MA45779A - Polypeptides immunomdulateurs et compositions et procédés associés - Google Patents

Polypeptides immunomdulateurs et compositions et procédés associés

Info

Publication number
MA45779A
MA45779A MA045779A MA45779A MA45779A MA 45779 A MA45779 A MA 45779A MA 045779 A MA045779 A MA 045779A MA 45779 A MA45779 A MA 45779A MA 45779 A MA45779 A MA 45779A
Authority
MA
Morocco
Prior art keywords
immunomdulators
polypeptides
processes
related compositions
compositions
Prior art date
Application number
MA045779A
Other languages
English (en)
Inventor
Allen Ebens
Collin Hauskins
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MA45779A publication Critical patent/MA45779A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57554Prolactin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596Molecules with a "CD"-designation not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
MA045779A 2016-07-29 2017-07-28 Polypeptides immunomdulateurs et compositions et procédés associés MA45779A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662369017P 2016-07-29 2016-07-29

Publications (1)

Publication Number Publication Date
MA45779A true MA45779A (fr) 2019-06-05

Family

ID=59631857

Family Applications (1)

Application Number Title Priority Date Filing Date
MA045779A MA45779A (fr) 2016-07-29 2017-07-28 Polypeptides immunomdulateurs et compositions et procédés associés

Country Status (10)

