MA38678A1 - Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués - Google Patents

Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués

Info

Publication number
MA38678A1
MA38678A1 MA38678A MA38678A MA38678A1 MA 38678 A1 MA38678 A1 MA 38678A1 MA 38678 A MA38678 A MA 38678A MA 38678 A MA38678 A MA 38678A MA 38678 A1 MA38678 A1 MA 38678A1
Authority
MA
Morocco
Prior art keywords
azido
deoxy
nucleoside derivatives
fluoro substituted
vhc
Prior art date
Application number
MA38678A
Other languages
English (en)
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of MA38678A1 publication Critical patent/MA38678A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne les dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués qui sont utiles en tant qu'inhibiteurs de la réplication d'arn du réplicon du vhc. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes d'utilisation desdits composés pour le traitement du vhc.
MA38678A 2013-05-16 2014-05-15 Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués MA38678A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824034P 2013-05-16 2013-05-16
PCT/US2014/038288 WO2014193663A1 (fr) 2013-05-16 2014-05-15 Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués

Publications (1)

Publication Number Publication Date
MA38678A1 true MA38678A1 (fr) 2017-07-31

Family

ID=51895939

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38678A MA38678A1 (fr) 2013-05-16 2014-05-15 Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués

Country Status (19)

Country Link
US (2) US9249176B2 (fr)
EP (1) EP2996696A4 (fr)
JP (1) JP2016519146A (fr)
KR (1) KR20160039154A (fr)
CN (1) CN105307661A (fr)
AU (1) AU2014272055A1 (fr)
BR (1) BR112015028765A2 (fr)
CA (1) CA2912684A1 (fr)
CL (1) CL2015003358A1 (fr)
CR (1) CR20150649A (fr)
EA (1) EA201592185A1 (fr)
HK (2) HK1219901A1 (fr)
MA (1) MA38678A1 (fr)
MX (1) MX2015015781A (fr)
PE (1) PE20160119A1 (fr)
PH (1) PH12015502589A1 (fr)
SG (1) SG11201509427RA (fr)
WO (1) WO2014193663A1 (fr)
ZA (1) ZA201509055B (fr)

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AU2017239338B2 (en) * 2016-03-25 2020-08-27 Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. Uridine phosphoramide prodrug, preparation method therefor, and medicinal uses thereof
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
CN121974842A (zh) 2016-05-10 2026-05-05 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
WO2017197046A1 (fr) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Dégronimères de type glutarimide liés au carbone c3 pour la dégradation de protéines cibles
EP4717317A3 (fr) 2017-06-20 2026-06-03 C4 Therapeutics, Inc. Dégrons et dégrons liés à n/o pour dégradation protéique
EP3684374B1 (fr) * 2017-09-21 2025-07-30 Riboscience LLC Dérivés nucléosidiques à substitution 4'-fluoro-2'-méthyle utilisés comme inhibiteurs de la réplication de l'arn du vhc

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Also Published As

Publication number Publication date
EP2996696A1 (fr) 2016-03-23
HK1219901A1 (zh) 2017-04-21
US9249176B2 (en) 2016-02-02
EA201592185A1 (ru) 2016-05-31
US20160220596A1 (en) 2016-08-04
JP2016519146A (ja) 2016-06-30
AU2014272055A1 (en) 2015-12-24
US20140341848A1 (en) 2014-11-20
CR20150649A (es) 2016-03-09
CN105307661A (zh) 2016-02-03
KR20160039154A (ko) 2016-04-08
PE20160119A1 (es) 2016-02-24
MX2015015781A (es) 2016-06-02
SG11201509427RA (en) 2015-12-30
US9694028B2 (en) 2017-07-04
WO2014193663A1 (fr) 2014-12-04
ZA201509055B (en) 2017-03-29
CA2912684A1 (fr) 2014-12-04
CL2015003358A1 (es) 2016-10-14
PH12015502589A1 (en) 2016-02-29
HK1217295A1 (zh) 2017-01-06
EP2996696A4 (fr) 2016-12-21
BR112015028765A2 (pt) 2017-07-25

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