31
BRPI0719112A2 (pt) 2013-12-10

Similar Documents

Publication Publication Date Title
EA200900638A1 (ru) СОЛИ И КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 2-МЕТИЛ-2-[4-(3-МЕТИЛ-2-ОКСО-8-ХИНОЛИН-3-ИЛ-2,3-ДИГИДРОИМИДАЗО[4,5-c]ХИНОЛИН-1-ИЛ)ФЕНИЛ]ПРОПИОНИТРИЛА
MA32230B1 (fr) Formes cristallines et deux formes solvatées de lactates de 4-amino-5-fluoro -3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one
EA201101243A1 (ru) 3h-имидазо[4,5-c]пиридин-6-карбоксамиды в качестве противовоспалительных средств
MA33332B1 (fr) Dérivés de la 1h-imidazo[4,5-c]quinolinone
MX2009005279A (es) Derivados de n-(metil)-1h-pirazol-3-amina, n-(metil)-piridin-2-ami na y n-(metil)-tiazol-2-amina para el tratamiento de enfermedades asociadas con proteinas amiloides o tipo amiloide, tal como por ejemplo alzheimer.
MA32226B1 (fr) Compositions et leurs procedes de preparation et d'utilisation
MA28935B1 (fr) Preparation et utilisation de derives de biphenyl-4-yl-carbonylamino-acide dans le traitement de l'obesite
BG106825A (en) Substituted oxazolidinones and their use in the field of blood coagulation
WO2005032471A3 (fr) Inhibiteurs de type benzylether et benzylamino de beta-secretase pour le traitement de la maladie d'alzheimer
GEP20105025B (en) Pharmaceutical compositions for treatent of atherosclerosis and related conditions and use thereof for treatment of these diseases
WO2005004802A3 (fr) Inhibiteurs de la beta-secretase a base de n-alkyle phenylcarboxamide pour le traitement de la maladie d'alzheimer
EP2210092A4 (fr) Compositions comprenant des sémaphorines pour le traitement de maladies associées à l'angiogenèse et leurs procédés de sélection
JP2021534129A5 (fr)
MA34655B1 (fr) Dérivés de 2,3- dihydroimidazo[1,2-c]quinazoléine substitués par un aminoalcool utiles pour traiter des troubles hyperprolifératifs et des maladies associées à l'angiogenèse
MX2008013836A (es) Derivados de 2-piridona para el tratamiento de enfermedades o condiciones en las cuales es benefica la inhibicion de la actividad de elastasa de neutrofilos.
TW200606162A (en) Pyrazolopyridine derivatives
EA200601212A1 (ru) Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
WO2005051914A8 (fr) Inhibiteurs de benzylether et benzylamino de beta-secretase pour traiter la maladie d'alzheimer
EP2651439A4 (fr) Compositions et procédés pour le traitement ou la prévention d'une infection par l'adénovirus 36 humain
ATE453646T1 (de) 3-substituierte n-(aryl- oder heteroaryl)pyrazoä1,5-aüpyrimidine als kinaseinhibitoren
NO20085271L (no) Muscarin reseptoragonister som er effektive i behandling av smerte, Alzheimers sykdom og schizofreni
MA46268A (fr) Dérivés de 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro-1h-isoindol-1-one et leur utilisation en tant qu'inhibiteurs doubles de phosphatidylinositol 3-kinase delta & gamma
NO20092539L (no) Antibakterielle kinolin-derivater
EA201492097A1 (ru) 5-амино[1,4]тиазины в качестве ингибиторов бета-секретазы 1
MA29950B1 (fr) Nouveau derive de la pleuromutiline et son utilisation