MA32768B1 - Composes antibiotiques oxazolidinone tricyclique - Google Patents
Composes antibiotiques oxazolidinone tricycliqueInfo
- Publication number
- MA32768B1 MA32768B1 MA33812A MA33812A MA32768B1 MA 32768 B1 MA32768 B1 MA 32768B1 MA 33812 A MA33812 A MA 33812A MA 33812 A MA33812 A MA 33812A MA 32768 B1 MA32768 B1 MA 32768B1
- Authority
- MA
- Morocco
- Prior art keywords
- designated
- hydroxyalkyl
- alkyl
- antibiotic compounds
- coch
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSÉS ANTIBACTÉRIENS DE FORMULE (I) ET DES SELS DE TELS COMPOSÉS. DANS LA FORMULE (I), ?-----? DÉSIGNE UNE LIAISON OU EST ABSENT, V DÉSIGNE CH, CR 6 OU N; R 0 DÉSIGNE H OU, IF ?-----? DÉSIGNE UNE LIAISON, IL PEUT ÉGALEMENT DÉSIGNER ALKOXY; R 1 DÉSIGNE NOTAMMENT H OU HALOGÈNE; U DÉSIGNE CH OU N LORSQUE ?-----? DÉSIGNE UNE LIAISON, OU, SI ?-----? EST ABSENT, U DÉSIGNE CH 2, NH OU NR 9; R 2 DÉSIGNE H, ALKYLCARBONYLE OU ?CH 2 -R 3; R 3 DÉSIGNE H, ALKYLE OU HYDROXYALKYLE; R 4 DÉSIGNE H OU, SI N NE DÉSIGNE PAS 0 ET R 5 DÉSIGNE H, IL PEUT ÉGALEMENT DÉSIGNER OH; R 5 DÉSIGNE H, ALKYLE, HYDROXYALKYLE, AMINOALKYLE, ALKOXYALKYLE, CARBOXY OU ALKOXYCARBONYLE; R6 DÉSIGNE HYDROXYALKYLE, CARBOXY, ALKOXYCARBONYLE OU -(CH2 ) Q -NR 7 R 8, Q DÉSIGNANT 1, 2 OU 3 ET CHACUN DE R 7 ET R 8 DÉSIGNANT INDÉPENDAMMENT H OU ALKYLE OU R 7 ET R 8 FORMANT UN ANNEAU AVEC L'ATOME N LES PORTANT; R 9 DÉSIGNE ALKYLE OU HYDROXYALKYLE; A DÉSIGNE -(CH 2 ) P -, -CH 2 CH 2 CH(OH)- OU -COCH 2 CH(OH)-; G DÉSIGNE UN PHÉNYLE SUBSTITUÉ OU G 1 OU G 2, Q DÉSIGNANT O OU S ET X DÉSIGNANT CH OU N; ET Y 1, Y 2 ET Y 3 POUVANT CHACUN DÉSIGNER CH OU N; ET N DÉSIGNE 0 LORSQUE A DÉSIGNE -CH 2 CH 2 CH(OH)- OU -COCH 2 CH(OH)-, ET N DÉSIGNE 0, 1 OU 2 LORSQUE A DÉSIGNE -(CH 2 ) P -, P DÉSIGNANT 1, 2, 3 OU 4, À LA CONDITION QUE LA SOMME DE N ET DE P DÉSIGNE ALORS 2, 3 OU 4.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008054109 | 2008-10-07 | ||
| IB2009051059 | 2009-03-13 | ||
| IB2009052843 | 2009-06-30 | ||
| PCT/IB2009/054357 WO2010041194A1 (fr) | 2008-10-07 | 2009-10-06 | Composés antibiotiques oxazolidinone tricyclique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32768B1 true MA32768B1 (fr) | 2011-11-01 |
Family
ID=41402623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33812A MA32768B1 (fr) | 2008-10-07 | 2011-05-05 | Composes antibiotiques oxazolidinone tricyclique |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8618092B2 (fr) |
| EP (1) | EP2344495B1 (fr) |
| JP (1) | JP4833385B1 (fr) |
| KR (1) | KR101294962B1 (fr) |
| CN (3) | CN102164925B (fr) |
| AR (1) | AR073774A1 (fr) |
| AU (1) | AU2009302075B2 (fr) |
| BR (1) | BRPI0920895A8 (fr) |
| CA (1) | CA2739373C (fr) |
| CY (1) | CY1116155T1 (fr) |
| DK (1) | DK2344495T3 (fr) |
| ES (1) | ES2533217T3 (fr) |
| HR (1) | HRP20150370T1 (fr) |
| IL (1) | IL212139A (fr) |
| MA (1) | MA32768B1 (fr) |
| MX (1) | MX2011003370A (fr) |
| MY (1) | MY158520A (fr) |
