MA35233B1 - Molecules de liaison bispecifiques se liant à dii4 et ang2 - Google Patents

Molecules de liaison bispecifiques se liant à dii4 et ang2

Info

Publication number
MA35233B1
MA35233B1 MA36275A MA36275A MA35233B1 MA 35233 B1 MA35233 B1 MA 35233B1 MA 36275 A MA36275 A MA 36275A MA 36275 A MA36275 A MA 36275A MA 35233 B1 MA35233 B1 MA 35233B1
Authority
MA
Morocco
Prior art keywords
ang2
binding
binding molecules
dii4
bispecific binding
Prior art date
Application number
MA36275A
Other languages
English (en)
Inventor
Andreas Gschwind
Rene Georg Ott
Joachim Boucneau
Marie-Ange Buyse
Erik Depla
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44314095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35233(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA35233B1 publication Critical patent/MA35233B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des molécules de liaison bispécifiques se liant à la fois à dll4 et ang2, de préférence sous la forme de domaines variables uniques d'immunoglobuline comme vhhs et d'anticorps de domaine, les compositions pharmaceutiques contenant celles-ci et leur utilisation dans le traitement de maladies qui sont associées à des effets médiés par dll4 et/ou ang2 sur l'angiogenèse. De plus, l'invention concerne aussi les acides nucléiques codant les molécules de liaison bispécifiques, les cellules hôtes et les procédés pour la préparation de ceux-ci.
MA36275A 2011-04-01 2013-09-27 Molecules de liaison bispecifiques se liant à dii4 et ang2 MA35233B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11160920 2011-04-01
PCT/EP2012/055897 WO2012131076A1 (fr) 2011-04-01 2012-03-30 Molécules de liaison bispécifiques se liant à dll4 et ang2

Publications (1)

Publication Number Publication Date
MA35233B1 true MA35233B1 (fr) 2014-07-03

Family

ID=44314095

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36275A MA35233B1 (fr) 2011-04-01 2013-09-27 Molecules de liaison bispecifiques se liant à dii4 et ang2

Country Status (23)

Country Link
US (1) US20130078247A1 (fr)
EP (1) EP2694545B1 (fr)
JP (1) JP2014511682A (fr)
KR (1) KR20140016345A (fr)
CN (2) CN103596977B (fr)
AP (1) AP2013007086A0 (fr)
AR (1) AR085919A1 (fr)
AU (1) AU2012234218A1 (fr)
BR (1) BR112013025294A2 (fr)
CA (1) CA2827809A1 (fr)
CL (1) CL2013002622A1 (fr)
CO (1) CO6801638A2 (fr)
EA (1) EA201301109A1 (fr)
EC (1) ECSP13012996A (fr)
MA (1) MA35233B1 (fr)
MX (1) MX337115B (fr)
PE (1) PE20141157A1 (fr)
PH (1) PH12013502031A1 (fr)
SG (1) SG193557A1 (fr)
TN (1) TN2013000389A1 (fr)
TW (2) TWI551612B (fr)
UY (1) UY33997A (fr)
WO (1) WO2012131076A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
PL2831111T3 (pl) * 2012-03-30 2019-09-30 Boehringer Ingelheim International Gmbh Cząsteczki wiążące Ang2
US20140093498A1 (en) * 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents
WO2014049100A1 (fr) * 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Combinaisons pharmaceutiques comprenant des liants doubles angiopoïétine-2/dll4 et des agents anti-vegf
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
CN107540747B (zh) * 2017-08-09 2020-01-24 苏州大学附属儿童医院 抗人dll4单克隆抗体6f12
CN110950967B (zh) * 2019-12-13 2022-05-13 山东民康生物科技有限公司 抗人血清白蛋白纳米抗体与il-2融合蛋白及制备方法
EP4400512A4 (fr) * 2021-09-10 2025-07-23 Soter Biopharma Pte Ltd Anticorps anti-ang2, son procédé de préparation et son utilisation
JP2025533028A (ja) * 2022-09-28 2025-10-03 科▲興▼生物制▲薬▼股▲ふん▼有限公司 Ａｎｇ－２を認識できる抗体または抗原結合断片及びｖｅｇｆとａｎｇ－２を同時に認識できる二重抗体
CN116444675B (zh) * 2023-05-11 2023-12-22 亲和(武汉)生命科技有限责任公司 一种Pfu DNA聚合酶纳米抗体及其制备方法和应用
KR20260117748A (ko) * 2023-11-28 2026-07-29 에프. 호프만-라 로슈 아게 혈관형성, 염증 및/또는 섬유화 인자를 표적으로 하는 다중특이적 융합 단백질

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DE69334275D1 (de) 1992-08-21 2009-05-20 Univ Bruxelles Immunoglobuline ohne Leichtkette
EP0739981A1 (fr) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Fragments variables d'immunoglobulines-utilisation thérapeutique ou vétérinaire
US6329516B1 (en) 1997-04-28 2001-12-11 Fmc Corporation Lepidopteran GABA-gated chloride channels
US6926898B2 (en) 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
EP1361892A4 (fr) 2001-01-17 2004-10-13 Trubion Pharmaceuticals Inc Proteines de fusion d'immunoglobuline de domaine de liaison
JP4303105B2 (ja) 2001-06-28 2009-07-29 ドマンティス リミテッド 二重特異性リガンドとその利用
WO2003059934A2 (fr) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Proteines de fusion d'albumine
NZ540194A (en) * 2002-11-08 2008-07-31 Ablynx Nv Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
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JP5087274B2 (ja) 2003-06-30 2012-12-05 ドマンティス リミテッド ポリペプチド
PT1687338E (pt) 2003-11-07 2011-01-20 Ablynx Nv Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações
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Also Published As

Publication number Publication date
AP2013007086A0 (en) 2013-08-31
CA2827809A1 (fr) 2012-10-04
TW201302789A (zh) 2013-01-16
PH12013502031A1 (en) 2013-12-16
TWI535735B (zh) 2016-06-01
CO6801638A2 (es) 2013-11-29
MX2013011032A (es) 2013-12-06
CL2013002622A1 (es) 2014-02-14
AR085919A1 (es) 2013-11-06
EP2694545B1 (fr) 2016-08-24
NZ614243A (en) 2015-04-24
KR20140016345A (ko) 2014-02-07
TWI551612B (zh) 2016-10-01
JP2014511682A (ja) 2014-05-19
ECSP13012996A (es) 2013-12-31
US20130078247A1 (en) 2013-03-28
SG193557A1 (en) 2013-11-29
CN103596977A (zh) 2014-02-19
CN106046167A (zh) 2016-10-26
BR112013025294A2 (pt) 2017-06-13
UY33997A (es) 2012-09-28
CN103596977B (zh) 2016-07-06
TN2013000389A1 (en) 2015-01-20
EA201301109A1 (ru) 2014-08-29
PE20141157A1 (es) 2014-09-24
AU2012234218A1 (en) 2013-09-05
TW201302797A (zh) 2013-01-16
EP2694545A1 (fr) 2014-02-12
WO2012131076A1 (fr) 2012-10-04
MX337115B (es) 2016-02-12

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