MX2017002013A - Polimorfos de selinexor. - Google Patents
Polimorfos de selinexor.Info
- Publication number
- MX2017002013A MX2017002013A MX2017002013A MX2017002013A MX2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A
- Authority
- MX
- Mexico
- Prior art keywords
- structural formula
- crystalline forms
- compound
- compositions
- selinexor
- Prior art date
Links
- DEVSOMFAQLZNKR-RJRFIUFISA-N (z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-n'-pyrazin-2-ylprop-2-enehydrazide Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C2=NN(\C=C/C(=O)NNC=3N=CC=NC=3)C=N2)=C1 DEVSOMFAQLZNKR-RJRFIUFISA-N 0.000 title 1
- 229950010613 selinexor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 2
- 101100004408 Arabidopsis thaliana BIG gene Proteins 0.000 abstract 1
- 101100485279 Drosophila melanogaster emb gene Proteins 0.000 abstract 1
- 102100029095 Exportin-1 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101100485284 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CRM1 gene Proteins 0.000 abstract 1
- 101150094313 XPO1 gene Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108700002148 exportin 1 Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invencion se refiere a formas cristalinas del compuesto representado por la Formula estructural I y a composiciones que comprenden formas cristalinas del compuesto representado por la Formula estructural I descrita en la presente. Las formas cristalinas del compuesto de Formula estructural I y las composiciones que comprenden las formas cristalinas del compuesto de Formula estructural I proporcionadas en la presente, en particular, la Forma cristalina unica A, se pueden incorporar en composiciones farmaceuticas, las cuales se pueden utilizar para tratar varios trastornos asociados con la actividad de CRM1, incluido el cancer. En la presente tambien se describen metodos para preparar el compuesto de Formula estructural I y sus formas cristalinas unicas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038069P | 2014-08-15 | 2014-08-15 | |
| PCT/US2015/045395 WO2016025904A1 (en) | 2014-08-15 | 2015-08-14 | Polymorphs of selinexor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017002013A true MX2017002013A (es) | 2017-05-12 |
| MX388170B MX388170B (es) | 2025-03-19 |
Family
ID=53969460
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017002013A MX388170B (es) | 2014-08-15 | 2015-08-14 | Polimorfos de selinexor |
| MX2021014128A MX2021014128A (es) | 2014-08-15 | 2017-02-14 | Polimorfos de selinexor. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021014128A MX2021014128A (es) | 2014-08-15 | 2017-02-14 | Polimorfos de selinexor. |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US10519139B2 (es) |
| EP (2) | EP3180331B1 (es) |
| JP (3) | JP6777626B2 (es) |
| KR (1) | KR102608259B1 (es) |
| CN (3) | CN107072992B (es) |
| AU (4) | AU2015301484B2 (es) |
| CA (1) | CA2957266A1 (es) |
| CO (1) | CO2017001884A2 (es) |
| DK (1) | DK3180331T3 (es) |
| EA (1) | EA201790384A1 (es) |
| ES (1) | ES2926377T3 (es) |
| IL (1) | IL250328B (es) |
| MA (1) | MA40254B1 (es) |
| MX (2) | MX388170B (es) |
| SG (2) | SG10201808624VA (es) |
| UA (1) | UA123535C2 (es) |
| WO (1) | WO2016025904A1 (es) |
| ZA (1) | ZA201700880B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4234545A3 (en) | 2011-07-29 | 2023-09-06 | Karyopharm Therapeutics Inc. | Hydrazide containing nuclear transport modulators and uses thereof |
| WO2013170068A2 (en) | 2012-05-09 | 2013-11-14 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP2968278B8 (en) | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| ME03421B (me) | 2013-06-21 | 2020-01-20 | Karyopharm Therapeutics Inc | 1,2,4-triazoli kao modulatori nuklearnog transporta i njihova upotreba |
| KR102608259B1 (ko) | 2014-08-15 | 2023-11-29 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 셀리넥소의 다형태 |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| WO2017118940A1 (en) | 2016-01-08 | 2017-07-13 | Dr. Reddy's Laboratories Limited | Solid forms of selinexor and process for their preparation |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| EP3565813A1 (en) | 2017-01-05 | 2019-11-13 | Watson Laboratories, Inc. | Novel crystalline forms of selinexor and process for their preparation |
| CN106831731B (zh) * | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| WO2019232724A1 (en) | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| WO2020072008A1 (en) * | 2018-10-04 | 2020-04-09 | Deva Holding Anonim Sirketi | Novel solid dispersions of selinexor |
| BR112021016762A2 (pt) | 2019-03-20 | 2021-10-19 | Johnson Matthey Public Limited Company | Cocristal de selinexor, composição farmacêutica, método de tratamento de doenças, e, processo para a preparação de cocristal de selinexor |
| CN114040909B (zh) | 2019-05-01 | 2025-06-03 | 卡尔约药物治疗公司 | 用于制备xpo1抑制剂以及用于制备xp01抑制剂的中间体的方法 |
| WO2020232439A1 (en) * | 2019-05-16 | 2020-11-19 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3808742A1 (en) | 2019-10-16 | 2021-04-21 | Sandoz AG | Polymorph of selinexor |
| WO2022087218A1 (en) | 2020-10-21 | 2022-04-28 | Karyopharm Therapeutics Inc. | Crystalline form of selinexor |
| CN112679477B (zh) * | 2020-12-17 | 2021-10-26 | 佛山奕安赛医药科技有限公司 | 塞利尼索及其中间体的制备方法 |
| WO2023122014A1 (en) * | 2021-12-20 | 2023-06-29 | Raytheon Technologies Corporation | Particle enhancement of ceramic matrix composites, method of manufacture thereof and articles comprising the same |
| CN116675677B (zh) * | 2023-08-02 | 2023-09-26 | 中国林业科学研究院林产化学工业研究所 | 一种c8漆酚衍生物及其制备方法和应用 |
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-
2015
- 2015-08-14 KR KR1020177006680A patent/KR102608259B1/ko active Active
- 2015-08-14 EP EP15754099.8A patent/EP3180331B1/en active Active
- 2015-08-14 SG SG10201808624VA patent/SG10201808624VA/en unknown
- 2015-08-14 DK DK15754099.8T patent/DK3180331T3/da active
- 2015-08-14 EA EA201790384A patent/EA201790384A1/ru unknown
- 2015-08-14 MX MX2017002013A patent/MX388170B/es unknown
- 2015-08-14 WO PCT/US2015/045395 patent/WO2016025904A1/en not_active Ceased
- 2015-08-14 CA CA2957266A patent/CA2957266A1/en active Pending
- 2015-08-14 CN CN201580056017.1A patent/CN107072992B/zh active Active
- 2015-08-14 ES ES15754099T patent/ES2926377T3/es active Active
- 2015-08-14 UA UAA201702169A patent/UA123535C2/uk unknown
- 2015-08-14 AU AU2015301484A patent/AU2015301484B2/en active Active
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