ECSP13012405A - Compuestos heterocíclicos fusionados - Google Patents

Compuestos heterocíclicos fusionados

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Publication number
ECSP13012405A
ECSP13012405A ECSP13012405A ECSP13012405A EC SP13012405 A ECSP13012405 A EC SP13012405A EC SP13012405 A ECSP13012405 A EC SP13012405A EC SP13012405 A ECSP13012405 A EC SP13012405A
Authority
EC
Ecuador
Prior art keywords
ring
optionally substituted
group
formula
heterocyclic group
Prior art date
Application number
Other languages
English (en)
Inventor
John F Quinn
Masato Yoshikawa
Takahiko Taniguchi
Kasei Miura
Tomoaki Hasui
Eiji Honda
Keisuke Imamura
Makoto Kamata
Haruhi Kamisaki
Joseph Raker
Fatoumata Camara
Yi Wang
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44317888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012405(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of ECSP13012405A publication Critical patent/ECSP13012405A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto que tiene el efecto de la inhibición de PDE y que es de utilidad como un agente para prevenir o tratar esquizofrenia, etc. Un compuesto representado por la fórmula (I): (I)en dondeanillo A representa un anillo de 6 miembros opcionalmente sustituido; uno o dos cualesquiera de Z1 a Z4 representa -N= y los otros representan -CH=; Y representa un átomo de oxígeno, un átomo de azufre, un grupo metileno opcionalmente sustituido o -NRc-; Rc representa un átomo de hidrógeno o un sustituyente; yR representa (1) un grupo representado por la fórmula:en dondeR1 representa un grupo fenilo o grupo heterocíclico de 5 a 10 miembros, cada uno de los cuales está opcionalmente sustituido; L representa un átomo de azufre, un átomo de oxígeno, un grupo metileno opcionalmente sustituido, -CO-, -NRa-, -CH2O-, -NRaCOO-, -NRaCONRb-, -NRaCOCH2-, -NRaCO-, o ; Ra y Rb son iguales o diferentes y cada uno representa un átomo de hidrógeno o un grupo alquilo C1-6 opcionalmente sustituido, oL y R1 opcionalmente forman, en combinación, un grupo heterocíclico fusionado bi- o tricíclico opcionalmente sustituido; yel anillo B1 representa un anillo benceno, un anillo piridina, un anillo pirimidina, un anillo pirazina o un anillo piridazina, cada uno de los cuales está opcionalmente sustituido; o(2) un grupo representado por la fórmula:en dondeR2 representa un grupo fenilo o grupo heterocíclico de 5 a 10 miembros, cada uno de los cuales está opcionalmente sustituido; el anillo B2 representa un anillo benceno, un anillo piridina, un anillo pirimidina, un anillo pirazina o un anillo piridazina, cada uno de los cuales está opcionalmente sustituido; yel anillo D representa un anillo de 5 ó 6 miembros también opcionalmente sustituido; o una de sus sales.
ECSP13012405 2010-06-24 2013-01-24 Compuestos heterocíclicos fusionados ECSP13012405A (es)

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