Country Link
US (1) US12304935B2 (fr)
EP (1) EP3490585B1 (fr)
JP (2) JP7295795B2 (fr)
CN (1) CN110087672A (fr)
AU (1) AU2017301880C1 (fr)
CA (1) CA3031955A1 (fr)
ES (1) ES2951552T3 (fr)
MA (1) MA45779A (fr)
MX (1) MX2019001185A (fr)
WO (1) WO2018023093A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3443001B1 (fr) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
CA3031955A1 (fr) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Polypeptides immunomdulateurs et compositions et procedes associes
CN111094330A (zh) 2017-07-03 2020-05-01 转矩医疗股份有限公司 编码免疫刺激融合分子的多核苷酸及其用途
BR112020018670A2 (pt) 2018-03-14 2021-01-05 Seattle Children's Hospital (dba Seattle Children's Research Institute) Receptor de antígeno quimérico de receptor alfa 2 da il-13 (il13ra2) para imunoterapia com células t específicas para tumor
EP4491718A3 (fr) 2018-03-14 2025-03-26 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Immunothérapie de lymphocytes t dirigée par zetakine, ciblant le récepteur alpha 2 d'il-13
WO2019222294A1 (fr) * 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Polypeptides de cytokine activables et leurs procédés d'utilisation
CN112533957B (zh) 2018-06-04 2026-01-16 普瑞赛格恩公司 Muc16特异性嵌合抗原受体及其用途
CN109306016B (zh) * 2018-08-15 2021-10-22 华东师范大学 共表达细胞因子il-7的nkg2d-car-t细胞及其用途
WO2020051493A1 (fr) * 2018-09-07 2020-03-12 Unum Therapeutics Inc. Polypeptides récepteurs chimériques en association avec des molécules métaboliques trans modulant des concentrations intracellulaires en lactate et utilisations thérapeutiques associées
JP7391984B2 (ja) * 2019-03-12 2023-12-05 重▲慶▼精准生物技▲術▼有限公司 低酸素調節プロモーター及びその応用
CN111848811B (zh) * 2019-04-27 2024-10-01 张晋宇 一种蛋白质异二聚体及其用途
AU2020279112A1 (en) 2019-05-17 2021-12-02 Xencor, Inc. IL-7-Fc-fusion proteins
CN112294760B (zh) * 2019-07-26 2025-12-12 宁波新致生物科技有限公司 一种液体制剂及其应用
WO2021081345A1 (fr) * 2019-10-25 2021-04-29 Mayo Foundation For Medical Education And Research Bipeptide ayant une affinité avec des protéines ou des cellules de la matrice extracellulaire et avec des facteurs de croissance permettant la cicatrisation et la régénération de tissus
EP4069291A1 (fr) 2019-12-03 2022-10-12 Evotec International GmbH Protéines de liaison à l'antigène associées à l'interféron et leurs utilisations
WO2021115333A1 (fr) * 2019-12-10 2021-06-17 苏州克睿基因生物科技有限公司 Protéine de fusion et cellule immunitaire modifiée exprimant celle-ci et application de cellule immunitaire modifiée
IL293978A (en) 2019-12-20 2022-08-01 Regeneron Pharma New il2 agonists and methods of using them
CN111153961B (zh) * 2020-01-08 2022-02-18 郑州大学 一种亲和pd-1的肽及其应用
US20230111460A1 (en) * 2020-01-30 2023-04-13 Purdue Research Foundation Ligand-mediated delivery of therapeutic proteins and the uses thereof
CN111533785B (zh) * 2020-02-11 2022-03-08 北京市肿瘤防治研究所 靶向免疫检查点tim3结合肽及其应用
US12508309B2 (en) * 2020-02-18 2025-12-30 Vacdiagn Biotechnology Co., Ltd. Recombinant viral vector, immunogenic composition comprising same, and uses
CN115698268A (zh) * 2020-05-04 2023-02-03 萨利欧基因治疗公司 基于转座的疗法
CN112063588A (zh) * 2020-08-13 2020-12-11 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CA3192383A1 (fr) * 2020-09-17 2022-03-24 Robin Barbour Vaccin a base de ?-amyloide pour le traitement de la maladie d'alzheimer
US12234473B2 (en) 2020-12-31 2025-02-25 Immatics US, Inc. CD8 polypeptides, compositions, and methods of using thereof
CN114907485B (zh) * 2021-02-08 2024-04-26 浙江大学 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体
CN112877294B (zh) * 2021-02-23 2021-08-24 赛浦生物科技(长春)有限公司 基因修饰的间充质干细胞外泌体的制备及其应用
CA3226924A1 (fr) 2021-07-19 2023-01-26 Regeneron Pharmaceuticals, Inc. Agonistes du recepteur de l'il12 et leurs procedes d'utilisation
WO2023015822A1 (fr) * 2021-08-13 2023-02-16 上海鑫湾生物科技有限公司 Facteur de transcription artificiel déclenché par l'hypoxie et système de régulation de la transcription déclenché par l'hypoxie, et application associée
US20230103980A1 (en) * 2021-10-04 2023-04-06 California Institute Of Technology Thermal state switches in macrophages
CN116103239A (zh) * 2021-11-11 2023-05-12 南京北恒生物科技有限公司 工程化免疫细胞及其用途
US20230151095A1 (en) 2021-11-12 2023-05-18 Xencor, Inc. Bispecific antibodies that bind to b7h3 and nkg2d
WO2023137069A2 (fr) * 2022-01-12 2023-07-20 St. Jude Children's Research Hospital, Inc. Récepteurs antigéniques chimériques bispécifiques ciblant grp78 et cd123 ou grp78 et b7h3
WO2024102636A1 (fr) 2022-11-07 2024-05-16 Xencor, Inc. Anticorps bispécifiques qui se lient à b7h3 et mica/b
US20250243279A1 (en) 2023-10-17 2025-07-31 Xencor, Inc. Bispecific antibodies that bind to nkp46 and mica/b
WO2025129120A2 (fr) * 2023-12-15 2025-06-19 Port Therapeutics, Inc. Utilisation de bio-commutateurs thermiques pour le traitement de maladies auto-immunes
CN117986386B (zh) * 2024-02-06 2024-11-29 康立泰生物医药(青岛)有限公司 重组人白细胞介素-35及其制备方法和应用
WO2025176860A1 (fr) 2024-02-23 2025-08-28 Charité - Universitätsmedizin Berlin Körperschaft des öffentlichen Rechts Construction de récepteur antigénique chimérique double ciblant cea et epcam

