MA45125B1 - Anticorps anti-alpha-synucléine et leurs utilisations - Google Patents

Anticorps anti-alpha-synucléine et leurs utilisations

Info

Publication number
MA45125B1
MA45125B1 MA45125A MA45125A MA45125B1 MA 45125 B1 MA45125 B1 MA 45125B1 MA 45125 A MA45125 A MA 45125A MA 45125 A MA45125 A MA 45125A MA 45125 B1 MA45125 B1 MA 45125B1
Authority
MA
Morocco
Prior art keywords
alpha
synuclein
antibodies
methods
synuclein antibodies
Prior art date
Application number
MA45125A
Other languages
English (en)
Other versions
MA45125A (fr
Inventor
Darren Schofield
Michael Perkinton
Lorraine Irving
George Thom
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of MA45125A publication Critical patent/MA45125A/fr
Publication of MA45125B1 publication Critical patent/MA45125B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des anticorps qui se lient spécifiquement à la alpha-synucléine humaine avec une affinité élevée et réduisent l'étalement de l'alpha-synucléine in vivo, des polypeptides recombinants comprenant lesdits anticorps ou un fragment de liaison à l'antigène de ceux-ci et des procédés permettant de générer lesdits polypeptides, ainsi que des compositions et des procédés pour générer des anticorps anti-alpha-synucléine, et des procédés d'utilisation d'anticorps anti-alpha-synucléine pour le traitement de maladies du système nerveux central, en particulier des alpha-synucléinopathies.
MA45125A 2016-06-02 2017-06-01 Anticorps anti-alpha-synucléine et leurs utilisations MA45125B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662344746P 2016-06-02 2016-06-02
PCT/EP2017/063406 WO2017207739A1 (fr) 2016-06-02 2017-06-01 Anticorps anti-alpha-synucléine et leurs utilisations

Publications (2)

Publication Number Publication Date
MA45125A MA45125A (fr) 2021-06-02
MA45125B1 true MA45125B1 (fr) 2021-11-30

Family

ID=59021492

Family Applications (1)

Application Number Title Priority Date Filing Date
MA45125A MA45125B1 (fr) 2016-06-02 2017-06-01 Anticorps anti-alpha-synucléine et leurs utilisations

Country Status (37)

Country Link
US (5) US10160800B2 (fr)
EP (2) EP3463435B1 (fr)
JP (3) JP7078552B2 (fr)
KR (1) KR102499438B1 (fr)
CN (2) CN109475616B (fr)
AR (1) AR108663A1 (fr)
AU (2) AU2017272804B2 (fr)
BR (1) BR112018074978A2 (fr)
CA (1) CA3025987A1 (fr)
CL (1) CL2018003438A1 (fr)
CO (1) CO2018014010A2 (fr)
CY (1) CY1124896T1 (fr)
DK (1) DK3463435T3 (fr)
EA (2) EA038358B1 (fr)
EC (1) ECSP18096095A (fr)
ES (1) ES2903402T3 (fr)
GE (2) GEAP202114964A (fr)
HR (1) HRP20211935T1 (fr)
HU (1) HUE057214T2 (fr)
IL (1) IL263243A (fr)
LT (1) LT3463435T (fr)
MA (1) MA45125B1 (fr)
MD (1) MD3463435T2 (fr)
MX (1) MX393740B (fr)
MY (1) MY188183A (fr)
PE (2) PE20190440A1 (fr)
PH (1) PH12018502538A1 (fr)
PL (1) PL3463435T3 (fr)
PT (1) PT3463435T (fr)
RS (1) RS62682B1 (fr)
SG (1) SG11201810420YA (fr)
SI (1) SI3463435T1 (fr)
SM (1) SMT202200008T1 (fr)
TW (2) TW202309093A (fr)
UA (1) UA124733C2 (fr)
WO (1) WO2017207739A1 (fr)
ZA (1) ZA201808582B (fr)

Families Citing this family (17)

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GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
MA46836A (fr) 2016-11-15 2019-09-25 H Lundbeck As Agents, utilisations et procédés pour le traitement d'une synucléinopathie
EP3555127B1 (fr) 2016-12-16 2024-12-18 H. Lundbeck A/S Agents, utilisations et procédés
US10364286B2 (en) 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
EA201991720A1 (ru) 2017-02-17 2020-01-20 Бристол-Маерс Сквибб Компани Антитела к альфа-синуклеину и их применения
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
WO2020079113A1 (fr) * 2018-10-19 2020-04-23 Janssen Vaccines & Prevention B.V. Anticorps anti-synucléine
TWI734279B (zh) 2018-12-14 2021-07-21 美商美國禮來大藥廠 抗α-突觸核蛋白抗體及其用途
KR20210154179A (ko) 2019-04-18 2021-12-20 에이씨 이뮨 에스.에이. 치료 및 진단용 신규한 분자
CN110172098B (zh) * 2019-05-27 2023-03-10 长春工业大学 抗α-突触核蛋白的单克隆抗体及其应用
WO2021055881A1 (fr) 2019-09-20 2021-03-25 Denali Therapeutics Inc. Anticorps anti-alpha-synucléine et leurs procédés d'utilisation
KR102239512B1 (ko) * 2020-09-10 2021-04-12 서울대학교산학협력단 다중기능성 마이크로캡슐 조성물 및 그 제조방법
US20250320283A1 (en) 2020-10-16 2025-10-16 Ac Immune Sa Antibodies Binding to Alpha-Synuclein for Therapy and Diagnosis
CN112920274A (zh) * 2021-03-17 2021-06-08 江苏贝格尔生物医药有限公司 一种检测alpha-synuclein蛋白的鼠单克隆抗体及其应用
CN113912716B (zh) * 2021-12-15 2022-03-01 北京凯祥弘康生物科技有限公司 针对α-突触核蛋白抗原的抗体及其应用
WO2024141576A1 (fr) 2022-12-29 2024-07-04 Astrazeneca Ab Compositions et méthodes de traitement d'alpha-synucléinopathies

