MA40170A - Dérivés hétérocycliques de morphinan et leur utilisation - Google Patents

Dérivés hétérocycliques de morphinan et leur utilisation

Info

Publication number
MA40170A
MA40170A MA040170A MA40170A MA40170A MA 40170 A MA40170 A MA 40170A MA 040170 A MA040170 A MA 040170A MA 40170 A MA40170 A MA 40170A MA 40170 A MA40170 A MA 40170A
Authority
MA
Morocco
Prior art keywords
heterocyclic
morphinan derivatives
morphinan
derivatives
solvates
Prior art date
Application number
MA040170A
Other languages
English (en)
Inventor
Laykea Tafesse
Mark A Youngman
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of MA40170A publication Critical patent/MA40170A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés de formule (i) et des sels et solvates pharmaceutiquement acceptables de ceux-ci. Dans la formule (i), r
MA040170A 2014-06-13 2015-06-12 Dérivés hétérocycliques de morphinan et leur utilisation MA40170A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462011696P 2014-06-13 2014-06-13

Publications (1)

Publication Number Publication Date
MA40170A true MA40170A (fr) 2017-04-19

Family

ID=54834422

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040170A MA40170A (fr) 2014-06-13 2015-06-12 Dérivés hétérocycliques de morphinan et leur utilisation

Country Status (6)

Country Link
US (1) US10131666B2 (fr)
EP (1) EP3154971A4 (fr)
JP (2) JP2017521488A (fr)
CA (1) CA2952124A1 (fr)
MA (1) MA40170A (fr)
WO (1) WO2015192039A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10138207B2 (en) 2012-11-09 2018-11-27 Purdue Pharma, L.P. Benzomorphan analogs and the use thereof
US9656962B2 (en) 2013-12-26 2017-05-23 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
EP3087078B1 (fr) 2013-12-26 2019-05-15 Purdue Pharma LP Analogues 7-bêta-alkyle d'orvinols
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
EP3087073B1 (fr) 2013-12-26 2018-07-04 Purdue Pharma LP Hydantoïnes de morphinane substitués en position 10
EP3086790A4 (fr) 2013-12-27 2017-07-19 Purdue Pharma LP Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
CA2951697A1 (fr) 2014-06-13 2015-12-17 Purdue Pharma L.P. Derives d'azamophinan et leur utilisation
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
EA037481B1 (ru) 2016-01-13 2021-04-01 Грюненталь Гмбх Производные 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана
MX379359B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
BR112018014302B1 (pt) 2016-01-13 2023-10-17 Grünenthal GmbH Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
DK3402785T3 (da) 2016-01-13 2020-04-20 Gruenenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater
AU2017206908B2 (en) 2016-01-13 2020-07-09 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
WO2018125716A1 (fr) 2017-01-02 2018-07-05 Purdue Pharma L.P. Dérivés de morphinane et leur utilisation
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2067200C (fr) * 1989-10-16 1998-06-30 Kenner C. Rice Synthese totale d'enantiomeres de la northebaine, normorphine, noroxymorphone et de leurs derives par des intermediaires n-nor
IT1270612B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Derivati eterociclo-condensatori di morfinoidi
ES2188888T3 (es) * 1996-01-10 2003-07-01 Glaxosmithkline Spa Derivados morfinoides 8ii) con condensados con heterociclos.
WO1998047869A1 (fr) 1997-04-22 1998-10-29 Cocensys, Inc. Semicarbazones et thiosemicarbazones carbocycliques et heterocycliques substitues et leur utilisation
ES2352739T3 (es) 1997-11-21 2011-02-22 Purdue Neuroscience Company 2-aminoacetamidas sustituidas y el uso de las mismas.
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
ES2345921T3 (es) 1999-03-26 2010-10-06 Euro-Celtique S.A. Pirazoles, imidazoles, oxazoles, tiazoles y pirroles sustituidos con arilo y su uso.
WO2000061188A1 (fr) 1999-04-09 2000-10-19 Euro-Celtique S.A. Composition de blocage du canal sodique et leur utilisation
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
CA2400778C (fr) 2000-03-24 2011-05-03 Purdue Pharma L.P. Pyrazoles, triazoles et tetrazoles a substitution aryle et leur utilisation
NZ521870A (en) 2000-03-31 2004-08-27 Euro Celtique S Aminopyridines and their use as anticonvulsants and sodium channel blockers
CA2453633A1 (fr) 2001-07-16 2003-01-30 Euro-Celtique S.A. Thiazolidinones a substitution aryle et utilisations
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
EA200401120A1 (ru) 2002-03-13 2005-02-24 Еуро-Селтик С. А. Арилзамещенные пиримидины и их применение
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
BR0313084A (pt) 2002-07-31 2005-06-28 Euro Celtique Sa Composto, composição farmacêutica, método para a produção de um composto, método de tratamento, prevenção ou melhora de uma desordem, e método de tratamento de um mamìfero
MXPA05000812A (es) 2002-07-31 2005-04-19 Euro Celtique Sa Bencimidazoles aril sustituidos y su uso como bloqueadores del canal de sodio.
US20040152696A1 (en) 2002-08-01 2004-08-05 Euro-Celtique S.A. 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers
WO2005014849A2 (fr) 2003-07-03 2005-02-17 Euro-Celtique, S.A. Genes associes a des reponses a des douleurs neuropathiques
CN101481376A (zh) * 2008-01-10 2009-07-15 中国科学院上海药物研究所 一类杂环并14-羟基-吗啡喃类化合物、制备方法及用途
EP2582666B1 (fr) 2010-06-16 2014-08-13 Purdue Pharma L.P. Indoles à substitution aryle et leur utilisation en tant que bloqueur des canaux sodium
JP2013531687A (ja) 2010-07-16 2013-08-08 パーデュー、ファーマ、リミテッド、パートナーシップ ナトリウムチャネル遮断剤としてのピリジン化合物
EP2616441B1 (fr) 2010-09-17 2019-08-07 Purdue Pharma L.P. Composés de pyridine et ses utilisations
AU2011311238A1 (en) 2010-10-05 2013-04-04 Purdue Pharma L.P. Quinazoline compounds as sodium channel blockers
JP2014500303A (ja) 2010-12-22 2014-01-09 パーデュー、ファーマ、リミテッド、パートナーシップ ナトリウムチャネル遮断剤としての置換ピリジン
AU2012300567B2 (en) 2011-09-02 2016-03-10 Purdue Pharma L.P. Pyrimidines as sodium channel blockers
AU2012324010A1 (en) 2011-10-31 2013-05-16 Purdue Pharma L.P. Heteroaryl compounds as sodium channel blockers
AU2012321111A1 (en) 2011-10-31 2013-05-16 Purdue Pharma L.P. Quaternized amines as sodium channel blockers
WO2013072758A1 (fr) 2011-11-15 2013-05-23 Purdue Pharma L.P. Pyrimidine diol amides comme bloqueurs des canaux sodiques
AU2013203824A1 (en) 2012-03-16 2013-10-03 Purdue Pharma L.P. Substituted pyridines and pryimidines as sodium channel blockers
ES2631197T3 (es) 2012-12-14 2017-08-29 Purdue Pharma Lp Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
EP2931725B1 (fr) 2012-12-14 2017-02-15 Purdue Pharma LP Dérivés de morphinane contenant de l'azote et leur utilisation
WO2014096941A1 (fr) 2012-12-20 2014-06-26 Purdue Pharma L.P. Sulfonamides cycliques en tant que bloquants des canaux sodiques
US9120786B2 (en) 2013-03-04 2015-09-01 Purdue Pharma, L.P. Triazine carboxamides as sodium channel blockers
AU2014224310B2 (en) 2013-03-04 2017-02-09 Purdue Pharma L.P. Pyrimidine carboxamides as sodium channel blockers
CA3082427A1 (fr) 2013-03-15 2014-09-25 Purdue Pharma L.P. Derives de carboxamide et leur utilisation
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
CA2913558C (fr) 2013-05-24 2021-06-29 Rhodes Technologies Composes cetal opioides et leurs utilisations
US9359330B2 (en) 2013-08-26 2016-06-07 Purdue Pharma L.P. Substituted piperidines as sodium channel blockers
US9828348B2 (en) 2013-11-08 2017-11-28 Purdue Pharma L.P. Benzimidazole derivatives and use thereof
US9340504B2 (en) 2013-11-21 2016-05-17 Purdue Pharma L.P. Pyridine and piperidine derivatives as novel sodium channel blockers
US9695144B2 (en) 2013-12-23 2017-07-04 Purdue Pharma L.P. Dibenzazepine derivatives and use thereof
EP3089978B1 (fr) 2013-12-30 2018-08-29 Purdue Pharma L.P. Analogues de morphinane pyridone-sulfones utilisés comme ligands de récepteurs opioïdes
WO2015112801A1 (fr) 2014-01-24 2015-07-30 Purdue Pharma L.P. Pyridines et pyrimidines, et leur utilisation
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof

