BRPI0607797A2 - processos para a fabricação do composto, e para a desproteção de um composto, e, composto - Google Patents

processos para a fabricação do composto, e para a desproteção de um composto, e, composto Download PDF

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Publication number
BRPI0607797A2
BRPI0607797A2 BRPI0607797-8A BRPI0607797A BRPI0607797A2 BR PI0607797 A2 BRPI0607797 A2 BR PI0607797A2 BR PI0607797 A BRPI0607797 A BR PI0607797A BR PI0607797 A2 BRPI0607797 A2 BR PI0607797A2
Authority
BR
Brazil
Prior art keywords
compound
processes
manufacture
deprotection
iclaprim
Prior art date
Application number
BRPI0607797-8A
Other languages
English (en)
Inventor
Peter Schneider
Chouaib Tahtaoui
Original Assignee
Arpida Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arpida Ag filed Critical Arpida Ag
Publication of BRPI0607797A2 publication Critical patent/BRPI0607797A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

PROCESSOS PARA A FABRICAçãO DO COMPOSTO, E PARA A DESPROTEçãO DE UM COMPOSTO, E, COMPOSTO. A presente invenção diz respeito a novos processos para a preparação do composto da fórmula (1) (Iclaprim), relacionados com os inibidores da diidrofoliato redutase e aos intermediários valiosos destes processos.
BRPI0607797-8A 2005-02-18 2006-02-10 processos para a fabricação do composto, e para a desproteção de um composto, e, composto BRPI0607797A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2005001695 2005-02-18
PCT/EP2006/001185 WO2006087143A1 (en) 2005-02-18 2006-02-10 Novel processes for the preparation of a 2h-chromene

Publications (1)

Publication Number Publication Date
BRPI0607797A2 true BRPI0607797A2 (pt) 2010-10-19

Family

ID=36283919

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0607797-8A BRPI0607797A2 (pt) 2005-02-18 2006-02-10 processos para a fabricação do composto, e para a desproteção de um composto, e, composto
BRPI0607758-7A BRPI0607758A2 (pt) 2005-02-18 2006-02-10 processos para a fabricaÇço do composto e para a reduÇço do composto, e, composto

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0607758-7A BRPI0607758A2 (pt) 2005-02-18 2006-02-10 processos para a fabricaÇço do composto e para a reduÇço do composto, e, composto

Country Status (22)

Country Link
US (2) US20080221324A1 (pt)
EP (3) EP1856109A1 (pt)
JP (2) JP2009505943A (pt)
KR (2) KR20070106635A (pt)
CN (4) CN101115746A (pt)
AU (2) AU2006215785A1 (pt)
BG (2) BG109938A (pt)
BR (2) BRPI0607797A2 (pt)
CA (2) CA2596669A1 (pt)
CZ (2) CZ2007536A3 (pt)
EE (2) EE200700051A (pt)
HU (2) HUP0700605A3 (pt)
IL (2) IL184405A0 (pt)
MX (2) MX2007009283A (pt)
NO (2) NO20073678L (pt)
NZ (1) NZ556800A (pt)
RO (2) RO122912B8 (pt)
RU (2) RU2397980C2 (pt)
TR (1) TR200705187T1 (pt)
TW (2) TW200640914A (pt)
WO (2) WO2006087143A1 (pt)
ZA (2) ZA200706422B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101115746A (zh) * 2005-02-18 2008-01-30 阿皮德公开股份有限公司 用于制备苯并呋喃的新方法
US7947293B2 (en) 2008-04-08 2011-05-24 Arpida Ag Aqueous pharmaceutical formulation
WO2009124586A1 (en) * 2008-04-08 2009-10-15 Arpida Ag Aqueous pharmaceutical formulation
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
CN110606831A (zh) * 2018-06-14 2019-12-24 上海度德医药科技有限公司 一种Iclaprim的新中间体及其制备方法和应用
CN110818693B (zh) * 2018-08-07 2023-06-02 上海度德医药科技有限公司 一种艾拉普林甲磺酸盐晶型b及其制备方法
CN109988156B (zh) * 2019-03-12 2021-12-28 广东中科药物研究有限公司 一种氨基嘧啶化合物
CN110372746A (zh) * 2019-07-11 2019-10-25 辽宁石油化工大学 一种合成β-胺基膦氧化合物的方法
CN110713483B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法
CN110642792B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体的制备方法
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
CN110746361B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110724135B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110724108B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110790753B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN113493461A (zh) * 2020-04-01 2021-10-12 上海医药工业研究院 一种七元杂环化合物或其盐、其制备方法及应用
CN117700410B (zh) * 2023-05-20 2025-07-04 山东康诺生物工程有限公司 一种3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2-a]嘧啶-4-酮的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709634A1 (de) * 1977-03-05 1978-09-07 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
EP1149834A1 (en) * 1995-12-04 2001-10-31 F. Hoffmann-La Roche Ag Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
US7365205B2 (en) * 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
CA2531757A1 (en) * 2003-07-11 2005-01-20 Arpida Ag Benzofuran derivatives and their use in the treatment of microbial infections
WO2005014586A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes
CN101115746A (zh) * 2005-02-18 2008-01-30 阿皮德公开股份有限公司 用于制备苯并呋喃的新方法

