MA40254A - Polymorphes du selinexor - Google Patents

Polymorphes du selinexor

Info

Publication number
MA40254A
MA40254A MA040254A MA40254A MA40254A MA 40254 A MA40254 A MA 40254A MA 040254 A MA040254 A MA 040254A MA 40254 A MA40254 A MA 40254A MA 40254 A MA40254 A MA 40254A
Authority
MA
Morocco
Prior art keywords
selinexor
polymorphs
selinexor polymorphs
Prior art date
Application number
MA040254A
Other languages
English (en)
Other versions
MA40254B1 (fr
Inventor
Brian Clinton Austad
David G Roe
Original Assignee
Karyopharm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karyopharm Therapeutics Inc filed Critical Karyopharm Therapeutics Inc
Publication of MA40254A publication Critical patent/MA40254A/fr
Publication of MA40254B1 publication Critical patent/MA40254B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
MA40254A 2014-08-15 2015-08-14 Polymorphes du selinexor MA40254B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462038069P 2014-08-15 2014-08-15
PCT/US2015/045395 WO2016025904A1 (fr) 2014-08-15 2015-08-14 Formes polymorphes de selinexor

Publications (2)

Publication Number Publication Date
MA40254A true MA40254A (fr) 2021-05-19
MA40254B1 MA40254B1 (fr) 2022-09-30

Family

ID=53969460

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40254A MA40254B1 (fr) 2014-08-15 2015-08-14 Polymorphes du selinexor

Country Status (18)

Country Link
US (7) US10519139B2 (fr)
EP (2) EP4112615A1 (fr)
JP (3) JP6777626B2 (fr)
KR (1) KR102608259B1 (fr)
CN (3) CN111481553B (fr)
AU (4) AU2015301484B2 (fr)
CA (1) CA2957266A1 (fr)
CO (1) CO2017001884A2 (fr)
DK (1) DK3180331T3 (fr)
EA (1) EA201790384A1 (fr)
ES (1) ES2926377T3 (fr)
IL (1) IL250328B (fr)
MA (1) MA40254B1 (fr)
MX (2) MX388170B (fr)
SG (2) SG11201700789SA (fr)
UA (1) UA123535C2 (fr)
WO (1) WO2016025904A1 (fr)
ZA (1) ZA201700880B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR087342A1 (es) 2011-07-29 2014-03-19 Karyopharm Therapeutics Inc Moduladores del transporte nuclear que contienen hidrazida y sus usos
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US10202366B2 (en) 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
KR102322794B1 (ko) 2013-06-21 2021-11-05 카리오팜 쎄라퓨틱스, 인코포레이티드 핵수송 조절인자 및 이의 용도
SG11201700789SA (en) * 2014-08-15 2017-02-27 Karyopharm Therapeutics Inc Polymorphs of selinexor
US10526295B2 (en) 2015-12-31 2020-01-07 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US10709706B2 (en) 2015-12-31 2020-07-14 Karopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US11034675B2 (en) 2016-01-08 2021-06-15 Dr. Reddy's Laboratories Limited Solid forms of Selinexor and process for their preparation
WO2018098472A1 (fr) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Inhibiteurs de crm1 pour le traitement de l'épilepsie
EP3565813A1 (fr) 2017-01-05 2019-11-13 Watson Laboratories, Inc. Nouvelles formes cristallines de sélinexor et leur procédé de préparation
CN106831731B (zh) * 2017-01-17 2019-11-08 广州市闻皓生物科技有限公司 一种Selinexor原料药的合成方法
WO2019232724A1 (fr) 2018-06-06 2019-12-12 Xw Laboratories, Inc. Composés en tant que modulateurs de transport nucléaire et leurs utilisations
WO2020072008A1 (fr) * 2018-10-04 2020-04-09 Deva Holding Anonim Sirketi Nouvelles dispersions solides de sélinexor
BR112021016762A2 (pt) * 2019-03-20 2021-10-19 Johnson Matthey Public Limited Company Cocristal de selinexor, composição farmacêutica, método de tratamento de doenças, e, processo para a preparação de cocristal de selinexor
EP3962898A1 (fr) 2019-05-01 2022-03-09 Karyopharm Therapeutics, Inc. Procédé de préparation d'inhibiteurs de xpo1 et intermédiaires destinés à être utilisés dans la préparation d'inhibiteurs de xpo1
US20220218725A1 (en) * 2019-05-16 2022-07-14 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3808742A1 (fr) 2019-10-16 2021-04-21 Sandoz AG Polymorphe de selinexor
WO2022087218A1 (fr) 2020-10-21 2022-04-28 Karyopharm Therapeutics Inc. Forme cristalline de sélinexor
CN112679477B (zh) * 2020-12-17 2021-10-26 佛山奕安赛医药科技有限公司 塞利尼索及其中间体的制备方法
AU2022276509A1 (en) 2021-05-20 2023-12-07 Karyopharm Therapeutics Inc. Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
WO2023122014A1 (fr) * 2021-12-20 2023-06-29 Raytheon Technologies Corporation Amélioration de particules de composites à matrice céramique, son procédé de fabrication et articles la comprenant
CN116675677B (zh) * 2023-08-02 2023-09-26 中国林业科学研究院林产化学工业研究所 一种c8漆酚衍生物及其制备方法和应用

