MA32768B1 - Composes antibiotiques oxazolidinone tricyclique - Google Patents
Composes antibiotiques oxazolidinone tricycliqueInfo
- Publication number
- MA32768B1 MA32768B1 MA33812A MA33812A MA32768B1 MA 32768 B1 MA32768 B1 MA 32768B1 MA 33812 A MA33812 A MA 33812A MA 33812 A MA33812 A MA 33812A MA 32768 B1 MA32768 B1 MA 32768B1
- Authority
- MA
- Morocco
- Prior art keywords
- designated
- hydroxyalkyl
- alkyl
- antibiotic compounds
- coch
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSÉS ANTIBACTÉRIENS DE FORMULE (I) ET DES SELS DE TELS COMPOSÉS. DANS LA FORMULE (I), ?-----? DÉSIGNE UNE LIAISON OU EST ABSENT, V DÉSIGNE CH, CR 6 OU N; R 0 DÉSIGNE H OU, IF ?-----? DÉSIGNE UNE LIAISON, IL PEUT ÉGALEMENT DÉSIGNER ALKOXY; R 1 DÉSIGNE NOTAMMENT H OU HALOGÈNE; U DÉSIGNE CH OU N LORSQUE ?-----? DÉSIGNE UNE LIAISON, OU, SI ?-----? EST ABSENT, U DÉSIGNE CH 2, NH OU NR 9; R 2 DÉSIGNE H, ALKYLCARBONYLE OU ?CH 2 -R 3; R 3 DÉSIGNE H, ALKYLE OU HYDROXYALKYLE; R 4 DÉSIGNE H OU, SI N NE DÉSIGNE PAS 0 ET R 5 DÉSIGNE H, IL PEUT ÉGALEMENT DÉSIGNER OH; R 5 DÉSIGNE H, ALKYLE, HYDROXYALKYLE, AMINOALKYLE, ALKOXYALKYLE, CARBOXY OU ALKOXYCARBONYLE; R6 DÉSIGNE HYDROXYALKYLE, CARBOXY, ALKOXYCARBONYLE OU -(CH2 ) Q -NR 7 R 8, Q DÉSIGNANT 1, 2 OU 3 ET CHACUN DE R 7 ET R 8 DÉSIGNANT INDÉPENDAMMENT H OU ALKYLE OU R 7 ET R 8 FORMANT UN ANNEAU AVEC L'ATOME N LES PORTANT; R 9 DÉSIGNE ALKYLE OU HYDROXYALKYLE; A DÉSIGNE -(CH 2 ) P -, -CH 2 CH 2 CH(OH)- OU -COCH 2 CH(OH)-; G DÉSIGNE UN PHÉNYLE SUBSTITUÉ OU G 1 OU G 2, Q DÉSIGNANT O OU S ET X DÉSIGNANT CH OU N; ET Y 1, Y 2 ET Y 3 POUVANT CHACUN DÉSIGNER CH OU N; ET N DÉSIGNE 0 LORSQUE A DÉSIGNE -CH 2 CH 2 CH(OH)- OU -COCH 2 CH(OH)-, ET N DÉSIGNE 0, 1 OU 2 LORSQUE A DÉSIGNE -(CH 2 ) P -, P DÉSIGNANT 1, 2, 3 OU 4, À LA CONDITION QUE LA SOMME DE N ET DE P DÉSIGNE ALORS 2, 3 OU 4.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008054109 | 2008-10-07 | ||
| IB2009051059 | 2009-03-13 | ||
| IB2009052843 | 2009-06-30 | ||
| PCT/IB2009/054357 WO2010041194A1 (fr) | 2008-10-07 | 2009-10-06 | Composés antibiotiques oxazolidinone tricyclique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32768B1 true MA32768B1 (fr) | 2011-11-01 |
Family
ID=41402623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33812A MA32768B1 (fr) | 2008-10-07 | 2011-05-05 | Composes antibiotiques oxazolidinone tricyclique |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8618092B2 (fr) |
| EP (1) | EP2344495B1 (fr) |
| JP (1) | JP4833385B1 (fr) |
| KR (1) | KR101294962B1 (fr) |
| CN (3) | CN104151316B (fr) |
| AR (1) | AR073774A1 (fr) |
| AU (1) | AU2009302075B2 (fr) |
| BR (1) | BRPI0920895A8 (fr) |
| CA (1) | CA2739373C (fr) |
| CY (1) | CY1116155T1 (fr) |
| DK (1) | DK2344495T3 (fr) |
| ES (1) | ES2533217T3 (fr) |
| HR (1) | HRP20150370T1 (fr) |
| IL (1) | IL212139A (fr) |
| MA (1) | MA32768B1 (fr) |
| MX (1) | MX2011003370A (fr) |
| MY (1) | MY158520A (fr) |
| NZ (1) | NZ592642A (fr) |
| PL (1) | PL2344495T3 (fr) |
| PT (1) | PT2344495E (fr) |
| RU (1) | RU2530884C2 (fr) |
| SI (1) | SI2344495T1 (fr) |
| TW (1) | TWI415853B (fr) |
| WO (1) | WO2010041194A1 (fr) |
| ZA (1) | ZA201103332B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201309689A (zh) | 2011-02-07 | 2013-03-01 | Daiichi Sankyo Co Ltd | 含胺基之吡咯啶酮衍生物 |
| KR20130002712A (ko) | 2011-06-29 | 2013-01-08 | 현대자동차주식회사 | 하이브리드 자동차의 파워트레인 제어방법 |
| CA2840611A1 (fr) * | 2011-06-30 | 2013-01-03 | Dsm Ip Assets B.V. | Monomere contenant de la silicone |