Also Published As

Publication number Publication date
AU2006215788A1 (en) 2006-08-24
NO20073701L (no) 2007-09-03
CN101115743A (zh) 2008-01-30
AU2006215785A1 (en) 2006-08-24
WO2006087140A1 (en) 2006-08-24
CN102140094B (zh) 2012-06-06
TW200640914A (en) 2006-12-01
EE200700050A (et) 2007-12-17
CN102079727A (zh) 2011-06-01
RO122912B1 (ro) 2010-04-30
CN102140094A (zh) 2011-08-03
JP2009505943A (ja) 2009-02-12
ZA200706421B (en) 2008-11-26
RU2007134583A (ru) 2009-03-27
TR200705187T1 (tr) 2007-11-21
AU2006215788B2 (en) 2011-10-20
US20080221324A1 (en) 2008-09-11
RO122912B8 (ro) 2010-09-30
HUP0700605A3 (en) 2008-02-28
EE200700051A (et) 2007-12-17
EP1856106A1 (en) 2007-11-21
JP2008530156A (ja) 2008-08-07
BRPI0607758A2 (pt) 2010-03-23
WO2006087143A8 (en) 2008-11-27
KR20070106636A (ko) 2007-11-02
KR20070106635A (ko) 2007-11-02
CN101115746A (zh) 2008-01-30
HUP0700604A2 (en) 2008-01-28
TW200640912A (en) 2006-12-01
BG109937A (bg) 2008-05-30
NZ556800A (en) 2011-01-28
EP1856109A1 (en) 2007-11-21
US20080161561A1 (en) 2008-07-03
IL184404A0 (en) 2007-10-31
RU2397980C2 (ru) 2010-08-27
HUP0700605A2 (en) 2008-01-28
CA2596669A1 (en) 2006-08-24
HUP0700604A3 (en) 2008-02-28
BG109938A (bg) 2008-05-30
RU2007134584A (ru) 2009-03-27
ZA200706422B (en) 2008-09-25
IL184405A0 (en) 2007-10-31
CA2596668A1 (en) 2006-08-24
EP2270003A1 (en) 2011-01-05
WO2006087143A1 (en) 2006-08-24
RO122853B1 (ro) 2010-03-30
NO20073678L (no) 2007-09-03
CN101115743B (zh) 2011-04-13
CZ2007536A3 (cs) 2008-02-20
CZ2007537A3 (cs) 2008-02-20
MX2007009283A (es) 2008-02-19
MX2007009282A (es) 2008-02-19

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Legal Events

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO PARECER DA PROCURADORIA MEMO/INPI/PROC/NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO.

B25G Requested change of headquarter approved

Owner name: ARPIDA AG (CH)

Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 020110081386/RJ DE 03/08/2011.

B25A Requested transfer of rights approved

Owner name: ADIPRA AG (CH)

Free format text: TRANSFERIDO DE: ARPIDA AG

B25A Requested transfer of rights approved

Owner name: ACINO PHARMA AG (CH)

Free format text: TRANSFERIDO POR FUSAO DE: ADIPRA AG

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2257 DE 08/04/2014.