MA31554B1 - Indazoles à substitution amide utilises comme inhibiteurs de la poly(adp-ribose)polymérase (parp). - Google Patents

Indazoles à substitution amide utilises comme inhibiteurs de la poly(adp-ribose)polymérase (parp).

Info

Publication number
MA31554B1
MA31554B1 MA32111A MA32111A MA31554B1 MA 31554 B1 MA31554 B1 MA 31554B1 MA 32111 A MA32111 A MA 32111A MA 32111 A MA32111 A MA 32111A MA 31554 B1 MA31554 B1 MA 31554B1
Authority
MA
Morocco
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
MA32111A
Other languages
English (en)
Inventor
Carsten Schultz-Fademrecht
Philip Jones
Ontoria Jesus Maria Ontoria
Rita Scarpelli
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39246752&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31554(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0700432.8A external-priority patent/GB0700432D0/en
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of MA31554B1 publication Critical patent/MA31554B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSÉS REPRÉSENTÉS PAR LA FORMULE (I) ET DES SELS PHARMACEUTIQUEMENT ACCEPTABLES, DES STÉRÉOISOMÈRES OU DES TAUTOMÈRES DE CEUX-CI UTILISÉS COMME INHIBITEURS DE LA POLY (ADP-RIBOSE) POLYMÉRASE (PARP), ET DONC UTILES POUR TRAITER LE CANCER, LES MALADIES INFLAMMATOIRES, LES LÉSIONS DE REPERFUSION, LES ÉTATS ISCHÉMIQUES, LES ATTAQUES, LES INSUFFISANCES RÉNALES, LES MALADIES CARDIO-VASCULAIRES, LES MALADIES VASCULAIRES AUTRES QUE LES MALADIES CARDIO-VASCULAIRES, LE DIABÈTE, LES MALADIES NEURODÉGÉNÉRATIVES, LES INFECTIONS RÉTROVIRALES, LES LÉSIONS RÉTINIENNES OU LA SÉNESCENCE DE LA PEAU, ET LES LÉSIONS CUTANÉES INDUITES PAR LES U.V.; ET COMME CHIMIOSENSIBILISATEURS ET/OU RADIOSENSIBILISATEURS POUR TRAITER LE CANCER.
MA32111A 2007-01-10 2009-07-20 Indazoles à substitution amide utilises comme inhibiteurs de la poly(adp-ribose)polymérase (parp). MA31554B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02

Publications (1)

Publication Number Publication Date
MA31554B1 true MA31554B1 (fr) 2010-08-02

Family

ID=39246752

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32111A MA31554B1 (fr) 2007-01-10 2009-07-20 Indazoles à substitution amide utilises comme inhibiteurs de la poly(adp-ribose)polymérase (parp).

Country Status (31)