| WO2013021363A1 (fr) | 2011-08-11 | 2013-02-14 | Actelion Pharmaceuticals Ltd | Dérivés de quinazoline-2,4-dione |
| IN2014CN04126A (fr) | 2011-11-08 | 2015-07-10 | Actelion Pharmaceuticals Ltd | |
| TW201326180A (zh) | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| WO2014024056A1 (fr) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Dérivés de pyrrolidine possédant des propriétés antibactériennes |
| WO2014108832A1 (fr) | 2013-01-09 | 2014-07-17 | Actelion Pharmaceuticals Ltd | Dérivés d'oxazolone antibactériens |
| JP2016504408A (ja) | 2013-01-09 | 2016-02-12 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌活性を有するオキサジアゾロン誘導体 |
| MA38588B1 (fr) | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés bi-aromatiques antibactériens |
| WO2014181266A1 (fr) | 2013-05-08 | 2014-11-13 | Actelion Pharmaceuticals Ltd | Dérivés de phtalide antibactériens |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| UY36851A (es) * | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| RU2602503C1 (ru) * | 2015-09-23 | 2016-11-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА) | Трициклические соединения, обладающие противобактериальной активностью, способ их получения и содержащее их фармацевтическое средство |
| WO2017113288A1 (fr) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| US10912780B2 (en) | 2017-06-08 | 2021-02-09 | Bugworks Research, Inc. | Heterocyclic compounds useful as anti-bacterial agents and method for production thereof |
| CN111527093B (zh) * | 2017-11-29 | 2023-06-09 | 巴格沃克斯研究有限公司 | 抗菌杂环化合物及其合成 |
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| US5298518A (en) * | 1989-09-29 | 1994-03-29 | Eisai Co., Ltd. | Biphenylmethane derivative and pharmacological use |
| US5254682A (en) | 1989-12-08 | 1993-10-19 | Merck & Co., Inc. | Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs |
| CZ141399A3 (cs) | 1996-10-24 | 1999-07-14 | Novartis Ag | Substituované aminoalkanfosfonové kyseliny, způsob jejich přípravy a farmaceutické prostředky, které je obsahují |
| DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
| GB9822450D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
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| KR20080016577A (ko) | 2005-05-24 | 2008-02-21 | 아스트라제네카 아베 | 항균 활성을 갖는 아미노피페리딘 퀴놀린 및 이들의아자이소스테릭 유사체 |
| GB0511190D0 (en) | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
| WO2007016610A2 (fr) | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | Agents antibactériens |
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| WO2007071936A1 (fr) * | 2005-12-22 | 2007-06-28 | Glaxo Group Limited | Composés hétérocycliques, leur synthèse et leur utilisation en tant qu'antibactériens |
| ES2331930T3 (es) | 2006-02-14 | 2010-01-20 | Pfizer Products Inc. | Oxazolidinonas con benzoxazinonas y benzoxazepinonas como agentes antibacterianos. |
| DE602007006927D1 (en) | 2006-03-23 | 2010-07-15 | Actelion Pharmaceuticals Ltd | Antibiotische cyclohexyl- oder piperidinylcarboxamid-derivate |
| ATE481406T1 (de) | 2006-04-06 | 2010-10-15 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| GB0608263D0 (en) | 2006-04-26 | 2006-06-07 | Glaxo Group Ltd | Compounds |
| EP2404912A3 (fr) | 2006-06-16 | 2012-07-25 | Pharma Mar S.A. | Procédé et intermédiaires pour la préparation de composés antitumoraux de dihydropyran-2-one |
