MA32928B1 - Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer - Google Patents

Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer

Info

Publication number
MA32928B1
MA32928B1 MA33784A MA33784A MA32928B1 MA 32928 B1 MA32928 B1 MA 32928B1 MA 33784 A MA33784 A MA 33784A MA 33784 A MA33784 A MA 33784A MA 32928 B1 MA32928 B1 MA 32928B1
Authority
MA
Morocco
Prior art keywords
cxcr4
cancer
treatment
antibodies
cxcr4 antibodies
Prior art date
Application number
MA33784A
Other languages
Arabic (ar)
English (en)
Inventor
Christine Klinguer-Hamour
Véronique Grenier-Caussanel
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MA32928B1 publication Critical patent/MA32928B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN NOUVEL ANTICORPS ISOLÉ, OU LES COMPOSÉS DÉRIVÉS OU DES FRAGMENTS FONCTIONNELS DE CELUI-CI, CAPABLES DE SE LIER À CXCR4 MAIS ÉGALEMENT D'INDUIRE DES CHANGEMENTS DE CONFORMATION DES HOMODIMÈRES ET/OU HÉTÉRODIMÈRES DE CXCR4. PLUS PARTICULIÈREMENT, LA PRÉSENTE INVENTION CONCERNE LES ANTICORPS 414H5 ET 515H7, SPÉCIFIQUES DE LA PROTÉINE CXCR4, AINSI QUE LEUR UTILISATION POUR LE TRAITEMENT DU CANCER. LA PRÉSENTE INVENTION CONCERNE EN OUTRE DES COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELS ANTICORPS ET UN PROCÉDÉ POUR LA SÉLECTION DE TELS ANTICORPS.
MA33784A 2008-10-01 2009-10-01 Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer MA32928B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13677208P 2008-10-01 2008-10-01
EP08305631A EP2172485A1 (fr) 2008-10-01 2008-10-01 Nouveaux anticorps anti CXCR4 et leur utilisation dans le traitement contre le cancer
US17374309P 2009-04-29 2009-04-29
PCT/EP2009/062787 WO2010037831A1 (fr) 2008-10-01 2009-10-01 Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer

Publications (1)

Publication Number Publication Date
MA32928B1 true MA32928B1 (fr) 2012-01-02

Family

ID=40361774

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33784A MA32928B1 (fr) 2008-10-01 2009-10-01 Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer

Country Status (28)

Country Link
US (4) US8557964B2 (fr)
EP (2) EP2172485A1 (fr)
JP (1) JP5723279B2 (fr)
KR (1) KR101671039B1 (fr)
CN (1) CN102209730B (fr)
AR (1) AR073748A1 (fr)
AU (1) AU2009299787B2 (fr)
BR (1) BRPI0920531A2 (fr)
CA (1) CA2738782C (fr)
CL (1) CL2011000730A1 (fr)
CY (1) CY1115572T1 (fr)
DK (1) DK2342233T3 (fr)
ES (1) ES2503732T3 (fr)
GE (1) GEP20146084B (fr)
HR (1) HRP20140899T1 (fr)
IL (1) IL212066A (fr)
MA (1) MA32928B1 (fr)
MX (1) MX2011003509A (fr)
NZ (1) NZ592363A (fr)
PL (1) PL2342233T3 (fr)
PT (1) PT2342233E (fr)
RS (1) RS53578B1 (fr)
RU (1) RU2573897C2 (fr)
SI (1) SI2342233T1 (fr)
TW (1) TWI469792B (fr)
UA (1) UA102867C2 (fr)
WO (1) WO2010037831A1 (fr)
ZA (1) ZA201102969B (fr)