Country Link
US (1) US8071623B2 (fr)
EP (4) EP3536690A1 (fr)
JP (1) JP4611444B2 (fr)
KR (1) KR101591656B1 (fr)
AR (1) AR064777A1 (fr)
AU (1) AU2008204380B2 (fr)
BR (1) BRPI0806245B1 (fr)
CA (1) CA2674436C (fr)
CL (1) CL2008000046A1 (fr)
CO (1) CO6210732A2 (fr)
CY (3) CY1111584T1 (fr)
DK (1) DK2805945T3 (fr)
DO (1) DOP2009000170A (fr)
EA (1) EA016079B1 (fr)
EC (1) ECSP099484A (fr)
GE (1) GEP20115337B (fr)
GT (1) GT200900190A (fr)
HR (2) HRP20110447T1 (fr)
HU (1) HUS1800022I1 (fr)
IL (1) IL199264A (fr)
LT (1) LTC2109608I2 (fr)
MA (1) MA31554B1 (fr)
MX (1) MX2009007200A (fr)
NL (1) NL300937I2 (fr)
NO (1) NO2018016I2 (fr)
PL (3) PL2109608T3 (fr)
RS (2) RS51780B (fr)
SI (1) SI2805945T1 (fr)
SV (1) SV2009003321A (fr)
TN (1) TN2009000286A1 (fr)
WO (1) WO2008084261A1 (fr)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035365A2 (fr) * 2002-10-16 2004-04-29 Transport Systems, Inc. Systeme de tri sur monorail
RU2447889C2 (ru) * 2005-07-18 2012-04-20 Бипар Сайенсиз, Инк. Способ лечения рака (варианты)
US20090275619A1 (en) * 2006-04-03 2009-11-05 BOUERES Julia Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors
CA2662337A1 (fr) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition de la synthese d'acides gras au moyen d'inhibiteurs parp et methodes de traitement associees
CN101522609A (zh) 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
CA2674644A1 (fr) 2007-01-10 2008-07-17 F. Hoffmann-La Roche Ag Derives de sulfonamide en tant qu'inhibiteurs de la chymase
JP2011503111A (ja) 2007-11-12 2011-01-27 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
US20120156134A1 (en) 2007-12-20 2012-06-21 Shayne Squires Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease
NZ586675A (en) * 2008-01-08 2012-04-27 Merck Sharp & Dohme Pharmaceutically acceptable salts of 2-{ 4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide
US9101537B2 (en) 2008-07-25 2015-08-11 Reven Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of cardiovascular diseases
KR20110113648A (ko) * 2009-02-04 2011-10-17 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제와 함께 성장인자 억제제를 사용한 폐암의 치료
WO2011058367A2 (fr) 2009-11-13 2011-05-19 Astrazeneca Ab Test de diagnostic pour prédire la sensibilité à un traitement par un inhibiteur de poly(adp-ribose) polymérase
WO2011123795A1 (fr) 2010-04-02 2011-10-06 Battelle Memorial Institute Procédés permettant d'associer des matériaux hôtes à un structurant organique métallique ou de les en dissocier, systèmes permettant d'associer des matériaux hôtes à une série de structurants organiques métalliques ou de les en dissocier, et ensembles séparation de gaz
JP2013532661A (ja) 2010-07-22 2013-08-19 リベン ファーマシューティカルズ インコーポレイテッド 磁気双極子安定化溶液の使用を含む疾患を処置または改善する方法および行動を向上させる方法
WO2012177927A1 (fr) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Animaux transgéniques pouvant être induits pour éliminer des cellules sénescentes
JP5902299B2 (ja) * 2011-07-26 2016-04-13 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Ｐａｒｐ−１阻害剤としての３−オキソ−２，３−ジヒドロ−１ｈ−インダゾール−４−カルボキサミド誘導体
WO2013049062A2 (fr) 2011-09-26 2013-04-04 Nitto Denko Corporation Chromophores hautement fluorescents et photo-stables permettant une plus grande efficacité de récupération de l'énergie solaire
WO2013052381A2 (fr) 2011-10-05 2013-04-11 Nitto Denko Corporation Film de conversion de longueur d'onde ayant une couche adhésive sensible à la pression pour améliorer le rendement de collecte solaire
JP2015502366A (ja) 2011-12-13 2015-01-22 バック インスティテュート フォー リサーチ オン エイジング 薬物療法を改善するための方法
WO2013158664A2 (fr) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Utilisation de virus modifiés pour tuer spécifiquement les cellules sénescentes
AR091731A1 (es) 2012-07-19 2015-02-25 Merck Sharp & Dohme Antagonistas del receptor de mineralocorticoides
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
DK2928865T3 (en) 2012-12-07 2018-06-18 Merck Sharp & Dohme BIOCATALYTIC TRANSAMINATION PROCEDURE
US9580407B2 (en) 2012-12-07 2017-02-28 Merck Sharp & Dohme Corp. Regioselective N-2 arylation of indazoles
WO2015051766A1 (fr) * 2013-10-12 2015-04-16 Betta Pharmaceuticals Co., Ltd Dérivés d'indazole à substitution amide en tant qu'inhibiteurs de poly (adp-ribose) polymérase
PL3157566T3 (pl) 2014-06-17 2019-10-31 Vertex Pharma Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr
JP6871169B2 (ja) 2015-03-02 2021-05-12 シナイ ヘルス システム 相同組換え因子
EP3277321B1 (fr) 2015-04-01 2024-08-14 AnaptysBio, Inc. Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3)
KR102678021B1 (ko) 2015-09-30 2024-06-26 버텍스 파마슈티칼스 인코포레이티드 Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물
JP7257789B2 (ja) 2015-12-14 2023-04-14 エフ エム シー コーポレーション 複素環置換二環式アゾール農薬
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
FI3478286T3 (fi) 2016-06-29 2024-03-14 Tesaro Inc Menetelmiä munasarjasyövän hoitamiseksi
CN119606965A (zh) 2016-07-29 2025-03-14 詹森药业有限公司 治疗前列腺癌的方法
SG11201903867YA (en) 2016-11-01 2019-05-30 Anaptysbio Inc Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
EP3666794A1 (fr) 2016-11-01 2020-06-17 AnaptysBio, Inc. Anticorps dirigés contre la mort programmée 1 (pd -1)
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
WO2018122168A1 (fr) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinaisons d'inhibiteurs de kinase bub1 et d'inhibiteurs de parp
JP7118073B2 (ja) 2017-01-09 2022-08-15 テサロ， インコーポレイテッド 抗ｔｉｍ－３抗体を用いてがんを処置する方法
EP3565844B8 (fr) 2017-01-09 2023-04-12 Tesaro, Inc. Procédés de traitement du cancer à l'aide d'anticorps anti-pd-1
WO2018136009A1 (fr) 2017-01-20 2018-07-26 Aslan Pharmaceuticals Pte Ltd Polythérapie
WO2018136010A1 (fr) 2017-01-20 2018-07-26 Aslan Pharmaceuticals Pte Ltd Polythérapie
EA201992177A1 (ru) * 2017-03-27 2020-02-25 Тесаро, Инк. Композиции на основе нирапариба
WO2018187187A1 (fr) * 2017-04-04 2018-10-11 Combiphos Catalysts, Inc. (s)-2-(4-(pipéridin-3-yl)phényl)-2h-indazole-7-carboxamide deutéré
EA201992430A1 (ru) * 2017-04-13 2020-02-28 Янссен Фармацевтика Нв Комбинированная терапия рака предстательной железы
CN110753684A (zh) 2017-04-24 2020-02-04 特沙诺有限公司 尼拉帕利的制造方法
SG11201909395TA (en) 2017-04-27 2019-11-28 Tesaro Inc Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
TW202444417A (zh) 2017-05-09 2024-11-16 美商提薩羅有限公司 治療癌症的組合療法
EP3624850A1 (fr) 2017-05-18 2020-03-25 Tesaro, Inc. Polythérapies pour le traitement du cancer
CN109081828B (zh) 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
WO2018237296A1 (fr) * 2017-06-23 2018-12-27 City Of Hope Inhibiteurs parg et procédé d'utilisation de ceux-ci
