MA33758B1 - Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes - Google Patents

Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes

Info

Publication number
MA33758B1
MA33758B1 MA34878A MA34878A MA33758B1 MA 33758 B1 MA33758 B1 MA 33758B1 MA 34878 A MA34878 A MA 34878A MA 34878 A MA34878 A MA 34878A MA 33758 B1 MA33758 B1 MA 33758B1
Authority
MA
Morocco
Prior art keywords
antagonists
antibody
tnfr1
stable anti
polypeptides
Prior art date
Application number
MA34878A
Other languages
Arabic (ar)
English (en)
Inventor
Silva Inusha De
Armin Sepp
Adriaan Allart Stoop
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43382391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33758(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA33758B1 publication Critical patent/MA33758B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention concerne des domaines variables uniques de l'anticorps anti-TNFR1 stable à l'entreposage (d Abs), des antagonistes et des ligands multispécifiques, ainsi que des méthodes et des utilisations de ceux-ci. Les polypeptides anti-TNFR1, les domaines variables uniques de l'anticorps (d Abs), les antagonistes et les ligands multispécifiques sont utiles pour le traitement et/ou la prévention d'une maladie inflammatoire, telle que la BPCO, ainsi que pour l'administration par voie pulmonaire ou orale ou l'acheminement au poumon ou au tractus gastro-intestinal.
MA34878A 2009-10-27 2012-05-18 Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes MA33758B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25523509P 2009-10-27 2009-10-27
PCT/EP2010/066046 WO2011051217A1 (fr) 2009-10-27 2010-10-25 Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes

Publications (1)

Publication Number Publication Date
MA33758B1 true MA33758B1 (fr) 2012-11-01

Family

ID=43382391

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34878A MA33758B1 (fr) 2009-10-27 2012-05-18 Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes

Country Status (27)

Country Link
US (1) US20150210767A1 (fr)
EP (1) EP2493504B1 (fr)
JP (1) JP2013507978A (fr)
KR (1) KR20120101417A (fr)
CN (1) CN102686239B (fr)
AR (1) AR078763A1 (fr)
AU (1) AU2010311640B2 (fr)
BR (1) BR112012010114A2 (fr)
CA (1) CA2777312A1 (fr)
CL (1) CL2012001055A1 (fr)
CO (1) CO6612254A2 (fr)
CR (1) CR20120197A (fr)
DO (1) DOP2012000113A (fr)
EA (1) EA022898B1 (fr)
ES (1) ES2552177T3 (fr)
IL (1) IL218860A0 (fr)
MA (1) MA33758B1 (fr)
MX (1) MX2012005024A (fr)
NZ (1) NZ599114A (fr)
PE (1) PE20121564A1 (fr)
PH (1) PH12012500826A1 (fr)
SG (1) SG10201500274TA (fr)
TW (1) TW201125877A (fr)
UA (1) UA107200C2 (fr)
UY (1) UY32969A (fr)
WO (1) WO2011051217A1 (fr)
ZA (1) ZA201203052B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011008799A (es) * 2009-02-19 2011-09-27 Glaxo Group Ltd Polipeptidos, dominios variables de anticuerpos, y antagonistas anti-tnfr1 mejorados.
US20140112929A1 (en) * 2011-06-17 2014-04-24 Glaxo Group Limited Tumour necrosis factor receptor 1 antagonists
JP2016504918A (ja) * 2013-01-31 2016-02-18 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ タンパク質を製造する方法
WO2015104322A1 (fr) 2014-01-09 2015-07-16 Glaxosmithkline Intellectual Property Development Limited Traitement de maladies inflammatoires avec des antagonistes anti-tnfr1 non compétitifs
BR112018070452A2 (pt) * 2016-04-05 2019-02-05 Baliopharm Ag um inibidor do receptor de hutnfr1, uma preparação farmacêutica compreendendo o referido inibidor, um método de produção do referido inibidor, uso do referido inibidor na fabricação de um produto para tratamento de um indivíduo humano, um ácido nucleico isolado que codifica o referido inibidor, vetor de expressão e células hospedeiras compreendendo o referido ácido nucleico
WO2020172218A1 (fr) 2019-02-21 2020-08-27 Enosi Life Sciences Corp. Anticorps et énomomères
CA3193273A1 (fr) 2020-08-27 2022-03-03 Enosi Therapeutics Corporation Methodes et compositions pour traiter des maladies auto-immunes et un cancer
WO2022117569A1 (fr) 2020-12-02 2022-06-09 Oncurious Nv Anticorps antagoniste de ccr8 en combinaison avec un anticorps agoniste du récepteur bêta de la lymphotoxine en thérapie contre le cancer
CN114699533B (zh) * 2022-05-06 2023-05-09 郑州大学 一种核酸适配体和多肽交联的双靶点复合核酸纳米药物制备方法与应用
WO2025049818A1 (fr) 2023-08-29 2025-03-06 Enosi Therapeutics Corporation Antagonistes tnfr1 dépourvus d'activité agoniste et leurs utilisations

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GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
JP3095168B2 (ja) 1988-02-05 2000-10-03 エル． モリソン，シェリー ドメイン‐変性不変部を有する抗体
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
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JP5087274B2 (ja) 2003-06-30 2012-12-05 ドマンティス リミテッド ポリペプチド
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KR20070084069A (ko) * 2004-10-08 2007-08-24 도만티스 리미티드 Ｔｎｆｒ1에 대한 단일 도메인 항체 및 이의 사용 방법
GB0521621D0 (en) 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
GB0724331D0 (en) * 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
CA2688434A1 (fr) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, domaines variables d'anticorps et antagonistes
MX2011008799A (es) * 2009-02-19 2011-09-27 Glaxo Group Ltd Polipeptidos, dominios variables de anticuerpos, y antagonistas anti-tnfr1 mejorados.
AR075505A1 (es) * 2009-02-19 2011-04-06 Glaxo Group Ltd Variantes de union a anti- albumina de suero mejoradas

Also Published As

Publication number Publication date
KR20120101417A (ko) 2012-09-13
ES2552177T3 (es) 2015-11-26
EP2493504A1 (fr) 2012-09-05
DOP2012000113A (es) 2012-08-15
WO2011051217A1 (fr) 2011-05-05
IL218860A0 (en) 2012-06-28
NZ599114A (en) 2014-09-26
PH12012500826A1 (en) 2013-01-07
BR112012010114A2 (pt) 2017-08-08
ZA201203052B (en) 2013-09-25
CL2012001055A1 (es) 2012-10-05
CA2777312A1 (fr) 2011-05-05
SG10201500274TA (en) 2015-03-30
EA201290172A1 (ru) 2013-04-30
TW201125877A (en) 2011-08-01
JP2013507978A (ja) 2013-03-07
EA022898B1 (ru) 2016-03-31
CN102686239A (zh) 2012-09-19
AR078763A1 (es) 2011-11-30
PE20121564A1 (es) 2012-11-29
UA107200C2 (uk) 2014-12-10
UY32969A (es) 2011-05-31
EP2493504B1 (fr) 2015-10-07
CR20120197A (es) 2012-06-22
AU2010311640B2 (en) 2015-01-29
CO6612254A2 (es) 2013-02-01
AU2010311640A1 (en) 2012-05-10
MX2012005024A (es) 2012-09-07
US20150210767A1 (en) 2015-07-30
CN102686239B (zh) 2016-02-03

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