BRPI0920895A8 - Compostos antibióticos de oxazolidinona tricíclica - Google Patents

Compostos antibióticos de oxazolidinona tricíclica

Info

Publication number
BRPI0920895A8
BRPI0920895A8 BRPI0920895A BRPI0920895A BRPI0920895A8 BR PI0920895 A8 BRPI0920895 A8 BR PI0920895A8 BR PI0920895 A BRPI0920895 A BR PI0920895A BR PI0920895 A BRPI0920895 A BR PI0920895A BR PI0920895 A8 BRPI0920895 A8 BR PI0920895A8
Authority
BR
Brazil
Prior art keywords
hydroxyalkyl
alkyl
bond
compounds
antibiotic compounds
Prior art date
Application number
BRPI0920895A
Other languages
English (en)
Inventor
Hubschwerlen Christian
Ritz Daniel
Rueedi Georg
Surivet Jean-Philippe
Zumbrunn Acklin Cornelia
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41402623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0920895(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0920895A2 publication Critical patent/BRPI0920895A2/pt
Publication of BRPI0920895A8 publication Critical patent/BRPI0920895A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS ANTIBIÓTICOS DE OXAZOLIDINONA TRICÍCLICA Trata-se de compostos antibacterianos de fórmula (I) em que "-----" é uma ligação ou está ausente, V é CH, CR6 ou N; R0 é H ou, se "-----" for uma ligação, também poderá ser alcóxi; R1 é notavelmente H ou halogênio; U é CH ou N quando "-----" é uma ligação, ou, se "-----" estiver ausente, U é CH2, NH ou NR9; R2 é H, alquilcarbonila ou CH2 -R3; R3 é H, alquila ou hidróxialquila; R4 é H ou, se n não for 0 e R5 for H, também poderá ser OH; R5 é H, alquila, hidróxialquila, aminoalquila, alcóxialquila, carbóxi ou alcóxicarbonila; R6 é hidróxialquila, carbóxi, alcóxicarbonila ou -(CH2) q -NR7R8, q sendo 1, 2 ou 3 e cada dentre R7 e R8, independentemente, sendo H ou alquila ou R7 e R8 formando com o átomo N que porta os mesmos um anel; R9 é alquila ou hidróxialquila; A é -(CH2)p -, -CH2CH2CH(OH)- ou -COCH2CH (OH)-; G é fenila substituída ou G1 ou G2, em que Q é O ou S e X é CH ou N; e Y1, Y2, e Y3 pode, cada um, ser CH ou N; e n é 0 quando A é -CH2CH2CH (OH)- ou -COCH2 CH (OH)- , e n é 0, 1 ou 2 quando A é -(CH2)p -, p sendo 1, 2, 3 ou 4, com a condição de que a soma de n e p seja, então, 2, 3 ou 4; e para sais de tais compostos.
BRPI0920895A 2008-10-07 2009-10-06 Compostos antibióticos de oxazolidinona tricíclica BRPI0920895A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IB2008054109 2008-10-07
IB2009051059 2009-03-13
IB2009052843 2009-06-30
PCT/IB2009/054357 WO2010041194A1 (en) 2008-10-07 2009-10-06 Tricyclic oxazolidinone antibiotic compounds

Publications (2)

Publication Number Publication Date
BRPI0920895A2 BRPI0920895A2 (pt) 2015-12-22
BRPI0920895A8 true BRPI0920895A8 (pt) 2017-12-26

Family

ID=41402623

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0920895A BRPI0920895A8 (pt) 2008-10-07 2009-10-06 Compostos antibióticos de oxazolidinona tricíclica

Country Status (25)

Country Link
US (3) US8618092B2 (pt)
EP (1) EP2344495B1 (pt)
JP (1) JP4833385B1 (pt)
KR (1) KR101294962B1 (pt)
CN (3) CN104151315B (pt)
AR (1) AR073774A1 (pt)
AU (1) AU2009302075B2 (pt)
BR (1) BRPI0920895A8 (pt)
CA (1) CA2739373C (pt)
CY (1) CY1116155T1 (pt)
DK (1) DK2344495T3 (pt)
ES (1) ES2533217T3 (pt)
HR (1) HRP20150370T1 (pt)
IL (1) IL212139A (pt)
MA (1) MA32768B1 (pt)
MX (1) MX2011003370A (pt)
MY (1) MY158520A (pt)
NZ (1) NZ592642A (pt)
PL (1) PL2344495T3 (pt)
PT (1) PT2344495E (pt)
RU (1) RU2530884C2 (pt)
SI (1) SI2344495T1 (pt)
TW (1) TWI415853B (pt)
WO (1) WO2010041194A1 (pt)
ZA (1) ZA201103332B (pt)

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Also Published As

Publication number Publication date
IL212139A0 (en) 2011-06-30
TWI415853B (zh) 2013-11-21
HRP20150370T1 (hr) 2015-05-08
US20140142093A1 (en) 2014-05-22
CN104151316B (zh) 2016-06-15
MX2011003370A (es) 2011-04-28
IL212139A (en) 2016-07-31
AU2009302075B2 (en) 2015-04-16
TW201018697A (en) 2010-05-16
AR073774A1 (es) 2010-12-01
BRPI0920895A2 (pt) 2015-12-22
KR20110063836A (ko) 2011-06-14
US9346804B2 (en) 2016-05-24
CN104151316A (zh) 2014-11-19
US9822114B2 (en) 2017-11-21
WO2010041194A1 (en) 2010-04-15
RU2011117412A (ru) 2012-11-20
CA2739373A1 (en) 2010-04-15
SI2344495T1 (sl) 2015-03-31
US20160237088A1 (en) 2016-08-18
PL2344495T3 (pl) 2015-06-30
CY1116155T1 (el) 2017-02-08
CN104151315A (zh) 2014-11-19
US20110195961A1 (en) 2011-08-11
KR101294962B1 (ko) 2013-08-12
RU2530884C2 (ru) 2014-10-20
JP4833385B1 (ja) 2011-12-07
PT2344495E (pt) 2015-04-01
EP2344495B1 (en) 2014-12-31
EP2344495A1 (en) 2011-07-20
HK1159611A1 (en) 2012-08-03
US8618092B2 (en) 2013-12-31
AU2009302075A1 (en) 2010-04-15
ZA201103332B (en) 2012-10-31
CN102164925A (zh) 2011-08-24
MA32768B1 (fr) 2011-11-01
NZ592642A (en) 2012-11-30
ES2533217T3 (es) 2015-04-08
JP2012505199A (ja) 2012-03-01
CN104151315B (zh) 2017-01-11
CA2739373C (en) 2017-01-24
MY158520A (en) 2016-10-14
DK2344495T3 (en) 2015-02-02
CN102164925B (zh) 2015-04-08

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