EP3668857B1 (fr) 2017-08-14 2023-07-05 Teva Pharmaceuticals International GmbH Procédés de préparation de niraparib et intermédiaires de celui-ci
AU2018341479B2 (en) 2017-09-26 2022-02-17 Tesaro, Inc. Niraparib formulations
KR20200086664A (ko) 2017-09-30 2020-07-17 테사로, 인코포레이티드 암을 치료하기 위한 조합 요법
MA50618A (fr) 2017-10-06 2020-08-12 Tesaro Inc Polyrhérapies et leurs utilisations
WO2019083456A1 (fr) 2017-10-25 2019-05-02 Aslan Pharmaceuticals Pte Ltd Varlitinib destinée à être utilisé dans le traitement du cancer pour normaliser l'angiogenèse dans une masse cancéreuse
WO2019083457A1 (fr) 2017-10-25 2019-05-02 Aslan Pharmaceuticals Pte Ltd Varlitinib destiné à être utilisé dans le traitement du cancer chez un patient identifié comme ayant une mutation de la voie de la bêta-caténine
WO2019083458A1 (fr) 2017-10-25 2019-05-02 Aslan Pharmaceuticals Pte Ltd Varlitinib s'utilisant dans le traitement du cancer pour réduire l'hypoxie
WO2019083455A1 (fr) 2017-10-25 2019-05-02 Aslan Pharmaceuticals Pte Ltd Varlitinib destiné à être utilisé dans le traitement du cancer chez un patient identifié comme présentant des cellules cancéreuses à récepteurs her1, her2 et/ou her3 activés
BR112020011417A2 (pt) 2017-12-07 2020-11-24 Reven Ip Holdco Llc composições e métodos para o tratamento de condições metabólicas
CA3087060A1 (fr) 2017-12-27 2019-07-04 Tesaro, Inc. Methodes de traitement du cancer
CN111989137A (zh) 2018-01-05 2020-11-24 赛博克萨1公司 用于治疗涉及酸性或缺氧性患病组织的疾病的化合物、组合物和方法
EP3749352A1 (fr) 2018-02-05 2020-12-16 Tesaro Inc. Formulations pédiatriques de niraparib et procédés de traitement pédiatrique
US12226424B2 (en) 2018-04-09 2025-02-18 Shanghaitech University Target protein degradation compounds, their anti-tumor use, their intermediates and use of intermediates
TWI852940B (zh) 2018-09-04 2024-08-21 美商泰沙羅公司 治療癌症之方法
US20210347758A1 (en) 2018-10-03 2021-11-11 Tesaro, Inc. Crystalline Forms of Niraparib Freebase
WO2020072860A1 (fr) 2018-10-05 2020-04-09 Johnson Matthey Public Limited Company Forme solide de niraparib
JP2022510501A (ja) 2018-10-30 2022-01-26 リペア セラピューティクス インコーポレイテッド 化合物、医薬組成物、ならびに化合物の調製方法及びａｔｒキナーゼ阻害剤としてのその使用方法
US12582641B2 (en) 2019-02-25 2026-03-24 Shanghaitech University Sulfur-containing compound based on glutarimide skeleton and application thereof
EP3966782A2 (fr) 2019-05-06 2022-03-16 Tesaro, Inc. Procédés de caractérisation et méthodes de traitement d'un type de cancer à l'aide d'images de cancer
CN110156751B (zh) * 2019-05-28 2022-01-18 江苏食品药品职业技术学院 一种制备尼拉帕尼及其中间体的新方法
EA202290027A1 (ru) * 2019-06-12 2022-03-29 РИВЕН АйПи ХОЛДКО ЭлЭлСи Способы и композиции для улучшения результатов лечения пациентов с раком
KR20220052918A (ko) 2019-07-10 2022-04-28 싸이브렉사 2, 인크. 치료제로서의 사이토톡신의 펩티드 접합체
PH12022550037A1 (en) 2019-07-10 2023-04-12 Cybrexa 3 Inc Peptide conjugates of microtubule-targeting agents as therapeutics
CN112321566B (zh) 2019-08-05 2022-06-10 上海科技大学 Egfr蛋白降解剂及其抗肿瘤应用
AU2021269115A1 (en) 2020-05-08 2023-01-19 Janssen Pharmaceutica Nv Treatment of prostate cancer with a combination of abiraterone acetate and niraparib
MX2023008146A (es) 2021-01-08 2023-07-24 Cybrexa 2 Inc Proceso para preparar un resto enlazador de conjugados.
WO2022155172A1 (fr) 2021-01-13 2022-07-21 Cybrexa 3, Inc. Conjugués peptidiques d'agents thérapeutiques
EP4319729A4 (fr) * 2021-04-09 2025-02-26 Cardiff Oncology, Inc. Cancérothérapie à l'aide d'inhibiteurs de parp et d'inhibiteurs de plk1
EP4373491A1 (fr) 2021-07-19 2024-05-29 JANSSEN Pharmaceutica NV Traitement du cancer métastatique de la prostate résistant à la castration avec niraparib
MX2024009626A (es) 2022-02-04 2024-08-09 Janssen Pharmaceutica Nv Niraparib y acetato de abiraterona mas prednisona para mejorar los resultados clinicos en pacientes con cancer de prostata resistente a la castracion metastasico y alteraciones del hrr.
US20250352534A1 (en) 2022-02-15 2025-11-20 Tesaro, Inc. Use of Niraparib for the Treatment of Brain Cancer
WO2023201338A1 (fr) 2022-04-15 2023-10-19 Ideaya Biosciences, Inc. Polythérapie comprenant un inhibiteur de mat2a et un inhibiteur de parp
CN119451954A (zh) 2022-06-01 2025-02-14 伊迪亚生物科学有限公司 作为DNA聚合酶θ抑制剂的噻二唑基衍生物及其用途
WO2024054898A1 (fr) * 2022-09-08 2024-03-14 Cardiff Oncology, Inc. Combinaison d'onvansertib et d'inhibiteur de parp
EP4583983A1 (fr) 2022-09-11 2025-07-16 Cardiff Oncology, Inc. Inhibiteur de plk1 en combinaison avec des anti-angiogéniques pour le traitement du cancer métastatique
WO2024142096A1 (fr) * 2022-12-29 2024-07-04 Dr. Reddy’S Laboratories Limited Procédé de préparation de tosylate de niraparib et de ses intermédiaires
CN121712509A (zh) 2023-05-04 2026-03-20 锐新医药公司 用于ras相关疾病或病症的组合疗法
EP4712976A1 (fr) 2023-05-17 2026-03-25 Tesaro, Inc. Nouvelle utilisation d'un inhibiteur de la poly-adp-ribose polymérase (parp) dans le traitement du cancer
WO2025017711A1 (fr) * 2023-07-20 2025-01-23 Natco Pharma Limited Procédé amélioré pour la préparation de monohydrate de tosylate de niraparib
WO2025027138A1 (fr) 2023-08-02 2025-02-06 Janssen Pharmaceutica Nv Combinaison de niraparib et d'abiratérone destinée à être utilisée dans le traitement du cancer de la prostate résistant à la castration métastatique
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
IL327306A (en) 2023-10-12 2026-05-01 Revolution Medicines Inc Macrocyclic RAS inhibitors
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
WO2025217307A1 (fr) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Procédés de prédiction de la réponse à un inhibiteur de ras(on) et polythérapies
WO2025240847A1 (fr) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Inhibiteurs de ras
WO2025255438A1 (fr) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Procédés de traitement d'une maladie ou d'un trouble lié à la protéine ras
WO2025265060A1 (fr) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026015790A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015796A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015825A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026015801A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026050446A1 (fr) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026072904A2 (fr) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions et méthodes de traitement du cancer du poumon
WO2026090116A2 (fr) 2024-10-21 2026-04-30 Revolution Medicines, Inc. Inhibiteurs de ras
US20260108528A1 (en) 2024-10-22 2026-04-23 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2026090245A1 (fr) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Utilisation d'inhibiteurs ras pour traiter un cancer

