MA33285B1 - Anticorps anti-cxcr4 pour le traitement du vih - Google Patents

Anticorps anti-cxcr4 pour le traitement du vih

Info

Publication number
MA33285B1
MA33285B1 MA34368A MA34368A MA33285B1 MA 33285 B1 MA33285 B1 MA 33285B1 MA 34368 A MA34368 A MA 34368A MA 34368 A MA34368 A MA 34368A MA 33285 B1 MA33285 B1 MA 33285B1
Authority
MA
Morocco
Prior art keywords
cxcr4
hiv
treatment
antibodies
relates
Prior art date
Application number
MA34368A
Other languages
Arabic (ar)
English (en)
Inventor
Christine Klinguer-Hamour
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41060014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33285(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MA33285B1 publication Critical patent/MA33285B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention porte sur de nouveaux anticorps isolés, ou les composés dérivés ou les fragments fonctionnels de ceux-ci, aptes à se fixer au CXCR4 mais également à induire un changement de conformation des homodimères de CXCR4 et aptes à inhiber la réplication d'isolats primaires du VIH-1 dans les PBMC. Plus particulièrement, la présente invention porte sur les anticorps monoclonaux 515H7 et 301aE5, spécifiques vis-à-vis de la protéine CXCR4, ainsi que sur leur utilisation pour le traitement d'une infection à VIH. L'invention porte également sur des compositions pharmaceutiques composées de tels anticorps et sur un procédé pour la sélection de tels anticorps.
MA34368A 2009-04-29 2010-04-29 Anticorps anti-cxcr4 pour le traitement du vih MA33285B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17368009P 2009-04-29 2009-04-29
EP09159076A EP2246364A1 (fr) 2009-04-29 2009-04-29 Anticorps anti CXCR4 pour le traitement du VIH
PCT/EP2010/055863 WO2010125162A1 (fr) 2009-04-29 2010-04-29 Anticorps anti-cxcr4 pour le traitement du vih

Publications (1)

Publication Number Publication Date
MA33285B1 true MA33285B1 (fr) 2012-05-02

Family

ID=41060014

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34368A MA33285B1 (fr) 2009-04-29 2010-04-29 Anticorps anti-cxcr4 pour le traitement du vih

Country Status (25)

Country Link
US (3) US9090686B2 (fr)
EP (2) EP2246364A1 (fr)
JP (1) JP5800802B2 (fr)
KR (1) KR20120039525A (fr)
CN (1) CN102459343B (fr)
AU (1) AU2010243526B2 (fr)
BR (2) BRPI1011540A2 (fr)
CA (1) CA2759989A1 (fr)
CL (1) CL2011002664A1 (fr)
CO (1) CO6390114A2 (fr)
ES (1) ES2534313T3 (fr)
GE (1) GEP20146181B (fr)
HU (1) HUE025083T2 (fr)
IL (1) IL215919A0 (fr)
MA (1) MA33285B1 (fr)
MX (1) MX2011011285A (fr)
MY (1) MY155400A (fr)
NZ (1) NZ596712A (fr)
PL (1) PL2424897T3 (fr)
RU (1) RU2573902C2 (fr)
SG (1) SG175353A1 (fr)
TN (1) TN2011000534A1 (fr)
UA (1) UA107929C2 (fr)
WO (1) WO2010125162A1 (fr)
ZA (1) ZA201108330B (fr)

Families Citing this family (22)

