MA35443B1 - Composes benzofuranes pour le traitement d'infections par le virus de l'hepatite c - Google Patents

Composes benzofuranes pour le traitement d'infections par le virus de l'hepatite c

Info

Publication number
MA35443B1
MA35443B1 MA36832A MA36832A MA35443B1 MA 35443 B1 MA35443 B1 MA 35443B1 MA 36832 A MA36832 A MA 36832A MA 36832 A MA36832 A MA 36832A MA 35443 B1 MA35443 B1 MA 35443B1
Authority
MA
Morocco
Prior art keywords
infections
treatment
hepatitis
virus
compounds
Prior art date
Application number
MA36832A
Other languages
English (en)
Inventor
Pek Yoke Chong
John F Miller
Andrew James Peat
John Brad Shotwell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47746761&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35443(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA35443B1 publication Critical patent/MA35443B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de la formule (i) et des sels de ceux-ci, des compositions pharmaceutiques comportant lesdits composés, et des utilisations de tels composés dans le traitement ou la prévention d'infections virales, telles que des infections par le vhc, et des maladies associées à de telles infections.
MA36832A 2011-08-19 2014-03-13 Composes benzofuranes pour le traitement d'infections par le virus de l'hepatite c MA35443B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161525440P 2011-08-19 2011-08-19
US201261650681P 2012-05-23 2012-05-23
PCT/US2012/050268 WO2013028371A1 (fr) 2011-08-19 2012-08-10 Composés benzofuranes pour le traitement d'infections par le virus de l'hépatite c

Publications (1)

Publication Number Publication Date
MA35443B1 true MA35443B1 (fr) 2014-09-01

Family

ID=47746761

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36832A MA35443B1 (fr) 2011-08-19 2014-03-13 Composes benzofuranes pour le traitement d'infections par le virus de l'hepatite c

Country Status (38)

Country Link
US (2) US8927593B2 (fr)
EP (2) EP3199531A1 (fr)
JP (2) JP6367712B2 (fr)
KR (1) KR101913800B1 (fr)
CN (1) CN103732065B (fr)
AR (1) AR087563A1 (fr)
AU (1) AU2012299295B2 (fr)
BR (1) BR112014002845A2 (fr)
CA (1) CA2844086A1 (fr)
CL (2) CL2014000393A1 (fr)
CO (1) CO6862153A2 (fr)
CR (1) CR20140078A (fr)
CY (1) CY1118399T1 (fr)
DK (1) DK2744332T3 (fr)
DO (1) DOP2014000034A (fr)
EA (1) EA032841B1 (fr)
ES (1) ES2611731T3 (fr)
HR (1) HRP20161743T1 (fr)
HU (1) HUE030300T2 (fr)
IL (1) IL230487B (fr)
IN (1) IN2014CN00572A (fr)
JO (1) JO3281B1 (fr)
LT (1) LT2744332T (fr)
MA (1) MA35443B1 (fr)
ME (1) ME02588B (fr)
MX (1) MX354676B (fr)
PE (1) PE20141201A1 (fr)
PH (1) PH12014500385A1 (fr)
PL (1) PL2744332T3 (fr)
PT (1) PT2744332T (fr)
RS (1) RS55462B1 (fr)
SG (1) SG10201606883QA (fr)
SI (1) SI2744332T1 (fr)
SM (2) SMT201700028T1 (fr)
TW (1) TWI538915B (fr)
UY (1) UY34274A (fr)
WO (1) WO2013028371A1 (fr)
ZA (1) ZA201401020B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201606646RA (en) * 2011-08-17 2016-09-29 Glaxosmithkline Llc Therapeutic methods
IN2014CN00572A (fr) 2011-08-19 2015-04-03 Glaxo Group Ltd
EP3218485A1 (fr) * 2014-11-10 2017-09-20 Glaxosmithkline Intellectual Property (No. 2) Limited Compositions pharmaceutiques à action prolongée contre l'hépatite c
SG11201703646SA (en) * 2014-11-10 2017-06-29 Glaxosmithkline Intellectual Property (No 2) Ltd Combination long acting compositions and methods for hepatitis c
KR20180006522A (ko) 2016-07-07 2018-01-18 삼성디스플레이 주식회사 액정 조성물 및 이를 포함하는 액정 표시 장치
WO2018026656A1 (fr) * 2016-08-01 2018-02-08 University Of Pittsburgh -Of The Commonwealth System Of Higher Education Carbonates d'éthers de boryle, et acétals cycliques utilisés comme véhicules d'administration de médicaments déclenchés par oxydation
AU2018227811A1 (en) * 2017-03-02 2019-09-19 Assembly Biosciences, Inc. Cyclic sulfamide compounds and methods of using same
IL276013B2 (en) * 2018-01-17 2024-03-01 Glaxosmithkline Ip Dev Ltd Pi4kiiibeta inhibitors
WO2021079984A1 (fr) * 2019-10-25 2021-04-29 大日本住友製薬株式会社 Nouveau composé cyclique condensé substitué
CN111026203B (zh) * 2019-12-02 2021-01-26 宁波德晶元科技有限公司 一种适用于真空热水壶的加热控制方法与系统
JP2023554665A (ja) * 2020-12-18 2023-12-28 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド ホウ素含有ピラゾール化合物、それらを含む組成物、それらの方法及び使用