Family Cites Families (345)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
US2789118A (en) 1956-03-30 1957-04-16 American Cyanamid Co 16-alpha oxy-belta1, 4-pregnadienes
US2990401A (en) 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3048581A (en) 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3749712A (en) 1970-09-25 1973-07-31 Sigma Tau Ind Farmaceuti Triamcinolone acetonide esters and process for their preparation
SE378110B (fr) 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (fr) 1972-05-19 1975-08-18 Bofors Ab
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4294926A (en) 1979-06-15 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4911165A (en) 1983-01-12 1990-03-27 Ethicon, Inc. Pliabilized polypropylene surgical filaments
US5032617A (en) 1985-05-03 1991-07-16 Sri International Substituted benzamide radiosensitizers
US5041653A (en) 1985-05-03 1991-08-20 Sri International Substituted benzamide radiosensitizers
US5215738A (en) 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4885314A (en) 1987-06-29 1989-12-05 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4782084A (en) 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5180589A (en) 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5030447A (en) 1988-03-31 1991-07-09 E. R. Squibb & Sons, Inc. Pharmaceutical compositions having good stability
US4916239A (en) 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
EP0360390A1 (fr) 1988-07-25 1990-03-28 Glaxo Group Limited Dérivés de spirolactames
US5118853A (en) 1988-10-13 1992-06-02 Sandoz Ltd. Processes for the synthesis of 3-disubstituted aminoacroleins
US5290946A (en) 1988-10-13 1994-03-01 Sandoz Ltd. Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
WO1990005525A1 (fr) 1988-11-23 1990-05-31 Pfizer Inc. Derives de quinuclidine en tant qu'antagonsites de substance p
US4929437A (en) 1989-02-02 1990-05-29 Merck & Co., Inc. Coenzyme Q10 with HMG-CoA reductase inhibitors
US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
US5189164A (en) 1989-05-22 1993-02-23 Sandoz Ltd. Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
IE903957A1 (en) 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2654725B1 (fr) 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2654726B1 (fr) 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
UA41251C2 (uk) 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5232929A (en) 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
EP0515681A4 (en) 1990-02-15 1993-12-29 Fujisawa Pharmaceutical Co., Ltd. Peptide compound
US5420245A (en) 1990-04-18 1995-05-30 Board Of Regents, The University Of Texas Tetrapeptide-based inhibitors of farnesyl transferase
GB9011833D0 (en) 1990-05-25 1990-07-18 Collins Mary K L Inhibition of viral infection
AU648317B2 (en) 1990-06-01 1994-04-21 Pfizer Inc. 3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them
DK0540526T3 (da) 1990-07-23 1995-04-18 Pfizer Quinuclidinderivater
EP0550635B1 (fr) 1990-09-28 1995-04-19 Pfizer Inc. Analogues cycliques d'heterocycles non aromatiques contenant de l'azote
GB9023116D0 (en) 1990-10-24 1990-12-05 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
DE69114117T2 (de) 1990-12-21 1996-03-21 Fujisawa Pharmaceutical Co Neue Verwendung von Peptidderivat.
WO1992012151A1 (fr) 1991-01-10 1992-07-23 Pfizer Inc. Sels de n-alkyle quinuclidinium utilises comme antagonistes de substance p
US5242930A (en) 1991-02-11 1993-09-07 Merck Sharp & Dohme Ltd. Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
ES2065175T3 (es) 1991-03-01 1995-02-01 Pfizer Derivados de 1-azabiciclo(3.2.2)nonan-3-amina.
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
JPH0794440B2 (ja) 1991-03-26 1995-10-11 フアイザー・インコーポレイテツド 置換ピペリジンの立体選択的製造
FR2677361A1 (fr) 1991-06-04 1992-12-11 Adir Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2676053B1 (fr) 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676446B1 (fr) 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole et leur preparation.
FR2676447B1 (fr) 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives du thiopyranopyrrole et leur preparation.
FR2676442B1 (fr) 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
PL172069B1 (pl) 1991-05-22 1997-07-31 Pfizer Sposób wytwarzania nowych pochodnych podstawionej 3-aminochinuklidyny PL PL PL PL PL
WO1992020661A1 (fr) 1991-05-22 1992-11-26 Merck & Co., Inc. N, n-diacylpiperazines
CA2102179C (fr) 1991-05-31 1998-10-27 Fumitaka Ito Derives quinuclidine
GB9113219D0 (en) 1991-06-19 1991-08-07 Fujisawa Pharmaceutical Co Peptide compound,processes for preparation thereof and pharmaceutical composition comprising the same
HU224443B1 (hu) 1991-06-20 2005-09-28 Pfizer Inc. Fluor-alkoxi-benzaldehid-származékok
TW202432B (fr) 1991-06-21 1993-03-21 Pfizer
US5288730A (en) 1991-06-24 1994-02-22 Merck Sharp & Dohme Limited Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
WO1993001169A2 (fr) 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique
EP0536817A1 (fr) 1991-07-05 1993-04-14 MERCK SHARP & DOHME LTD. Composés azabicycliques comme antagonistes des tachykinines
WO1993001160A1 (fr) 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique
ATE133658T1 (de) 1991-07-10 1996-02-15 Merck Sharp & Dohme Aromatische verbindungen diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische verwendung
US5495047A (en) 1991-07-10 1996-02-27 Merck, Sharp & Dohme (Ltd.) Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
EP0600952B1 (fr) 1991-08-20 1996-04-17 MERCK SHARP & DOHME LTD. Composes azacycliques, procedes de preparation et compositions pharmaceutiques les contenant
JP2535134B2 (ja) 1991-09-16 1996-09-18 ファイザー・インコーポレーテッド 縮合三環式窒素含有複素環
EP1082959A1 (fr) 1991-09-20 2001-03-14 Glaxo Group Limited Utilisation des NK1-antagonistes pour le traitement de la depression
US5753674A (en) 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
JP2553020B2 (ja) 1991-11-07 1996-11-13 吉富製薬株式会社 キヌクリジン化合物およびその医薬用途
FI942187A7 (fi) 1991-11-12 1994-05-11 Pfizer Asyklisiä etyleenidiamiinijohdannaisia aine P-reseptoriantagonisteina
EP0545478A1 (fr) 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Composés hétérocycliques comme tachykinine antagonistes
HU217629B (hu) 1991-12-12 2000-03-28 Novartis Ag. Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására
GB9200535D0 (en) 1992-01-10 1992-02-26 Fujisawa Pharmaceutical Co New compound
GB9201179D0 (en) 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
US5328927A (en) 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
JP2656702B2 (ja) 1992-03-23 1997-09-24 ファイザー製薬株式会社 ペプチド性キヌクリジン
FR2689888B1 (fr) 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP0636130A1 (fr) 1992-04-15 1995-02-01 Merck Sharp & Dohme Ltd. Composes azacycliques
GB2266529A (en) 1992-05-01 1993-11-03 Merck Sharp & Dohme Tetrahydroisoquinoline derivatives
ATE209186T1 (de) 1992-05-18 2001-12-15 Pfizer Überbrückte azabicyclische derivate als substanz p antagonisten
GB9211193D0 (en) 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
IL106142A (en) 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
US5637699A (en) 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
AU4713293A (en) 1992-07-13 1994-01-31 Merck Sharp & Dohme Limited Heterocyclic amide derivatives as tachykinin derivatives
EP1251170A3 (fr) 1992-07-17 2002-10-30 Ribozyme Pharmaceuticals, Inc. Procédé et réactif pour le traitement de maladies animales dépendants de NF-kappaB
GB2268931A (en) 1992-07-22 1994-01-26 Merck Sharp & Dohme Azabicyclic tachykinin-receptor antagonists
ES2124318T3 (es) 1992-07-28 1999-02-01 Merck Sharp & Dohme Compuestos azaciclicos.
GB2269170A (en) 1992-07-29 1994-02-02 Merck Sharp & Dohme Azatricyclic tachykinin antagonists
WO1994003429A1 (fr) 1992-07-31 1994-02-17 Merck Sharp & Dohme Limited Amines substituees utiles comme antagonistes du recepteur de la tachykinine
CA2141051A1 (fr) 1992-08-04 1994-02-17 Terry J. Rosen Derives de substitution d'heterocycles azotes
GB9216911D0 (en) 1992-08-10 1992-09-23 Merck Sharp & Dohme Therapeutic agents
EP1000930A3 (fr) 1992-08-13 2003-10-29 Warner-Lambert Company Antagonistes de tachykinines
US5721255A (en) 1992-08-19 1998-02-24 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
US5387595A (en) 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