| GB0613208D0 (en) * | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| WO2008066899A2 (fr) | 2006-11-28 | 2008-06-05 | Marinus Pharmaceuticals | Formulations de nanoparticules et procédés de préparation et d'utilisation de celles-ci |
| ATE495743T1 (de) | 2006-12-01 | 2011-02-15 | Galapagos Nv | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
| CL2007003693A1 (es) | 2006-12-22 | 2008-06-27 | Actelion Pharmaceuticals Ltd | Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas. |
| GB0705672D0 (en) | 2007-03-23 | 2007-05-02 | Glaxo Group Ltd | Compounds |
| EP2141154A4 (fr) * | 2007-03-30 | 2011-06-01 | Inst Med Molecular Design Inc | Dérivé d'oxazolidinone ayant une activité inhibitrice sur la 11 -hydroxystéroïde déshydrogénase de type i |
| WO2008120003A1 (fr) | 2007-04-03 | 2008-10-09 | Astrazeneca Ab | Pipéridines substituées destinées à être utilisées dans le traitement d'infections bactériennes |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| EP1980251A1 (fr) | 2007-04-13 | 2008-10-15 | Glaxo Group Limited | Derivées de pyrrolo[3,2,1-ij]quinoline-4-one pour traiter la tuberculose |
| PT2137196E (pt) | 2007-04-20 | 2010-12-16 | Glaxo Group Ltd | Compostos tricíclicos contendo azoto como agentes antibacterianos |
| GB0707706D0 (en) | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| GB0707708D0 (en) | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| EP2154965A4 (fr) | 2007-05-29 | 2011-08-17 | Glaxosmithkline Llc | Dérivés de naphtyridine en tant qu'inhibiteurs de p13 kinase |
| AR066879A1 (es) | 2007-06-08 | 2009-09-16 | Novartis Ag | Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus |
| CA2689102C (fr) | 2007-06-15 | 2016-07-26 | Actelion Pharmaceuticals Ltd | Derives de 3-amino-6-(1-amino-ethyl)-tetrahydropyrane |
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| JP5323088B2 (ja) | 2007-12-18 | 2013-10-23 | アクテリオン ファーマシューティカルズ リミテッド | ５−アミノシクリルメチル−オキサゾリジン−２−オン誘導体 |
| GB0800367D0 (en) | 2008-01-09 | 2008-02-20 | Glaxo Group Ltd | Compounds |
| BRPI0907892A2 (pt) * | 2008-02-20 | 2015-07-28 | Actelion Pharmaceuticals Ltd | Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo |
| CA2713187C (fr) | 2008-02-22 | 2016-06-07 | Actelion Pharmaceuticals Ltd | Derives d'oxazolidinone |
| TWI426683B (zh) * | 2009-03-17 | 2014-02-11 | Vasstek Int Corp | A voice coil motor with a flat coil |
| TW201103661A (en) * | 2009-07-17 | 2011-02-01 | chao-qin Shi | Manufacturing method of tooth-type restraint belt (II) |
| IN2014CN04126A (fr) | 2011-11-08 | 2015-07-10 | Actelion Pharmaceuticals Ltd | |
| JP2016504408A (ja) | 2013-01-09 | 2016-02-12 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌活性を有するオキサジアゾロン誘導体 |
| MA38588B1 (fr) | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés bi-aromatiques antibactériens |
| WO2014181266A1 (fr) | 2013-05-08 | 2014-11-13 | Actelion Pharmaceuticals Ltd | Dérivés de phtalide antibactériens |
-
2009
- 2009-10-06 JP JP2011530605A patent/JP4833385B1/ja not_active Expired - Fee Related
- 2009-10-06 CN CN201410352890.2A patent/CN104151316B/zh not_active Expired - Fee Related
- 2009-10-06 RU RU2011117412/04A patent/RU2530884C2/ru not_active IP Right Cessation
- 2009-10-06 CA CA2739373A patent/CA2739373C/fr not_active Expired - Fee Related
- 2009-10-06 AU AU2009302075A patent/AU2009302075B2/en not_active Ceased
- 2009-10-06 HR HRP20150370TT patent/HRP20150370T1/hr unknown
- 2009-10-06 KR KR1020117008964A patent/KR101294962B1/ko not_active Expired - Fee Related
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