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
IN165717B (fr) 1986-08-07 1989-12-23 Battelle Memorial Institute
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
ES2067018T3 (es) 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
WO1992008796A1 (fr) 1990-11-13 1992-05-29 Immunex Corporation Genes de fusion selectionnables bifonctionnels
DE4228458A1 (de) 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
AU6953394A (en) 1993-05-21 1994-12-20 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US5891680A (en) 1995-02-08 1999-04-06 Whitehead Institute For Biomedical Research Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
US20020150914A1 (en) 1995-06-30 2002-10-17 Kobenhavns Universitet Recombinant antibodies from a phage display library, directed against a peptide-MHC complex
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
WO1997034634A1 (fr) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Produits de recombinaison d'anticorps diriges contre le gd2, constitues d'un fragment variable (fv) a chaine simple
US6653105B2 (en) 1998-02-11 2003-11-25 Vitagen, Inc. Clonal cells and cell lines derived from C3A cells and methods of making and using them
WO2000014257A1 (fr) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Recepteurs de fusion specifiques a l'antigene prostatique specifique membranaire et ses utilisations
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
BR0013231A (pt) * 1999-08-09 2002-07-23 Lexigen Pharm Corp Complexos citocina-anticorpo múltiplos
AU3958101A (en) 2000-03-15 2001-09-24 Univ Pohang Genes of il-12p40 subunit mutated for improving the activity of il-12 and use thereof for dna vaccine adjuvant
AU5473201A (en) 2000-03-24 2001-10-03 Bayer Aktiengesellschaft Regulation of human mas oncogene-related g protein-coupled receptor
CA2410510A1 (fr) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Cellules presentatrices d'antigene artificiel et leurs methodes d'utilisation
AU2001297703B2 (en) 2000-11-07 2006-10-19 City Of Hope CD19-specific redirected immune cells
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US7939059B2 (en) 2001-12-10 2011-05-10 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
EP1418184A1 (fr) 2002-11-08 2004-05-12 Cell Center Cologne GmbH Protéine recombinante comprenant les subunités p40 et p35 de IL-12 et un scFv et leur utilisation
GB0228465D0 (en) 2002-12-06 2003-01-08 Univ Belfast A method of treating disease
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
KR101281208B1 (ko) 2005-05-11 2013-07-26 필로겐 에스.피.에이. 피브로넥틴 ed-b에 대한 항체 l19 및 인터루킨12의 융합 단백질
EP1966238B1 (fr) * 2005-12-30 2012-04-25 Merck Patent GmbH Variants de polypeptides p40 de l'interleukine 12 ayant une stabilité améliorée
US7833754B2 (en) 2006-01-13 2010-11-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services IL-12 for expression in mammalian cell
WO2008136869A2 (fr) 2006-12-06 2008-11-13 Burnham Institute For Medical Research Procédés et compositions relatives au ciblage de lésions, de tissu de régénération et de tumeurs
US8536113B2 (en) * 2006-12-21 2013-09-17 Janssen Biotech, Inc. EGFR binding peptides and uses thereof
PL2856876T3 (pl) 2007-03-30 2018-06-29 Memorial Sloan-Kettering Cancer Center Konstytutywna ekspresja ligandów kostymulujących na limfocytach T poddanych transferowi adoptywnemu
EP3293266B1 (fr) 2007-05-04 2025-12-24 University Health Network Immunothérapie par il-12 pour le cancer
ES2640216T3 (es) 2007-12-07 2017-11-02 Miltenyi Biotec Gmbh Sistemas y métodos para procesamiento de células
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
WO2009140206A1 (fr) 2008-05-11 2009-11-19 The Gov. Of The U. S. A., As Represented By The Secretary Of The Dept. Of Health And Human Services Expression améliorée d'hétérodimères de la famille il-12
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
AU2010241864B2 (en) 2009-04-30 2014-02-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inducible interleukin-12
WO2011112935A2 (fr) * 2010-03-12 2011-09-15 The Regents Of The University Of California Protéines de fusion de type anticorps ayant une activité de liaison à l'héparine perturbée
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9987308B2 (en) 2011-03-23 2018-06-05 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
AU2012236068A1 (en) 2011-04-01 2013-10-17 Eureka Therapeutics, Inc. T cell receptor-like antibodies specific for a WT1 peptide presented by HLA-A2
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
WO2013014149A1 (fr) 2011-07-27 2013-01-31 Philogen S.P.A. Immunoconjugué d'il-12
EP2755487B1 (fr) 2011-09-16 2018-12-19 Baylor College Of Medicine Ciblage du microenvironnement tumoral au moyen de cellules nkt modifiées
US10208086B2 (en) 2011-11-11 2019-02-19 Fred Hutchinson Cancer Research Center Cyclin A1-targeted T-cell immunotherapy for cancer
EP3594245A1 (fr) 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Récepteurs d'antigènes chimériques bispécifiques et leurs utilisations thérapeutiques
WO2013126726A1 (fr) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Lymphocytes t doubles transgéniques comportant un car et un tcr, et leurs procédés d'utilisation
CN107557334B (zh) 2012-05-03 2021-06-25 弗雷德哈钦森癌症研究中心 增强亲和力的t细胞受体及其制备方法
PL3824905T3 (pl) 2012-08-20 2025-05-05 Fred Hutchinson Cancer Center Sposób i kompozycje do immunoterapii komórkowej
SG11201502598SA (en) 2012-10-02 2015-05-28 Sloan Kettering Inst Cancer Compositions and methods for immunotherapy
JP5372297B1 (ja) 2012-12-20 2013-12-18 三菱電機株式会社 車載装置及びプログラム
BR112015020516A2 (pt) 2013-02-26 2017-10-10 Memorial Sloan Kettering Cancer Center composições e métodos para imunoterapia
WO2014139468A1 (fr) 2013-03-15 2014-09-18 Admark Healthcare, Llc Molécules de protéine de fusion et leur procédé d'utilisation
EP2994530A4 (fr) * 2013-05-10 2016-11-16 Whitehead Biomedical Inst Modification protéique de cellules vivantes à l'aide de sortase
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
CA3031955A1 (fr) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Polypeptides immunomdulateurs et compositions et procedes associes