ATE161530T1 (de) 1992-09-04 1998-01-15 Takeda Chemical Industries Ltd Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
AU4973693A (en) 1992-09-10 1994-03-29 Merck Sharp & Dohme Limited Alcohols and ethers with aromatic substituents as tachykinin-antagonists
GB9220286D0 (en) 1992-09-25 1992-11-11 Merck Sharp & Dohme Therapeutic agents
JP2656699B2 (ja) 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
GB9222262D0 (en) 1992-10-23 1992-12-09 Merck Sharp & Dohme Therapeutic agents
GB9222486D0 (en) 1992-10-26 1992-12-09 Merck Sharp & Dohme Therapeutic agents
JP2656700B2 (ja) 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
CA2146767A1 (fr) 1992-10-28 1994-05-11 Timothy Harrison 4-arylmethyloxymethylpiperidines, antagonistes de la tachykinine
AU5342894A (en) 1992-10-30 1994-05-24 Merck Sharp & Dohme Limited Tachykinin antagonists
US5886009A (en) 1992-11-12 1999-03-23 Pfizer Inc. Quinuclidine derivative as a substance P antagonist
US5261188A (en) 1992-11-23 1993-11-16 The Standard Products Company Belt weatherstrip with bulb
EP0675886B1 (fr) 1992-12-10 2000-07-05 Pfizer Inc. Heterocycles non aromatiques substitues par aminomethylene et leur utilisation comme antagonistes de substance p
US5604260A (en) 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
EP0673367A1 (fr) 1992-12-14 1995-09-27 MERCK SHARP & DOHME LTD. 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperidines en tant qu'antagonistes du recepteur de tachykinine
EP0604181A1 (fr) 1992-12-21 1994-06-29 Eli Lilly And Company Compositions antitumeurs et méthodes de traitement
GB9226581D0 (en) 1992-12-21 1993-02-17 Merck Sharp & Dohme Therapeutic agents
GB9300051D0 (en) 1993-01-04 1993-03-03 Merck Sharp & Dohme Therapeutic agents
EP0679157B1 (fr) 1993-01-15 1997-11-19 G.D. Searle & Co. Nouveaux thiophenes 3,4-diaryle et leurs analogues utilises comme agents anti-inflammatoires
EP0610793A1 (fr) 1993-02-08 1994-08-17 Takeda Chemical Industries, Ltd. Dérivés de morpholine tétracycliques et leur utilisation comme analgésiques
ATE166867T1 (de) 1993-02-18 1998-06-15 Merck Sharp & Dohme Azacyclische verbindungen, sie enthaltende zusammensetzungen und ihre verwendung als tachykinin antagoniste
US5674889A (en) 1993-02-22 1997-10-07 Merck, Sharp & Dohme, Ltd. Aromatic compounds, compositions containing them and their use in therapy
WO1994019357A1 (fr) 1993-02-23 1994-09-01 Merrell Dow Pharmaceuticals Inc. Inhibiteurs de la transferase farnesyl:proteine utiles comme agents anticancereux
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
WO1994020500A1 (fr) 1993-03-04 1994-09-15 Pfizer Inc. Derives spiroazacycliques utilises comme antagonistes de la substance p
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
CA2118985A1 (fr) 1993-04-02 1994-10-03 Dinesh V. Patel Inhibiteurs heterocycliques de la farnesyl proteine transferase
US5496833A (en) 1993-04-13 1996-03-05 Merck Sharp & Dohme Limited Piperidine tachykinin receptor antagonists
HU224496B1 (hu) 1993-05-06 2005-10-28 Merrel Dow Pharmaceuticals Inc. Pirrolidin-3-il-alkil-piperidin-származékok és e vegyületeket tartalmazó gyógyászati készítmények
WO1994026723A2 (fr) 1993-05-14 1994-11-24 Genentech, Inc. INHIBITEURS DE LA ras FARNESYL-TRANSFERASE
US5602098A (en) 1993-05-18 1997-02-11 University Of Pittsburgh Inhibition of farnesyltransferase
IL109646A0 (en) 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
AU680020B2 (en) 1993-06-07 1997-07-17 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
US5436265A (en) 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
GB9602877D0 (en) 1996-02-13 1996-04-10 Merck Frosst Canada Inc 3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
EP0634402A1 (fr) 1993-07-14 1995-01-18 Takeda Chemical Industries, Ltd. Dérivés d'isoquinolinone, leur production et utilisation
EP0708771B1 (fr) 1993-07-15 1998-10-07 Pfizer Inc. Benzylaminoquinuclidines en tant qu'antagonistes de substance p
GB9315808D0 (en) 1993-07-30 1993-09-15 Merck Sharp & Dohme Therapeutic agents
TW365603B (en) 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
GB9317987D0 (en) 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
EP1209157A1 (fr) 1993-09-17 2002-05-29 Pfizer Inc. 3-Benzylaminométhyl-pipéridines à substitution hétéroarylamino et hétéroarylsulfonamido, et composés apparents
ES2217269T3 (es) 1993-09-17 2004-11-01 Pfizer Inc. Piperidinas 3-amino-5-carboxi sustituidas y pirrolidinas 3-amino-4-carboxi sustituidas como antagonistas de taquininas.
IS4208A (is) 1993-09-22 1995-03-23 Glaxo Group Limited 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
WO1995008542A1 (fr) 1993-09-22 1995-03-30 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de la farnesyl-transferase
EP0723539B1 (fr) 1993-10-15 2001-12-12 Schering Corporation Composes sulfonamides tricycliques servant a inhiber la fonction de la proteine g et au traitement de maladies proliferatives
IL111235A (en) 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
SG48750A1 (en) 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
US5719148A (en) 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5661152A (en) 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
FI961621L (fi) 1993-10-25 1996-04-12 Parke Davis & Co Proteiini:farnesyylitranseraasin substituoidut tetra- ja pentapeptidi-inhibiittorit
AU7947594A (en) 1993-10-27 1995-05-22 Merck Sharp & Dohme Limited Substituted amides as tachykinin antagonists
US5344991A (en) 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
DE69417012T2 (de) 1993-11-04 1999-10-07 Abbott Laboratories, Abbott Park Cyclobutan-derivate als inhibitoren der squalen-synthetase und der protein-farnesyltransferase
US5783593A (en) 1993-11-04 1998-07-21 Abbott Laboratories Inhibitors of squalene synthetase and protein farnesyltransferase
WO1995012612A1 (fr) 1993-11-05 1995-05-11 Warner-Lambert Company Inhibiteurs di- et tripeptidiques substitues de l'enzyme proteine:la farnesyle transferase
US6403577B1 (en) 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
IT1271462B (it) 1993-12-03 1997-05-28 Menarini Farma Ind Antagonisti delle tachichinine,procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche.
US5484799A (en) 1993-12-09 1996-01-16 Abbott Laboratories Antifungal dorrigocin derivatives
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
WO1995017382A1 (fr) 1993-12-21 1995-06-29 Eli Lilly And Company Antagonistes non peptidiques des recepteurs des tachykinines
NZ274915A (en) 1993-12-29 1997-11-24 Pfizer N-(hetero)aryl methyl diazabicycloalkane derivatives
DE69434063D1 (de) 1993-12-29 2004-11-11 Merck Sharp & Dohme Substituierte Morpholinderivate und ihre Verwendung als therapeutische Mittel
JPH09507500A (ja) 1994-01-13 1997-07-29 メルク シヤープ エンド ドーム リミテツド ｇｅｍ二置換アザシクロ系のタキキニン拮抗薬
EP0741704A1 (fr) 1994-01-28 1996-11-13 MERCK SHARP & DOHME LTD. Agents therapeutiques azacycliques avec substitution par un groupe aralkyamino
US5393790A (en) 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
GB9402688D0 (en) 1994-02-11 1994-04-06 Merck Sharp & Dohme Therapeutic agents
US5610165A (en) 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
WO1995024612A1 (fr) 1994-03-07 1995-09-14 International Business Machines Corporation Procede et dispositif d'interpolation rapide de valeurs intermediaires derivees de signaux periodiques dephases et de detection de defauts de corps rotatifs
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
HUT77406A (hu) 1994-03-15 1998-04-28 Eisai Co., Ltd., 1-(4-Amino-5-tio-pent-2-en)-il oldalláncot tartalmazó peptidomimetikumok és az ezeket tartalmazó gyógyszerkészítmények
FR2718136B1 (fr) 1994-03-29 1996-06-21 Sanofi Sa Composés aromatiques aminés, procédé pour leur obtention et compositions pharmaceutiques les contenant.
AU1615895A (en) 1994-03-31 1995-10-12 Bristol-Myers Squibb Company Imidazole-containing inhibitors of farnesyl protein transferase
US5523430A (en) 1994-04-14 1996-06-04 Bristol-Myers Squibb Company Protein farnesyl transferase inhibitors
US5610145A (en) 1994-04-15 1997-03-11 Warner-Lambert Company Tachykinin antagonists
PE27997A1 (es) 1994-04-29 1997-09-20 Lilly Co Eli Antagonistas de receptores de taquicininas
EP0758329A1 (fr) 1994-05-05 1997-02-19 MERCK SHARP & DOHME LTD. Derives de morpholine et utilisation comme antagonistes des tachykinines
