MA39746A - Compositions de sécrétion de polypeptides hétérologues et procédés associés - Google Patents

Compositions de sécrétion de polypeptides hétérologues et procédés associés

Info

Publication number
MA39746A
MA39746A MA039746A MA39746A MA39746A MA 39746 A MA39746 A MA 39746A MA 039746 A MA039746 A MA 039746A MA 39746 A MA39746 A MA 39746A MA 39746 A MA39746 A MA 39746A
Authority
MA
Morocco
Prior art keywords
heterological
compositions
associated processes
polypeptide secretion
secretion
Prior art date
Application number
MA039746A
Other languages
English (en)
Inventor
Dorothea Reilly
Yizhou Zhou
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA39746A publication Critical patent/MA39746A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA039746A 2014-03-14 2015-03-16 Compositions de sécrétion de polypeptides hétérologues et procédés associés MA39746A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953629P 2014-03-14 2014-03-14
US201562107981P 2015-01-26 2015-01-26
US201562108476P 2015-01-27 2015-01-27

Publications (1)

Publication Number Publication Date
MA39746A true MA39746A (fr) 2021-04-28

Family

ID=52829322

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039746A MA39746A (fr) 2014-03-14 2015-03-16 Compositions de sécrétion de polypeptides hétérologues et procédés associés

Country Status (18)

Country Link
US (2) US10435694B2 (fr)
EP (1) EP3116999B1 (fr)
JP (2) JP6644717B2 (fr)
KR (1) KR102561695B1 (fr)
CN (1) CN106103730B (fr)
AU (1) AU2015229035B2 (fr)
BR (1) BR112016020822A2 (fr)
CA (1) CA2941687A1 (fr)
ES (1) ES2897765T3 (fr)
HR (1) HRP20211748T1 (fr)
IL (1) IL247632B (fr)
MA (1) MA39746A (fr)
MX (2) MX2016011637A (fr)
PL (1) PL3116999T3 (fr)
RU (1) RU2748026C2 (fr)
SG (1) SG11201607519VA (fr)
SI (1) SI3116999T1 (fr)
WO (1) WO2015139046A1 (fr)

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JP2019532656A (ja) * 2016-10-27 2019-11-14 メディミューン，エルエルシー タンパク質の改善された分泌のためのシグナルポリペプチド
CN106676122B (zh) * 2017-01-24 2019-10-29 成都分子脉象生物科技有限公司 一种基于AraF信号肽的双功能DNA元件及其应用
JP7177445B2 (ja) 2017-05-19 2022-11-24 真吾 前田 Ｃｃｒ４阻害による制御性ｔ細胞浸潤抑制法およびイヌの腫瘍性疾患の治療法
GB201708277D0 (en) * 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
KR101946789B1 (ko) * 2018-01-26 2019-02-12 (주)휴온스 이황화결합 이성질화효소 신호 펩타이드를 포함하는 재조합 벡터 및 이의 용도
CN113454227B (zh) * 2018-12-19 2025-05-23 维萨梅布有限公司 编码蛋白质的rna
GB2590642B (en) * 2019-12-20 2024-02-14 Kymab Ltd Improved lambda antibodies
EP4010500B1 (fr) * 2019-08-05 2025-02-19 Wacker Chemie AG Souche bactérienne pour la libération d'une protéine recombinante dans un procédé de fermentation
SE544059C2 (en) * 2020-02-07 2021-11-30 Cloneopt Ab Synthetically evolved dna constructs for regulating signal peptide performance as well as vectors and host cells thereof
EP4100534A4 (fr) * 2020-02-07 2024-06-05 Xbrane Biopharma AB Constructions d'adn synthétiquement évoluées pour réguler les performances d'un peptide signal ainsi que de vecteurs, cellules hôtes et protéines recombinantes de celles-ci
SE543945C2 (en) * 2020-02-07 2021-10-05 Cloneopt Ab Synthetically evolved DNA constructs for regulating signal peptide performance as well as vectors and host cells thereof
AU2022349814A1 (en) * 2021-09-24 2024-05-02 Alvotech Hf Dna constructs and host cells for expressing recombinant protein

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BR112016020822A2 (pt) 2017-10-03
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RU2016140244A (ru) 2018-04-17
JP2020078305A (ja) 2020-05-28
PL3116999T3 (pl) 2021-12-27
US10435694B2 (en) 2019-10-08
MX2016011637A (es) 2017-04-13
CN106103730B (zh) 2021-06-08
AU2015229035B2 (en) 2021-08-05
US20200181625A1 (en) 2020-06-11
AU2015229035A1 (en) 2016-09-22
KR20160134758A (ko) 2016-11-23
RU2016140244A3 (fr) 2019-05-22
RU2748026C2 (ru) 2021-05-19
WO2015139046A1 (fr) 2015-09-17
ES2897765T3 (es) 2022-03-02
IL247632A0 (en) 2016-11-30
US11390872B2 (en) 2022-07-19
SI3116999T1 (sl) 2021-12-31
JP6644717B2 (ja) 2020-02-12
KR102561695B1 (ko) 2023-07-28
US20170029825A1 (en) 2017-02-02
CN106103730A (zh) 2016-11-09
HRP20211748T1 (hr) 2022-02-18
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CA2941687A1 (fr) 2015-09-17

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