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EP2246364A1 (fr) * 2009-04-29 2010-11-03 Pierre Fabre Médicament Anticorps anti CXCR4 pour le traitement du VIH
EP2371863A1 (fr) * 2010-03-30 2011-10-05 Pierre Fabre Médicament Anticorps humanisé anti CXCR4 pour le traitement du cancer
RU2013122770A (ru) * 2010-10-27 2014-12-10 Пьер Фабр Медикамент Антитела для лечения вич
US20140120555A1 (en) * 2011-06-20 2014-05-01 Pierre Fabre Medicament Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer
ES2758884T3 (es) 2011-06-24 2020-05-06 Stephen D Gillies Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
AR087364A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres
NL2010658C2 (en) * 2013-04-18 2014-10-21 Bosch Gmbh Robert Thermostat for a hvac.
AR097102A1 (es) * 2013-08-02 2016-02-17 Pfizer Anticuerpo anti-cxcr4 y conjugados de anticuerpo y fármaco
CN113801895A (zh) * 2013-09-23 2021-12-17 威尔逊沃夫制造公司 遗传修饰动物细胞的改进方法
AR104413A1 (es) * 2015-04-27 2017-07-19 Pf Medicament Anticuerpo de igf-1r y su utilización para diagnosticar cáncer
EP3307778A1 (fr) 2015-06-12 2018-04-18 Bristol-Myers Squibb Company Traitement du cancer par le blocage combiné des voies de signalisation pd-1 et cxcr4
CN108350052A (zh) 2015-11-09 2018-07-31 英属哥伦比亚大学 淀粉样蛋白β中间区域中的表位及其构象选择性抗体
KR20180094876A (ko) * 2015-11-09 2018-08-24 더 유니버시티 오브 브리티쉬 콜롬비아 아밀로이드 베타 에피토프 및 이에 대한 항체
EP3408378B1 (fr) 2016-01-25 2022-01-12 NantCell, Inc. Cellules nk présentant une signalisation cxcl12/cxcr4 modifiée
WO2017203799A1 (fr) * 2016-05-25 2017-11-30 株式会社東芝 Dispositif de gestion d'énergie, système de gestion, procédé de surveillance de consommation d'énergie et programme
TWI640536B (zh) 2016-06-20 2018-11-11 克馬伯有限公司 抗體
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
CN110234352A (zh) * 2017-01-31 2019-09-13 Msm蛋白质技术公司 抗cxcr4抗体
US12286469B2 (en) 2017-07-18 2025-04-29 The University Of British Columbia Humanized antibodies binding to amyloid-beta (A-beta)
CN112513079A (zh) 2018-03-13 2021-03-16 拉巴斯大学医院生物医学研究基金会 用于癌症免疫疗法的联合激活和扩增的自然杀伤细胞的抗cxcr4抗体
CN110804100A (zh) * 2019-11-01 2020-02-18 中国人民解放军陆军特色医学中心 融合多肽及其在增强干细胞归巢能力和抗凋亡能力中的应用和药物组合物
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
CN112661845B (zh) * 2020-12-25 2022-06-21 暨南大学 与cxcr4结合的亲和力成熟结合蛋白及其应用
CN112521500B (zh) * 2020-12-25 2022-06-24 暨南大学 与cxcr4结合的亲和力成熟结合蛋白及应用
WO2025049591A1 (fr) * 2023-08-28 2025-03-06 Regeneron Pharmaceuticals, Inc. Anticorps anti-cxcr4 et leurs utilisations
CN118255888A (zh) * 2023-08-31 2024-06-28 恺佧生物科技(上海)有限公司 一种Anti-CXCR4膜蛋白抗体及其制备方法和应用

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Also Published As

Publication number Publication date
CY1115572T1 (el) 2017-01-04
HK1163119A1 (en) 2012-09-07
NZ592363A (en) 2012-08-31
EP2342233A1 (fr) 2011-07-13
TW201018483A (en) 2010-05-16
US20110294156A1 (en) 2011-12-01
GEP20146084B (en) 2014-05-13
JP2012504401A (ja) 2012-02-23
RU2573897C2 (ru) 2016-01-27
AU2009299787A1 (en) 2010-04-08
RU2011115559A (ru) 2012-11-10
PL2342233T3 (pl) 2014-11-28
AR073748A1 (es) 2010-12-01
BRPI0920531A2 (pt) 2021-02-23
US20110287451A1 (en) 2011-11-24
AU2009299787B2 (en) 2015-06-18
RS53578B1 (sr) 2015-02-27
PT2342233E (pt) 2014-10-03
HRP20140899T1 (hr) 2014-11-07
KR20110081229A (ko) 2011-07-13
US20110020218A1 (en) 2011-01-27
KR101671039B1 (ko) 2016-11-01
US9388248B2 (en) 2016-07-12
WO2010037831A1 (fr) 2010-04-08
ES2503732T3 (es) 2014-10-07
JP5723279B2 (ja) 2015-05-27
CN102209730A (zh) 2011-10-05
CA2738782A1 (fr) 2010-04-08
CN102209730B (zh) 2014-11-05
IL212066A0 (en) 2011-06-30
MX2011003509A (es) 2011-05-02
UA102867C2 (uk) 2013-08-27
EP2172485A1 (fr) 2010-04-07
ZA201102969B (en) 2011-12-28
AU2009299787A2 (en) 2011-06-02
SI2342233T1 (sl) 2014-10-30
CL2011000730A1 (es) 2012-02-03
US20140050661A1 (en) 2014-02-20
TWI469792B (zh) 2015-01-21
CA2738782C (fr) 2017-11-28
DK2342233T3 (da) 2014-09-29
EP2342233B1 (fr) 2014-06-25
IL212066A (en) 2015-05-31
US8557964B2 (en) 2013-10-15

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