PL317127A1 (en) 1994-05-07 1997-03-17 Boehringer Ingelheim Kg Novel derivatives of amino acids, method of obtaining them and pharmaceutic agents containing such derivatives
US5510510A (en) 1994-05-10 1996-04-23 Bristol-Meyers Squibb Company Inhibitors of farnesyl protein transferase
US5563255A (en) 1994-05-31 1996-10-08 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
ATE206710T1 (de) 1994-06-06 2001-10-15 Warner Lambert Co Tachykinin (nk1) rezeptor antagonisten
JPH10501259A (ja) 1994-06-10 1998-02-03 ローン−プーラン・ロレ・ソシエテ・アノニム 新規ファルネシルトランスフェラーゼインヒビター、それらの製造およびそれらを含む医薬組成物
EP0686629A3 (fr) 1994-06-10 1999-02-10 Eli Lilly And Company Antagonistes des récepteurs de tachycinine cyclohexyliques
US5571792A (en) 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
CA2194471C (fr) 1994-07-12 2005-04-12 Sung-Yong Stephen Cho Antagoniste du recepteur de tachykinine bis-piperidinyl non-peptidyl
CA2154116A1 (fr) 1994-07-22 1996-01-23 Philip Arthur Hipskind Derives 1-aryl-2-acetamidopentanone, destines a servir d'antagonistes du recepteur de tachykinine
GB9415996D0 (en) 1994-08-08 1994-09-28 Merck Sharp & Dohme Therapeutic agents
GB9415997D0 (en) 1994-08-08 1994-09-28 Merck Sharp & Dohme Therapeutic agents
WO1996005529A1 (fr) 1994-08-09 1996-02-22 Micron Optics, Inc. Filtres de fabry-perot a fibres compense en temperature
TW432061B (en) 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
AU3192395A (en) 1994-08-11 1996-03-07 Banyu Pharmaceutical Co., Ltd. Substituted amide derivative
CA2155448A1 (fr) 1994-08-11 1996-02-12 Katerina Leftheris Inhibiteurs de la farnesyl-proteine-transferase
AU3192495A (en) 1994-08-12 1996-03-07 Banyu Pharmaceutical Co., Ltd. N,n-disubstituted amic acid derivative
PT699754E (pt) 1994-08-12 2001-04-30 Us Health Metodo para diagnosticar uma predisposicao para cancro da mama e do ovario
WO1996005306A2 (fr) 1994-08-12 1996-02-22 Myriad Genetics, Inc. Mutations et polymorphismes in vivo du gene de la susceptibilite au cancer du sein et des ovaires lie au 17q
ES2157337T3 (es) 1994-08-15 2001-08-16 Merck Sharp & Dohme Derivados de morfolina y su uso como agentes terapeuticos.
DE4429506B4 (de) 1994-08-19 2007-09-13 Degussa Gmbh Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
DE4429653C2 (de) 1994-08-20 1997-04-03 Anton Dr More Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
DK0777666T3 (da) 1994-08-25 1999-09-27 Merrell Pharma Inc Substituerede piperidiner anvendelige ved behandling af allergiske sygdomme
ES2107118T3 (es) 1994-08-29 1997-11-16 Akzo Nobel Nv Procedimiento para la preparacion de diesteres cuaternarios.
GB9417956D0 (en) 1994-09-02 1994-10-26 Merck Sharp & Dohme Therapeutic agents
GB9418545D0 (en) 1994-09-15 1994-11-02 Merck Sharp & Dohme Therapeutic agents
US5457107A (en) 1994-09-16 1995-10-10 Merck & Co., Inc. Polymorphic form of a tachykinin receptor antagonist
ES2172595T3 (es) 1994-09-30 2002-10-01 Novartis Ag Compuestos de 1-acil-4-alifatilaminopiperidina.
TW397825B (en) 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives
FR2725986B1 (fr) 1994-10-21 1996-11-29 Adir Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69534213T2 (de) 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
GB9421709D0 (en) 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
CA2162786A1 (fr) 1994-11-22 1996-05-23 Philip Arthur Hipskind Antagonistes heterocycliques des recepteurs des tachykinines
KR100389754B1 (ko) 1994-11-22 2003-10-17 코닌클리즈케 필립스 일렉트로닉스 엔.브이. 반도체장치
FR2727411B1 (fr) 1994-11-30 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
JPH10510261A (ja) 1994-12-09 1998-10-06 ワーナー−ランバート・カンパニー タンパク質：ファルネシルトランスフェラーゼの置換テトラーおよびペンタペプチド阻害剤
PE38997A1 (es) 1994-12-13 1997-10-02 Novartis Ag Antagonista de taquicinina
US5589483A (en) 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
GB9426103D0 (en) 1994-12-23 1995-02-22 Merck Sharp & Dohme Therapeutic agents
WO1996021701A2 (fr) 1995-01-09 1996-07-18 Magla International Ltd. Impression d'image resistant a l'usure sur des surfaces en latex
JP3925662B2 (ja) 1995-01-12 2007-06-06 グラクソ，グループ，リミテッド タキキニンアンタゴニスト活性を有するピペリジン誘導体
JP3929069B2 (ja) 1995-01-12 2007-06-13 ユニバーシティ オブ ピッツバーグ プレニルトランスフェラーゼの阻害剤
FR2729390A1 (fr) 1995-01-18 1996-07-19 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2729951B1 (fr) 1995-01-30 1997-04-18 Sanofi Sa Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2730491B1 (fr) 1995-02-09 1997-03-14 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2730492B1 (fr) 1995-02-09 1997-03-14 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
US5633272A (en) 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
GB9505492D0 (en) 1995-03-18 1995-05-03 Merck Sharp & Dohme Therapeutic agents
GB9505491D0 (en) 1995-03-18 1995-05-03 Merck Sharp & Dohme Therapeutic agents
US5554641A (en) 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists
GB9505692D0 (en) 1995-03-21 1995-05-10 Glaxo Group Ltd Chemical compounds
US5684013A (en) 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
TW394773B (en) 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
US5700806A (en) 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117580A0 (en) 1995-03-29 1996-07-23 Merck & Co Inc Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
US5565568A (en) 1995-04-06 1996-10-15 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists
US5891872A (en) 1995-04-07 1999-04-06 Schering Corporation Tricyclic compounds
US5712280A (en) 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
CA2217351C (fr) 1995-04-07 2003-03-18 Schering Corporation Composes de piperazinyle et de piperidinyle carbonyles inhibant la transferase de proteine farnesyle
IL117798A (en) 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
CA2217006C (fr) 1995-04-13 2001-05-22 Hoechst Marion Roussel, Inc. Nouveaux derives de piperazine substitues presentant une activite d'antagonistes des recepteurs de la tachykinine
US5831115A (en) 1995-04-21 1998-11-03 Abbott Laboratories Inhibitors of squalene synthase and protein farnesyltransferase
IL118101A0 (en) 1995-05-03 1996-09-12 Abbott Lab Inhibitors of farnesyltransferase
WO1996037489A1 (fr) 1995-05-25 1996-11-28 Fujisawa Pharmaceutical Co., Ltd. Derives de 1-benzoyl-2-(indolyl-3-alkyl)-piperazine utilises comme antagonistes du recepteur de la neurokinine
WO1997000252A1 (fr) 1995-06-16 1997-01-03 Warner-Lambert Company Inhibiteurs tricycliques de farnesyltransferase de proteines
GB9513118D0 (en) 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
GB9513121D0 (en) 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
GB9513117D0 (en) 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
JP3042894B2 (ja) 1995-07-07 2000-05-22 ファイザー製薬株式会社 サブスタンスｐアンタゴニストとしての置換ベンゾラクタム化合物
FR2736641B1 (fr) 1995-07-10 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
AT402617B (de) 1995-07-11 1997-07-25 Datacon Schweitzer & Zeindl Gm Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
FR2736638B1 (fr) 1995-07-12 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
CH690163A5 (fr) 1995-07-28 2000-05-31 Symphar Sa Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
PT841924E (pt) 1995-08-02 2003-02-28 Univ Newcastle Ventures Ltd Compostos de benzimidazolo
TW340842B (en) 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
US6020343A (en) 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
WO1997014671A1 (fr) 1995-10-18 1997-04-24 Merck & Co., Inc. Antagonistes des recepteurs de la cyclopentyle-tachykinine
WO1997017070A1 (fr) 1995-11-06 1997-05-15 University Of Pittsburgh Inhibiteurs de proteine-isoprenyle-transferases
DE19541283A1 (de) 1995-11-06 1997-05-07 Boehringer Ingelheim Kg Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB9523244D0 (en) 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
ATE218556T1 (de) 1995-11-17 2002-06-15 Biotechnolog Forschung Gmbh Epothilon-derivate und deren herstellung
JP2000500502A (ja) 1995-11-22 2000-01-18 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
WO1997019084A1 (fr) 1995-11-23 1997-05-29 Merck Sharp & Dohme Limited Derives de spiro-piperidine et leur utilisation en tant qu'antagonistes de tachykinine
GB9524157D0 (en) 1995-11-25 1996-01-24 Pfizer Ltd Therapeutic agents
HU224225B1 (hu) 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
