MA38478A1 - Anticorps anti-pac1 humains - Google Patents

Anticorps anti-pac1 humains

Info

Publication number
MA38478A1
MA38478A1 MA38478A MA38478A MA38478A1 MA 38478 A1 MA38478 A1 MA 38478A1 MA 38478 A MA38478 A MA 38478A MA 38478 A MA38478 A MA 38478A MA 38478 A1 MA38478 A1 MA 38478A1
Authority
MA
Morocco
Prior art keywords
antibodies
pac1
antigen
binding fragments
human anti
Prior art date
Application number
MA38478A
Other languages
English (en)
Inventor
Cen Xu
Agnes Eva Hamburger
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA38478A1 publication Critical patent/MA38478A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des anticorps et des fragments de liaison à un antigène de ceux-ci qui se lient à pac1 humain. L'invention concerne des acides nucléiques codant pour les anticorps et des fragments de liaison à un antigène de ceux-ci, des vecteurs, et des cellules codant pour ceux-ci. Les anticorps et fragments de liaison à un antigène de ceux-ci peuvent inhiber la liaison de pac1 à pacap et sont utiles dans un nombre de troubles associés à pac1, comprenant le traitement et/ou la prévention de troubles de maux de tête, comprenant la migraine et l'algie vasculaire de la face.
MA38478A 2013-03-15 2014-03-14 Anticorps anti-pac1 humains MA38478A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361792678P 2013-03-15 2013-03-15
PCT/US2014/029128 WO2014144632A2 (fr) 2013-03-15 2014-03-14 Anticorps anti-pac1 humains

Publications (1)

Publication Number Publication Date
MA38478A1 true MA38478A1 (fr) 2017-11-30

Family

ID=50439531

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38478A MA38478A1 (fr) 2013-03-15 2014-03-14 Anticorps anti-pac1 humains

Country Status (24)

Country Link
US (7) US9676851B2 (fr)
EP (2) EP2970470B1 (fr)
JP (3) JP6283408B2 (fr)
KR (1) KR102215405B1 (fr)
CN (1) CN105143267B (fr)
AP (1) AP2015008732A0 (fr)
AR (1) AR095611A1 (fr)
AU (2) AU2014228924B2 (fr)
CA (1) CA2906737C (fr)
CL (1) CL2015002750A1 (fr)
CR (1) CR20150575A (fr)
EA (1) EA032830B1 (fr)
ES (1) ES2770976T3 (fr)
HK (2) HK1219958A1 (fr)
IL (2) IL241382A0 (fr)
MA (1) MA38478A1 (fr)
MX (1) MX378292B (fr)
PE (1) PE20151923A1 (fr)
PH (1) PH12015502126A1 (fr)
SG (1) SG11201507416WA (fr)
TN (1) TN2015000425A1 (fr)
TW (2) TWI636064B (fr)
UY (1) UY35483A (fr)
WO (1) WO2014144632A2 (fr)

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CA3020839A1 (fr) 2016-04-15 2017-10-19 Alder Biopharmaceuticals, Inc. Anticorps anti-pacap et leurs utilisations
AR113022A1 (es) * 2017-09-29 2020-01-15 Lilly Co Eli Anticuerpo anti-pacap
SG11202003114UA (en) 2017-10-04 2020-05-28 Amgen Inc Transthyretin immunoglobulin fusions
JP7317016B2 (ja) 2017-12-19 2023-07-28 スロゼン オペレーティング， インコーポレイテッド 抗ｌｒｐ５／６抗体及び使用方法
US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
WO2019140216A1 (fr) * 2018-01-12 2019-07-18 Amgen Inc. Anticorps pac1 et leurs utilisations
EP3774881A1 (fr) 2018-04-02 2021-02-17 Amgen Inc. Compositions d'érénumab et utilisations de celles-ci
MA52204A (fr) 2018-04-12 2021-02-17 Amgen Inc Procédés de préparation de compositions protéiques stables
US20220363770A1 (en) 2019-06-28 2022-11-17 Amgen Inc. Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins
IL310329A (en) 2021-07-29 2024-03-01 Cephalon Llc Preparations and methods for anti-PACAP antibodies
JP2024530003A (ja) * 2021-08-06 2024-08-14 アムジエン・インコーポレーテツド 治療用タンパク質の単離
TW202330607A (zh) * 2021-09-30 2023-08-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｃｇｒｐ和ｐａｃａｐ的抗原結合分子及其醫藥用途
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WO2025226754A1 (fr) 2024-04-23 2025-10-30 Amgen Inc. Procédé de prédiction de l'osmolalité de solutions protéiques

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Also Published As

Publication number Publication date
JP2016514458A (ja) 2016-05-23
US20170247451A1 (en) 2017-08-31
US20150010560A1 (en) 2015-01-08
JP2019024501A (ja) 2019-02-21
HK1218554A1 (zh) 2017-02-24
US10472417B2 (en) 2019-11-12
CL2015002750A1 (es) 2016-03-04
JP6283408B2 (ja) 2018-02-21
US10294298B2 (en) 2019-05-21
US10793631B2 (en) 2020-10-06
AP2015008732A0 (en) 2015-09-30
IL262804A (en) 2018-12-31
EP2970470A2 (fr) 2016-01-20
US20160039939A1 (en) 2016-02-11
PH12015502126A1 (en) 2016-01-25
PE20151923A1 (es) 2016-01-14
EA201591791A1 (ru) 2016-03-31
US10053507B2 (en) 2018-08-21
SG11201507416WA (en) 2015-10-29
CN105143267A (zh) 2015-12-09
WO2014144632A2 (fr) 2014-09-18
JP2018076373A (ja) 2018-05-17
ES2770976T3 (es) 2020-07-06
AU2014228924B2 (en) 2019-04-18
US9822178B2 (en) 2017-11-21
CA2906737A1 (fr) 2014-09-18
JP6443870B2 (ja) 2018-12-26
WO2014144632A3 (fr) 2014-11-20
KR102215405B1 (ko) 2021-02-10
EA032830B1 (ru) 2019-07-31
CR20150575A (es) 2016-01-06
WO2014144632A8 (fr) 2015-12-30
TN2015000425A1 (en) 2017-01-03
US20180362645A1 (en) 2018-12-20
EP2970470B1 (fr) 2019-12-04
MX378292B (es) 2025-03-10
US20180094055A1 (en) 2018-04-05
US9365653B2 (en) 2016-06-14
CN105143267B (zh) 2020-06-26
BR112015023429A8 (pt) 2018-01-23
TW201522375A (zh) 2015-06-16
UY35483A (es) 2014-08-29
AR095611A1 (es) 2015-10-28
HK1219958A1 (zh) 2017-04-21
AU2014228924A9 (en) 2016-06-16
IL241382A0 (en) 2015-11-30
US9676851B2 (en) 2017-06-13
US20160251432A1 (en) 2016-09-01
TWI636064B (zh) 2018-09-21
TW201902931A (zh) 2019-01-16
MX2015013181A (es) 2015-12-11
CA2906737C (fr) 2023-08-15
AU2014228924A1 (en) 2015-10-01
US20200172614A1 (en) 2020-06-04
KR20150128982A (ko) 2015-11-18
AU2019204980A1 (en) 2019-08-01
EP3683237A1 (fr) 2020-07-22
BR112015023429A2 (pt) 2017-11-28

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