Also Published As

Publication number Publication date
JP2017521488A (ja) 2017-08-03
JP2019031519A (ja) 2019-02-28
US10131666B2 (en) 2018-11-20
EP3154971A4 (fr) 2017-11-01
CA2952124A1 (fr) 2015-12-17
US20180111934A1 (en) 2018-04-26
EP3154971A1 (fr) 2017-04-19
WO2015192039A1 (fr) 2015-12-17

Similar Documents

Publication Publication Date Title
MA40171A (fr) Dérivés d'azamophinan et leur utilisation
PH12019501321B1 (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k-delta related disorders
MD20160106A2 (ro) Compuşi aril sau heteroaril biciclici condensaţi şi utilizarea acestora ca inhibitori IRAK4
TW201613872A (en) IRAK4 inhibiting agents
AU2014267235A8 (en) Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
MA40058A (fr) Composés inhibiteurs de kinases se liant à tank
JO3317B1 (ar) مركبات تترا هيدروبيرولو ثيازين
MA39749A (fr) Dérivés de pipéridine-dione
MA39866A (fr) Amides 2-amino-6-méthyl-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yle
MX2017003930A (es) Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank.
CR20150470A (es) Derivados de triazolona de piridinilo y piridinilo fusionado
MX368066B (es) Derivados de quinazolin-4-ona sustituida.
MX2015016451A (es) Compuestos heterocíclicos como inhibidores de la ruta de señalización hedgehog.
MX2018001992A (es) Compuestos triciclicos heterociclicos como inhibidores de fosfoinositol 3-quinasa.
MX367554B (es) Derivados heterocíclicos y sus usos.
JO3318B1 (ar) مثبطات bace
MX390051B (es) Antagonistas de ep4.
SA517381678B1 (ar) مركبات داي هيدرو بيريميدين-2-أون واستخدامها الطبي
MX2015013224A (es) Inhibidores macrociclicos y biciclicos del virus de la hepatitis c.
JOP20190163B1 (ar) منشط nrf2
IN2013MU03862A (fr)
EA201791099A1 (ru) Хинолин карбоксамиды для применения в лечении лейкоза
EA201491227A1 (ru) Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2
PH12016502480A1 (en) Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
PH12016501645A1 (en) Aminopyrazolone derivative