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SMT202000347T1 (it) 2012-05-09 2020-07-08 Biogen Ma Inc Modulatori di trasporto nucleare e loro usi
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Also Published As

Publication number Publication date
CN107072992B (zh) 2020-03-10
JP2020143144A (ja) 2020-09-10
NZ728850A (en) 2024-03-22
US20240208943A1 (en) 2024-06-27
AU2020203246A1 (en) 2020-06-04
AU2015301484B2 (en) 2020-02-20
ZA201700880B (en) 2020-01-29
AU2024202835B2 (en) 2026-07-09
WO2016025904A1 (fr) 2016-02-18
AU2021286266B2 (en) 2024-02-01
EP3180331A1 (fr) 2017-06-21
CA2957266A1 (fr) 2016-02-18
US11807629B2 (en) 2023-11-07
CN111484483B (zh) 2023-05-26
JP7218323B2 (ja) 2023-02-06
US11078190B2 (en) 2021-08-03
CN107072992A (zh) 2017-08-18
US12371420B2 (en) 2025-07-29
AU2021286266A1 (en) 2022-01-06
US20220135545A1 (en) 2022-05-05
US20230242516A1 (en) 2023-08-03
KR20170043561A (ko) 2017-04-21
JP7558310B2 (ja) 2024-09-30
JP6777626B2 (ja) 2020-10-28
US20260152489A1 (en) 2026-06-04
EP3180331B1 (fr) 2022-06-08
JP2017527549A (ja) 2017-09-21
KR102608259B1 (ko) 2023-11-29
US20200283419A1 (en) 2020-09-10
SG11201700789SA (en) 2017-02-27
AU2015301484A1 (en) 2017-03-02
MX2021014128A (es) 2022-01-04
CN111481553B (zh) 2023-09-01
SG10201808624VA (en) 2018-11-29
EA201790384A1 (ru) 2017-08-31
US10519139B2 (en) 2019-12-31
IL250328A0 (en) 2017-03-30
MA40254B1 (fr) 2022-09-30
DK3180331T3 (da) 2022-09-12
EP4112615A1 (fr) 2023-01-04
CN111484483A (zh) 2020-08-04
MX388170B (es) 2025-03-19
IL250328B (en) 2022-05-01
UA123535C2 (uk) 2021-04-21
US11753401B2 (en) 2023-09-12
US20230242517A1 (en) 2023-08-03
CN111481553A (zh) 2020-08-04
ES2926377T3 (es) 2022-10-25
US20180215733A1 (en) 2018-08-02
US11746102B2 (en) 2023-09-05
JP2023052622A (ja) 2023-04-11
AU2020203246B2 (en) 2021-09-16
AU2024202835A1 (en) 2024-05-23
CO2017001884A2 (es) 2017-07-19
MX2017002013A (es) 2017-05-12

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