EE03484B1 (et) 1995-12-08 2001-08-15 Janssen Pharmaceutica N.V. Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine
GB9525296D0 (en) 1995-12-11 1996-02-07 Merck Sharp & Dohme Therapeutic agents
CZ292791B6 (cs) 1995-12-22 2003-12-17 Schering Corporation Tricyklické amidy, které se používají pro inhibici G-proteinové funkce a k léčení proliferativních onemocnění
US6008372A (en) 1996-01-16 1999-12-28 Warner-Lambert Company Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase
US6673927B2 (en) 1996-02-16 2004-01-06 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farnesyl transferase inhibitors
CA2249601A1 (fr) 1996-04-03 1997-10-23 Thorsten E. Fisher Inhibiteurs de la farnesyl-proteine transferase
WO1997038986A1 (fr) 1996-04-12 1997-10-23 G.D. Searle & Co. Derives benzenesulfonamide substitue utilisables comme precurseurs des inhibiteurs du cox-2
IL126833A0 (en) 1996-05-22 1999-08-17 Warner Lambert Co Inhibitors of protein farnesyl transferase
AU709409B2 (en) 1996-07-15 1999-08-26 Bristol-Myers Squibb Company Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
US5861419A (en) 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
EP1886677A1 (fr) 1996-07-26 2008-02-13 Susan P. Perrine Composition comprenant un agent d'induction et agent antiviral pour le traitement de maladies sanguines, virales et cellulaires
US6242469B1 (en) 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
AU5719598A (en) 1996-12-30 1998-07-31 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU6013998A (en) 1996-12-30 1998-07-31 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1999059973A1 (fr) 1998-05-15 1999-11-25 Guilford Pharmaceuticals Inc. Composes de carboxamide, compositions et methodes d'inhibition de l'activite de type poly(adp-ribose) polymerase (parp)
IL142760A (en) 1998-10-30 2005-12-18 Lonza Ag Method for producing 4-Ä(2',5'-diamino-6'- halopyrimidine-4' -yl) aminoÜ-cyclopent -2- enyl-methanols
EP1391457B1 (fr) * 1998-11-03 2013-12-25 AbbVie Deutschland GmbH & Co KG 2-Phénylbenzimidazoles substitués et leur utilisation comme inhibiteurs de PARP
AU755694B2 (en) 1998-11-17 2002-12-19 Basf Aktiengesellschaft 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
USRE39608E1 (en) 1998-11-27 2007-05-01 Abbott Gmbh & Co. Kg Substituted benzimidazoles and their use as PARP inhibitors
JP2002536968A (ja) 1999-01-29 2002-11-05 イムクローン システムズ インコーポレイティド Ｋｄｒに特異的な抗体およびその使用
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
AU4972900A (en) 1999-04-08 2000-11-14 Arch Development Corporation Use of anti-vegf antibody to enhance radiation in cancer therapy
DE19918211A1 (de) * 1999-04-22 2000-10-26 Basf Ag Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
DE19920936A1 (de) * 1999-05-07 2000-11-09 Basf Ag Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
WO2001021615A1 (fr) 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Dérivés de benzimidazole
ES2263501T3 (es) 1999-10-27 2006-12-16 Cytokinetics, Inc. Procedimiento y composiciones que utilizan quinazolinonas.
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7041675B2 (en) * 2000-02-01 2006-05-09 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as PARP inhibitors
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
US6992082B2 (en) 2001-01-19 2006-01-31 Cytokinetics, Inc. Phenothiazine kinesin inhibitors
US20040132830A1 (en) 2001-01-19 2004-07-08 Finer Jeffrey T Triphenylmethane kinesin inhibitors
JPWO2002068407A1 (ja) 2001-02-28 2004-06-24 山之内製薬株式会社 ベンゾイミダゾール化合物
WO2002083139A1 (fr) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibiteurs de l'activite d'akt
ATE400274T1 (de) 2001-04-10 2008-07-15 Merck & Co Inc Hemmstoffe der akt aktivität
WO2002083140A1 (fr) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibiteurs de l'activite d'akt
AU2002251266A1 (en) 2001-04-10 2002-10-28 Merck Sharp And Dohme Limited Inhibitors of akt activity
WO2003007959A1 (fr) 2001-07-16 2003-01-30 Fujisawa Pharmaceutical Co., Ltd. Derives de quinoxaline ayant une action inhibitrice sur parp
WO2003013526A1 (fr) 2001-08-08 2003-02-20 Merck & Co. Inc. Composes anticoagulants
AU2002363429B2 (en) 2001-11-07 2008-05-08 Merck & Co., Inc. Mitotic kinesin inhibitors
AU2002363960B2 (en) 2001-12-06 2008-07-10 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
WO2003049679A2 (fr) 2001-12-06 2003-06-19 Merck & Co., Inc. Inhibiteurs mitotiques de la kinésine
ATE424388T1 (de) 2001-12-06 2009-03-15 Merck & Co Inc Mitotische kinesinhemmer
CA2467726A1 (fr) 2001-12-06 2003-06-19 Merck & Co., Inc. Inhibiteurs mitotiques de la kinesine
US7378411B2 (en) 2001-12-06 2008-05-27 Merck & Co., Inc. Substituted thienopyrimidinones as a mitotic kinesin inhibitor
CA2473039C (fr) 2002-01-18 2014-09-23 Pierre Fabre Medicament Nouveaux anticorps anti-igf-ir et leurs applications
WO2003062234A1 (fr) 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Composes de quinoxaline
AU2003249597B2 (en) 2002-03-08 2007-06-28 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
WO2003086394A1 (fr) 2002-04-08 2003-10-23 Merck & Co., Inc. Inhibiteurs de l'activite akt
US7273869B2 (en) 2002-04-08 2007-09-25 Merck & Co., Inc. Inhibitors of Akt activity
WO2003086403A1 (fr) 2002-04-08 2003-10-23 Merck & Co., Inc. Inhibiteurs de l'activite de akt
WO2003086279A2 (fr) 2002-04-08 2003-10-23 Merck & Co., Inc. Inhibiteurs de l'activite de akt
AU2003231799A1 (en) 2002-05-23 2003-12-12 Merck & Co., Inc. Mitotic kinesin inhibitors
CA2485343A1 (fr) 2002-05-23 2004-05-13 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
EP1515949B1 (fr) 2002-06-14 2007-03-14 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
KR20050010515A (ko) 2002-06-14 2005-01-27 머크 앤드 캄파니 인코포레이티드 유사분열 키네신 억제제
US20040034078A1 (en) 2002-06-14 2004-02-19 Agouron Pharmaceuticals, Inc. Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase
AU2003252315A1 (en) 2002-08-09 2004-02-25 Kyorin Pharmaceutical Co., Ltd. 4-substituted-quinoline-8-carboxylic amide derivatives and pharmacologically acceptable addition salts thereof
AU2003287057B2 (en) 2002-10-18 2008-08-21 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
JP2006516140A (ja) 2002-12-20 2006-06-22 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害剤
WO2004058700A2 (fr) 2002-12-20 2004-07-15 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
CA2509202A1 (fr) * 2003-01-06 2004-07-29 Eli Lilly And Company Derives heterocycliques fusionnes utilises en tant que modulateurs ppar
WO2004087050A2 (fr) 2003-03-28 2004-10-14 Merck & Co., Inc. Inhibiteurs des kinesines mitotiques
HU0301154D0 (en) 2003-04-28 2003-07-28 Hideg Kalman Dr Pharmaceutical composition
US7544707B2 (en) 2003-12-22 2009-06-09 Eli Lilly And Company Bicyclic derivatives as PPAR modulators
CA2557547A1 (fr) 2004-02-26 2005-09-09 Inotek Pharmaceuticals Corporation Derives d'isoquinoline et methodes d'utilisation
WO2006003150A1 (fr) * 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Derives de 2-alkyl quinazolinone substitues en tant qu'inhibiteurs de parp
EP1791827A1 (fr) 2004-08-26 2007-06-06 Kudos Pharmaceuticals Limited Derives de phtalazinone substitues par un groupe 4-heteroarylmethyle
PL1794163T3 (pl) * 2004-09-22 2010-06-30 Pfizer Sposób wytwarzania inhibitorów poli(adp-rybozo)polimerazy
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
WO2006110683A1 (fr) * 2005-04-11 2006-10-19 Abbott Laboratories 1h-benzimidazole-4-carboxamides 2-substitues en tant qu'inhibiteurs de parp
CA2623822C (fr) * 2005-09-29 2013-11-12 Abbott Laboratories 1h-benzimidazole-4-carboxamides a substitution phenyle en position 2, utilises comme inhibiteurs de la parp
WO2007059230A2 (fr) * 2005-11-15 2007-05-24 Abbott Laboratories 1h-benzimidazole-4-carboxamides substitues efficaces en tant qu’inhibiteurs de parp
US20090275619A1 (en) * 2006-04-03 2009-11-05 BOUERES Julia Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors
US20070259937A1 (en) * 2006-05-02 2007-11-08 Giranda Vincent L Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
US20090062268A1 (en) * 2007-08-27 2009-03-05 Lead Therapeutics, Inc. Novel inhibitors of poly(adp-ribose)polymerase (parp)
WO2009099736A2 (fr) * 2008-02-06 2009-08-13 Lead Therapeutics, Inc. Inhibiteurs à base de composés benzoxazole-carboxamide de l’activité poly(adp-ribose)polymérase (parp)