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EP2082749A3 (fr) 2000-07-07 2010-06-30 Bioarctic Neuroscience AB Prévention et traitement de la maladie d'Alzheimer
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US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
PL1633189T3 (pl) 2003-05-19 2017-12-29 Prothena Biosciences Limited Skrócone fragmenty alfa-synukleiny w chorobie z ciałami lewy'ego
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PL2118300T3 (pl) 2007-02-23 2015-11-30 Prothena Biosciences Ltd Zapobieganie i leczenie synukleinopatii i amyloidozy
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JP4934074B2 (ja) 2007-03-07 2012-05-16 株式会社アルファ スイッチ固定構造
DK2282758T3 (en) 2008-04-29 2019-02-25 Bioarctic Ab ANTIBODIES AND VACCINES FOR USE IN THERAPEUTIC AND DIAGNOSTIC PROCEDURES FOR ALPHA-SYNUCLEIN-RELATED DISORDERS
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JP4654348B1 (ja) 2010-02-23 2011-03-16 多摩川精機株式会社 検出装置用巻線の正弦波巻線方法
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HRP20230065T1 (hr) 2011-10-28 2023-03-03 Prothena Biosciences Limited Humanizirana protutijela koja prepoznaju alfa-sinuklein
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
US9534044B2 (en) * 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
CA2924268C (fr) * 2013-11-21 2021-05-18 F. Hoffmann-La Roche Ag Anticorps anti-alpha-synucleine et leurs methodes d'utilisation
KR102781223B1 (ko) 2014-11-10 2025-03-12 메디뮨 리미티드 Cd73에 특이적인 결합 분자 및 이의 용도

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Publication number Publication date
JP2024123247A (ja) 2024-09-10
HRP20211935T1 (hr) 2022-03-18
TW202309093A (zh) 2023-03-01
US10160800B2 (en) 2018-12-25
JP2022110117A (ja) 2022-07-28
PT3463435T (pt) 2021-11-22
MX2018014456A (es) 2019-08-12
MD3463435T2 (ro) 2022-03-31
CO2018014010A2 (es) 2019-01-18
EA038358B1 (ru) 2021-08-13
ECSP18096095A (es) 2019-01-31
JP7078552B2 (ja) 2022-05-31
US10889639B2 (en) 2021-01-12
CY1124896T1 (el) 2023-01-05
SI3463435T1 (sl) 2022-02-28
MX393740B (es) 2025-03-24
KR102499438B1 (ko) 2023-02-14
EP3463435B1 (fr) 2021-10-13
GEAP202114964A (en) 2021-01-25
UA124733C2 (uk) 2021-11-10
CN109475616B (zh) 2022-10-18
AU2017272804A1 (en) 2018-12-13
ZA201808582B (en) 2021-08-25
AU2017272804B2 (en) 2023-11-23
LT3463435T (lt) 2021-12-27
PE20190440A1 (es) 2019-03-27
US20210179698A1 (en) 2021-06-17
EA202191380A1 (ru) 2021-08-26
PH12018502538A1 (en) 2019-04-08
CL2018003438A1 (es) 2019-03-22
TWI765890B (zh) 2022-06-01
KR20190013923A (ko) 2019-02-11
CN109475616A (zh) 2019-03-15
US20250263477A1 (en) 2025-08-21
TW201802119A (zh) 2018-01-16
JP7823118B2 (ja) 2026-03-03
ES2903402T3 (es) 2022-04-01
DK3463435T3 (da) 2021-11-22
AU2024200601A1 (en) 2024-04-18
JP2019527194A (ja) 2019-09-26
EA201892548A1 (ru) 2019-06-28
IL263243A (en) 2018-12-31
PE20250392A1 (es) 2025-02-11
NZ748616A (en) 2025-08-29
EP4000632A1 (fr) 2022-05-25
EP3463435A1 (fr) 2019-04-10
AR108663A1 (es) 2018-09-12
CA3025987A1 (fr) 2017-12-07
SMT202200008T1 (it) 2022-03-21
MA45125A (fr) 2021-06-02
BR112018074978A2 (pt) 2019-03-12
US11560424B2 (en) 2023-01-24
WO2017207739A1 (fr) 2017-12-07
US20230331830A1 (en) 2023-10-19
SG11201810420YA (en) 2018-12-28
RS62682B1 (sr) 2021-12-31
CN116120445A (zh) 2023-05-16
PL3463435T3 (pl) 2022-02-14
GEP20217253B (en) 2021-05-13
US20180002411A1 (en) 2018-01-04
HUE057214T2 (hu) 2022-04-28
US20190276522A1 (en) 2019-09-12
MY188183A (en) 2021-11-24

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