| NZ (1) | NZ592642A (fr) |
| PL (1) | PL2344495T3 (fr) |
| PT (1) | PT2344495E (fr) |
| RU (1) | RU2530884C2 (fr) |
| SI (1) | SI2344495T1 (fr) |
| TW (1) | TWI415853B (fr) |
| WO (1) | WO2010041194A1 (fr) |
| ZA (1) | ZA201103332B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2674430A4 (fr) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | Dérivé de pyrrolidinone contenant un groupe amino |
| KR20130002712A (ko) | 2011-06-29 | 2013-01-08 | 현대자동차주식회사 | 하이브리드 자동차의 파워트레인 제어방법 |
| WO2013001096A1 (fr) * | 2011-06-30 | 2013-01-03 | Dsm Ip Assets B.V. | Monomère contenant de la silicone |
| RU2014108919A (ru) | 2011-08-11 | 2015-09-20 | Актелион Фармасьютиклз Лтд | Хиназолин-2,4-дионовые производные |
| SG11201401710PA (en) | 2011-11-08 | 2014-09-26 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| TW201326180A (zh) | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| WO2014024056A1 (fr) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Dérivés de pyrrolidine possédant des propriétés antibactériennes |
| TW201429972A (zh) | 2013-01-09 | 2014-08-01 | Actelion Pharmaceuticals Ltd | 抗菌噁唑酮衍生物 |
| JP2016504408A (ja) | 2013-01-09 | 2016-02-12 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌活性を有するオキサジアゾロン誘導体 |
| KR20150143720A (ko) | 2013-04-16 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 항균성 이방향족 유도체 |
| CN105164118A (zh) * | 2013-05-08 | 2015-12-16 | 埃科特莱茵药品有限公司 | 抗菌性苯酞衍生物 |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| TW201722965A (zh) * | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| RU2602503C1 (ru) * | 2015-09-23 | 2016-11-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА) | Трициклические соединения, обладающие противобактериальной активностью, способ их получения и содержащее их фармацевтическое средство |
| WO2017113288A1 (fr) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| PT3634968T (pt) | 2017-06-08 | 2023-04-14 | Bugworks Res Inc | Compostos heterocíclicos úteis como agentes anti-bacterianos e método para a sua produção |
| CN111527093B (zh) * | 2017-11-29 | 2023-06-09 | 巴格沃克斯研究有限公司 | 抗菌杂环化合物及其合成 |
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| SG11201401710PA (en) | 2011-11-08 | 2014-09-26 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| JP2016504408A (ja) | 2013-01-09 | 2016-02-12 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌活性を有するオキサジアゾロン誘導体 |
| KR20150143720A (ko) | 2013-04-16 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 항균성 이방향족 유도체 |
| CN105164118A (zh) | 2013-05-08 | 2015-12-16 | 埃科特莱茵药品有限公司 | 抗菌性苯酞衍生物 |
-
2009
- 2009-10-06 DK DK09740759.7T patent/DK2344495T3/en active
- 2009-10-06 TW TW098133867A patent/TWI415853B/zh not_active IP Right Cessation
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- 2009-10-06 WO PCT/IB2009/054357 patent/WO2010041194A1/fr not_active Ceased
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2015
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