Also Published As

Publication number Publication date
JP4611444B2 (ja) 2011-01-12
PL2805945T3 (pl) 2019-09-30
SI2805945T1 (sl) 2019-09-30
ECSP099484A (es) 2009-10-30
EP2336120B1 (fr) 2014-07-16
HRP20190972T1 (hr) 2019-09-20
EP2805945A1 (fr) 2014-11-26
EP2805945B1 (fr) 2019-04-03
CY2018014I2 (el) 2018-09-05
RS58936B1 (sr) 2019-08-30
NO2018016I1 (no) 2018-05-14
WO2008084261A1 (fr) 2008-07-17
HRP20110447T1 (hr) 2011-08-31
CA2674436A1 (fr) 2008-07-17
MX2009007200A (es) 2009-07-15
EA200970674A1 (ru) 2010-02-26
LTC2109608I2 (lt) 2019-05-10
EP3536690A1 (fr) 2019-09-11
PL2336120T3 (pl) 2014-12-31
BRPI0806245B1 (pt) 2022-01-25
CA2674436C (fr) 2012-07-17
BRPI0806245A2 (pt) 2011-09-06
CY1121751T1 (el) 2020-07-31
US20080167345A1 (en) 2008-07-10
EA016079B1 (ru) 2012-01-30
KR101591656B1 (ko) 2016-02-19
US8071623B2 (en) 2011-12-06
IL199264A (en) 2013-06-27
GT200900190A (es) 2010-11-03
TN2009000286A1 (en) 2010-12-31
NO2018016I2 (no) 2018-05-14
CL2008000046A1 (es) 2008-05-09
AU2008204380A1 (en) 2008-07-17
AR064777A1 (es) 2009-04-22
KR20090097191A (ko) 2009-09-15
DK2805945T3 (da) 2019-07-15
EP2109608A1 (fr) 2009-10-21
EP2336120A1 (fr) 2011-06-22
NL300937I2 (nl) 2019-01-08
EP2109608B1 (fr) 2011-03-23
DOP2009000170A (es) 2010-12-31
HK1154386A1 (en) 2012-04-20
HUS1800022I1 (hu) 2018-06-28
AU2008204380B2 (en) 2013-08-15
RS51780B (sr) 2011-12-31
LTPA2018009I1 (lt) 2018-05-25
SV2009003321A (es) 2010-01-19
CY1111584T1 (el) 2015-10-07
PL2109608T3 (pl) 2011-08-31
HK1131137A1 (en) 2010-01-15
JP2010515715A (ja) 2010-05-13
CY2018014I1 (el) 2018-09-05
CO6210732A2 (es) 2010-10-20
GEP20115337B (en) 2011-11-25

Similar Documents

Publication Publication Date Title
TN2009000286A1 (en) Amide substituted indazoles as poly (adp-ribose)polymerase (parp) inhibitors
MA32135B1 (fr) Inhibiteurs de pim kinase et leurs procedes d'utilisation
MY147789A (en) Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
MX2010005070A (es) Derivados de piridazinona como inhibidores de parp.
WO2008121861A3 (fr) Composés à base de pyrazole et de pyrrole utiles dans le traitement de troubles du métabolisme du fer
WO2010045251A3 (fr) Composés spiro-oxindole et leur utilisation comme agents thérapeutiques
WO2008147864A3 (fr) Procédés d'utilisaton de composés pipérazine dans le traitement de maladies ou états médiés par le canal sodium
MA42145A (fr) Triazoles agonistes du récepteur apj
WO2008103277A3 (fr) Cétones d'hétérocyclyle contenant de l'azote et procédés d'utilisation
MA31090B1 (fr) Derives de dihydropyridine utiles en tant qu'inhibiteurs de la proteine kinase
TN2011000454A1 (fr) Derives de benzofurannyle utilises comme inhibiteurs de glucokinase
WO2007138351A3 (fr) Dérivés de pyridinone et de pyridazinone inhibiteurs de la poly(adp-ribose)polymérase (parp)
WO2008094909A3 (fr) Composés de quinazolinone et de pyrimidinone fusionnés et leur utilisation dans le traitement de maladies ou d'affections induites par les canaux sodiques
EP2571876A4 (fr) Composés hétérocycliques substitués à sept chaînons en tant qu'inhibiteurs de la dipeptidyl-peptidase iv pour le traitement du diabète
MA31419B1 (fr) Derives de pyridine
MA43169B1 (fr) Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma
EP1819674A4 (fr) Aminopiperidines fusionnees utilisees comme inhibiteurs de la dipeptidyle peptidase-iv permettant de traiter ou de prevenir le diabete
EP2091328A4 (fr) Composés de spiropipéridine inhibiteurs de la bêta-sécrétase pour le traitement de la maladie d'alzheimer
MA31869B1 (fr) Aminothiazoles et leurs utilisations
MA46462B1 (fr) Composés substitués de pyrazolo[1,5-a]pyridine en tant qu'inhibiteurs de la kinase ret
GB0417559D0 (en) Therapeutic compounds
MA51146B1 (fr) Composés hétérocycliques bicycliques substitués utilisés en tant qu'inhibiteurs de prmt5
MA52331A1 (fr) Macrocycles à groupes hétérocycliques p2' servant d'inhibiteurs du facteur xia