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EP2371863A1 (fr) * 2010-03-30 2011-10-05 Pierre Fabre Médicament Anticorps humanisé anti CXCR4 pour le traitement du cancer
CA2814908A1 (fr) * 2010-10-27 2012-05-03 Pierre Fabre Medicament Anticorps utilises pour traiter le vih
EP3604339B1 (fr) 2011-01-14 2021-03-10 The Regents Of The University Of California Anticorps thérapeutiques contre la protéine ror-1 et leurs procédés d'utilisation
US20140120555A1 (en) * 2011-06-20 2014-05-01 Pierre Fabre Medicament Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer
EP2723380B1 (fr) 2011-06-24 2019-08-21 Stephen D. Gillies Protéines hybrides d'immunoglobuline à chaîne légère et leurs procédés d'utilisation
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
US10308707B2 (en) 2013-12-02 2019-06-04 Aaron Diamond Aids Research Center Bispecific HIV-1-neutralizing antibodies
CA2932405A1 (fr) * 2013-12-02 2015-06-11 Aaron Diamond Aids Research Center Amelioration de la puissance et du spectre d'anticorps neutralisant le vih-1, par ancrage d'un recepteur cellulaire avec des anticorps bispecifiques a architecture native
JP6732915B2 (ja) 2015-12-15 2020-07-29 ギリアード サイエンシーズ， インコーポレイテッド ヒト免疫不全ウイルス中和抗体
RU2769282C2 (ru) 2016-06-20 2022-03-30 Кимаб Лимитед Анти-PD-L1 и IL-2 цитокины
AR112257A1 (es) 2017-06-21 2019-10-09 Gilead Sciences Inc Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos
US11180575B2 (en) 2018-12-28 2021-11-23 Corn Products Development, Inc. Thermally inhibited starch and process for making
CN120943884A (zh) 2018-03-27 2025-11-14 百时美施贵宝公司 使用紫外线信号实时监测滴度
CN111214650A (zh) * 2018-11-23 2020-06-02 广州溯原生物科技有限公司 一种hiv抗原-受体三聚体复合物的解离因子的应用
US20220135619A1 (en) 2019-02-24 2022-05-05 Bristol-Myers Squibb Company Methods of isolating a protein
KR20220012292A (ko) 2019-05-23 2022-02-03 브리스톨-마이어스 스큅 컴퍼니 세포 배양 배지를 모니터링하는 방법
US20230138520A1 (en) * 2020-01-16 2023-05-04 Caerus Therapeutics, Inc. Humanized antibodies specific for myeloma and ovarian cancer cells
CN116406369A (zh) 2020-10-05 2023-07-07 百时美施贵宝公司 用于浓缩蛋白质的方法
JP2025509274A (ja) 2022-03-09 2025-04-11 ブリストル－マイヤーズ スクイブ カンパニー 治療用タンパク質の一過性発現
US12006353B2 (en) * 2022-07-25 2024-06-11 Long Chen Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof
CN115724993A (zh) * 2022-07-26 2023-03-03 陈龙 Scfv蛋白的应用、car基因表达载体、car-t细胞及应用
CN120076829A (zh) 2022-10-18 2025-05-30 明治制果药业株式会社 T细胞肿瘤的治疗剂

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Also Published As

Publication number Publication date
ZA201108330B (en) 2012-09-26
JP5800802B2 (ja) 2015-10-28
PL2424897T3 (pl) 2015-07-31
CO6390114A2 (es) 2012-02-29
BRPI1011540A2 (pt) 2019-04-30
EP2246364A1 (fr) 2010-11-03
IL215919A0 (en) 2011-12-29
RU2011148077A (ru) 2013-06-10
RU2573902C2 (ru) 2016-01-27
EP2424897A1 (fr) 2012-03-07
KR20120039525A (ko) 2012-04-25
CN102459343A (zh) 2012-05-16
CL2011002664A1 (es) 2012-12-14
US9090686B2 (en) 2015-07-28
HUE025083T2 (en) 2016-02-29
BR112013009984A2 (pt) 2017-07-18
EP2424897B1 (fr) 2015-01-07
AU2010243526B2 (en) 2015-02-12
MY155400A (en) 2015-10-15
NZ596712A (en) 2013-10-25
US20110088104A1 (en) 2011-04-14
ES2534313T3 (es) 2015-04-21
UA107929C2 (en) 2015-03-10
CA2759989A1 (fr) 2010-11-04
AU2010243526A1 (en) 2011-12-22
US20160031995A1 (en) 2016-02-04
JP2012525129A (ja) 2012-10-22
WO2010125162A1 (fr) 2010-11-04
SG175353A1 (en) 2011-11-28
MX2011011285A (es) 2012-01-20
US20130174288A1 (en) 2013-07-04
TN2011000534A1 (en) 2013-05-24
HK1165813A1 (en) 2012-10-12
CN102459343B (zh) 2015-09-16
GEP20146181B (en) 2014-10-27

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