MA34663B1 - Composés 3-phénylsulfanylméthyl-bicyclo[3.1.0]hexane 4-substitués en tant qu'antagonistes de mglur 2/3 - Google Patents
Composés 3-phénylsulfanylméthyl-bicyclo[3.1.0]hexane 4-substitués en tant qu'antagonistes de mglur 2/3Info
- Publication number
- MA34663B1 MA34663B1 MA35898A MA35898A MA34663B1 MA 34663 B1 MA34663 B1 MA 34663B1 MA 35898 A MA35898 A MA 35898A MA 35898 A MA35898 A MA 35898A MA 34663 B1 MA34663 B1 MA 34663B1
- Authority
- MA
- Morocco
- Prior art keywords
- phenylsulfanylmethyl
- mglur
- bicyclo
- antagonists
- substituted
- Prior art date
Links
- -1 4-SUBSTITUTED 3-PHENYLSULFANYLMETHYL-BICYCLO [3.1.0] HEXANE COMPOUNDS Chemical class 0.000 title 1
- 229940127592 mGluR2/3 antagonist Drugs 0.000 title 1
- 101001071429 Homo sapiens Metabotropic glutamate receptor 2 Proteins 0.000 abstract 1
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne un antagoniste du récepteur mGlu2/3 de formule (I) : ses utilisations, et ses procédés de préparation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41512110P | 2010-11-18 | 2010-11-18 | |
| PCT/US2011/060730 WO2012068067A1 (fr) | 2010-11-18 | 2011-11-15 | Composés 3-phénylsulfanylméthyl-bicyclo[3.1.0]hexane 4-substitués en tant qu'antagonistes de mglur 2/3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34663B1 true MA34663B1 (fr) | 2013-11-02 |
Family
ID=45099188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35898A MA34663B1 (fr) | 2010-11-18 | 2013-05-13 | Composés 3-phénylsulfanylméthyl-bicyclo[3.1.0]hexane 4-substitués en tant qu'antagonistes de mglur 2/3 |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8629169B2 (fr) |
| EP (1) | EP2640697B1 (fr) |
| JP (1) | JP5877847B2 (fr) |
| KR (2) | KR20150140876A (fr) |
| CN (1) | CN103228625B (fr) |
| AR (1) | AR083845A1 (fr) |
| AU (1) | AU2011329076B2 (fr) |
| BR (1) | BR112013012118A2 (fr) |
| CA (1) | CA2818116C (fr) |
| CL (1) | CL2013001345A1 (fr) |
| CO (1) | CO6761385A2 (fr) |
| CR (1) | CR20130178A (fr) |
| DK (1) | DK2640697T3 (fr) |
| DO (1) | DOP2013000099A (fr) |
| EA (1) | EA021724B1 (fr) |
| EC (1) | ECSP13012629A (fr) |
| ES (1) | ES2650139T3 (fr) |
| GT (1) | GT201300126A (fr) |
| HR (1) | HRP20171649T1 (fr) |
| HU (1) | HUE037457T2 (fr) |
| IL (1) | IL225843A (fr) |
| LT (1) | LT2640697T (fr) |
| MA (1) | MA34663B1 (fr) |
| MX (1) | MX339973B (fr) |
| NO (1) | NO2640697T3 (fr) |
| NZ (1) | NZ609816A (fr) |
| PE (1) | PE20140997A1 (fr) |
| PH (1) | PH12013500991A1 (fr) |
| PL (1) | PL2640697T3 (fr) |
| PT (1) | PT2640697T (fr) |
| RS (1) | RS56535B1 (fr) |
| SG (1) | SG189959A1 (fr) |
| SI (1) | SI2640697T1 (fr) |
| TW (1) | TWI520935B (fr) |
| UA (1) | UA110039C2 (fr) |
| WO (1) | WO2012068067A1 (fr) |
| ZA (1) | ZA201302918B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
| EP3000814A1 (fr) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Pyrazoloquinazolinones et pyrroloquinazolinones substitués en tant que modulateurs allostériques des récepteurs métabotropiques du glutamate du groupe II |
| CN109071418B (zh) | 2016-04-18 | 2022-03-18 | 大正制药株式会社 | 氨基酸衍生物的前药 |
| JP2020506895A (ja) | 2017-01-17 | 2020-03-05 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | インドールアミン２，３−ジオキシゲナーゼおよび／またはトリプトファンジオキシゲナーゼの阻害剤として有用な化合物 |
| US11046649B2 (en) | 2018-07-17 | 2021-06-29 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0669928B2 (ja) | 1987-10-06 | 1994-09-07 | 宇部興産株式会社 | 光重合性歯科材料 |
| JP2589812B2 (ja) | 1989-07-05 | 1997-03-12 | 松下電器産業株式会社 | スチームアイロン |
| ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| BR9611521A (pt) * | 1995-11-16 | 1999-06-29 | Lilly Co Eli | Antagonistas de receptor de aminoácido excitador |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| BR9908850A (pt) * | 1998-03-17 | 2000-11-21 | Pfizer Prod Inc | Biciclo [2.2.1]|heptanos e compostos relacionados |