Also Published As

Publication number Publication date
JP2023062104A (ja) 2023-05-02
CN110087672A (zh) 2019-08-02
EP3490585B1 (fr) 2023-05-17
AU2017301880B2 (en) 2021-11-04
AU2017301880A1 (en) 2019-02-07
EP3490585A1 (fr) 2019-06-05
ES2951552T3 (es) 2023-10-23
JP7295795B2 (ja) 2023-06-21
CA3031955A1 (fr) 2018-02-01
MX2019001185A (es) 2019-10-21
US12304935B2 (en) 2025-05-20
US20190194283A1 (en) 2019-06-27
WO2018023093A1 (fr) 2018-02-01
AU2017301880C1 (en) 2022-04-21
JP2019531704A (ja) 2019-11-07

Similar Documents

Publication Publication Date Title
IL285286A (en) Transposase polypeptides and uses thereof
IL282704A (en) De novo binding domain containing polypeptides and uses thereof
MA43380A (fr) Récepteurs chimériques modifiés et compositions et procédés associés
DK3443009T3 (da) Anti-tim-3-antistoffer og sammensætninger
EP3503879A4 (fr) Compositions et procédés associés
DK3495023T3 (da) Semifluorerede forbindelser og sammensætninger deraf
IL248979B (en) Syntac polypeptides and uses thereof
KR102090294B9 (ko) 가소제 조성물 및 이를 포함하는 수지 조성물
DK3316909T5 (da) Anti-ntb-a-antistoffer og relaterede sammensætninger og fremgangsmåder
KR20180084891A (ko) 구조 조성물 및 방법
DK3494119T3 (da) Forbindelser og sammensætninger og anvendelser deraf
MA39746A (fr) Compositions de sécrétion de polypeptides hétérologues et procédés associés
EP3606465A4 (fr) Schémas posologiques et compositions et procédés associés
DK3528902T3 (da) Ringegelsammensætning
EP3498777A4 (fr) Composition d'émulsion d'organopolysiloxane, et composition de résine
MA51162A (fr) Schémas posologiques et compositions et procédés associés
EP3433587A4 (fr) Balance et procédés associés
EP3480228A4 (fr) Composition
DK3388085T3 (da) Farmaceutisk sammensætning og anvendelser deraf
EP3556804A4 (fr) Composition
EP3349788A4 (fr) Compositions antimalariques et procédés
EP3524627A4 (fr) Composition
DK3416502T3 (da) Glykæmisk-reducerende sammensætning
EP3537876A4 (fr) Composition anthelminthique
MA46711A (fr) Polysaccharide et procédés