MA33166B1 - Utilisation de dérivés de pyrimidylaminobenzamide pour le traitement de la fibrose - Google Patents

Utilisation de dérivés de pyrimidylaminobenzamide pour le traitement de la fibrose

Info

Publication number
MA33166B1
MA33166B1 MA33582A MA33582A MA33166B1 MA 33166 B1 MA33166 B1 MA 33166B1 MA 33582 A MA33582 A MA 33582A MA 33582 A MA33582 A MA 33582A MA 33166 B1 MA33166 B1 MA 33166B1
Authority
MA
Morocco
Prior art keywords
fibrosis
treatment
formula
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
MA33582A
Other languages
Arabic (ar)
English (en)
Inventor
Elisabeth Buchdunger
Paul W Manley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39765085&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33166(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA33166B1 publication Critical patent/MA33166B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation de pyrimidylaminobenzamides de formule (I) où les radicaux ont les significations comme présentement définies, ou d'un sel pharmaceutiquement acceptable de ceux-ci pour la fabrication de compositions pharmaceutiques pour utilisation dans le traitement de la fibrose, l'utilisation de pyrimidylaminobenzamides de formule (I) ou d'un sel pharmaceutiquement acceptable de ceux-ci dans le traitement de la fibrose, un procédé de traitement d'animaux à sang chaud comprenant des humains souffrant de fibrose par administration audit animal nécessitant un tel traitement d'une dose efficace d'un pyrimidylaminobenzamide de formule I ou un sel pharmaceutiquement acceptable de celui-ci, et des combinaisons comprenant (a) au moins un pyrimidylaminobenzamide de formule (I) et (b) au moins un composé choisi parmi des antagonistes de récepteur AT
MA33582A 2008-07-14 2009-07-14 Utilisation de dérivés de pyrimidylaminobenzamide pour le traitement de la fibrose MA33166B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08160366 2008-07-14
PCT/EP2009/058940 WO2010007034A1 (fr) 2008-07-14 2009-07-14 Utilisation de dérivés de pyrimidylaminobenzamide pour le traitement de la fibrose

Publications (1)

Publication Number Publication Date
MA33166B1 true MA33166B1 (fr) 2012-04-02

Family

ID=39765085

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33582A MA33166B1 (fr) 2008-07-14 2009-07-14 Utilisation de dérivés de pyrimidylaminobenzamide pour le traitement de la fibrose

Country Status (17)

Country Link
US (2) US20110124670A1 (fr)
EP (1) EP2300014A1 (fr)
JP (1) JP2011528015A (fr)
KR (1) KR20110051194A (fr)
CN (1) CN102099039A (fr)
AU (1) AU2009272814A1 (fr)
BR (1) BRPI0915905A2 (fr)
CA (1) CA2730225A1 (fr)
CL (1) CL2011000073A1 (fr)
IL (1) IL210290A0 (fr)
MA (1) MA33166B1 (fr)
MX (1) MX2011000511A (fr)
NZ (1) NZ590177A (fr)
RU (1) RU2011105059A (fr)
TW (1) TW201006823A (fr)
WO (1) WO2010007034A1 (fr)
ZA (1) ZA201009153B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013016718A1 (fr) * 2011-07-28 2013-01-31 Cellworks Research India Private Limited Compositions, procédé de préparation desdites compositions et méthode de traitement de maladies inflammatoires
AR090835A1 (es) 2012-04-24 2014-12-10 Chugai Pharmaceutical Co Ltd Derivados de quinazolindiona
CA2871237A1 (fr) * 2012-04-24 2013-10-31 Chugai Seiyaku Kabushiki Kaisha Derive de benzamide
CN103965195B (zh) * 2013-02-01 2016-09-28 中国科学院广州生物医药与健康研究院 用于盘状结构域受体小分子抑制剂的化合物及其应用
US10005739B2 (en) 2013-10-23 2018-06-26 Chugai Seiyaku Kabushiki Kaisha Quinazolinone and isoquinolinone derivative
CN106282033A (zh) * 2016-08-15 2017-01-04 郑毅男 一株新青霉菌及其代谢产物安他拟酸a
KR102914830B1 (ko) * 2019-10-15 2026-01-19 재단법인 한국파스퇴르연구소 2-메톡시에스트라디올 유도체 및 이들의 의약 용도
CN115010720B (zh) * 2022-06-02 2023-08-11 中国科学院昆明植物研究所 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2426674A1 (fr) * 2000-10-25 2002-05-02 Takeda Chemical Industries, Ltd. Agents pour prevenir ou traiter l'hypertension portale
US20050124624A1 (en) * 2002-03-15 2005-06-09 Gilbert Richard E. 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl]-benzamide for threating ang ii-mediated diseases
CN101035536A (zh) * 2004-10-08 2007-09-12 诺瓦提斯公司 有机化合物的组合
WO2007022041A2 (fr) * 2005-08-11 2007-02-22 Novartis Ag Mutations et polymorphismes de l'hdac3
WO2007051862A1 (fr) * 2005-11-07 2007-05-10 Novartis Ag Combinaison de composés organiques
JP2009537606A (ja) * 2006-05-25 2009-10-29 ノバルティス アクチエンゲゼルシャフト チロシンキナーゼ阻害剤
CA2660701A1 (fr) * 2006-08-25 2008-03-06 Novartis Ag Derives d'imidazole fusionnes destines a traiter les troubles medies par l'aldosterone synthase et/ou par 11-beta-hydroxylase et/ou aromatase
ES2409756T3 (es) * 2006-12-04 2013-06-27 Promedior, Inc. Combinación de SAP y de enalapril para su uso en tratamiento de trastornos fibróticos o fibroproliferativos
EP2094669A2 (fr) * 2006-12-18 2009-09-02 Novartis AG Derives d`imidazoles substitues en position 1 et leur utilisation en tant qu`inhibiteurs de l`aldosterone-synthetase
KR20090090395A (ko) * 2006-12-18 2009-08-25 노파르티스 아게 4-이미다졸릴-1,2,3,4-테트라히드로퀴놀린 유도체 및 알도스테론/11-베타-히드록실라제 억제제로서의 그의 용도

Also Published As

Publication number Publication date
US20110124670A1 (en) 2011-05-26
IL210290A0 (en) 2011-03-31
US20130267549A1 (en) 2013-10-10
MX2011000511A (es) 2011-02-24
AU2009272814A1 (en) 2010-01-21
EP2300014A1 (fr) 2011-03-30
CN102099039A (zh) 2011-06-15
NZ590177A (en) 2012-12-21
RU2011105059A (ru) 2012-08-20
CL2011000073A1 (es) 2011-07-15
JP2011528015A (ja) 2011-11-10
ZA201009153B (en) 2011-11-30
WO2010007034A1 (fr) 2010-01-21
TW201006823A (en) 2010-02-16
BRPI0915905A2 (pt) 2018-02-20
KR20110051194A (ko) 2011-05-17
CA2730225A1 (fr) 2010-01-21

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