| GB9815542D0 (en) | 1998-07-17 | 1998-09-16 | Lilly Co Eli | Bicyclohexane derivatives |
| CH694053A5 (de) | 1998-09-03 | 2004-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten. |
| WO2002068380A1 (fr) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Acides amines excitateurs synthetiques |
| PT1459765E (pt) | 2001-12-27 | 2008-10-03 | Taisho Pharmaceutical Co Ltd | Derivados de 6-fluorobiciclo [3.1.0] hexano |
| US7371872B2 (en) | 2002-06-11 | 2008-05-13 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| PL1637517T3 (pl) | 2003-06-26 | 2011-04-29 | Taisho Pharmaceutical Co Ltd | Pochodne estrowe kwasu 2-aminobicyklo[3.1.0]heksano-2,6-dikarboksylowego |
| WO2005000790A1 (fr) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | Derive d'acide 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylique |
| JP2007063129A (ja) | 2003-06-26 | 2007-03-15 | Taisho Pharmaceut Co Ltd | ２−アミノ−３−アルコキシビシクロ［３．１．０］ヘキサン誘導体 |
| AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
-
2011
- 2011-11-11 TW TW100141326A patent/TWI520935B/zh not_active IP Right Cessation
- 2011-11-11 AR ARP110104219A patent/AR083845A1/es unknown
- 2011-11-15 EA EA201390498A patent/EA021724B1/ru not_active IP Right Cessation
- 2011-11-15 SI SI201131304T patent/SI2640697T1/sl unknown
- 2011-11-15 PT PT117916924T patent/PT2640697T/pt unknown
- 2011-11-15 NO NO11791692A patent/NO2640697T3/no unknown
- 2011-11-15 LT LTEP11791692.4T patent/LT2640697T/lt unknown
- 2011-11-15 BR BR112013012118A patent/BR112013012118A2/pt not_active IP Right Cessation
- 2011-11-15 PH PH1/2013/500991A patent/PH12013500991A1/en unknown
- 2011-11-15 MX MX2013005622A patent/MX339973B/es active IP Right Grant
- 2011-11-15 SG SG2013030507A patent/SG189959A1/en unknown
- 2011-11-15 EP EP11791692.4A patent/EP2640697B1/fr active Active
- 2011-11-15 KR KR1020157034547A patent/KR20150140876A/ko not_active Ceased
- 2011-11-15 HR HRP20171649TT patent/HRP20171649T1/hr unknown
- 2011-11-15 CA CA2818116A patent/CA2818116C/fr active Active
- 2011-11-15 NZ NZ609816A patent/NZ609816A/en not_active IP Right Cessation
- 2011-11-15 KR KR1020137012697A patent/KR20130101094A/ko not_active Abandoned
- 2011-11-15 DK DK11791692.4T patent/DK2640697T3/en active
- 2011-11-15 PL PL11791692T patent/PL2640697T3/pl unknown
- 2011-11-15 ES ES11791692.4T patent/ES2650139T3/es active Active
- 2011-11-15 JP JP2013539938A patent/JP5877847B2/ja active Active
- 2011-11-15 HU HUE11791692A patent/HUE037457T2/hu unknown
- 2011-11-15 PE PE2013001215A patent/PE20140997A1/es not_active Application Discontinuation
- 2011-11-15 RS RS20171082A patent/RS56535B1/sr unknown
- 2011-11-15 CN CN201180055263.7A patent/CN103228625B/zh active Active
- 2011-11-15 US US13/296,384 patent/US8629169B2/en active Active
- 2011-11-15 AU AU2011329076A patent/AU2011329076B2/en not_active Ceased
- 2011-11-15 WO PCT/US2011/060730 patent/WO2012068067A1/fr not_active Ceased
- 2011-11-15 UA UAA201305835A patent/UA110039C2/ru unknown
-
2013
- 2013-04-18 IL IL225843A patent/IL225843A/en not_active IP Right Cessation
- 2013-04-22 ZA ZA2013/02918A patent/ZA201302918B/en unknown
- 2013-04-24 CR CR20130178A patent/CR20130178A/es unknown
- 2013-05-08 DO DO2013000099A patent/DOP2013000099A/es unknown
- 2013-05-13 MA MA35898A patent/MA34663B1/fr unknown
- 2013-05-15 GT GT201300126A patent/GT201300126A/es unknown
- 2013-05-15 CL CL2013001345A patent/CL2013001345A1/es unknown
- 2013-05-17 EC ECSP13012629 patent/ECSP13012629A/es unknown
- 2013-05-30 CO CO13133036A patent/CO6761385A2/es unknown
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