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WO2001002601A2 (fr) * 1999-07-07 2001-01-11 Du Pont Pharmaceuticals Company Systemes de dosage cellulaire destines a l'examen de l'activite de la protease ns3 hcv
PT3078667T (pt) 2001-01-25 2018-12-28 The United States Of America Represented By The Sec Dep Of Health And Human Services Formulação de compostos de ácido borónico
UA79834C2 (en) * 2002-11-01 2007-07-25 Viropharma Inc Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
BRPI0619132A2 (pt) * 2005-12-01 2011-09-13 Wyeth Corp composto métodos para inibir a replicação de um vìrus de hepatite c, para tratar ou prevenir uma infecção viral de hepatite c em um mamìfero e para inibir rna polimerase dependente do rna de hepatite c, e, composição farmacêutica
NZ570257A (en) 2006-02-16 2011-11-25 Anacor Pharmaceuticals Inc Boron-containing small molecules as anti-inflammatory agents
CA2651212A1 (fr) * 2006-05-02 2007-11-15 Anacor Pharmaceuticals, Inc. Substances therapeutiques contenant du bore resistant a l'hydrolyse et methodes d'utilisation
US20070286822A1 (en) 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
CA2963784A1 (fr) * 2007-06-08 2008-12-18 Mannkind Corporation Inhibiteurs d'ire-1.alpha
GB0719366D0 (en) * 2007-10-03 2007-11-14 Smithkline Beecham Corp Compounds
WO2009111676A2 (fr) 2008-03-06 2009-09-11 Anacor Pharmaceuticals, Inc Petites molécules contenant du bore utilisées en tant qu'agents anti-inflammatoires
JP2011512341A (ja) 2008-02-14 2011-04-21 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス性複素環化合物
WO2009137500A1 (fr) 2008-05-05 2009-11-12 Wyeth Composés de benzofurane substitués en 6 pour traiter l’infection par le virus de l’hépatite c
WO2009137493A1 (fr) 2008-05-05 2009-11-12 Wyeth Composés benzofurane substitués en position 2 pour traiter une infection par le virus de l'hépatite c
TW201008933A (en) 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
EP2348863A4 (fr) 2008-09-04 2012-03-07 Anacor Pharmaceuticals Inc Petites molécules contenant du bore
WO2011050284A1 (fr) * 2009-10-23 2011-04-28 Glaxosmithkline Llc Agents antiviraux de pyrazolylpyridine
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AR080433A1 (es) 2010-03-02 2012-04-11 Merck Sharp & Dohme Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen.
WO2012067663A1 (fr) 2010-11-18 2012-05-24 Glaxo Group Limited Composés
WO2012067664A1 (fr) 2010-11-18 2012-05-24 Glaxo Group Limited Composés
SG10201606646RA (en) * 2011-08-17 2016-09-29 Glaxosmithkline Llc Therapeutic methods
WO2013025975A1 (fr) * 2011-08-17 2013-02-21 Glaxosmithkline Llc Traitements combinés pour l'hépatite c
IN2014CN00572A (fr) 2011-08-19 2015-04-03 Glaxo Group Ltd

Also Published As

Publication number Publication date
UY34274A (es) 2013-04-05
SMT201700028T1 (it) 2017-03-08
BR112014002845A2 (pt) 2017-02-21
SMT201700028B (it) 2017-03-08
HUE030300T2 (en) 2017-04-28
EP2744332A4 (fr) 2015-01-14
US20130237501A1 (en) 2013-09-12
DK2744332T3 (en) 2017-01-16
EP3199531A1 (fr) 2017-08-02
PL2744332T3 (pl) 2017-03-31
JO3281B1 (ar) 2018-09-16
ZA201401020B (en) 2020-11-25
ES2611731T3 (es) 2017-05-10
CN103732065A (zh) 2014-04-16
TW201321390A (zh) 2013-06-01
IL230487B (en) 2019-06-30
US8927593B2 (en) 2015-01-06
LT2744332T (lt) 2017-01-10
HRP20161743T1 (hr) 2017-02-24
TWI538915B (zh) 2016-06-21
WO2013028371A1 (fr) 2013-02-28
PE20141201A1 (es) 2014-10-03
AU2012299295A1 (en) 2014-02-20
KR20140054287A (ko) 2014-05-08
US9682999B2 (en) 2017-06-20
JP2017125010A (ja) 2017-07-20
MX2014001989A (es) 2014-02-27
CL2014000393A1 (es) 2014-08-01
CL2017000293A1 (es) 2017-10-06
CA2844086A1 (fr) 2013-02-28
EA201490213A1 (ru) 2014-07-30
MX354676B (es) 2018-03-15
IN2014CN00572A (fr) 2015-04-03
AU2012299295B2 (en) 2016-03-31
CO6862153A2 (es) 2014-02-10
SG10201606883QA (en) 2016-10-28
EA032841B1 (ru) 2019-07-31
KR101913800B1 (ko) 2018-11-01
IL230487A0 (en) 2014-03-31
DOP2014000034A (es) 2014-06-01
JP2014527529A (ja) 2014-10-16
CY1118399T1 (el) 2017-06-28
EP2744332B1 (fr) 2016-10-26
PT2744332T (pt) 2017-01-24
US20150080343A1 (en) 2015-03-19
PH12014500385A1 (en) 2020-06-22
ME02588B (fr) 2017-06-20
RS55462B1 (sr) 2017-04-28
CR20140078A (es) 2014-03-20
CN103732065B (zh) 2016-10-26
EP2744332A1 (fr) 2014-06-25
JP6367712B2 (ja) 2018-08-01
AR087563A1 (es) 2014-04-03
SI2744332T1 (sl) 2017-01-31

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